期刊
CLINICAL INFECTIOUS DISEASES
卷 72, 期 -, 页码 S140-S145出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciab746
关键词
schistosomiasis; modeling; morbidity control; EPHP; MDA
资金
- Bill and Melinda Gates Foundation [OPP1184344]
- NTD Modelling Consortium
- Bill and Melinda Gates Foundation [OPP1184344] Funding Source: Bill and Melinda Gates Foundation
This study explores different mass drug administration (MDA) strategies to maintain the goals of controlling morbidity due to schistosomiasis and attaining elimination as a public health problem (EPHP). The findings suggest that in moderate-prevalence settings, less frequent MDAs may be sufficient to maintain the goals, while in high-transmission settings, reducing control efforts after achieving the goals could lead to a high risk of recrudescence.
Background. The World Health Organization previously set goals of controlling morbidity due to schistosomiasis by 2020 and attaining elimination as a public health problem (EPHP) by 2025 (now adjusted to 2030 in the new neglected tropical diseases roadmap). As these milestones are reached, it is important that programs reassess their treatment strategies to either maintain these goals or progress from morbidity control to EPHP and ultimately to interruption of transmission. In this study, we consider different mass drug administration (MDA) strategies to maintain the goals. Methods. We used 2 independently developed, individual-based stochastic models of schistosomiasis transmission to assess the optimal treatment strategy of a multiyear program to maintain the morbidity control and the EPHP goals. Results. We found that, in moderate-prevalence settings, once the morbidity control and EPHP goals are reached it may be possible to maintain the goals using less frequent MDAs than those that are required to achieve the goals. On the other hand, in some high-transmission settings, if control efforts are reduced after achieving the goals, particularly the morbidity control goal, there is a high chance of recrudescence. Conclusions. To reduce the risk of recrudescence after the goals are achieved, programs have to re-evaluate their strategies and decide to either maintain these goals with reduced efforts where feasible or continue with at least the same efforts required to reach the goals.
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