Review
Medicine, General & Internal
Hitoshi Terui, Yoshihide Asano
Summary: Psoriasis is a chronic inflammatory skin disease associated with a high prevalence of cardiovascular disease, obesity, dyslipidemia, hypertension, diabetes mellitus, and metabolic syndrome. Cardiovascular disease is the leading cause of morbidity and mortality in psoriasis patients. Biologics targeting inflammatory cytokines have shown efficacy in improving psoriasis and reducing the risk of cardiovascular disease. This review discusses the cardiovascular risk in psoriasis patients, the association between psoriatic inflammation and atherosclerosis, and the efficacy of biologics in reducing the risk of cardiovascular diseases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Maria J. E. Visser, Gareth Tarr, Etheresia Pretorius
Summary: Psoriasis is a common inflammatory skin disorder driven by interleukin-17, with a multifactorial etiology and increased risk for multiple comorbid conditions, particularly cardiovascular disease. The presence of a hypercoagulable state in psoriatic patients may contribute to the association with cardiovascular disease. Inflammation and coagulation are closely related in the pathophysiology of Psoriasis and its comorbid conditions.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Peripheral Vascular Disease
Brittany Weber, Joseph F. Merola, M. Elaine Husni, Marcelo Di Carli, Jeffrey S. Berger, Michael S. Garshick
Summary: Psoriasis is associated with increased cardiovascular risk, and recent studies have identified mechanisms such as vascular endothelial dysfunction, platelet activation, dyslipidemia, and cardiometabolic comorbidities. Biologic therapies have shown promise in reducing cardiovascular risk in psoriasis patients, but further research is needed to confirm these findings.
CURRENT ATHEROSCLEROSIS REPORTS
(2021)
Article
Dermatology
Stefano Piaserico, Evangelia Papadavid, Annagrazia Cecere, Gloria Orlando, Konstantrinos Theodoropoulos, Pelagia Katsimbri, George Makavos, Penelope Rafouli-Stergiou, Sabino Iliceto, Mauro Alaibac, Francesco Tona, Ignatios Ikonomidis
Summary: Severe psoriasis is associated with an increased cardiovascular risk, and coronary microvascular dysfunction (CMD) has been shown to predict a poor cardiovascular prognosis. This study evaluated the prevalence and predictors of CMD in a large cohort of patients with psoriasis without clinical cardiovascular disease. The results showed that higher PASI, longer disease duration, the presence of psoriatic arthritis, and hypertension were independently associated with CMD.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Review
Immunology
Gloria Orlando, Barbara Molon, Antonella Viola, Mauro Alaibac, Roberta Angioni, Stefano Piaserico
Summary: Psoriasis is a chronic inflammatory skin disease associated with various comorbidities, including cardiovascular diseases. Current research focuses on the pathways linking psoriatic plaques to the cardiovascular system, as well as the potential involvement of endothelial cells in this process.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Youssef A. Elnabawi, Michael S. Garshick, Michael Tawil, Tessa J. Barrett, Edward A. Fisher, Kristen Lo Sicco, Andrea L. Neimann, Jose U. Scher, James Krueger, Jeffrey S. Berger
Summary: The study demonstrated that CCL20 expression is closely associated with vascular endothelial inflammation in psoriasis patients and may serve as a potential biomarker of impaired vascular health. CCL20, IL-6, and IL-17A were the top three circulating proinflammatory cytokines in psoriasis.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Dermatology
A. Gonzalez-Cantero, W. H. Boehncke, J. De Sutter, J. L. Zamorano, J. Lambert, L. Puig
Summary: This study aims to provide dermatologists with a tool to systematize the treatment of dyslipidemia in psoriasis and aid in decision-making. The study resulted in a list of concepts and recommendations for managing cardiovascular risk and using statin therapy in moderate-severe psoriasis patients. The application of these recommendations will help dermatologists manage patients' dyslipidemia and reduce their cardiovascular risk.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Medicine, Research & Experimental
Daciana Elena Branisteanu, Alin Codrut Nicolescu, Daniel Constantin Branisteanu, Catalina Ioana Branisteanu, Andreea Corina Dragoi, Camelia Margareta Bogdanici, Mihaela Paula Toader, Andreea Lorena Tucaliuc, Andreea Dimitriu, Doru Daogaru, Ruxandra Angela Pirvulescu, Elena Andrese Porumb
Summary: Psoriasis, previously considered as a skin-limited condition, is now recognized as a chronic, immune-mediated inflammatory disease with systemic manifestations. Besides the skin changes, it is associated with important comorbidities, such as psoriatic arthritis, cardiovascular disease, diabetes, and inflammatory bowel disease. Psoriasis is also an independent risk factor for cardiovascular diseases, and biological therapy may have an effect on atherosclerosis regression.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Review
Physiology
Karsten Krueger, Paulos Tirekoglou, Christopher Weyh
Summary: Exercise has positive effects on the treatment of dyslipidemia, potentially through mechanisms of increased energy consumption and substrate metabolism regulation. Additionally, exercise can influence immune processes and have anti-inflammatory effects.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Dermatology
J. J. Wu, A. Kavanaugh, M. G. Lebwohl, R. Gniadecki, J. F. Merola
Summary: Psoriasis is a chronic inflammatory disorder that is often associated with comorbidities, particularly metabolic syndrome. The underlying pathophysiology of psoriasis and metabolic syndrome appears to involve genetic predispositions and inflammatory pathways. Biologic treatments for psoriasis may not only improve skin lesions but also reduce the risk of developing atherosclerosis and cardiovascular diseases.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marco Casciaro, Eleonora Di Salvo, Sebastiano Gangemi
Summary: Psoriasis is a pathology characterized by systemic inflammation, enhanced keratinocytes proliferation, and abnormal cell maturation. Several proinflammatory mediators and alarmins, including HMGB1, are increased in the skin and blood of psoriasis patients. Blocking HMGB1 has shown effectiveness in ameliorating psoriasis.
Article
Dermatology
Michael S. Garshick, Yvonne Baumer, Amit K. Dey, Ryan Grattan, Qimin Ng, Heather L. Teague, Zu-Xi Yu, Marcus Y. Chen, Michael Tawil, Tessa J. Barrett, James Underberg, Edward A. Fisher, James Krueger, Tiffany M. Powell-Wiley, Martin P. Playford, Jeffrey S. Berger, Nehal N. Mehta
Summary: The study found that PCSK9 levels were elevated in psoriasis patients, correlated with disease severity, and associated with cardiovascular risk factors in both animal models and human cohorts.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Immunology
Silje Michelsen Solberg, Anders Krogh Aarebrot, Irene Sarkar, Aleksandra Petrovic, Lene Froyen Sandvik, Brith Bergum, Roland Jonsson, Yenan Troy Bryceson, Silke Appel
Summary: This study analyzed peripheral blood mononuclear cells (PBMCs) in psoriasis patients and healthy controls, finding an increase in certain immune cells in severe psoriasis patients, and relief of systemic inflammation after biological treatment.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kohsuke Shirakawa, Motoaki Sano
Summary: Advances in secondary prevention of cardiovascular diseases have greatly improved prognosis, but CVDs remain a leading cause of global mortality, warranting a re-evaluation of cardiovascular risk and optimal therapy. Inflammation, pro-thrombotic factors, and gene mutations have emerged as potential therapeutic targets for CVDs, with recent studies suggesting the possibility of anti-inflammatory therapy. Osteopontin (OPN) has shown dual roles in cardiovascular pathology, with acute increases having protective effects and chronic increases predicting a poor prognosis, highlighting its potential as a therapeutic target.
Review
Physiology
Jun Ren, Ne N. Wu, Shuyi Wang, James R. Sowers, Yingmei Zhang
Summary: The rise in heart failure prevalence is partly due to increasing rates of overweight and obesity. Evidence supports the existence of obesity cardiomyopathy as a unique disease entity that develops independently of other heart diseases. Clinical and experimental research have identified pathological changes in myocardial structure and function in obesity, highlighting various cellular and molecular mechanisms underlying this condition.
PHYSIOLOGICAL REVIEWS
(2021)
Article
Allergy
Maria Rasmussen Rinnov, Anne-Sofie Halling, Trine Gerner, Nina Haarup Ravn, Mette Hjorslev Knudgaard, Simon Trautner, Susan M. Goorden, Karen J. M. Ghauharali-van der Vlugt, Femke S. Stet, Lone Skov, Simon Francis Thomsen, Alexander Egeberg, Aske L. L. Rosted, Troels Petersen, Ivone Jakasa, Christoph Riethmuller, Sanja Kezic, Jacob P. Thyssen
Summary: This study found that levels and chain length of certain lipids were altered in infants who later developed AD, and that TARC/CCL17 levels were higher in these infants.
Article
Dermatology
Amanda Kvist-Hansen, Laura Perez-Alos, Rownaq Fares Al-Sofi, Line Dam Heftdal, Sebastian Rask Hamm, Dina Leth Moller, Mia Marie Pries-Heje, Kamille Fogh, Cecilie Bo Hansen, Rasmus Bo Hasselbalch, Johannes Roth Madsen, Jose Juan Almagro Armenteros, Ruth Frikke-Schmidt, Linda Hilsted, Erik Sorensen, Sisse Rye Ostrowski, Henning Bundgaard, Susanne Dam Nielsen, Kasper Iversen, Claus Zachariae, Peter Garred, Lone Skov
Summary: This study examined the long-term immunity after mRNA-based COVID-19 vaccination in psoriasis patients on immunomodulatory therapy. The study found that patients receiving anti-TNF treatment had a faster decline in immunity markers compared to the control group at the 6-month mark.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Ida Vittrup, Yuki M. F. Andersen, Lone Skov, Jashin J. Wu, Tove Agner, Simon F. Thomsen, Alexander Egeberg, Jacob P. Thyssen
Summary: In this cross-sectional study, the association between hospital-managed pediatric atopic dermatitis, school performance, and cognitive function was examined. The study found that children with atopic dermatitis, especially when severe, performed worse in lower secondary school, but not in upper secondary school. Additionally, young men with atopic dermatitis scored lower in IQ testing than those without it. This highlights the importance of addressing the impact of atopic dermatitis on academic achievements and cognitive function.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Anna M. Andersson, Hannah Kaiser, Lone Skov, Anders Koch, Jacob P. Thyssen
Summary: The overall prevalence of physician-diagnosed atopic dermatitis in Greenlandic children aged 0-7 years is 35%, indicating a high prevalence and a likely increase over the past 20 years. Atopic dermatitis is significantly associated with Inuit descent, parental atopic disposition, and higher socioeconomic status.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Allergy
Malin Glindvad Ahlstrom, Lone Skov, Steffen Heegaard, Claus Zachariae, Lene Heise Garvey, Jeanne Duus Johansen
Summary: A retrospective study in a Danish tertiary dermatology department found that allergic contact dermatitis (ACD) in the eye region caused by topical eye medications is difficult to diagnose and may be overlooked. The study identified phenylephrine, timolol, and ketotifen as the main culprits of contact allergy to topical eye allergens/medications. Patients often had previous diagnoses of cataract or glaucoma and reported multiple previous reactions, with symptoms including edema, erythema, and dermatitis in the eye region.
CONTACT DERMATITIS
(2023)
Article
Allergy
Anne-Sofie Halling, Maria Rasmussen Rinnov, Iben Frier Ruge, Trine Gerner, Nina Haarup Ravn, Mette Hjorslev Knudgaard, Simon Trautner, Nikolai Loft, Lone Skov, Simon F. Thomsen, Alexander Egeberg, Emma Guttman-Yassky, Aske L. L. Rosted, Troels Petersen, Ivone Jakasa, Sanja Kezic, Jacob P. Thyssen
Summary: This study aimed to investigate whether skin biomarkers collected in infancy can predict the onset of atopic dermatitis (AD) and be used in future prevention trials. The results showed that skin biomarkers collected at birth did not predict the onset of AD. However, elevated levels of certain immune and barrier biomarkers collected at 2 months of age increased the risk of AD.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Dermatology
Tu Hu, Tanja Todberg, David Adrian Ewald, Ilka Hoof, Joel Correa da Rosa, Lone Skov, Thomas Litman
Summary: The skin transcriptome of atopic dermatitis (AD) is stable over time, with the largest variation due to disease, individual, and skin site. AD-specific differentially expressed genes revealed disrupted skin barrier and activated immune response as the main features of AD. Potential novel targets in AD were also identified. This study provides new methods and insights for future skin research.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Letter
Dermatology
Amy X. Du, Zarqa Ali, Kawa K. Ajgeiy, Maiken G. Dalager, Tomas N. Dam, Alexander Egeberg, Christoffer V. S. Nissen, Lone Skov, Simon Francis Thomsen, Sepideh Emam, Robert Gniadecki
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Review
Dermatology
Diva Amiri, Christopher Willy Schwarz, Lise Gether, Lone Skov
Summary: Facial and genital psoriasis can significantly impact the quality of life and are difficult to treat. Topical calcineurin inhibitors have been recognized as an effective off-label treatment for these sensitive areas, but limited data on safety and efficacy are available. A systematic review of the literature found positive efficacy in all 24 included studies, with statistically significant reductions in psoriasis severity observed in 11 studies. The most common short-term adverse effects reported were local stinging, burning, and itching. Topical calcineurin inhibitors play an important role in the treatment of facial and genital psoriasis, demonstrating effectiveness and generally good tolerability with minimal adverse effects.
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Allergy
Lise Gether, Heidi Storgaard, Sanja Kezic, Ivone Jakasa, Bolette Hartmann, Kirsa Skov-Jeppesen, Jens J. Holst, Anders J. Pedersen, Julie Forman, Gerrit van Hall, Ole E. Sorensen, Lone Skov, Mads A. Ropke, Filip K. Knop, Jacob Pontoppidan Thyssen
Summary: This study investigated whether whole-body treatment with topical corticosteroids for atopic dermatitis could lead to insulin resistance and increased bone resorption. The results showed that short-term use of these corticosteroids did not affect glucose metabolism but had a negative impact on bone formation.
Article
Health Care Sciences & Services
Mette Gyldenlove, Howraman Meteran, Jennifer A. Sorensen, Simon Fage, Yiqiu Yao, Jesper Lindhardsen, Christoffer V. Nissen, Tanja Todberg, Simon F. Thomsen, Lone Skov, Claus Zachariae, Lars Iversen, Mia -Louise Nielsen, Alexander Egeberg
Summary: This study demonstrates the efficacy and safety of oral roflumilast in treating moderate-to-severe psoriasis, suggesting that it may serve as a cost-effective and convenient alternative treatment option.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Dermatology
Maria Rasmussen Rinnov, Trine Gerner, Anne-Sofie Halling, Mie Sylow Liljendahl, Nina Haarup Ravn, Mette Hjorslev Knudgaard, Simon Trautner, Lone Skov, Simon Francis Thomsen, Alexander Egeberg, Ivone Jakasa, Sanja Kezic, Andreas Petersen, Anders Rhod Larsen, Casper Dam-Nielsen, Jens Otto Jarlov, Jacob P. Thyssen
Summary: This study found that colonization of Staphylococcus aureus was more common at 2 months of age in children who later developed atopic dermatitis (AD). However, there was no association between S. aureus colonization and the severity or age at onset of AD.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Mie S. Liljendahl, Nikolai Loft, Tri-Long Nguyen, Lone Skov, Alexander Egeberg
Summary: This study provides the first estimation of the proportion of patients with moderate-to-severe psoriasis in Denmark who are eligible for systemic therapy but do not receive it. The results showed that a large number of patients with moderate-to-severe psoriasis are candidates for systemic therapy but do not receive it. Furthermore, the study found that the time on conventional systemic therapy has become shorter and more patients are initiating biologics as second-line therapy.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Urology & Nephrology
Anne Kristine Rondbjerg, Mette Gyldenlove, Dorrit Krustrup, Marianne Rix, Ilse Vejborg, Lars Lonn, Niklas Rye Jorgensen, Andreas Pasch, Lone Skov, Ditte Hansen
Summary: This study investigated the presence of cutaneous calcifications in non-lesional tissue in patients with chronic kidney disease and their relation to systemic vascular calcification. The study found no cutaneous vascular calcifications in non-lesional skin biopsies. However, breast arterial calcification was present in patients with chronic kidney disease and calcific uremic arteriolopathy, but not in the control group. These findings suggest a high burden of systemic vascular calcification in patients with chronic kidney disease.
JOURNAL OF NEPHROLOGY
(2023)
Article
Dermatology
V. W. Nielsen, C. B. Johansen, T. Todberg, L. Skov, C. V. Nissen, R. Dodge, A. Egeberg, J. P. Thyssen, S. F. Thomsen
Summary: This study evaluated a value-based healthcare model for psoriasis patients, remunerating treatment based on patient reported outcomes and successfully predicting expected outcomes to incentivize over-performance.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)