Article
Oncology
Sara Caceres, Beatriz Monsalve, Angela Alonso-Diez, Belen Crespo, Maria Jose Illera, Paloma Jimena de Andres, Gema Silvan, Juan Carlos Illera
Summary: Through experimental studies on canine and human inflammatory breast cancer, it was found that anti-aromatase and anti-sulfatase therapies have inhibitory effects on tumors in vitro, while anti-sulfatase can increase tumor progression; letrozole effectively reduces tumor progression by decreasing estrogen levels.
Article
Obstetrics & Gynecology
Willem Jan van Weelden, Roy I. Lalisang, Johan Bulten, Kristina Lindemann, Heleen J. van Beekhuizen, Hans Trum, Dorry Boll, Henrica M. J. Werner, Luc R. C. W. van Lonkhuijzen, Refika Yigit, David Forsse, Petronella O. Witteveen, Khadra Galaal, Alexandra van Ginkel, Eliana Bignotti, Vit Weinberger, Sanne Sweegers, Judith R. Kroep, Silvia Cabrera, Marc P. L. M. Snijders, Marcia A. Inda, Ane Gerda Z. Eriksson, Camilla Krakstad, Andrea Romano, Anja van de Stolpe, Johanna M. A. Pijnenborg
Summary: This study aimed to improve the efficacy of hormonal therapy in advanced or recurrent endometrial cancer by analyzing hormone receptor expressions and pathway activity. Results showed that using a 50% cutoff level for hormone receptor expression significantly enhanced the prediction of response to hormonal treatment.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Oncology
Sixten Harborg, Maria Feldt, Deirdre Cronin-Fenton, Marie Klintman, Susanne O. Dalton, Ann H. Rosendahl, Signe Borgquist
Summary: The purpose of this study was to examine the association between obesity and clinical outcomes in early breast cancer and assess if patient, tumor, and treatment characteristics modify such associations. The study found that obesity is associated with a higher risk of breast cancer recurrence and death, especially in patients with low socioeconomic position, larger tumors, estrogen-receptor-negative breast cancer, and those receiving adjuvant chemotherapy. Therefore, weight management is crucial in the treatment of breast cancer patients.
CANCER & METABOLISM
(2023)
Article
Oncology
Steven Davies, Ioannis A. Voutsadakis
Summary: This study found that adjuvant chemotherapy is associated with better adherence to hormonal therapy in early ER-positive breast cancer patients, while patients with psychiatric co-morbidities are more likely to be non-adherent to hormonal therapy.
EUROPEAN JOURNAL OF CANCER CARE
(2022)
Article
Oncology
Mathilde M. M. Almekinders, Michael Schaapveld, Bram Thijssen, Lindy L. Visser, Tycho Bismeijer, Joyce Sanders, Edoardo Isnaldi, Ingrid Hofland, Marjolijn Mertz, Lodewyk F. A. Wessels, Annegien Broeks, Erik Hooijberg, Wilbert Zwart, Esther H. Lips, Christine Desmedt, Jelle Wesseling
Summary: The study suggests that the size of breast adipocytes and COX-2 protein expression in DCIS cells are associated with the risk of subsequent invasive breast cancer. Large breast adipocytes and high COX-2 expression in DCIS are linked to a higher risk of developing invasive breast cancer.
Review
Oncology
Saikat Mitra, Mashia Subha Lami, Avoy Ghosh, Rajib Das, Trina Ekawati Tallei, Fatimawali, Fahadul Islam, Kuldeep Dhama, M. Yasmin Begum, Afaf Aldahish, Kumarappan Chidambaram, Talha Bin Emran
Summary: Hormone therapy is a common treatment approach for severe and recurrent gynecological cancers, and it works by reducing hormone levels or inhibiting their biological activity. This therapy has shown promising results in halting or slowing cancer progression. However, the response rates and therapeutic effects vary among patients. Therefore, this review explores the use of hormonal therapies for gynecological cancers and identifies the current gaps in knowledge.
Article
Oncology
Michelino De Laurentiis, Roberta Caputo, Manuelita Mazza, Mauro Mansutti, Riccardo Masetti, Zelmira Ballatore, Rosalba Torrisi, Andrea Michelotti, Alberto Zambelli, Antonella Ferro, Daniele Generali, Patrizia Vici, Luigi Coltelli, Alessandra Fabi, Paolo Marchetti, Alberto Ballestrero, Simon Spazzapan, Antonio Frassoldati, Maria Giuseppina Sarobba, Donatella Grasso, Claudio Zamagni
Summary: In the Italian subpopulation, the safety and efficacy profiles of Ribociclib plus letrozole were consistent with the global study results, reaffirming it as a frontline treatment option for patients with HR+, HER2- ABC.
Review
Oncology
Jing Xu, Bo Cao, Chunyu Li, Guohui Li
Summary: Breast cancer is a global health concern. Endocrine therapy is crucial in treating estrogen-positive breast cancer, but it often leads to osteoporosis-related adverse events. These events increase the risk of fractures and reduce the patients' quality of life. This review explores the possibility of endocrine therapy-induced osteoporosis in estrogen-positive breast cancer treatment and discusses the mechanisms involved and the potential of drug therapies and combinations.
FRONTIERS IN ONCOLOGY
(2023)
Review
Chemistry, Medicinal
Ankita Sood, Damanpreet Kaur Lang, Rajwinder Kaur, Balraj Saini, Sandeep Arora
Summary: Treatment for breast cancer remains challenging, with aromatase inhibitors showing significantly improved efficacy and safety compared to other drugs.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Xuanzi Qin, Peter Huckfeldt, Jean Abraham, Douglas Yee, Beth A. Virnig
Summary: Generic entry of aromatase inhibitors (AIs) allows for increased switching, which leads to improved adherence and better management of treatment-related side effects. However, patients and physicians may lack understanding of Part D benefit design, highlighting the need for improved education and communication to enhance decision-making.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Oncology
Kristen D. Brantley, Oana A. Zeleznik, Barbra A. Dickerman, Raji Balasubramanian, Clary B. Clish, Julian Avila-Pacheco, Bernard Rosner, Rulla M. Tamimi, A. Heather Eliassen
Summary: This nested case-control study investigated the association between lipid and polar metabolites and breast cancer risk in pre- and postmenopausal women. The results showed that metabolomic adiposity scores were inversely related to breast cancer risk in premenopausal women, while they were positively associated with risk in postmenopausal women. These findings suggest that metabolic dysregulation may have different effects on pre- and postmenopausal breast cancer.
BRITISH JOURNAL OF CANCER
(2022)
Article
Nutrition & Dietetics
Erika Cortes-Macias, Marta Selma-Royo, Cecilia Martinez-Costa, Maria Carmen Collado
Summary: Breastfeeding plays a crucial role in neonatal microbial and immune system development, with pre-pregnancy BMI and weight gain during pregnancy affecting milk microbiota composition. Normal-weight women with exclusive breastfeeding habits showed higher abundance of Bifidobacterium genus and alpha-diversity in breast milk. Further research is needed to understand the potential impact of maternal factors on milk and infant development and health.
Article
Oncology
Edoardo Isnaldi, Francois Richard, Maxim De Schepper, Sophia Leduc, Marion Maetens, Tatjana Geukens, Karen Van Baelen, Ha-Linh Nguyen, Ghizlane Rouas, Gabriele Zoppoli, Fatima Cardoso, Christos Sotiriou, Denis Larsimont, Giuseppe Floris, Elia Biganzoli, Christine Desmedt
Summary: The impact of adiposity on the efficacy of endocrine treatment in patients with estrogen receptor positive breast cancer was investigated retrospectively. It was found that obesity and larger adipocyte diameter are associated with a higher likelihood of anti-proliferative response in neoadjuvant treatment.
Article
Nutrition & Dietetics
Jordana Carolina Marques Godinho-Mota, Larissa Vaz-Goncalves, Isis Danyelle Dias Custodio, Jaqueline Schroeder de Souza, Joao Felipe Mota, Maria Cristina Gonzalez, Priscylla Rodrigues Vilella, Karine Anusca Martins, Yara Cristina de Paiva Maia, Sara Maria Moreira Lima Verde, Aline Porciuncula Frenzel, Patricia Faria Di Pietro, Eduarda da Costa Marinho, Ruffo Freitas-Junior
Summary: This study aimed to investigate the effect of chemotherapy (CT) and its different types of regimens on the anthropometry and body composition of women with breast cancer. The results showed that CT negatively impacted body composition and different regimens had different effects. The study highlights the importance of nutritional monitoring of breast cancer patients throughout the entire CT treatment.
Article
Cell Biology
Tiago V. Augusto, Cristina Amaral, Cristina F. Almeida, Natercia Teixeira, Georgina Correia-da-Silva
Summary: The study investigated the effects of AIs on breast cancer cells and found that non-steroidal AIs induce cell senescence while Exe promotes autophagy, impacting hormonal environment. In hormone-enriched conditions, AIs block estrogen signaling, whereas in hormone-depleted conditions, AR and ERα crosstalk occurs.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rocio Jurado, Paulina Fraczek, Melissa Droetto, Purificacion Sanchez, Elsa Valero, Jose M. Dominguez-Vera, Natividad Galvez
JOURNAL OF INORGANIC BIOCHEMISTRY
(2016)
Review
Oncology
Paulina Fraczek, Aneta Kilian-Kita, Miroslawa Puskulluoglu, Krzysztof Krzemieniecki
WSPOLCZESNA ONKOLOGIA-CONTEMPORARY ONCOLOGY
(2016)
Article
Dentistry, Oral Surgery & Medicine
Przemyslaw A. Pekala, Brandon Michael Henry, Jakub R. Pekala, Paulina A. Fraczek, Dominik Taterra, Konstantinos Natsis, Maria Piagkou, Janusz Skrzat, Iwona M. Tomaszewska
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2017)
Article
Anatomy & Morphology
I. M. Tomaszewska, P. Fraczek, M. Gomulska, M. Pliczko, A. Sliwinska, K. Salapa, R. Chrzan, P. Kowalski, M. Nowakowski, J. A. Walocha
FOLIA MORPHOLOGICA
(2014)
Review
Anatomy & Morphology
Brandon Michael Henry, Przemyslaw A. Pekala, Paulina A. Fraczek, Jakub R. Pekala, Konstantinos Natsis, Maria Piagkou, Krzysztof A. Tomaszewski, Iwona M. Tomaszewska
SURGICAL AND RADIOLOGIC ANATOMY
(2020)
Article
Medicine, Research & Experimental
Mateusz K. Holda, Elzbieta Szczepanek, Joanna Bielawska, Natalia Palka, Dorota Wojtysiak, Paulina Fraczek, Micha Nowakowski, Natalia Sowinska, Zbigniew Arent, Piotr Podolec, Grzegorz Kopec
JOURNAL OF TRANSLATIONAL MEDICINE
(2020)
Article
Medicine, General & Internal
Paulina Fraczek, Marta Krzysztofik, Andrzej Stanisz, Anetta Undas
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2019)
Article
Hematology
Sarah Goldman, Paulina Fraczek, Krzysztof Szklanny, Elzbieta Papuga-Szela, Andrzej Stanisz, Anetta Undas
THROMBOSIS AND HAEMOSTASIS
(2018)