Review
Biochemistry & Molecular Biology
Chien-An Chu, Yi-Wen Wang, Yi-Lin Chen, Hui-Wen Chen, Jing-Jing Chuang, Hong-Yi Chang, Chung-Liang Ho, Chen Chang, Nan-Haw Chow, Chung-Ta Lee
Summary: PIK3C3, as a member of the PI3K family, plays a critical role in autophagy and tumor development. Inhibition of PIK3C3 can suppress autophagy and affect tumor cell proliferation, growth, and invasion. Discovery of pharmacological inhibitors targeting PIK3C3 may provide new strategies for improving treatment outcomes in PIK3C3-mediated diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Wenqiang Song, J. Luke Postoak, Guan Yang, Xingyi Guo, Heather H. Pua, Jackie Bader, Jeffrey C. Rathmell, Hanako Kobayashi, Volker H. Haase, Katrina L. Leaptrot, Alexandra C. Schrimpe-Rutledge, Stacy D. Sherrod, John A. McLean, Jianhua Zhang, Lan Wu, Luc Van Kaer
Summary: The lipid kinase PIK3C3 plays a crucial role in maintaining adipose tissue homeostasis and systemic metabolism. Its deficiency disrupts adipocyte autophagy and hinders adipocyte differentiation, survival, and function, leading to abnormalities in adipose tissue and the development of metabolic diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Guan Yang, Wenqiang Song, J. Luke Postoak, Jin Chen, Jennifer Martinez, Jianhua Zhang, Lan Wu, Luc Van Kaer
Summary: PIK3C3 plays a critical role in T cell metabolism and function, with its deficiency leading to impaired metabolism and differentiation of T cells, as well as reduced levels of active mitochondria. Interestingly, Pik3c3 deletion did not significantly affect the ability of animals to clear tumor metastases.
Review
Neurosciences
Yan-Yan Li, Zheng-Hong Qin, Rui Sheng
Summary: Autophagy plays an important role in neurological diseases by degrading abnormal proteins and damaged organelles, regulating apoptosis and inflammation, and maintaining cellular homeostasis in the nervous system. Multiple signaling pathways are involved in the regulation of autophagy and can serve as potential therapeutic targets for neurological diseases.
NEUROSCIENCE BULLETIN
(2023)
Article
Cell Biology
Zehan Hu, Devanarayanan Siva Sankar, Bich Vu, Alexandre Leytens, Christine Vionnet, Wenxian Wu, Michael Stumpe, Esther Martinez-Martinez, Bjoern Stork, Joern Dengjel
Summary: ULK1 kinase complex is a key regulator of autophagy, phosphorylating autophagy-relevant proteins for autophagosome maturation and turnover. It also interacts closely with various phosphatase complexes, such as PP2A, to coordinate protein degradation through autophagy.
Editorial Material
Cell Biology
Wenqiang Song, J. Luke Postoak, Lan Wu, Luc Van Kaer
Summary: Adipose tissue plays an important role in health and metabolic diseases. Deficiency of lipid kinase PIK3C3/VPS34 in adipocytes leads to defects in adipocyte differentiation, survival and function, resulting in reduced adipose tissue mass, abnormal blood lipid levels, fatty liver disease, diabetes, and impaired body temperature control. These findings suggest that targeting adipocyte PIK3C3/VPS34 could be a potential therapeutic intervention for metabolic diseases.
Article
Cell Biology
Guan Yang, J. Luke Postoak, Wenqiang Song, Jennifer Martinez, Jianhua Zhang, Lan Wu, Luc Van Kaer
Summary: The study revealed a critical role of PIK3C3 in DC function and the pathogenicity of these cells during EAE, with important implications for the development of immunotherapies for autoimmune diseases such as MS.
Article
Pharmacology & Pharmacy
Daewon Han, Deokryong Kim, Haeil Kim, Jeonga Lee, Jungmook Lyu, Jong-Seok Kim, Jongdae Shin, Jeong Sig Kim, Do Kyung Kim, Hwan-Woo Park
Summary: In this study, it was found that Methylsulfonylmethane (MSM) can enhance the autophagy flux through the AMPK/mTOR/ULK1 pathway, improving hepatic steatosis and potentially serving as a treatment for obesity-related MAFLD.
FRONTIERS IN PHARMACOLOGY
(2023)
Editorial Material
Cell Biology
Cansu Karabiyik, David C. Rubinsztein
Summary: During glucose starvation, activation of AMPK, ULK1, and PIKFYVE kinases via a non-canonical signaling pathway leads to the formation of autophagosomes containing PtdIns5P, increasing autophagy flux and facilitating the clearance of autophagy substrates.
Article
Environmental Sciences
Yinyue Luo, Dongxin Da, Qingqing Weng, Shuran Yao, Hao Zhang, Xinxin Han, Ying Zhang
Summary: This study found that overexpression of miR-296-5p can accelerate autophagy in fluoride-induced dental fluorosis, while its underexpression has an inhibitory effect on autophagy. MiR-296-5p may improve the secretion of autophagic mediators by activating AMPK/ULK1 expression, suggesting it as a potential therapeutic target under high fluoride stimulation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Nobuyuki Fujiwara, Shusaku Shibutani, Takashi Ohama, Koichi Sato
Summary: Autophagy is regulated by the Beclin 1/Vps34 complex, and the protein phosphatase 6 (PP6) inhibits autophagy by binding to Beclin 1 and causing dissociation of Vps34. The phosphatase activity of PP6 is not involved in this regulatory mechanism.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Geriatrics & Gerontology
Jia Song, Jidong Liu, Chen Cui, Huiqing Hu, Nan Zang, Mengmeng Yang, Jingwen Yang, Ying Zou, Jinquan Li, Lingshu Wang, Qin He, Xinghong Guo, Ruxing Zhao, Fei Yan, Fuqiang Liu, Xinguo Hou, Zheng Sun, Li Chen
Summary: Human umbilical cord mesenchymal stromal cells (hucMSCs) and hucMSC-derived exosomes (MSC-EXO) can alleviate diabetes- and obesity-induced muscle atrophy by enhancing AMPK/ULK1-mediated autophagy, suggesting their potential as a treatment for muscle atrophy.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Pharmacology & Pharmacy
Dina Zakaria Mohamed, Alaa El-Din El-Sayed El-Sisi, Samia Salim Sokar, Abdelhadi Mohamed Shebl, Sally El-Sayed Abu-Risha
Summary: This study showed that OCT induced protective autophagy to protect liver against HIR injury in rats, while MLT reversed the hepatoprotective effects of OCT by inhibiting autophagy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Mengshu Jia, Xiao Yue, Weixia Sun, Qianjun Zhou, Cheng Chang, Weihua Gong, Jian Feng, Xie Li, Ruonan Zhan, Kemin Mo, Lijuan Zhang, Yajie Qian, Yuying Sun, Aoxue Wang, Yejun Zou, Weicai Chen, Yan Li, Li Huang, Yi Yang, Yuzheng Zhao, Xiawei Cheng
Summary: In this study, it was found that lactate dehydrogenase A (LDHA) is activated upon UNC-51-like kinase 1 (ULK1) activation under nutrient deprivation, and promotes lactate production through Vps34 lactylation. These findings describe the interplay between autophagy and glycolysis.
Article
Multidisciplinary Sciences
Qing-Bo Lu, Yi Ding, Yao Liu, Zi-Chao Wang, Yu-Jie Wu, Kai -Ming Niu, Ke-Xue Li, Ji -Ru Zhang, Hai-Jian Sun
Summary: Metrnl plays a protective role in diabetic cardiomyopathy and may serve as a therapeutic target or regimen.
JOURNAL OF ADVANCED RESEARCH
(2023)