Article
Nutrition & Dietetics
Tomasz Dzierianowski, Jacek Sobocki
Summary: Home parenteral nutrition (HPN) may improve survival in patients with malignant bowel obstruction, but certain clinical and laboratory markers need to be considered to accurately select patients who would benefit from HPN. Discontinuation of chemotherapy, anemia, severe hypoalbuminemia, and water retention may be correlated with shorter survival and in these cases, routine initiation of HPN may not be beneficial. The decision to initiate HPN should be made in conjunction with continuing or beginning chemotherapy.
Article
Nutrition & Dietetics
Loris Pironi, Kurt Boeykens, Federico Bozzetti, Francisca Joly, Stanislaw Klek, Simon Lal, Marek Lichota, Stefan Muehlebach, Andre Van Gossum, Geert Wanten, Carolyn Wheatley, Stephan C. Bischoff
Summary: This guideline provides information and recommendations for healthcare professionals and patients on appropriate and safe home parenteral nutrition (HPN) provision. It is based on previous guidelines and includes 71 recommendations covering various aspects of HPN. The evidence was evaluated and clinical recommendations were developed using the Scottish Intercollegiate Guidelines Network methodology. The guideline was commissioned and supported by ESPEN.
CLINICAL NUTRITION
(2023)
Review
Nutrition & Dietetics
Dominique S. V. M. Clement, Sarah E. Brown, Mani Naghibi, Sheldon C. Cooper, Margot E. T. Tesselaar, Monique E. van Leerdam, John K. Ramage, Rajaventhan Srirajaskanthan
Summary: Maintaining adequate nutrition is a challenge for small bowel neuroendocrine tumour (NETs) patients. Surgical resection may cause short bowel syndrome (SBS), while without surgical resection there is a risk of ischemia or inoperable malignant bowel obstruction (IMBO). This systematic review shows the feasibility of HPN in NETs patients with intestinal failure (IF), with a reasonable 1-year survival rate and low complication rate.
Review
Nutrition & Dietetics
John K. DiBaise, James S. Scolapio
Summary: This article highlights the importance of home parenteral and enteral nutrition in clinical nutrition and the development of these therapies to support patients. It emphasizes the need for healthcare providers to understand all aspects of HPEN in order to provide safe, effective, and cost-effective support to patients.
Article
Gastroenterology & Hepatology
Mariana Ferreira, Paula Guerra, Cristina Ferreras, Maria do Ceu Espinheira, Eunice Trindade, Jorge Amil Dias
Summary: By comparing individually tailored prescriptions with available commercial PN formulations, it was found that adjustments in home PN are more effective for long term use in pediatric patients, while standard PN solutions may be appropriate for a larger proportion of patients in short term use.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Medicine, General & Internal
Dayoung Ko, Hee-Beom Yang, Joong Youn, Hyun-Young Kim
Summary: A study of 66 pediatric CIPO patients revealed a higher proportion of early-onset CIPO and patients with urologic symptoms, as well as a majority of cases with generalized involvement. Factors such as duration of PN, PN use, and home management were found to impact outcomes, while mortality was associated with pathologic type.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Toshiyuki Sato, Motoi Uchino, Jiro Takeuchi, Yutaro Fujihira, Kazuma Shimizu, Keiko Yokoyama, Soichi Yagi, Koji Kaku, Yusuke Takashima, Maiko Ikenouchi, Kentaro Kojima, Mikio Kawai, Kazuko Nagase, Koji Kamikozuru, Yoko Yokoyama, Tetsuya Takagawa, Hiroki Ikeuchi, Kenji Watanabe, Shinichiro Shinzaki
Summary: This study investigated the short-term effects of TED on CD patients with SBS-IF and found that TED significantly reduced the need for parenteral support. Some patients were able to successfully discontinue home parenteral support after using TED.
CLINICAL NUTRITION
(2023)
Article
Surgery
Savas T. Tsikis, Scott C. Fligor, Thomas I. Hirsch, Paul D. Mitchell, Amy Pan, Kamila Moskowitzova, Ashlyn E. Whitlock, Greta Loring, Eric First, Arthur Nedder, Kathleen M. Gura, Mark Puder
Summary: In a porcine model of short bowel syndrome with intestinal failure, the use of an immobilized lipase cartridge (ILC) in conjunction with enteral feeding reduced parenteral nutrition (PN) dependence, improved nutrient absorption, and increased bowel growth.
Article
Nutrition & Dietetics
Stephan C. Bischoff, Peter Austin, Kurt Boeykens, Michael Chourdakis, Cristina Cuerda, Cora Jonkers-Schuitema, Marek Lichota, Ibolya Nyulasi, Stephane M. Schneider, Zeno Stanga, Loris Pironi
Summary: This practical guideline by ESPEN provides concise information on the indications, contraindications, implementation, and monitoring of home enteral nutrition (HEN). It also serves as a resource for patients in need of HEN.
CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Loris Pironi, Cristina Cuerda, Palle Bekker Jeppesen, Francisca Joly, Cora Jonkers, Zeljko Krznaric, Simon Lal, Georg Lamprecht, Marek Lichota, Manpreet S. Mundi, Stephane Michel Schneider, Kinga Szczepanek, Andre Van Gossum, Geert Wanten, Carolyn Wheatley, Arved Weimann
Summary: ESPEN has published guidelines for Chronic Intestinal Failure (CIF) in adults and has now updated the guidelines specifically for CIF caused by benign diseases. The new guidelines include new evidence and provide recommendations on various topics such as IF centers, chronic enterocutaneous fistulas, caring for CIF patients during pregnancy, and transition of patients from pediatric to adult centers.
CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Lucas Wauters, Solene Dermine, Brune de Dreuille, Joanna Bettolo, Coralie Hutinet, Ashiq Mohamed, Emilie Lecoq, Lore Billiauws, Alexandre Nuzzo, Olivier Corcos, Francisca Joly
Summary: This study investigated the differences in outcomes after weaning off intravenous support in adult patients with chronic intestinal failure. Nutritional and functional markers were assessed, and it was found that malnutrition and reduced muscle mass were common in these patients. Treatment with teduglutide was effective in preventing these complications.
Article
Nutrition & Dietetics
Olivier Goulet, Anne Breton, Marie-Edith Coste, Beatrice Dubern, Emmanuelle Ecochard-Dugelay, Dominique Guimber, Irene Loras-Duclaux, Elie Abi Nader, Evelyne Marinier, Noel Peretti, Cecile Lambe
Summary: In France, the number of children enrolled in a HPN program continuously increased over a 6 years period. Short bowel syndrome (SBS) is the leading cause of CIF requiring HPN. The rate of catheter-related bloodstream infections (CRBSIs) dropped dramatically as the use of Taurolidine lock procedure (TLP) increased. Mortality rate was low and mainly in relation to the underlying disease (cancer, immune deficiency). Cholestasis and intestinal transplantation remained very rare.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Jessica Noelting, Leah Gramlich, Scott Whittaker, David Armstrong, Errol Marliss, Brian Jurewitsch, Matreyi Raman, Donald R. Duerksen, Danielle Stevenson, Wendy Lou, Sudipta Saha, Johane P. Allard
Summary: A study using the Canadian HPN Registry found that adult patients with nonmalignant SBS who receive HPN have a 5-year survival rate of over 80%. Intestinal anatomical factors, age, and sex do not significantly affect the survival of these patients.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Maja Kopczynska, Gordon Carlson, Antje Teubner, Arun Abraham, Michael Taylor, Sorrel T. Burden, Christian L. Hvas, Peter Jepsen, Simon Lal
Summary: This study compares outcomes and surgical decision-making in patients with short bowel syndrome (SBS) and fistulas. The authors found that patients who underwent reconstructive surgery had higher rates of nutritional autonomy, while older patients with higher comorbidity index were less likely to achieve cessation of home parenteral nutrition (HPN). There were no differences in long-term nutritional and survival outcomes or surgical decisions between patients with SBS and fistulas, or between enterocutaneous and enteroatmospheric fistulas.
Article
Nutrition & Dietetics
Hamed Nikoupour, Peyman Arasteh, Alireza Shamsaeefar, Fardin Ghanbari, Arash Boorboor, Ali Mosa Jafar Almayali, Mojtaba Shafiekhani, Pirouz Samidoust, Reza Shahriarirad, Alireza Shojazadeh, Keivan Ranjbar, Mohammad Hasan Darabi, Sina Tangestanipour, Seyed Morteza Hosseini, Leila Zahiri, Saman Nikeghbalian
Summary: This study reported the experiences of an intestinal rehabilitation unit (IRU) from a country without home parenteral nutrition (HPN). Among 349 patients admitted, 100 were diagnosed with intestinal failure (IF). The most common causes of IF were enterocutaneous fistulas, short-bowel syndrome, and chronic intestinal pseudo-obstruction.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Rahim M. Naimi, Mark K. Hvistendahl, Steen S. Poulsen, Hannelouise Kissow, Jens Pedersen, Nikolaj A. Nerup, Rikard Ambrus, Michael P. Achiam, Lars B. Svendsen, Palle B. Jeppesen
Summary: Glepaglutide, a long-acting GLP-2 analog, improved intestinal absorptive function by increasing plasma citrulline levels and morphological improvements. However, there were no significant changes in intestinal perfusion after three weeks of treatment.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Ashley Bond, Maja Kopczynska, Thomas Conley, Antje Teubner, Michael Taylor, Arun Abraham, Loris Pironi, Simon Lal
Summary: This study found that the occurrence of fungal CRBSI does not increase the risk of death.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Editorial Material
Nutrition & Dietetics
Francisca Joly, Manpreet Mundi, Rocco Barazzoni, Mette M. Berger, Frederico Bozzetti, Cristina Cuerda, Palle B. Jeppesen, Simon Lal, Georg Lamprecht, Kinga Szczepanek, Andre Van Gossum, Stephane Schneider, Alan Shenkin, Geert Wanten, Loris Pironi
CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Loris Pironi, Kurt Boeykens, Federico Bozzetti, Francisca Joly, Stanislaw Klek, Simon Lal, Marek Lichota, Stefan Muehlebach, Andre Van Gossum, Geert Wanten, Carolyn Wheatley, Stephan C. Bischoff
Summary: This guideline provides information and recommendations for healthcare professionals and patients on appropriate and safe home parenteral nutrition (HPN) provision. It is based on previous guidelines and includes 71 recommendations covering various aspects of HPN. The evidence was evaluated and clinical recommendations were developed using the Scottish Intercollegiate Guidelines Network methodology. The guideline was commissioned and supported by ESPEN.
CLINICAL NUTRITION
(2023)
Review
Nutrition & Dietetics
Astrid Verbiest, Palle Bekker Jeppesen, Francisca Joly, Tim Vanuytsel
Summary: Short bowel syndrome (SBS) is a rare gastrointestinal condition caused by extensive surgical resection, resulting in less than 200 cm of remaining small intestine. This condition is associated with a high risk for intestinal failure (IF) and requires parenteral support (PS). This review focuses on the role of the colon in SBS-IF, including intestinal adaptation, energy salvage, and the impact of the microbiota. Additionally, the effects of glucagon-like peptide-2 (GLP-2) analogs, a disease-modifying treatment, in SBS-IF patients with and without a colon are discussed. Overall, this review emphasizes the importance of preserving the colon in SBS-IF.
Article
Nutrition & Dietetics
Benjamin Hess, Martin Cahenzli, Alastair Forbes, Rosa Burgos, Federico Coccolini, Olivier Corcos, Mette Holst, Oivind Irtun, Stanislaw Klek, Loris Pironi, Henrik Hojgaard Rasmussen, Mireille J. Serlie, Ronan Thibault, Simon Gabe, Annika Reintam Blaser
Summary: This survey assesses current attitudes and practices in managing acute mesenteric ischemia (AMI) worldwide. Results show that diagnosis of AMI is often delayed but rarely missed. Abdominopelvic CT-scan with intravenous contrast was suggested as the most useful diagnostic test. Treatment approaches vary greatly, indicating the need for updated guidelines.
CLINICAL NUTRITION ESPEN
(2023)
Review
Nutrition & Dietetics
Loris Pironi, Johane P. P. Allard, Francisca Joly, Parnia Geransar, Elisabeth Genestin, Ulrich-Frank Pape
Summary: Short bowel syndrome (SBS) is a rare gastrointestinal disorder associated with intestinal failure (SBS-IF) and poor health-related outcomes. Patients with SBS-IF require long-term intravenous supplementation (IVS) and the goal of treatment is to reduce or eliminate the need for IVS. Teduglutide, a glucagon-like peptide 2 analog, has been shown to be effective in reducing IVS dependence and improving the quality of life for SBS-IF patients. The management of SBS-IF patients is complex and requires close monitoring.
NUTRITION IN CLINICAL PRACTICE
(2023)
Review
Nutrition & Dietetics
Loris Pironi
Summary: Short bowel syndrome (SBS) is a clinical condition characterized by malabsorption, diarrhea, fatty stools, malnutrition, and dehydration due to a small bowel length of less than 200 cm from the ligament of Treitz. SBS is the main cause of chronic intestinal failure (CIF), which requires intravenous supplementation (IVS) to maintain the absorption of nutrients and water. SBS can be classified anatomically, evolutionally, pathophysiologically, clinically, and by the severity of CIF. Proper patient categorization is crucial for effective communication in clinical practice and research.
NUTRITION IN CLINICAL PRACTICE
(2023)
Article
Gastroenterology & Hepatology
Charlotte Lock Rud, Steven Brantlov, Josephine Reinert Quist, Trine Levring Wilkens, Jens Frederik Dahlerup, Simon Lal, Palle Bekker Jeppesen, Christian Lodberg Hvas
Summary: This study investigated the prevalence of sodium depletion in patients with an ileostomy and found a high proportion of patients with chronic sodium depletion. These findings suggest the need for further research to develop methods for assessing and monitoring fluid status, as well as treatments to address sodium depletion in these patients.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Claudio Ricci, Francesco Serbassi, Laura Alberici, Carlo Ingaldi, Leonardo H. Eusebi, Emilio De Raffele, Loris Pironi, Anna S. Sasdelli, Cristina Mosconi, Valentina Vicennati, Riccardo Casadei
Summary: Immunonutrition can reduce infectious complications and length of stay in patients undergoing pancreatic surgery. However, the small differences in mortality, morbidity, and postoperative pancreatic fistula rates make it impossible to exclude type II error due to large sample sizes.
Article
Nutrition & Dietetics
Loris Pironi, Denise Jezerski, Jacek Sobocki, Simon Lal, Tim Vanuytsel, Miriam Theilla, Anna S. Sasdelli, Cecile Chambrier, Konrad Matysiak, Umberto Aimasso, Henrik H. Rasmussen, Amelia Jukes, Marek Kunecki, David Seguy, Stephane M. Schneider, Joanne Daniels, Florian Poullenot, Manpreet S. Mundi, Przemyslaw Matras, Marcin Folwarski, Adriana Crivelli, Nicola Wyer, Lars Ellegard, Lidia Santarpia, Marianna Arvanitakis, Corrado Spaggiari, Georg Lamprecht, Francesco W. Guglielmi, Antonella Lezo, Sabrina Layec, Esther Ramos Boluda, Anat Guz-Mark, Paolo Gandullia, Cristina Cuerda, Emma Osland, Maria I. Spagnuolo, Zeljko Krznaric, Luisa Masconale, Brooke Chapman, Maria Maiz-Jimenez, Paolo Orlandoni, Mariana Hollanda Martins da Rocha, M. Nuria Virgili-Casas, Maryana Doitchinova-Simeonova, Laszlo Czako, Andre Van Gossum, Lorenzo D'Antiga, Looi C. Ee, Daruneewan Warodomwichit, Marina Taus, Sanja Kolacek, Ronan Thibault, Giovanna Verlato, Aurora E. Serralde-Zuniga, Jose I. Botella-Carretero, Pilar Serrano Aguayo, Gabriel Olveira, Sirinuch Chomtho, Veeradej Pisprasert, Georgijs Moisejevs, Ana Zugasti Murillo, Ma Estrella Petrina Jauregui, Marta Bueno Diez, Mohammad Shukri Jahit, Narumon Densupsoontorn, Ali Tamer, Giorgia Brillanti, Francisca Joly
Summary: This study investigated the incidence and severity of COVID-19 infection in patients receiving home parenteral nutrition (HPN) for chronic intestinal failure (CIF) from a European database. The results showed a significant variation in infection rates among countries, with the majority of cases being asymptomatic or mild but a significant proportion of infected patients experiencing severe or fatal outcomes. Lack of vaccination was associated with a higher risk of death.
CLINICAL NUTRITION ESPEN
(2023)
Article
Nutrition & Dietetics
Loris Pironi, Cristina Cuerda, Palle Bekker Jeppesen, Francisca Joly, Cora Jonkers, Zeljko Krznaric, Simon Lal, Georg Lamprecht, Marek Lichota, Manpreet S. Mundi, Stephane Michel Schneider, Kinga Szczepanek, Andre Van Gossum, Geert Wanten, Carolyn Wheatley, Arved Weimann
Summary: ESPEN has published guidelines for Chronic Intestinal Failure (CIF) in adults and has now updated the guidelines specifically for CIF caused by benign diseases. The new guidelines include new evidence and provide recommendations on various topics such as IF centers, chronic enterocutaneous fistulas, caring for CIF patients during pregnancy, and transition of patients from pediatric to adult centers.
CLINICAL NUTRITION
(2023)
Article
Psychiatry
Lucia Brodosi, Michele Stecchi, Francesca Marchignoli, Elisabetta Lucia, Lucia Magnani, Valeria Guarneri, Maria Letizia Petroni, Giulio Marchesini, Loris Pironi
Summary: This study aimed to evaluate the association between metabolic dysfunction-associated steatotic liver disease (MASLD) and eating disorders. The results showed that binge eating disorder (BED) was present in approximately 17.8% of MASLD patients screened in a specialized metabolic disorders unit. This study highlights the importance of addressing eating disorders in the treatment of MASLD.
EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
(2023)
