Tuberous sclerosis complex as a model disease for developing new therapeutics for epilepsy
出版年份 2016 全文链接
标题
Tuberous sclerosis complex as a model disease for developing new therapeutics for epilepsy
作者
关键词
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出版物
Expert Review of Neurotherapeutics
Volume 16, Issue 4, Pages 437-447
出版商
Informa UK Limited
发表日期
2016-02-09
DOI
10.1586/14737175.2016.1151788
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Clinical Electroencephalographic Biomarker for Impending Epilepsy in Asymptomatic Tuberous Sclerosis Complex Infants
- (2016) Joyce Y. Wu et al. PEDIATRIC NEUROLOGY
- Somatic Mutations in theMTORgene cause focal cortical dysplasia type IIb
- (2015) Mitsuko Nakashima et al. ANNALS OF NEUROLOGY
- Familial focal epilepsy with focal cortical dysplasia due toDEPDC5mutations
- (2015) Stéphanie Baulac et al. ANNALS OF NEUROLOGY
- Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia
- (2015) Alissa M. D'Gama et al. ANNALS OF NEUROLOGY
- Intermittent dosing of rapamycin maintains antiepileptogenic effects in a mouse model of tuberous sclerosis complex
- (2015) Nicholas Rensing et al. EPILEPSIA
- Tuberous Sclerosis Complex
- (2015) Francis J. DiMario et al. PEDIATRIC CLINICS OF NORTH AMERICA
- Developmental brain abnormalities in tuberous sclerosis complex: A comparative tissue analysis of cortical tubers and perituberal cortex
- (2014) Véronique Ruppe et al. EPILEPSIA
- ILAE Official Report: A practical clinical definition of epilepsy
- (2014) Robert S. Fisher et al. EPILEPSIA
- Mammalian Target of Rapamycin Inhibitors for Intractable Epilepsy and Subependymal Giant Cell Astrocytomas in Tuberous Sclerosis Complex
- (2014) Michael Cardamone et al. JOURNAL OF PEDIATRICS
- The Neurology of mTOR
- (2014) Jonathan O. Lipton et al. NEURON
- Cardiovascular Manifestations of Tuberous Sclerosis Complex and Summary of the Revised Diagnostic Criteria and Surveillance and Management Recommendations From the International Tuberous Sclerosis Consensus Group
- (2014) Robert B. Hinton et al. Journal of the American Heart Association
- Everolimus treatment of refractory epilepsy in tuberous sclerosis complex
- (2013) Darcy A. Krueger et al. ANNALS OF NEUROLOGY
- A critical review of mTOR inhibitors and epilepsy: from basic science to clinical trials
- (2013) Michael Wong Expert Review of Neurotherapeutics
- Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial
- (2013) John J Bissler et al. LANCET
- Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction
- (2013) Ethan M. Goldberg et al. NATURE REVIEWS NEUROSCIENCE
- Vigabatrin Inhibits Seizures and mTOR Pathway Activation in a Mouse Model of Tuberous Sclerosis Complex
- (2013) Bo Zhang et al. PLoS One
- Rapamycin Attenuates the Development of Posttraumatic Epilepsy in a Mouse Model of Traumatic Brain Injury
- (2013) Dongjun Guo et al. PLoS One
- Rapamycin Prevents Seizures After Depletion of STRADA in a Rare Neurodevelopmental Disorder
- (2013) W. E. Parker et al. Science Translational Medicine
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- Identification of new epilepsy treatments: Issues in preclinical methodology
- (2012) Aristea S. Galanopoulou et al. EPILEPSIA
- Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation
- (2012) Erwin A. van Vliet et al. EPILEPSIA
- The differential effects of prenatal and/or postnatal rapamycin on neurodevelopmental defects and cognition in a neuroglial mouse model of tuberous sclerosis complex
- (2012) Sharon W. Way et al. HUMAN MOLECULAR GENETICS
- Electrocorticographic evidence of perituberal cortex epileptogenicity in tuberous sclerosis complex
- (2012) Tracy S. Ma et al. Journal of Neurosurgery-Pediatrics
- De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly
- (2012) Jeong Ho Lee et al. NATURE GENETICS
- Intrinsic epileptogenicity of cortical tubers revealed by intracranial EEG monitoring
- (2012) A. R. Mohamed et al. NEUROLOGY
- Somatic Activation of AKT3 Causes Hemispheric Developmental Brain Malformations
- (2012) Annapurna Poduri et al. NEURON
- Post-treatment with rapamycin does not prevent epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy
- (2012) Anna Sliwa et al. NEUROSCIENCE LETTERS
- The Interaction between Early Life Epilepsy and Autistic-Like Behavioral Consequences: A Role for the Mammalian Target of Rapamycin (mTOR) Pathway
- (2012) Delia M. Talos et al. PLoS One
- Mechanism of action of vigabatrin: correcting misperceptions
- (2011) E. Ben-Menachem ACTA NEUROLOGICA SCANDINAVICA
- Antiepileptic treatment before the onset of seizures reduces epilepsy severity and risk of mental retardation in infants with tuberous sclerosis complex
- (2011) Sergiusz Jóźwiak et al. EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
- Rapamycin Suppresses Mossy Fiber Sprouting But Not Seizure Frequency in a Mouse Model of Temporal Lobe Epilepsy
- (2011) P. S. Buckmaster et al. JOURNAL OF NEUROSCIENCE
- Mechanisms of epileptogenesis and potential treatment targets
- (2011) Asla Pitkänen et al. LANCET NEUROLOGY
- Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by rapamycin
- (2011) Robert P. Carson et al. NEUROBIOLOGY OF DISEASE
- Incidence of epilepsy: A systematic review and meta-analysis
- (2011) A. K. Ngugi et al. NEUROLOGY
- Efficacy and Safety of Sirolimus in Lymphangioleiomyomatosis
- (2011) Francis X. McCormack et al. NEW ENGLAND JOURNAL OF MEDICINE
- Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex
- (2011) J. Goto et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Analysis of TSC Cortical Tubers by Deep Sequencing of TSC1, TSC2 and KRAS Demonstrates that Small Second-Hit Mutations in these Genes are Rare Events
- (2010) Wei Qin et al. BRAIN PATHOLOGY
- Therapeutic approaches to epileptogenesis-Hope on the horizon
- (2010) Asla Pitkänen EPILEPSIA
- Estimation of the burden of active and life-time epilepsy: A meta-analytic approach
- (2010) Anthony K. Ngugi et al. EPILEPSIA
- mTOR: from growth signal integration to cancer, diabetes and ageing
- (2010) Roberto Zoncu et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy
- (2010) Xiaoxing Huang et al. NEUROBIOLOGY OF DISEASE
- Biallelic TSC gene inactivation in tuberous sclerosis complex
- (2010) P. B. Crino et al. NEUROLOGY
- Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis
- (2010) Darcy A. Krueger et al. NEW ENGLAND JOURNAL OF MEDICINE
- Prevention or Modification of Epileptogenesis after Brain Insults: Experimental Approaches and Translational Research
- (2010) W. Loscher et al. PHARMACOLOGICAL REVIEWS
- Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia
- (2009) M. C. Ljungberg et al. Disease Models & Mechanisms
- The impact of genetics on the classification of epilepsy syndromes
- (2009) Federico Zara et al. EPILEPSIA
- The natural history of epilepsy in tuberous sclerosis complex
- (2009) Catherine J. Chu-Shore et al. EPILEPSIA
- Drug treatment of epilepsy in the century of the ILAE: The second 50 years, 1959-2009
- (2009) Simon D. Shorvon EPILEPSIA
- The Mammalian Target of Rapamycin Signaling Pathway Mediates Epileptogenesis in a Model of Temporal Lobe Epilepsy
- (2009) L.-H. Zeng et al. JOURNAL OF NEUROSCIENCE
- Pharmacological Inhibition of mTORC1 Suppresses Anatomical, Cellular, and Behavioral Abnormalities in Neural-Specific Pten Knock-Out Mice
- (2009) J. Zhou et al. JOURNAL OF NEUROSCIENCE
- Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex
- (2008) Ling-Hui Zeng et al. ANNALS OF NEUROLOGY
- The global burden and stigma of epilepsy
- (2008) Hanneke M. de Boer et al. EPILEPSY & BEHAVIOR
- Clinical Presentation and Diagnosis of Tuberous Sclerosis Complex in Infancy
- (2008) Anita N. Datta et al. JOURNAL OF CHILD NEUROLOGY
- Response of a Neuronal Model of Tuberous Sclerosis to Mammalian Target of Rapamycin (mTOR) Inhibitors: Effects on mTORC1 and Akt Signaling Lead to Improved Survival and Function
- (2008) L. Meikle et al. JOURNAL OF NEUROSCIENCE
- Tuberous sclerosis
- (2008) Paolo Curatolo et al. LANCET
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