Alum colloid encapsulated inside β-glucan particles enhance humoral and CTL immune responses of MUC1 vaccine

We have developed a MUC1 antigen-based antitumor vaccine loaded on alum colloid encapsulated inside beta-glucan particles (GP-Al). The constructed vaccine induced strong MUC1 antigen specific IgG antibody titers and enhanced CD8(+) T cells cytotoxic effect to kill tumor cells. These results indicated that GP-Al can be served as an efficient delivery system and adjuvant for the development of cancer vaccines especially small molecule antigens based cancer vaccines. (C) 2021 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Automated summary

The study developed an antitumor vaccine based on MUC1 antigen, which induced strong antigen-specific antibody response and enhanced the cytotoxic effect of CD8(+) T cells against tumor cells.