The NOP Receptor System in Neurological and Psychiatric Disorders: Discrepancies, Peculiarities and Clinical Progress in Developing Targeted Therapies

NOP receptor agonist attenuates nitroglycerin-induced migraine-like symptoms in mice

(2020) Katarzyna M. Targowska-Duda et al.   NEUROPHARMACOLOGY

Blockade of NOP receptor modulates anxiety-related behaviors in mice exposed to inescapable stress

(2020) Aldemara I. Silva et al.   PSYCHOPHARMACOLOGY

0502 Safety, Tolerability, and Efficacy of a Novel, Highly Potent and Selective Partial Agonist for Nociceptin/Orphanin-FQ Peptide (NOP) Receptors in Patients with Insomnia Disorder

(2020) M Zhou et al.   SLEEP

The Rewarding and Anxiolytic Properties of Ethanol within the Central Nucleus of the Amygdala: Mediated by Genetic Background and Nociceptin

(2020) Christopher P. Knight et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Fear expression is reduced after acute and repeated nociceptin/orphanin FQ (NOP) receptor antagonism in rats: therapeutic implications for traumatic stress exposure

(2020) Rachel M. Taylor et al.   PSYCHOPHARMACOLOGY

Effects of Cebranopadol on Cocaine-induced Hyperactivity and Cocaine Pharmacokinetics in Rats

(2020) Huimei Wei et al.   Scientific Reports

Differential modulation of ventral tegmental area circuits by the nociceptin/orphanin FQ system

(2020) Joseph R. Driscoll et al.   eNeuro

BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates

(2019) Norikazu Kiguchi et al.   BRITISH JOURNAL OF ANAESTHESIA

Nociceptin Receptors Upregulated in Cocaine Use Disorder: A Positron Emission Tomography Imaging Study Using [11C]NOP-1A

(2019) Rajesh Narendran et al.   AMERICAN JOURNAL OF PSYCHIATRY

Decreased Nociceptin Receptors Are Related to Resilience and Recovery in College Women Who Have Experienced Sexual Violence: Therapeutic Implications for Posttraumatic Stress Disorder

(2019) Rajesh Narendran et al.   BIOLOGICAL PSYCHIATRY

NOP Receptor Agonist Ro 64-6198 Decreases Escalation of Cocaine Self-Administration in Rats Genetically Selected for Alcohol Preference

(2019) Hongwu Li et al.   Frontiers in Psychiatry

A Paranigral VTA Nociceptin Circuit that Constrains Motivation for Reward

(2019) Kyle E. Parker et al.   CELL

Modulation of the NOP receptor signaling affects resilience to acute stress

(2019) Victor A D Holanda et al.   JOURNAL OF PSYCHOPHARMACOLOGY

NOP Receptor Antagonists Decrease Alcohol Drinking in the Dark in C57BL/6J Mice

(2019) Gloria Brunori et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

A Novel and Selective Nociceptin Receptor (NOP) Agonist (1-(1-((cis)-4-isopropylcyclohexyl)piperidin-4-yl)-1H-indol-2-yl)methanol (AT-312) Decreases Acquisition of Ethanol-Induced Conditioned Place Preference in Mice

(2018) Nurulain T. Zaveri et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Analysis of the distribution of spinal NOP receptors in a chronic pain model using NOP-eGFP knock-in mice

(2018) Akihiko Ozawa et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nociceptin/orphanin FQ opioid peptide (NOP) receptor and µ-opioid peptide (MOP) receptors both contribute to the anti-hypersensitive effect of cebranopadol in a rat model of arthritic pain

(2018) Klaus Schiene et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

ORL1 Activation Mediates a Novel ORL1 Receptor Agonist SCH221510 Analgesia in Neuropathic Pain in Rats

(2018) Qiang Wu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

NOP agonists prevent the antidepressant-like effects of nortriptyline and fluoxetine but not R-ketamine

(2018) Victor A. D. Holanda et al.   PSYCHOPHARMACOLOGY

A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates

(2018) Huiping Ding et al.   Science Translational Medicine

The Nociceptin Receptor (NOP) Agonist AT-312 Blocks Acquisition of Morphine- and Cocaine-Induced Conditioned Place Preference in Mice

(2018) Nurulain T. Zaveri et al.   Frontiers in Psychiatry

Cebranopadol, a novel first-in-class analgesic drug candidate

(2017) Annette Christoph et al.   PAIN

Antihyperalgesic, Antiallodynic, and Antinociceptive Effects of Cebranopadol, a Novel Potent Nociceptin/Orphanin FQ and Opioid Receptor Agonist, after Peripheral and Central Administration in Rodent Models of Neuropathic Pain

(2017) Thomas M. Tzschentke et al.   Pain Practice

Nociceptin Receptors in Alcohol Use Disorders: A Positron Emission Tomography Study Using [11C]NOP-1A

(2017) Rajesh Narendran et al.   BIOLOGICAL PSYCHIATRY

A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models

(2016) Linda M. Rorick-Kehn et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Proof-of-Concept Study to Assess the Nociceptin Receptor Antagonist LY2940094 as a New Treatment for Alcohol Dependence

(2016) Anke Post et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Genetic Deletion of the Nociceptin/Orphanin FQ Receptor in the Rat Confers Resilience to the Development of Drug Addiction

(2016) Marsida Kallupi et al.   NEUROPSYCHOPHARMACOLOGY

A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates

(2016) Huiping Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The nociceptin/orphanin FQ receptor agonist SR-8993 as a candidate therapeutic for alcohol use disorders: validation in rat models

(2016) Abdul Maruf Asif Aziz et al.   PSYCHOPHARMACOLOGY

A key role for the N/OFQ-NOP receptor system in modulating nicotine taking in a model of nicotine and alcohol co-administration

(2016) Andrea Cippitelli et al.   Scientific Reports

A selective small molecule NOP (ORL-1 receptor) partial agonist for the treatment of anxiety

(2015) Tina Morgan Ross et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mechanical hyperalgesia in rats with diabetic polyneuropathy is selectively inhibited by local peripheral nociceptin/orphanin FQ receptor and µ-opioid receptor agonism

(2015) Klaus Schiene et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Knock-In Mice with NOP-eGFP Receptors Identify Receptor Cellular and Regional Localization

(2015) Akihiko Ozawa et al.   JOURNAL OF NEUROSCIENCE

A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies

(2015) Anke Post et al.   NEUROPSYCHOPHARMACOLOGY

MT-7716, a potent NOP receptor agonist, preferentially reduces ethanol seeking and reinforcement in post-dependent rats

(2014) Giordano de Guglielmo et al.   ADDICTION BIOLOGY

Nociceptin/orphanin FQ peptide receptor antagonist JTC-801 reverses pain and anxiety symptoms in a rat model of post-traumatic stress disorder

(2014) Y Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

BU08073 a buprenorphine analogue with partial agonist activity at μ-receptorsin vitrobut long-lasting opioid antagonist activityin vivoin mice

(2014) T V Khroyan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Challenges for opioid receptor nomenclature: IUPHAR Review 9

(2014) Brian M Cox et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of the NOP agonist SCH221510 on producing and attenuating reinforcing effects as measured by drug self-administration in rats

(2014) Devki D. Sukhtankar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Restraint Stress Alters Nociceptin/Orphanin FQ and CRF Systems in the Rat Central Amygdala: Significance for Anxiety-Like Behaviors

(2014) R. Ciccocioppo et al.   JOURNAL OF NEUROSCIENCE

Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn

(2014) Rita Bardoni et al.   NEURON

Acute and subchronic treatments with selective serotonin reuptake inhibitors increase Nociceptin/Orphanin FQ (NOP) receptor density in the rat dorsal raphe nucleus; interactions between nociceptin/NOP system and serotonin

(2013) Erwan Le Maître et al.   BRAIN RESEARCH

Genetic identification of C fibres that detect massage-like stroking of hairy skin in vivo

(2013) Sophia Vrontou et al.   NATURE

The Sensory Neurons of Touch

(2013) Victoria E. Abraira et al.   NEURON

Differential effects of opioid-related ligands and NSAIDs in nonhuman primate models of acute and inflammatory pain

(2013) Devki D. Sukhtankar et al.   PSYCHOPHARMACOLOGY

Amygdala-Dependent Fear Is Regulated by Oprl1 in Mice and Humans with PTSD

(2013) R. Andero et al.   Science Translational Medicine

Rodent motor and neuropsychological behaviour measured in home cages using the integrated modular platform SmartCage™

(2012) Taline V Khroyan et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Retrodialysis of N/OFQ into the nucleus accumbens shell blocks cocaine-induced increases in extracellular dopamine and locomotor activity

(2012) Jacqueline Vazquez-DeRose et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Structure of the δ-opioid receptor bound to naltrindole

(2012) Sébastien Granier et al.   NATURE

Structure of the human κ-opioid receptor in complex with JDTic

(2012) Huixian Wu et al.   NATURE

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic

(2012) Aaron A. Thompson et al.   NATURE

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

(2012) Aashish Manglik et al.   NATURE

The First Universal Opioid Ligand, (2S)-2-[(5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylpentan-2-ol (BU08028): Characterization of the In Vitro Profile and In Vivo Behavioral Effects in Mouse Models of Acute Pain and Cocaine-Induced Reward

(2010) T. V. Khroyan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Nociceptin/orphanin FQ receptor knockout rats: In vitro and in vivo studies

(2010) Anna Rizzi et al.   NEUROPHARMACOLOGY

Dissociation of the Opioid Receptor Mechanisms that Control Mechanical and Heat Pain

(2009) Grégory Scherrer et al.   CELL

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Novel Non-Peptide Nociceptin/Orphanin FQ Receptor Agonist, 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole: Design, Synthesis, and Structure−Activity Relationship of Oral Receptor Occupancy in the Brain for Orally Potent Antianxiety Drug(1, 2)

(2009) Shigeo Hayashi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nociceptin/Orphanin FQ Receptor Activation Attenuates Antinociception Induced by Mixed Nociceptin/Orphanin FQ/ -Opioid Receptor Agonists

(2009) T. V. Khroyan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Comparison of the Antinociceptive and Antirewarding Profiles of Novel Bifunctional Nociceptin Receptor/ -Opioid Receptor Ligands: Implications for Therapeutic Applications

(2009) L. Toll et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Efficacy of a NOP1 Agonist (SCH486757) in Subacute Cough

(2009) Ashley Woodcock et al.   LUNG

Behavioral Effects of a Synthetic Agonist Selective for Nociceptin/Orphanin FQ Peptide Receptors in Monkeys

(2009) Mei-Chuan Ko et al.   NEUROPSYCHOPHARMACOLOGY

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli

(2009) D. J. Cavanaugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysregulation of Nociceptin/Orphanin FQ Activity in the Amygdala Is Linked to Excessive Alcohol Drinking in the Rat

(2008) Daina Economidou et al.   BIOLOGICAL PSYCHIATRY

Anxiolytic- and antidepressant-like activities of H-Dmt-Tic-NH-CH(CH2-COOH)-Bid (UFP-512), a novel selective delta opioid receptor agonist

(2007) Raffaella Vergura et al.   PEPTIDES