Review
Microbiology
Reka Borka Balas, Lorena Elena Melib, Ancua Lupu, Vasile Valeriu Lupu, Cristina Oana Marginean
Summary: Childhood obesity is a global public health problem associated with metabolic syndrome, liver disease, and psychosocial issues. Gut microbiota plays a significant role in obesity development, and the use of probiotics and prebiotics may have a positive effect in improving gut microbiota and reducing cardiovascular risk. However, clinical trial results are inconsistent.
Article
Food Science & Technology
Liangkui Li, Lu Zhang, Linkang Zhou, Meijun Jin, Li Xu
Summary: Long-chain inulin can prevent high-fat diet-induced obesity and associated metabolic disorders, while short-chain inulin has a similar but less effective impact. Both inulin types can alter gut microbiota composition and increase the production of short-chain fatty acids (SCFAs). However, the reduced serum levels of essential fatty acids, vitamins B1 and B3 caused by high-fat diet were further decreased by both inulin supplements.
FOOD SCIENCE & NUTRITION
(2021)
Article
Nutrition & Dietetics
Yung-Tsung Chen, Ai-Hua Hsu, Shiou-Yun Chiou, Yu-Chun Lin, Jin-Seng Lin
Summary: The study found that AB-Kefir significantly reduced the effects of obesity in HFD-fed mice by regulating weight, glucose metabolism, and adipose tissue size, but had limited impact on WD-fed mice. Additionally, AB-Kefir regulated the expression of related genes in HFD-fed mice, particularly affecting adipose tissue.
Article
Immunology
Mariusz Kaczmarczyk, Monika Szulinska, Igor Loniewski, Matylda Kregielska-Narozna, Karolina Skonieczna-Zydecka, Tomasz Kosciolek, Valentyn Bezshapkin, Pawel Bogdanski
Summary: Probiotic intervention alters the influence of microbiota on biochemical, physiological, and immunological parameters, but does not affect diversity and taxonomic composition of the microbiota. Baseline microbiota is not a predictor of therapeutic response to a multispecies probiotic.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Young-Sil Lee, Daeyoung Lee, Gun-Seok Park, Seung-Hyun Ko, Juyi Park, You-Kyung Lee, Jihee Kang
Summary: The study suggests that Lactobacillus plantarum HAC01 can alleviate hyperglycemia and type 2 diabetes by regulating glucose metabolism in the liver, protecting insulin-secreting cells, and restoring gut microbiota and short-chain fatty acids.
Review
Biochemistry & Molecular Biology
Natalia G. Vallianou, Dimitris Kounatidis, Dimitrios Tsilingiris, Fotis Panagopoulos, Gerasimos Socrates Christodoulatos, Angelos Evangelopoulos, Irene Karampela, Maria Dalamaga
Summary: Obesity and obesity-associated disorders are major health issues worldwide. Next-generation probiotics (NGPs) are showing promise as potential preventive and therapeutic agents against obesity, with candidate NGPs like Akkermansia muciniphila and Hafnia alvei already demonstrating encouraging results. However, safety issues and strict regulations should be continuously addressed. This review explores the current knowledge regarding NGPs, their utility in obesity and obesity-related disorders, their safety profile, and their therapeutic potential in overweight/obese individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Yung-Tsung Chen, Shiou-Yun Chiou, Ai-Hua Hsu, Yu-Chun Lin, Jin-Seng Lin
Summary: The study found that LRH05 significantly reduces body weight gain and WAT weight in mice, as well as improving hepatic steatosis and glucose intolerance. LRH05 can ameliorate the pro-inflammatory process by regulating gene expression and reducing inflammatory macrophage infiltration.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Ida Sogaard Larsen, Beatrice S. -Y. Choi, Bandik Foeh, Nanna Ny Kristensen, Adia Ouellette, Rune Falkenberg Haller, Peter Bjarke Olsen, Delphine Saulnier, Christian Sina, Benjamin A. H. Jensen, Andre Marette
Summary: Growing evidence supports the use of probiotics to prevent or mitigate obesity-related dysmetabolism and non-alcoholic fatty liver disease (NAFLD). However, the response to probiotic treatment varies depending on the obesogenic diets, highlighting the need to consider the impact of diet in preclinical and clinical probiotic studies.
Article
Multidisciplinary Sciences
Aarti Darra, Vandana Singh, Anuraag Jena, Priyanka Popli, Ritambhra Nada, Pankaj Gupta, Sanjay Kumar Bhadada, Anupam Kumar Singh, Vishal Sharma, Anish Bhattacharya, Anurag Agrawal, Usha Dutta
Summary: The gut microbiome plays a role in the development and progression of metabolic disorders, such as diabetes. This study explores the gut microbiota in the duodenal mucosa, which is less studied compared to stool, in individuals with hyperglycemia. The findings suggest that duodenal dysbiosis and altered local metabolism may be early events in hyperglycemia.
SCIENTIFIC REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Mariana Dias, Sandra Aparecida dos Reis Louzano, Lisiane Lopes da Conceicao, Rayssa da Conceicao Fernandes, Tiago Antonio de Oliveira Mendes, Solange Silveira Pereira, Leandro Licursi de Oliveira, Maria do Carmo Gouveia Peluzio
Summary: This study investigated the adjuvant treatment of obesity through potential probiotics and antibiotics, along with caloric restriction. The treatment was able to reduce biometric measures, increase brown adipose tissue, and alter the composition of the intestinal microbiota, showing promise as a treatment for obesity.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Review
Nutrition & Dietetics
Valentina Alvarez-Arrano, Sandra Martin-Pelaez
Summary: Intestinal microbiota plays a potential role in obesity development. Probiotics and synbiotics intake can lead to significant weight loss, with specific strains like Lactobacillus and Bifidobacterium showing the best results. These findings suggest that probiotics and synbiotics have the potential to aid in weight reduction in overweight and obese populations.
Article
Endocrinology & Metabolism
Eun-Ji Song, Eun-Sook Lee, Young In Kim, Dong-Uk Shin, Ji-Eun Eom, Hee Soon Shin, So-Young Lee, Young-Do Nam
Summary: L. paracasei AO356 has been found to have an anti-obesity effect and can modify the gut microbiota and metabolic pathways associated with obesity. Its safety has also been confirmed.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Food Science & Technology
Lingyan Ma, Aqian Zheng, Liyang Ni, Lianxin Wu, Luting Hu, Yufeng Zhao, Zhengwei Fu, Yinhua Ni
Summary: The longevity-promoting probiotic strain LKM512 shows potential in improving hepatic lipid accumulation, reducing inflammation, and enhancing insulin sensitivity in high-fat diet-induced obese mice. It also has an impact on the composition and function of gut microbiota in these mice.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Chemistry, Medicinal
Oliwia Gawlik-Kotelnicka, Dominik Strzelecki
Summary: Probiotics are shown to be effective in reducing depressive symptoms when used with antidepressants and may ameliorate some clinical components of metabolic diseases. However, standardized methodology regarding probiotics use in clinical trials is still lacking.
Article
Biochemistry & Molecular Biology
Zhengqi Liu, Chunqing Ai, Xinping Lin, Xiaoming Guo, Shuang Song, Beiwei Zhu
Summary: Sulfated polysaccharides from sea cucumber Stichopus japonicus (SCSPsj) modulate gut microbiota by promoting the growth of probiotics. This study investigated the effects of SCSPsj and Lactobacillus gasseri on gut microbiota-altered mice through gut microbiota and metabolomics analysis. The combination of SCSPsj and L. gasseri effectively ameliorated body weight gain and fat accumulation in mice treated with low-dose penicillin, with a better effect attributed to their synergistic effect.
Review
Endocrinology & Metabolism
Marina Caputo, Chiara Mele, Alice Ferrero, Ilaria Leone, Tommaso Daffara, Paolo Marzullo, Flavia Prodam, Gianluca Aimaretti
Summary: Aging and age-related diseases are hot topics of current research, influenced by genetic and environmental factors. Understanding the role of the endocrine system in aging is crucial for early assessment of endocrine function in aging individuals.
NEUROENDOCRINOLOGY
(2022)
Article
Gastroenterology & Hepatology
Sonia Facchin, Matteo Calgaro, Mattia Pandolfo, Federico Caldart, Matteo Ghisa, Eliana Greco, Eleonora Sattin, Giorgio Valle, Evan Dellon, Nicola Vitulo, Edoardo Vincenzo Savarino
Summary: This study aimed to collect and characterize the microbiome of adult patients with eosinophilic oesophagitis (EoE) and correlate the findings with disease activity. Preliminary data suggest that salivary metabarcoding analysis in combination with machine learning approaches could become a valid, cheap, non-invasive test to distinguish between EoE and non-EoE patients.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Editorial Material
Gastroenterology & Hepatology
Sonia Facchin, Matteo Calgaro, Mattia Pandolfo, Federico Caldart, Matteo Ghisa, Nicola Vitulo, Edoardo Vincenzo Savarino
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Endocrinology & Metabolism
F. Prodam, M. Caputo, M. Romanisio, S. Brasili, M. Zavattaro, M. T. Sama, A. Ferrero, S. Costelli, F. R. Lenzi, A. Petri, E. Basso, S. Bellone, G. Aimaretti
Summary: This study evaluated the clinical and epidemiological characteristics of outpatients transitioning from Pediatric Endocrine Department to Adult Endocrine Department in a tertiary center, as well as the features of the transition process and predictors of drop-out. The findings showed that the patients were heterogeneous, with different ages, follow-up durations, and types of endocrine diseases. The number of visits was associated with the number and type of endocrine diseases, and adherence to follow-up was predicted by thyroid disorders and multiple comorbidities. A study exploring a specific transition plan for chronic endocrine diseases.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Pediatrics
Valentina Mancioppi, Valentina Antoniotti, Arianna Solito, Elisabetta Mingoia, Alice Monzani, Giulia Genoni, Ivana Rabbone, Flavia Prodam, Simonetta Bellone
Summary: This study investigated subclinical hypothyroidism in newborns and observed the changes in thyroid hormone levels over time until four years of age. The results showed that more than half of the newborns did not require treatment and had either normal or slightly increased thyroid function. The study also suggested the importance of long-term follow-up to monitor thyroid hormone levels.
Article
Endocrinology & Metabolism
Cristina Partenope, Quincy Pedranzini, Antonella Petri, Ivana Rabbone, Flavia Prodam, Simonetta Bellone
Summary: The report presents a case of a 16-year-old boy who developed polyuria, polydipsia, and weight loss after receiving the COVID-19 vaccine. Diagnosis revealed neuroinfundibulohypophysitis, a rare disorder characterized by inflammation of the pituitary gland and stalk. Further studies are needed to explore the possible causal link between the COVID-19 vaccine and AVP deficiency.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
M. Caputo, T. Daffara, A. Ferrero, M. Romanisio, E. Monti, C. Mele, M. Zavattaro, S. Tricca, A. Siani, A. Clemente, C. Palumbo, S. De Cilla, A. Carriero, A. Volpe, P. Marzullo, G. Aimaretti, F. Prodam
Summary: The aim of this study was to identify risk factors for morphological changes in adrenal incidentalomas (AIs) during follow-up. High body weight, dehydroepiandrosterone sulfate (DHEAS), and direct renin concentration (DRC) were found to be associated with tumor enlargement, while aldosterone levels were lower in these cases. Additionally, glaucoma and dysglycemia had a higher prevalence in patients with tumor enlargement and were identified as independent predictors.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Martina Romanisio, Rosa Pitino, Alice Ferrero, Francesca Pizzolitto, Samuele Costelli, Valentina Antoniotti, Paolo Marzullo, Gianluca Aimaretti, Flavia Prodam, Marina Caputo
Summary: This study evaluated metabolic comorbidities in surgically treated acromegalic patients and found that the discrepancy between GH and IGF-1 levels does not appear to be a risk factor for their presence or persistence. Further extended studies are needed to confirm these results in the long term.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Valentina Mancioppi, Tommaso Daffara, Martina Romanisio, Giovanni Ceccarini, Caterina Pelosini, Ferruccio Santini, Simonetta Bellone, Simona Mellone, Alessio Baricich, Ivana Rabbone, Gianluca Aimaretti, Baris Akinci, Mara Giordano, Flavia Prodam
Summary: This article describes a rare lipodystrophy syndrome called congenital generalized lipodystrophy type 4 (CGL4), which is caused by mutations in the PTRF gene. Two early childhood patients presented with features such as reduced subcutaneous fat, muscular hypertrophy, distinctive facial features, myopathy, and atlantoaxial instability. Blood tests showed elevated CK and triglyceride levels, and undetectable leptin and adiponectin concentrations.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Edda Cava, Daniele Spadaccini, Gianluca Aimaretti, Paolo Marzullo, Beatrice Cavigiolo, Deborah Farinelli, Alessandra Gennari, Chiara Saggia, Maria Grazia Carbonelli, Sergio Riso, Flavia Prodam
Summary: This retrospective observational cohort study aimed to assess the impact of a Mediterranean diet on weight and anthropometric changes in women completing active breast cancer treatment. The study found that implementing a Mediterranean diet can lead to weight and anthropometric improvements in breast cancer survivors. However, further research is necessary to explore the long-term effects of weight loss on these individuals and consider specific predictors of dropout.
Article
Endocrinology & Metabolism
Valentina Antoniotti, Martina Amore, Marina Caputo, Chiara Fania, Valentina Mancioppi, Gloria Casoli, Sabrina Tini, Alessandro Antonioli, Gianluca Aimaretti, Ivana Rabbone, Simonetta Bellone, Flavia Prodam
Summary: This study aimed to explore the relationship between childhood obesity and insulin resistance, glucose alterations, hypertension, and the renin-angiotensin-aldosterone system (RAAS). The results showed that 87.6% of pediatric obesity patients had hypertension, and those with glucose alterations were more likely to have hypertension. Blood pressure levels were positively correlated with glucose alterations, and insulin sensitivity was lower in hypertensive individuals. The study highlights the importance of close clinical surveillance in specific risk categories.
JOURNAL OF THE ENDOCRINE SOCIETY
(2023)
Article
Biochemical Research Methods
Francesca Di Cesare, Matteo Calgaro, Veronica Ghini, Diletta Francesca Squarzanti, Annachiara De Prisco, Annalisa Visciglia, Paola Zanetta, Roberta Rolla, Paola Savoia, Angela Amoruso, Barbara Azzimonti, Nicola Vitulo, Leonardo Tenori, Claudio Luchinat, Marco Pane
Summary: This study investigated the effects of probiotic treatment on the metabolic profiles of human urine and serum using NMR-based metabonomic approach. The results showed significant impacts of probiotics on urinary and serum metabolomes, without altering their phenotypes. The study demonstrated the variations of metabolite levels resulting from different probiotic posologies.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Biochemical Research Methods
Matteo Calgaro, Chiara Romualdi, Davide Risso, Nicola Vitulo
Summary: This article presents benchdamic, a Bioconductor package for benchmarking methods for the identification of differentially abundant taxa.
Article
Endocrinology & Metabolism
Valentina Antoniotti, Simonetta Bellone, Filipa Patricia Goncalves Correia, Caterina Peri, Sabrina Tini, Roberta Ricotti, Valentina Mancioppi, Mara Gagliardi, Daniele Spadaccini, Marina Caputo, Marco Corazzari, Flavia Prodam
Summary: This study aimed to evaluate the relationship between markers of endoplasmic reticulum stress and metabolic alterations in children and adolescents with obesity. The findings suggest that PDIA3 and CALR may be early markers of obesity and metabolic syndrome risk.
FRONTIERS IN ENDOCRINOLOGY
(2022)