Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn’s disease

Synthesis of mannoheptose derivatives and their evaluation as inhibitors of the lectin LecB from the opportunistic pathogen Pseudomonas aeruginosa

(2015) Anna Hofmann et al.   CARBOHYDRATE RESEARCH

Development of Heptylmannoside-Based Glycoconjugate Antiadhesive Compounds against Adherent-Invasive Escherichia coli Bacteria Associated with Crohn's Disease

(2015) A. Sivignon et al.   mBio

Glycomimetics versus Multivalent Glycoconjugates for the Design of High Affinity Lectin Ligands

(2014) Samy Cecioni et al.   CHEMICAL REVIEWS

Mucosa-associated Faecalibacterium prausnitzii and Escherichia coli co-abundance can distinguish Irritable Bowel Syndrome and Inflammatory Bowel Disease phenotypes

(2014) Mireia Lopez-Siles et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Discovery of Two Classes of Potent Glycomimetic Inhibitors of Pseudomonas aeruginosa LecB with Distinct Binding Modes

(2013) Dirk Hauck et al.   ACS Chemical Biology

Structure-Based Optimization of the Terminal Tripeptide in Glycopeptide Dendrimer Inhibitors ofPseudomonas aeruginosaBiofilms Targeting LecA

(2013) Rameshwar U. Kadam et al.   CHEMISTRY-A EUROPEAN JOURNAL

Heptyl α-D-Mannosides Grafted on a β-Cyclodextrin Core To Interfere withEscherichia coliAdhesion: An In Vivo Multivalent Effect

(2013) Julie Bouckaert et al.   CHEMISTRY-A EUROPEAN JOURNAL

Thiazolylaminomannosides As Potent Antiadhesives of Type 1 Piliated Escherichia coli Isolated from Crohn’s Disease Patients

(2013) Sami Brument et al.   JOURNAL OF MEDICINAL CHEMISTRY

Relationship Between the Urinary Excretion Mechanisms of Drugs and Their Physicochemical Properties

(2013) Sumito Ito et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Chaperone-Usher Fimbriae of Escherichia coli

(2013) Daniël J. Wurpel et al.   PLoS One

Validation of Reactivity Descriptors to Assess the Aromatic Stacking within the Tyrosine Gate of FimH

(2013) Goedele Roos et al.   ACS Medicinal Chemistry Letters

Combinatorial Small-Molecule Therapy Prevents Uropathogenic Escherichia coli Catheter-Associated Urinary Tract Infections in Mice

(2012) Pascale S. Guiton et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Tyrosine Gate as a Potential Entropic Lever in the Receptor-Binding Site of the Bacterial Adhesin FimH

(2012) Adinda Wellens et al.   BIOCHEMISTRY

Inhibition of bacterial adhesion to live human cells: Activity and cytotoxicity of synthetic mannosides

(2012) Mirja Hartmann et al.   FEBS LETTERS

Antiadhesion Therapy for Urinary Tract Infections—A Balanced PK/PD Profile Proved To Be Key for Success

(2012) Xiaohua Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lead Optimization Studies on FimH Antagonists: Discovery of Potent and Orally Bioavailable Ortho-Substituted Biphenyl Mannosides

(2012) Zhenfu Han et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Flow Cytometry-Based Assay for Screening FimH Antagonists

(2011) Meike Scharenberg et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Metabolite-enabled eradication of bacterial persisters by aminoglycosides

(2011) Kyle R. Allison et al.   NATURE

Treatment and Prevention of Urinary Tract Infection with Orally Active FimH Inhibitors

(2011) C. K. Cusumano et al.   Science Translational Medicine

A bivalent glycopeptide to target two putative carbohydrate binding sites on FimH

(2010) Thisbe K Lindhorst et al.   Beilstein Journal of Organic Chemistry

Rapid Screening of Lectins for Multivalency Effects with a Glycodendrimer Microarray

(2010) Núria Parera Pera et al.   CHEMBIOCHEM

The functional valency of dodecamannosylated fullerenes with Escherichia coli FimH—towards novel bacterial antiadhesives

(2010) Maxime Durka et al.   CHEMICAL COMMUNICATIONS

Enterococcal Biofilm Formation and Virulence in an Optimized Murine Model of Foreign Body-Associated Urinary Tract Infections

(2010) P. S. Guiton et al.   INFECTION AND IMMUNITY

Structure-Based Drug Design and Optimization of Mannoside Bacterial FimH Antagonists

(2010) Zhenfu Han et al.   JOURNAL OF MEDICINAL CHEMISTRY

FimH Antagonists for the Oral Treatment of Urinary Tract Infections: From Design and Synthesis to in Vitro and in Vivo Evaluation

(2010) Tobias Klein et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of an aggregation assay to screen FimH antagonists

(2010) Daniela Abgottspon et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation

(2010) L. Dethlefsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early Severe Inflammatory Responses to Uropathogenic E. coli Predispose to Chronic and Recurrent Urinary Tract Infection

(2010) Thomas J. Hannan et al.   PLoS Pathogens

Crohn's disease adherent-invasiveEscherichia colicolonize and induce strong gut inflammation in transgenic mice expressing human CEACAM

(2009) Frédéric A. Carvalho et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Physicochemical Determinants of Human Renal Clearance

(2009) Manthena V. S. Varma et al.   JOURNAL OF MEDICINAL CHEMISTRY

A murine model of urinary tract infection

(2009) Chia-Suei Hung et al.   Nature Protocols

From carbohydrate leads to glycomimetic drugs

(2009) Beat Ernst et al.   NATURE REVIEWS DRUG DISCOVERY

Structural biology of the chaperone–usher pathway of pilus biogenesis

(2009) Gabriel Waksman et al.   NATURE REVIEWS MICROBIOLOGY

TLR4-mediated expulsion of bacteria from infected bladder epithelial cells

(2009) J. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Architectures and biogenesis of non-flagellar protein appendages in Gram-negative bacteria

(2008) Remi Fronzes et al.   EMBO JOURNAL

Antibiotic-Induced Perturbations of the Intestinal Microbiota Alter Host Susceptibility to Enteric Infection

(2008) I. Sekirov et al.   INFECTION AND IMMUNITY

Intervening with Urinary Tract Infections Using Anti-Adhesives Based on the Crystal Structure of the FimH–Oligomannose-3 Complex

(2008) Adinda Wellens et al.   PLoS One