Article
Psychiatry
Nicolas Hoertel, Marina Sanchez-Rico, Erich Gulbins, Johannes Kornhuber, Alexander Carpinteiro, Miriam Abellan, Pedro de la Muela, Raphael Vernet, Nathanael Beeker, Antoine Neuraz, Aude Delcuze, Jesus M. Alvarado, Celine Cougoule, Pierre Meneton, Frederic Limosin
Summary: The study found that the use of FIASMA psychotropic medications may reduce the risk of intubation or death in COVID-19 patients. Especially, patients taking FIASMA antidepressants have a lower risk compared to those taking non-FIASMA antidepressants. These findings are important for further evaluating the effectiveness of FIASMA medications against COVID-19.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Nicolas Hoertel, Marina Sanchez-Rico, Raphael Vernet, Nathanael Beeker, Anne-Sophie Jannot, Antoine Neuraz, Elisa Salamanca, Nicolas Paris, Christel Daniel, Alexandre Gramfort, Guillaume Lemaitre, Melodie Bernaux, Ali Bellamine, Cedric Lemogne, Guillaume Airagnes, Anita Burgun, Frederic Limosin
Summary: This study suggests that the use of antidepressants in patients hospitalized for COVID-19 may be associated with a lower risk of death or intubation. Antidepressants such as fluoxetine, paroxetine, escitalopram, venlafaxine, and mirtazapine showed significant associations with reduced risk. Further research in the form of double-blind controlled randomized clinical trials is recommended.
MOLECULAR PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Marina Sanchez-Rico, Frederic Limosin, Raphael Vernet, Nathanael Beeker, Antoine Neuraz, Carlos Blanco, Mark Olfson, Cedric Lemogne, Pierre Meneton, Christel Daniel, Nicolas Paris, Alexandre Gramfort, Guillaume Lemaitre, Pedro de la Muela, Elisa Salamanca, Melodie Bernaux, Ali Bellamine, Anita Burgun, Nicolas Hoertel
Summary: In a multicenter observational study, the use of the FIASMA hydroxyzine was associated with reduced mortality in patients hospitalized for COVID-19. Further research, including double-blind placebo-controlled randomized clinical trials, is needed to confirm these results and explore the potential use of hydroxyzine for outpatients and as post-exposure prophylaxis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Marina Sanchez-Rico, Pedro de la Muela, Juan J. Herrera-Morueco, Pierre A. Geoffroy, Frederic Limosin, Nicolas Hoertel
Summary: This multicenter retrospective observational study involving 58,562 adult patients hospitalized for COVID-19 found that melatonin use at a mean daily dose of 2.6 mg was not associated with reduced mortality.
JOURNAL OF TRAVEL MEDICINE
(2022)
Article
Medicine, General & Internal
Saleh Al-Muhsen, Nouf S. Al-Numair, Narjes Saheb Sharif-Askari, Roaa Basamh, Banan Alyounes, Amjad Jabaan, Fatemeh Saheb Sharif-Askari, Mohammed F. Alosaimi, Fahad Alsohime, Rabih Halwani, Haya Al-Saud
Summary: In moderate and severe COVID-19 patients, favipiravir does not appear to have a significant impact on reducing hospital stay length and in-hospital mortality. In fact, the use of favipiravir is associated with longer hospital stays and higher mortality rates.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Antonella D'Arminio Monforte, Alessandro Tavelli, Sara De Benedittis, Francesca Bai, Camilla Tincati, Lidia Gazzola, Ottavia Vigano, Marina Allegrini, Debora Mondatore, Daniele Tesoro, Diletta Barbanotti, Giovanni Mule, Roberto Castoldi, Anna De Bona, Teresa Bini, Davide Chiumello, Stefano Centanni, Sabrina Passarella, Nicola Orfeo, Giulia Marchetti, Alessandro Cozzi-Lepri
Summary: This observational study examined the protective effect of vaccination against progression after hospital admission for COVID-19. The results showed that fully vaccinated individuals had a 50% reduced risk of in-hospital death and mechanical ventilation/death compared to unvaccinated individuals.
Article
Genetics & Heredity
Louise Malle, Cynthia Gao, Chin Hur, Han Q. Truong, Nicole M. Bouvier, Bethany Percha, Xiao-Fei Kong, Dusan Bogunovic
Summary: This study analyzed individuals with Down syndrome who were hospitalized with COVID-19 in New York City and found that they were on average ten years younger than non-DS patients and had more severe disease, particularly with an increased incidence of sepsis and mechanical ventilation. Special care should be considered for both the prevention and treatment of COVID-19 in these patients.
GENETICS IN MEDICINE
(2021)
Article
Immunology
Cristiane de Freitas Paganoti, Rafaela Alkmin da Costa, Aris T. Papageorghiou, Fabricio da Silva Costa, Silvana Maria Quintana, Luciana Graziela de Godoi, Nataly Adriana Jimenez Monroy, Agatha Sacramento Rodrigues, Rossana Pulcineli Vieira Francisco
Summary: This study found that COVID-19 vaccination plays an important role in reducing the severity of COVID-19 infection among hospitalized pregnant and postpartum women, reducing the risk of intensive care unit admission, intubation, and death.
Article
Anesthesiology
Edwin Seet, Frances Chung, Chew Yin Wang, Stanley Tam, Chandra M. Kumar, Chalani U. Ubeynarayana, Carolyn C. Yim, Eleanor F. F. Chew, Carmen K. M. Lam, Benny C. P. Cheng, Matthew T. V. Chan
Summary: This study aimed to examine the association between obstructive sleep apnea (OSA) and difficult intubation or difficult mask ventilation, as well as explore the utility of the STOP-Bang score for difficult airway prediction. Results showed that moderate and severe OSA were associated with difficult intubation, while increasing neck circumference was associated with difficult mask ventilation.
ANESTHESIA AND ANALGESIA
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Augustin Lecler, Francois Cotton, Francois Lersy, Stephane Kremer, Francoise Heran
Summary: Among severe COVID-19 patients, approximately 7% exhibited abnormal nodules in the eyes on MRI imaging, which could lead to ophthalmological manifestations.
Article
Critical Care Medicine
Prasanth Balasubramanian, Shahin Isha, Abby J. Hanson, Anna Jenkins, Parthkumar Satashia, Arvind Balavenkataraman, Ivan A. Huespe, Vikas Bansal, Sean M. Caples, Syed Anjum Khan, Nitesh K. Jain, Rahul Kashyap, Rodrigo Cartin-Ceba, Joseph L. Nates, Dereddi R. S. Reddy, Ricardo Diaz Milian, Houssam Farres, Archer K. Martin, Parag C. Patel, Michael A. Smith, Anna B. Shapiro, Anirban Bhattacharyya, Sanjay Chaudhary, Sean P. Kiley, Quintin J. Quinones, Neal M. Patel, Pramod K. Guru, Pablo Moreno Franco, Devang K. Sanghavi
Summary: This study aims to evaluate the association between estimated plasma volume and plasma volume status on admission with outcomes in COVID-19-related acute respiratory distress syndrome patients. A retrospective multi-center study was conducted on COVID-19-related ARDS patients admitted to the Mayo Clinic Enterprise health system. Plasma volume was calculated using formulae for estimated plasma volume and plasma volume status, and these variables were analyzed for correlation with patient outcomes.
JOURNAL OF CRITICAL CARE
(2023)
Article
Medicine, General & Internal
Mitsuru Ichii, Masafumi Kurajoh, Yujiro Okute, Yasutaka Ihara, Takumi Imai, Tomoaki Morioka, Katsuhito Mori, Tetsuo Shoji, Yoshihiro Tsujimoto, Takanobu Ubai, Masanori Emoto
Summary: This retrospective observational study investigated the association between vaccination status and severe COVID-19 progression in 100 dialysis patients. The results showed that fully vaccinated patients had a significantly lower rate of progression to severe COVID-19.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Nicholas S. Hendren, James A. de Lemos, Colby Ayers, Sandeep R. Das, Anjali Rao, Spencer Carter, Anna Rosenblatt, Jason Walchok, Wally Omar, Rohan Khera, Anita A. Hegde, Mark H. Drazner, Ian J. Neeland, Justin L. Grodin
Summary: This study found that obese patients are more likely to be hospitalized with COVID-19, and are at higher risk of in-hospital death or mechanical ventilation, particularly if young (age <= 50 years). Additionally, obese patients are also at higher risk for venous thromboembolism and dialysis. These observations support clear public health messaging and rigorous adherence to COVID-19 prevention strategies in all obese individuals regardless of age.
Article
Gastroenterology & Hepatology
Linda C. Cummings, Chen Liang, Edward J. Mascha, Leif Saager, Zachary L. Smith, Sekar Bhavani, John J. Vargo, Kenneth C. Cummings
Summary: This study compared the effects of general anesthesia and sedation without planned intubation on the incidence of hypoxemia and hypotension during ERCP and explored risk factors for the conversion from sedation without planned intubation to general anesthesia. The results showed that general anesthesia was associated with a lower incidence of hypoxemia, while sedation without planned intubation was associated with a lower incidence of hypotension. However, neither approach showed a clear advantage in the combined incidence of hypoxemia and hypotension.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Immunology
Assim A. Alfadda, Khalid Siddiqui, Mohamed Rafiullah, Mohammad AlKhowaiter, Naif Alotaibi, Musa Alzahrani, Khalifa Binkhamis, Amira M. Youssef, Haifa Altalhi, Ibrahim Almaghlouth, Mohammed Alarifi, Saleh Albanyan, Mohammed F. Alosaimi, Arthur Isnani, Shaik S. Nawaz, Khalid Alayed
Summary: This study aimed to compare the early cytokine profile of mild and severe COVID-19 patients, as well as those with COVID-19-like symptoms but tested negative by RT-PCR. The results showed significantly elevated levels of CRP and IL-10 in the RT-PCR positive group, higher CRP and VEGF levels and lower IL-4 levels in severe cases. Elevated levels of IFN-γ and IL-10 were observed in mild cases, while MCP-1 levels were elevated in severe cases, categorized by length of hospital stay.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Clinical Neurology
Margaux Chene, Marina Sanchez-Rico, Carlos Blanco, Rachel Pascal De Raykeer, Cecile Hanon, Pierre Vandel, Frederic Limosin, Nicolas Hoertel
Summary: In older adults with major psychiatric disorders, all psychiatric symptoms are associated with increased mortality, mainly through a general psychopathology dimension. No BPRS item or lower order factor has a significant effect on mortality beyond the general psychopathology factor. Greater number of medical conditions, older age, male sex, and being hospitalized or institutionalized at baseline are significantly associated with this increased risk, independently from the general psychopathology factor.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Gastroenterology & Hepatology
Elise Payen, Antoine Neuraz, Letizia Zenzeri, Cecile Talbotec, Elie Abi Nader, Lucienne Chatenoud, Stephanie Chhun, Olivier Goulet, Frank M. Ruemmele, Benedicte Pigneur
Summary: The study found that early use of Adalimumab (ADA) in pediatric Crohn's disease patients can effectively maintain remission, especially when used as monotherapy.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2023)
Article
Infectious Diseases
Guillaume Martin-Blondel, Anne-Genevieve Marcelin, Cathia Soulie, Sofia Kaisaridi, Clovis Lusivika-Nzinga, Karen Zafilaza, Celine Dorival, Laura Nailler, Anais Boston, Anne-Marie Ronchetti, Clea Melenotte, Andre Cabie, Christophe Choquet, Albert Trinh-Duc, Karine Lacombe, Geraldine Gaube, Francois Coustilleres, Valerie Pourcher, Jean-Philippe Martellosio, Nathan Peiffer-Smadja, Marie Chauveau, Pierre Housset, Lionel Piroth, Mathilde Devaux, Gilles Pialoux, Aurelie Martin, Vincent Dubee, Jerome Frey, Audrey Le Bot, Charles Cazanave, Philippe Petua, Roland Liblau, Fabrice Carrat, Youri Yordanov
Summary: This study compared the clinical and virological outcomes in Omicron BA.1 and BA.2-infected patients who received sotrovimab and nirmatrelvir for the prevention of severe COVID-19. The results showed that early administration of nirmatrelvir was associated with faster viral clearance compared to sotrovimab, which may contribute to reducing transmission and preventing viral resistance.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Cardiac & Cardiovascular Systems
Levi-Dan Azoulay, Marine Bravetti, Fleur Cohen-Aubart, Jean-Francois Emile, Danielle Seilhean, Isabelle Plu, Frederic Charlotte, Xavier Waintraub, Fabrice Carrat, Zahir Amoura, Philippe Cluzel, Julien Haroche
Summary: This study investigated the prevalence and clinical features of cardiac involvement in Erdheim-Chester disease (ECD). It found that nearly half of the patients had cardiac involvement, which was associated with BRAFV600E mutation and complications (pericarditis, cardiac tamponade, and conduction disorders), but not with lower survival.
EUROPEAN HEART JOURNAL
(2023)
Letter
Dermatology
Eve Zakine, Loula Papageorgiou, Rim Bourguiba, Arsene Mekinian, Benjamin Terrier, Olivier Kosmider, Pierre Hirsch, Marie Jachiet, Sylvain Audia, Samuel Ardois, Leopold Adelaide, Adrien Bigot, Paul Duriez, Jean-Francois Emile, Estibaliz Lazaro, Damien Fayard, Joris Galland, Miguel Hie, Sebastien Humbert, Alexis Jean, Marie Kostine, Valentin Lacombe, Guillaume Le Guenno, Herve Lobbes, Nadine Magy-Bertrand, Paola Marianetti-Guingel, Alexis Mathian, Roderau Outh, Clemence Saillard, Maxime Samson, Guillaume Vial, Jean-David Bouaziz, Philippe Moguelet, Francois Chasset
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Laurent Lam, Helene Fontaine, Nathanael Lapidus, Jonathan Bellet, Clovis Lusivika-Nzinga, Jerome Nicol, Celine Dorival, Carole Cagnot, Gilles Hejblum, Stanislas Pol, Marc Bourliere, Fabrice Carrat, NRS AFEF HEPATHER Std Grp
Summary: This study evaluated the validity of algorithms for identifying patients with chronic HBV or HCV infection. The results showed that multi-criteria algorithms perform well in identifying these patients and can be used to estimate the public health burden associated with hepatitis B and C in France.
JOURNAL OF VIRAL HEPATITIS
(2023)
Article
Surgery
Claire Rives-Lange, Tigran Poghosyan, Aurelie Phan, Alexis Van Straaten, Yannick Girardeau, Jacky Nizard, Delphine Mitanchez, Cecile Ciangura, Muriel Coupaye, Claire Carette, Sebastien Czernichow, Anne-Sophie Jannot
Summary: Metabolic and bariatric surgery (MBS) is the most efficient therapeutic option for severe obesity. However, the scientific literature lacks high-quality data on the impact of MBS on obstetric, neonatal, and child outcomes. This study found an increased rate of small-for-gestational-age neonates and a decreased rate of large-for-gestational-age neonates after MBS. Additionally, MBS was associated with a lower risk of gestational hypertension and gestational diabetes for the mother, as well as a decrease in birth injuries, febrile convulsions, viral intestinal infections, and carbohydrate metabolism disorders in newborns. However, there was an elevated risk of respiratory failure associated with bronchiolitis after MBS.
Letter
Rheumatology
Marie Pean de Ponfilly-Sotier, Thibault Mahevas, Sebastien Riviere, Azeddine Dellal, Nabil Belfeki, Fabrice Carrat, Olivier Fain, Arsene Mekinian
Article
Gastroenterology & Hepatology
Clemence Moreau, Marine Roux, Jeremie Riou, Clemence M. Canivet, Etienne Audureau, Clovis Lusivika-Nzinga, Pierre Nahon, Fabrice Carrat, Jerome Boursier
Summary: This study aimed to evaluate whether the dynamics of multiple measurements of simple parameters after sustained viral response (SVR) enable the development of a personalized prediction of prognosis in patients with hepatitis C virus (HCV) chronic infection. The study found that FIB4 was a biomarker associated with liver-related complications (LRC) occurrence after SVR. The results suggest that dynamic modeling using repeated measurements of simple parameters predicts the individual residual risk of LRC and improves personalized medicine after SVR in HCV patients.
JOURNAL OF VIRAL HEPATITIS
(2023)
Article
Biochemistry & Molecular Biology
Bruce J. Kirenga, Levicatus Mugenyi, Marina Sanchez-Rico, Henry Kyobe, Winters Muttamba, Raymond Mugume, Eliya Mwesigwa, Ezra Kalimo, Vicky Nyombi, Ivan Segawa, Loryndah Olive Namakula, Rogers Sekibira, Wilberforce Kabweru, Rosemary Byanyima, Hellen Aanyu, Pauline Byakika-Kibwika, Henry G. Mwebesa, Nicolas Hoertel, William Bazeyo
Summary: Prior research suggests that fluvoxamine, an SSRI used for mental disorders, may be effective against COVID-19. This study found that fluvoxamine was associated with reduced mortality and increased symptom resolution in inpatients with COVID-19. However, further research is needed to confirm these findings and assess potential side effects.
MOLECULAR PSYCHIATRY
(2023)
Article
Chemistry, Medicinal
Nicolas Hoertel, Katayoun Rezaei, Marina Sanchez-Rico, Alfonso Delgado-Alvarez, Johannes Kornhuber, Erich Gulbins, Mark Olfson, Charles Ouazana-Vedrines, Alexander Carpinteiro, Celine Cougoule, Katrin Anne Becker, Jesus M. Alvarado, Frederic Limosin
Summary: The study suggests that the use of medications inhibiting acid sphingomyelinase (FIASMA) can reduce the risk of mortality in patients with SARS-CoV-2 infection. The multicenter retrospective observational study included 72,105 adult patients and found a significant association between FIASMA medication use and reduced 28-day mortality risk.
Article
Neurosciences
Nicolas Hoertel, Marina Sanchez-Rico, Pedro de la Muela, Miriam Abellan, Carlos Blanco, Marion Leboyer, Celine Cougoule, Erich Gulbins, Johannes Kornhuber, Alexander Carpinteiro, Katrin Anne Becker, Raphael Vernet, Nathanael Beeker, Antoine Neuraz, Jesus M. Alvarado, Juan Jose Herrera-Morueco, Guillaume Airagnes, Cedric Lemogne, Frederic Limosin
Summary: A retrospective cohort study found that psychiatric disorders are associated with an increased risk of COVID-19-related mortality, which may be explained by the higher prevalence of medical risk factors in this population rather than the psychiatric disorders themselves. These findings are important for understanding the factors influencing the risk of death in COVID-19 patients.
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE
(2023)
Letter
Pharmacology & Pharmacy
Marina Sanchez-Rico, Katayoun Rezaei, Eric J. Lenze, Frederic Limosin, Nicolas Hoertel
ANNALS OF PHARMACOTHERAPY
(2023)
Article
Psychiatry
Marina Sanchez-Rico, Katayoun Rezaei, Alfonso Delgado-Alvarez, Frederic Limosin, Nicolas Hoertel, Jesus M. Alvarado
Summary: Psychiatric and non-psychiatric comorbidity may be associated with increased 28-day mortality among patients with psychiatric disorders and COVID-19, with the exception of a lower risk of death observed in patients with mood disorders.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2023)