Article
Oncology
Peixin Chen, Hao Wang, Lishu Zhao, Haoyue Guo, Liping Zhang, Wei Zhang, Chenglong Sun, Sha Zhao, Wei Li, Jun Zhu, Jia Yu, Chunyan Wu, Yayi He
Summary: This study investigated the expression and mutation of OX40/OX40L in SCLC, as well as its correlation with prognosis and TME cell infiltration. Results showed that high OX40/OX40L expression was associated with better prognosis and increased immune cell infiltration in SCLC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Juanfeng Lao, Can Cao, Xiaoli Niu, Simei Deng, Siqi Ming, Siping Liang, Yuqi Shang, Yulin Yuan, Xiaomin Shi, Zibin Liang, Minhao Wu, Yongjian Wu
Summary: This study confirms the antitumor effects of anti-PD-1/OX40 combination in lung cancer patients and mouse models, providing a rationale for further clinical trials evaluating the therapeutic effect of this combination of antibodies for NSCLC immunotherapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Qi Zhang, Rober Abdo, Cristiana Iosef, Tomonori Kaneko, Matthew Cecchini, Victor K. Han, Shawn Shun-Cheng Li
Summary: Brain metastases (BrMs) are a common occurrence in lung cancer with poor prognosis. The tumor microenvironment in the brain undergoes extensive remodeling to create an immunosuppressive and fibrogenic niche for BrMs. Differential gene expression analysis identifies fibrosis and immune regulation as the major functional modules disrupted in both the lung and brain tumor microenvironments.
NATURE COMMUNICATIONS
(2022)
Review
Oncology
Chunsheng Yang, Yan Liang, Ning Liu, Meili Sun
Summary: Radiotherapy is a crucial intervention for non-small cell lung cancer, with ionizing radiation acting as a direct cytotoxic agent against cancer cells and also inducing antitumor immunological responses. A better understanding of the immunological pathways created by radiation can determine the most effective therapeutic combinations and enhance treatment outcomes for resistant malignancies.
RADIATION ONCOLOGY
(2023)
Article
Environmental Sciences
Jiguang Meng, Chunyang Zhang, Nengyang Zhu, Caiyun Zhang, Meng Liu, Zhihai Han, Yongqun Li
Summary: This study aimed to investigate the function of Epsin 3 (EPN3) in non-small cell lung cancer (NSCLC). The results showed that EPN3 was up-regulated in NSCLC patients and cells, indicating a lower overall survival. Loss of EPN3 weakened proliferation, migration, and invasion of NSCLC cells, induced apoptosis, and repressed epithelial-mesenchymal transition. EPN3 acted as an oncogene in NSCLC by activating the JAK1/2-STAT3 pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Qian Gou, Huiqing Chen, Mingjun Chen, Juanjuan Shi, Jianhua Jin, Qian Liu, Yongzhong Hou
Summary: Immune cells play a role in protecting against tumor progression, while aberrant expression of PD-L1 in cancer cells leads to tumor immune escape. This study found that ING4 induces the autophagic degradation of PD-L1, inhibiting immune escape in NSCLC. However, high expression of CK2 was found to correlate with low ING4 protein levels in NSCLC. Further analysis revealed that CK2 induces the phosphorylation of ING4-S150, leading to its degradation by JFK ubiquitin ligase. In contrast, CK2 gene knockout increased ING4 protein stability and T cell activity, inhibiting NSCLC immune escape. Additionally, the combination of a CK2 inhibitor and PD-1 antibody effectively enhanced antitumor immunotherapy.
Review
Immunology
Ding-Yu Rao, De-Fa Huang, Mao-Yan Si, Hua Lu, Zhi-Xian Tang, Zu-Xiong Zhang
Summary: As an important mediator of information transfer between cells, exosomes play a unique role in regulating tumor growth, supporting vascular proliferation, tumor invasion, and metastasis. Exosomes can be used as a potential tool for non-invasive liquid biopsy due to their presence in various body fluids. This study reviews the role of exosomes in liquid biopsy, tumor microenvironment formation, and epithelial-mesenchymal transition in non-small cell lung cancer (NSCLC). It also discusses the occurrence of EGFR+ exosomes and the role of exosomes and their contents in non-invasive detection and potential therapeutic targets in EGFR-mutated lung cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Max Backman, Carina Strell, Amanda Lindberg, Johanna S. M. Mattsson, Hedvig Elfving, Hans Brunnstrom, Aine O'Reilly, Martina Bosic, Miklos Gulyas, Johan Isaksson, Johan Botling, Klas Karre, Karin Jirstrom, Kristina Lamberg, Fredrik Ponten, Karin Leandersson, Artur Mezheyeuski, Patrick Micke
Summary: This study aimed to comprehensively characterize the distribution of immune cells in the tumor microenvironment of non-small cell lung cancer (NSCLC) and their association with prognosis. The results showed that CD4-Eff cells, CD8-Eff cells, and M1 macrophages were the most abundant immune cell types and were associated with a favorable prognosis. Additionally, the densities of lymphocytic subsets were independently associated with longer survival.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Kate L. Hertweck, Kunwar S. Vikramdeo, Jose N. Galeas, Stephen M. Marbut, Paramahansa Pramanik, Furhan Yunus, Seema Singh, Ajay P. Singh, Santanu Dasgupta
Summary: In this study, the authors identified a unique set of mitochondria-targeted genes that are differentially expressed in non-small-cell lung cancer subtypes. Altered expression of certain genes, such as SLC25A4, was associated with poor patient survival. These findings highlight the potential of these genes as biomarkers and therapeutic targets for lung cancer.
Article
Oncology
Judith Martha Neumann, Hinrich Freitag, Jasmin Saskia Hartmann, Karsten Niehaus, Michail Galanis, Martin Griesshammer, Udo Kellner, Hanna Bednarz
Summary: MALDI-MSI of small molecules was used to analyze fresh-frozen NSCLC tissues, revealing differences between AC and SqCC as well as between NSCLC tumor and tumor microenvironment. This approach can aid in subtyping NSCLC and may be beneficial in screening for rare mutations like IDH, promoting the development of tailored treatment strategies.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Plant Sciences
Rui Wang, Zhiyin Deng, Zhiming Zhu, Juanjuan Wang, Xiaobing Yang, Mengfei Xu, Xi Wang, Qing Tang, Qichun Zhou, Xinliang Wan, Wanyin Wu, Sumei Wang
Summary: Kaempferol inhibits non-small cell lung cancer (NSCLC) cell proliferation and promotes autophagy-induced cell death. It inhibits Met protein and mRNA expression, as well as the PI3K/AKT/mTOR signaling pathway. This study reveals a novel mechanism of kaempferol in inhibiting NSCLC through autophagy regulation of the Met and PI3K/AKT/mTOR signaling pathway.
Review
Medicine, General & Internal
Lin Jiang, Jingbo Zhang, Yan Xu, Heng Xu, Mengzhao Wang
Summary: The phosphosphatidylinositol-3-kinase (PI3K) signaling pathway plays a crucial role in the development of lung cancer. Traditional treatment methods have limited efficacy, but molecular targeted therapy has improved survival and prognosis for patients. There is a growing body of research focusing on NSCLC and the PI3K signaling pathway.
CHINESE MEDICAL JOURNAL
(2022)
Article
Multidisciplinary Sciences
Mingqi Han, Eric A. Bushong, Mayuko Segawa, Alexandre Tiard, Alex Wong, Morgan R. Brady, Milica Momcilovic, Dane M. Wolf, Ralph Zhang, Anton Petcherski, Matthew Madany, Shili Xu, Jason T. Lee, Masha Poyurovsky, Kellen Olszewski, Travis Holloway, Adrian Gomez, Maie St John, Steven M. Dubinett, Carla M. Koehler, Orian S. Shirihai, Linsey Stiles, Aaron Lisberg, Stefano Soatto, Saman Sadeghi, Mark H. Ellisman, David B. Shackelford
Summary: Mitochondria play a critical role in regulating metabolism and bioenergetics in cancer cells. The structural organization of mitochondrial networks defines their bioenergetic capacity. However, there is limited knowledge about the relationship between mitochondrial network structure and bioenergy activity.
Article
Biochemistry & Molecular Biology
Qi Tian, Tong Wu, Xiudi Zhang, Ke Xu, Xiaobo Yin, Xiaojie Wang, Shanshan Shi, Ping Wang, Liming Gao, Shufeng Xu, Xinyan Liu
Summary: This study found that circ_001678 acts as a sponge to up-regulate ZEB1 expression, inducing PD-1/PD-L1 pathway-dependent immune escape and promoting malignant progression of NSCLC.
HUMAN MOLECULAR GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Tsung-Ming Chang, Yao-Chang Chiang, Chiang-Wen Lee, Chieh-Mo Lin, Mei-Ling Fang, Miao-Ching Chi, Ju-Fang Liu, Yu Ru Kou
Summary: This study reveals the function of CXCL14 in promoting EMT and metastasis in lung cancer, with ACKR2 playing a role in this process. These findings can be used as prognostic biomarkers of lung cancer metastasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)