期刊
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
卷 619, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfa.2021.126512
关键词
Chitosan oligosaccharide; Prodrug; Controlled release; Targeted tumor; Chemotherapy
资金
- Science and Technology Commission of Shanghai Municipality [16410723700]
- [81460647]
A self-assembled prodrug nanoparticle (HA-DOX@HA-CSO-g-OA), based on chitosan oligosaccharide, was developed to reduce the risk of non-targeting leakage during chemotherapy delivery. The nanoparticle exhibited enhanced tumor cell apoptosis in vitro, indicating its potential as a promising vehicle for targeted co-delivery of cancer chemotherapy.
The premature leakage of chemotherapeutics during delivery impedes drugs from entering tumor cells, which produces considerable side effects in normal organs. Herein, we describe a hydrophobic-hydrophilic balanced self-assembled prodrug nanoparticle (HA-DOX@HA-CSO-g-OA), formed via a facile synthesis based on chitosan oligosaccharide to reduce the non-targeting risk of premature leakage of chemotherapeutics during their delivery. The HA-DOX@HA-CSO-g-OA have a suitable size (similar to 186 nm) with a doxorubicin (DOX) loading of 9.88% and an oleanolic acid (OA) loading efficiency of 27.34%. The release of DOX or OA is pH-dependent and responds particularly well to the acidic tumor microenvironment. In vitro antitumor activity studies revealed that HA-DOX@HA-CSO-g-OA had enhanced performance in promoting tumor apoptosis and displayed significant anticancer effects compared to mono-delivery. In vitro cell studies showed that HA-functionalized nanoparticles could enhance the cellular uptake in tumor cells. Therefore, HA-DOX@HA-CSO-g-OA is a promising vehicle for CD44-targeted co-delivery of cancer chemotherapy, which deserves further evaluation.
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