Article
Clinical Neurology
Valeria Isella, Daniele Licciardo, Giulia Nastasi, Valentina Impagnatiello, Francesca Ferri, Cristina Mapelli, Cinzia Crivellaro, Monica Musarra, Sabrina Morzenti, Ildebrando Appollonio, Carlo Ferrarese
Summary: Late-onset and early-onset dementia exhibit neurobiological and clinical differences. This study compared the clinical and FDG-PET features of posterior cortical atrophy (PCA), the visual variant of Alzheimer's disease, between late-onset and early-onset cases. The results showed that the main difference between the two groups was a higher prevalence of Balint-Holmes symptoms in the early-onset cases, which was associated with severe bilateral occipito-temporo-parietal hypometabolism. In the late-onset cases, there was a reduction of FDG uptake mainly in the right posterior regions. Age was found to be correlated with metabolism in different brain regions.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Dror Shir, Jonathan Graff-Radford, Mary M. Machulda, Nha Trang Thu Pham, Clifford R. Jack, Val J. Lowe, Jennifer L. Whitwell, Keith A. Josephs
Summary: This study found that primary occipital posterior cortical atrophy (PCA) is characterized by an older age at onset, more color perception dysfunction, less severe ideomotor apraxia, and less hypometabolism in the temporo-parietal meta-ROI compared to established phenotypes.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Mario Torso, Samrah Ahmed, Christopher Butler, Giovanna Zamboni, Mark Jenkinson, Steven Chance
Summary: Global cortical DTI derived measures were able to detect differences in both PCA and tAD patients compared to healthy controls. AngleR was the best measure to discriminate HC from tAD (AUC = 0.922), while PerpPD was the best measure to discriminate HC from PCA (AUC = 0.961). Finally, the best global measure to differentiate the two patient groups was ParlPD (AUC = 0.771).
JOURNAL OF NEUROLOGY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Maurizio Gallucci, Vittorio Fiore, Francesca Grassivaro, Chiara Da Ronch, Laura Bonanni
Summary: The F-18-FDG PET images of patients with dementia with Lewy bodies and posterior cortical atrophy showed reduced metabolism in the occipital lobe, but relative preservation of the primary visual cortex. A 3D stereotactic surface projection map provided clearer visualization of the occipital pole sign.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Neurosciences
Oleg Yerstein, Leila Parand, Li-Jung Liang, Adrienne Isaac, Mario F. Mendez
Summary: The study reviewed the clinical experience of 65 patients with PCA from 1995 to 2020, finding that most patients presented with visual localization complaints and visuospatial symptoms, with memory complaints and depression also common. Neurobehavioral testing showed difficulties in visuospatial constructions, memory, and naming in these patients. The research suggests modifying PCA criteria to include secondary memory and naming difficulties, as well as emphasizing the presence of Gerstmann's and Balint's syndromes.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Marie-Anne St-Georges, Linshan Wang, Marianne Chapleau, Raffaella Migliaccio, Thomas Carrier, Maxime Montembeault
Summary: This study compared the behavioral symptoms of individuals with early-stage posterior cortical atrophy (PCA) to healthy controls and other Alzheimer's disease variants. The results showed that PCA patients often experience anxiety, depression, apathy, and irritability. They also exhibited disorganized and reactive behaviors during cognitive testing. However, their social cognition and empathy were generally preserved. This study provides valuable insights into the non-visual symptoms of PCA and has implications for diagnosis and intervention strategies.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
M. Giunta, I. Libri, E. Premi, C. Brattini, B. Paghera, S. Archetti, R. Gasparotti, A. Padovani, B. Borroni, A. Benussi
Summary: This report presents a case of posterior cortical atrophy (PCA) in a patient with a known GRN mutation, excluding a concomitant AD pathological process. The multidimensional assessment revealed impairment of visual and constructional abilities, leading to a diagnosis of PCA according to the latest consensus criteria. The genetic screening identified a pathogenic GRN mutation, suggesting a new neurodegenerative pathway associated with PCA.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Mario F. Mendez, Youssef Khattab, Oleg Yerstein
Summary: The study showed that impaired visual search tasks of spatial localization can effectively differentiate patients with PCA from those with tAD and HC, highlighting the importance of visual search tasks in detecting and distinguishing PCA from more common dementia syndromes.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Review
Clinical Neurology
John Best, Marianne Chapleau, Gil D. Rabinovici
Summary: Posterior Cortical Atrophy (PCA) is a neurodegenerative disorder characterized by progressive atrophy of the parietal and occipital lobes, resulting in impairment of higher-order visual processing. The majority of individuals develop symptoms before 65 years of age, but delayed diagnosis is common due to misattribution of symptoms.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2023)
Article
Clinical Neurology
Samantha K. K. Holden, Brianne M. M. Bettcher, Christopher M. M. Filley, Dan Lopez-Paniagua, Victoria S. S. Pelak
Summary: This study explored the relationship between scores on the Colorado Posterior Cortical Questionnaire (CPC-Q) and white matter integrity. The results showed that CPC-Q scores were correlated with DTI FA of the averaged posterior white matter regions, with the DTI FA of the posterior thalamic radiations showing the strongest association. These findings suggest that the integrity of posterior white matter tracts is related to scores on the CPC-Q, providing further validation for this questionnaire.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Brian L. Day, Dilek Ocal, Amy Peters, Matthew J. Bancroft, David Cash, Diego Kaski, Sebastian J. Crutch, Keir X. X. Yong
Summary: Research suggests that the brain combines multisensory information to determine gravity direction and uprightness, involving the spatial transformation of sensory signals between different reference frames. Patients with posterior cortical atrophy (PCA) show disturbances in upright perception, with a model developed to combine vertical information from multiple sources in a statistically optimal way, indicating disruptions in spatial transformation of graviceptive information in both patient groups. Despite visual dysfunction being a typical feature of PCA, disturbances were greater in PCA than tAD, especially for haptic-vertical, suggesting posterior parietal vulnerability.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Biology
Catherine Brodeur, Emilie Belley, Lisa-Marie Deschenes, Adriana Enriquez-Rosas, Michelyne Hubert, Anik Guimond, Josee Bilodeau, Jean-Paul Soucy, Joel Macoir
Summary: This study focused on three patients with language complaints and clinical profiles consistent with posterior cortical atrophy (PCA). The results showed that PCA is characterized by visuospatial and visuoperceptual deficits, as well as primary and secondary language impairments in these patients.
Article
Clinical Neurology
Doeschka A. Ferro, Hugo J. Kuijf, Saima Hilal, Susanne J. van Veluw, Danielle van Veldhuizen, Narayanaswamy Venketasubramanian, Boon Yeow Tan, Geert Jan Biessels, Christopher Chen
Summary: This study found cortical atrophy surrounding CMIs, suggesting a perilesional effect in a cortical area many times larger than the CMI core. Our findings support the notion that CMIs affect brain structure beyond the actual lesion site.
Article
Geriatrics & Gerontology
Alice Naomi Preti, Lorenzo Diana, Rita Castaldo, Francesca Pischedda, Teresa Difonzo, Giorgio Fumagalli, Andrea Arighi, Giuseppe Sartori, Stefano Zago, Nadia Bolognini
Summary: This study investigated the change in handwritten signature in neurodegenerative diseases using a rater-based approach. The findings indicate that the change in handwritten signature is more evident in patients with Alzheimer's disease (AD) and frontotemporal dementia (FTD) compared to healthy participants, and the change is unrelated to their clinical and demographic characteristics.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Medicine, General & Internal
Dilek Ocal, Ian D. McCarthy, Teresa Poole, Silvia Primativo, Tatsuto Suzuki, Nick Tyler, Chris Frost, Sebastian J. Crutch, Keir X. X. Yong
Summary: Visual processing deficits in Alzheimer's disease are associated with diminished functional independence. The effects of clutter and color contrasts on performances of everyday actions were evaluated in patients with posterior cortical atrophy and memory-led typical Alzheimer's disease.
FRONTIERS IN MEDICINE
(2023)
Article
Neurosciences
Alexandra Plonka, Aurelie Mouton, Joel Macoir, Thi-Mai Tran, Alexandre Derremaux, Philippe Robert, Valeria Manera, Auriane Gros
Summary: The study found that writing pressure can differentiate patients with PPA, AD, and healthy subjects in different tasks. However, performance classification depended on the nature of the tasks.
Article
Otorhinolaryngology
Clair Vandersteen, Magali Payne, Louise-Emilie Dumas, Alexandra Plonka, Gregoire D'Andrea, David Chirio, Elisa Demonchy, Karine Risso, Philippe Robert, Xavier Fernandez, Florence Askenazy-Gittard, Charles Savoldelli, Nicolas Guevara, Laurent Castillo, Valeria Manera, Auriane Gros
Summary: The study showed that SST-12 is a quick and reliable tool for screening post-COVID-19 olfactory impaired patients on a large scale and can be used in daily clinical practice.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Medicine, General & Internal
Clair Vandersteen, Magali Payne, Louise-Emilie Dumas, Elisa Cancian, Alexandra Plonka, Gregoire D'Andrea, David Chirio, Elisa Demonchy, Karine Risso, Florence Askenazy-Gittard, Charles Savoldelli, Nicolas Guevara, Philippe Robert, Laurent Castillo, Valeria Manera, Auriane Gros
Summary: This study evaluated the efficacy of olfactory training (OT) on persistent post-viral olfactory disorders (PPVOD) after COVID-19 infection. The results showed that OT led to improvements in olfactory function and quality of life in patients with PPVOD. However, further research is needed to confirm the role of OT and explore new therapeutic strategies for the central aspects of PPVOD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Letter
Geriatrics & Gerontology
Olivier Beauchet, Kevin Galery, Constance Lafontaine, Kim Sawchuk, Alexandra Plonka, Auriane Gros, Gilles Allali
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Clinical Neurology
Hyunjung Kim, Jhii-Hyun Ahn, Sung Min Ko, Jin Woo Kim
Summary: The pre-navigation balloon technique significantly reduces the occurrence of distal embolism and increases the first-pass effect (FPE) during stent retriever thrombectomy. This technique is particularly effective for patients with ICA occlusion, improving clinical outcomes.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
Review
Clinical Neurology
Mehdi Khaleghi, Joshua Vignolles-Jeong, Bradley Otto, Ricardo Carrau, Daniel Prevedello
Summary: This study presented a rare case of symptomatic ectopic Rathke's cleft cyst (RCC), which was located posterior to the pituitary gland and caused extensive clival erosion. The surgical technique of wide marsupialization of the cyst using intraoperative ultrasound-assisted endoscopic endonasal transclival approach was described, and a systematic literature review of intracranial ectopic RCCs was conducted.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
Article
Clinical Neurology
Oscar H. Del Brutto, Denisse A. Rumbea, Aldo F. Costa, Maitri Patel, Mark J. Sedler, Robertino M. Mera
Summary: This study found an association between cognitive impairment and mortality risk in adults of Amerindian ancestry living in rural Ecuador.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
Article
Clinical Neurology
Yangjingyi Xia, Li Li, Yunze Li, Manyan Hu, Tianrui Zhang, Qinghua Feng, Wenlei Li, Yuan Zhu, Minghua Wu
Summary: This study shows that fasting blood glucose (FBG) level is significantly associated with unfavorable outcome after acute ischemic stroke (AIS) in patients. The risk of unfavorable outcome increases significantly when FBG is above 5.5 mmol/L.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)