Article
Clinical Neurology
Marlous C. M. van Der Weijden, Dayana Rodriguez-Contreras, Catherine C. S. Delnooz, Brooks G. Robinson, Alec F. Condon, Michelle L. Kielhold, Gilles N. Stormezand, Kai Yu Ma, Claudia Dufke, John T. Williams, Kim A. Neve, Marina A. J. Tijssen, Dineke S. Verbeek
Summary: This study described a unique dominantly inherited clinical phenotype in a 4-generation Dutch pedigree, identifying a novel DRD2 gene variant as likely causative. Functional characterization of the variant revealed altered D2 receptor activity in cell models and mouse brain slices, supporting its association with the hyperkinetic movement disorder in the pedigree.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Jan Kasper, Simon B. Eickhoff, Svenja Caspers, Jessica Peter, Imis Dogan, Robert Christian Wolf, Kathrin Reetz, Juergen Dukart, Michael Orth
Summary: Kasper et al. found that in Huntington's disease, the functional integrity of the dopamine receptor-rich caudate nucleus plays a crucial role in maintaining network function. Loss of caudate functional integrity leads to motor signs independent of atrophy. This finding may have implications for other neurodegenerative diseases.
Article
Neurosciences
Hector M. Estevez-Silva, Tomas Mediavilla, Bruno Lima Giacobbo, Xijia Liu, Fahad R. Sultan, Daniel J. Marcellino
Summary: This study investigated the disease-modifying effects of pridopidine in a SOD1 G93A mouse model of ALS. The results showed that pridopidine can modify ALS-associated cachexia and motor deficits, but did not extend the survival of the animals.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Review
Clinical Neurology
Shujun Chen, Tianyu Liang, Tao Xue, Shouru Xue, Qun Xue
Summary: Pridopidine was found to improve motor scores in HD patients, with no significant adverse effects observed in both short-term and long-term use. However, when the dosage exceeded 90 mg/day, improvements in motor scores were seen but with increased risk of adverse events, such as nasopharyngitis and insomnia. Further randomized controlled trials are needed to evaluate the efficacy and safety of pridopidine in Huntington's disease.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Julius Verrel, Fabian Chwolka, Elisa Filevich, Josephine Moye, Theresa Paulus, Simone Zittel, Tobias Baeumer, Alexander Muenchau, Anne Weissbach
Summary: The study aimed to test if FMD patients have difficulties in accurately judging and evaluating their own movements, and found that they showed impairments in both visuomotor decision-making and metacognitive evaluation of these decisions.
MOVEMENT DISORDERS
(2023)
Review
Psychiatry
Jian Zhang, Guojun Wang, Xi Yang, Keming Gao
Summary: A meta-analysis compared the efficacy and safety of ECT combination with medication versus medication alone in treating acute mania. ECT-combo was found to outperform Med-alone in reducing manic symptoms, but also had increased memory impairment. Larger studies are needed to further confirm these findings due to high heterogeneity in the included studies.
PSYCHIATRY RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Igor D. Grachev, Philipp M. Meyer, Georg A. Becker, Marcus Bronzel, Doug Marsteller, Gina Pastino, Ole Voges, Laura Rabinovich, Helena Knebel, Franziska Zientek, Michael Rullmann, Bernhard Sattler, Marianne Patt, Thilo Gerhards, Maria Strauss, Andreas Kluge, Peter Brust, Juha-Matti Savola, Mark F. Gordon, Michal Geva, Swen Hesse, Henryk Barthel, Michael R. Hayden, Osama Sabri
Summary: Pridopidine demonstrates high affinity for the S1R in clinical trials, with near complete occupancy at a clinically relevant single dose of 90 mg. Minimal occupancy is seen at the D2/D3R, indicating pridopidine's selectivity as an S1R ligand. The dose-S1R occupancy relationship suggests cooperative binding of pridopidine to the S1R.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Review
Medicine, General & Internal
Rajeshwar Andhale, Deepti Shrivastava
Summary: Huntington's disease is a completely penetrant neurological condition caused by a gene mutation. Recent progress has been made in studying the cellular pathology and structural changes in the brain as the disease advances. Current treatment mainly focuses on palliative therapy and symptom control, but new treatments aiming to reduce mutant protein are showing promise.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jaclyn Iannucci, Katherine O'Neill, Xuehua Wang, Sanjib Mukherjee, Jun Wang, Lee A. Shapiro
Summary: Traumatic brain injury (TBI) is a major health concern, affecting over 50 million individuals worldwide each year. Previous research has suggested a link between TBI and substance use disorders, particularly related to the dopaminergic system. This study explored changes in hippocampal D2 receptor expression following TBI and found that male mice exhibit higher baseline expression compared to female mice. TBI led to significant reductions in D2 expression in male mice, while female mice remained mostly unaffected. These results suggest that there may be sex differences in the vulnerability of the dopaminergic system to TBI-induced plasticity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Jayantee Kalita, Abhilasha Tripathi, Mahesh Jadhav, Ravindra S. Thakur, Devendra K. Patel
Summary: Movement disorder is an important manifestation of neurologic Wilson disease, but there is little information on dopaminergic pathways. In this study, we evaluate dopamine and its receptors in patients with NWD and correlate the changes with movement disorder and MRI changes.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Luca Magistrelli, Marco Ferrari, Alessia Furgiuele, Anna Vera Milner, Elena Contaldi, Cristoforo Comi, Marco Cosentino, Franca Marino
Summary: Parkinson's disease is a neurodegenerative disorder caused by loss of dopaminergic neurons. Treatment relies on dopaminergic replacement, but genetic factors can influence the clinical progression and drug response in patients. Understanding the genetic variability of dopaminergic receptors may provide insights into the development of personalized therapies for PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Yudai Takarada, Daichi Nozaki
Summary: This study found that producing a shout can enhance handgrip maximal voluntary force by increasing motor cortical excitability and possibly noradrenergic system activity. The enhancement effect may be related to changes in the motor system state and the pupil-linked neuromodulatory system state.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Analytical
Yuichi Nishikawa, Kohei Watanabe, Ales Holobar, Tetsuya Takahashi, Noriaki Maeda, Hirofumi Maruyama, Shinobu Tanaka, Allison S. Hyngstrom
Summary: The study revealed a moderate-to-strong correlation between degeneration of dopaminergic pathways and MU firing behavior in PD patients, indicating that abnormalities in MU activity can be used to predict central nervous system degeneration following PD.
Article
Pharmacology & Pharmacy
Dasiel O. Borroto-Escuela, Karolina Wydra, Ramon Fores-Pons, Lakshmi Vasudevan, Wilber Romero-Fernandez, Malgorzata Frankowska, Luca Ferraro, Sarah Beggiato, Minerva Crespo-Ramirez, Alicia Rivera, Luisa L. Rocha, Miguel Perez de la Mora, Christophe Stove, Malgorzata Filip, Kjell Fuxe
Summary: The widespread distribution of heteroreceptor complexes with allosteric receptor-receptor interactions in the CNS plays a key role in learning, memory, and the development of substance use disorders like morphine and cocaine use disorders. These complexes could be potential pharmacological targets to modulate reward and substance use disorders.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Benjamin E. Blass, Peng-Jen Chen, Michelle Taylor, Suzy A. Griffin, John C. Gordon, Robert R. Luedtke
Summary: Substance use disorder, particularly with cocaine, is a significant medical need with no approved therapies. The D3 dopamine receptor has been identified as a potential treatment target, and a new series of compounds with higher solubility and selectivity for D-3 has been discovered.
MEDICINAL CHEMISTRY RESEARCH
(2022)
Article
Medicine, General & Internal
Karl Kieburtz, Barbara C. Tilley, Jordan J. Elm, Debra Babcock, Robert Hauser, G. Webster Ross, Alicia H. Augustine, Erika U. Augustine, Michael J. Aminoff, Ivan G. Bodis-Wollner, James Boyd, Franca Cambi, Kelvin Chou, Chadwick W. Christine, Michelle Cines, Nabila Dahodwala, Lorelei Derwent, Richard B. Dewey, Katherine Hawthorne, David J. Houghton, Cornelia Kamp, Maureen Leehey, Mark F. Lew, Grace S. Lin Liang, Sheng T. Luo, Zoltan Mari, John C. Morgan, Sotirios Parashos, Adriana Perez, Helen Petrovitch, Suja Rajan, Sue Reichwein, Jessie Tatsuno Roth, Jay S. Schneider, Kathleen M. Shannon, David K. Simon, Tanya Simuni, Carlos Singer, Lewis Sudarsky, Caroline M. Tanner, Chizoba C. Umeh, Karen Williams, Anne-Marie Wills
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2015)
Article
Biochemistry & Molecular Biology
Timothy R. Sampson, Justine W. Debelius, Taren Thron, Stefan Janssen, Gauri G. Shastri, Zehra Esra Ilhan, Collin Challis, Catherine E. Schretter, Sandra Rocha, Viviana Gradinaru, Marie-Francoise Chesselet, Ali Keshavarzian, Kathleen M. Shannon, Rosa Krajmalnik-Brown, Pernilla Wittung-Stafshede, Rob Knight, Sarkis K. Mazmanian
Article
Clinical Neurology
Laurent Antunes, Sonia Frasquilho, Marek Ostaszewski, Jos. Weber, Laura Longhino, Paul Antony, Aidos Baumuratov, Manuel Buttini, Kathleen M. Shannon, Rudi Balling, Nico J. Diederich
MOVEMENT DISORDERS
(2016)
Article
Clinical Neurology
Andrew McGarry, Michael McDermott, Karl Kieburtz, Elisabeth A. de Blieck, Flint Beal, Karen Marder, Christopher Ross, Ira Shoulson, Peter Gilbert, William M. Mallonee, Mark Guttman, Joanne Wojcieszek, Rajeev Kumar, Mark S. LeDoux, Mary Jenkins, H. Diana Rosas, Martha Nance, Kevin Biglan, Peter Como, Richard M. Dubinsky, Kathleen M. Shannon, Padraig O'Suilleabhain, Kelvin Chou, Francis Walker, Wayne Martin, Vicki L. Wheelock, Elizabeth McCusker, Joseph Jankovic, Carlos Singer, Juan Sanchez-Ramos, Burton Scott, Oksana Suchowersky, Stewart A. Factor, Donald S. Higgins, Eric Molho, Fredy Revilla, John N. Caviness, Joseph H. Friedman, Joel S. Perlmutter, Andrew Feigin, Karen Anderson, Ramon Rodriguez, Nikolaus R. McFarland, Russell L. Margolis, Eric S. Farbman, Lynn A. Raymond, Valerie Suski, Sandra Kostyk, Amy Colcher, Lauren Seeberger, Eric Epping, Sherali Esmail, Nancy Diaz, Wai Lun Alan Fung, Alan Diamond, Samuel Frank, Philip Hanna, Neal Hermanowicz, Leon S. Dure, Merit Cudkowicz
Article
Clinical Neurology
Kevin Michael Biglan, Ira Shoulson, Karl Kieburtz, David Oakes, Elise Kayson, M. Aileen Shinaman, Hongwei Zhao, Megan Romer, Anne Young, Steven Hersch, Jack Penney, Karen Marder, Jane Paulsen, Kimberly Quaid, Eric Siemers, Caroline Tanner, William Mallonee, Greg Suter, Richard Dubinsky, Carolyn Gray, Martha Nance, Scott Bundlie, Dawn Radtke, Sandra Kostyk, Corrine Baic, James Caress, Francis Walker, Victoria Hunt, Christine O'Neill, Sylvain Chouinard, Stewart Factor, Timothy Greenamyre, Cathy Wood-Siverio, Jody Corey-Bloom, David Song, Guerry Peavy, Carol Moskowitz, Melissa Wesson, Ali Samii, Thomas Bird, Hillary Lipe, Karen Blindauer, Frederick Marshall, Carol Zimmerman, Jody Goldstein, Diana Rosas, Peter Novak, John Caviness, Charles Adler, Amy Duffy, Vicki Wheelock, Teresa Tempkin, David Richman, Lauren Seeberger, Roger Albin, Kelvin L. Chou, Brad Racette, Joel S. Perlmutter, Susan Perlman, Yvette Bordelon, Wayne Martin, Marguerite Wieler, Blair Leavitt, Lynn Raymond, Joji Decolongon, Lorne Clarke, Joseph Jankovic, Christine Hunter, Robert A. Hauser, Juan Sanchez-Ramos, Sarah Furtado, Oksana Suchowersky, Mary Lou Klimek, Mark Guttman, Rustom Sethna, Andrew Feigin, Marie Cox, Barbara Shannon, Alan Percy, Leon Dure, Madaline Harrison, William Johnson, Donald Higgins, Eric Molho, Constance Nickerson, Sharon Evans, Douglas Hobson, Carlos Singer, Nestor Galvez-Jimenez, Kathleen Shannon, Cynthia Comella, Christopher Ross, Marie H. Saint-Hilaire, Claudia Testa, Adam Rosenblatt, Penelope Hogarth, William Weiner, Peter Como, Rajeev Kumar, Candace Cotto, Julie Stout, Alicia Brocht, Arthur Watts, Shirley Eberly, Christine Weaver, Tatiana Foroud, James Gusella, Marcy MacDonald, Richard Myers, Stanley Fahn, Clifford Shults
Article
Clinical Neurology
T. A. Mestre, K. Shannon
PARKINSONISM & RELATED DISORDERS
(2017)
Article
Neurosciences
Phillip A. Engen, Hemraj B. Dodiya, Ankur Naqib, Christopher B. Forsyth, Stefan J. Green, Robin M. Voigt, Jeffrey H. Kordower, Ece A. Mutlu, Kathleen M. Shannon, Ali Keshavarzian
JOURNAL OF PARKINSONS DISEASE
(2017)
Article
Gastroenterology & Hepatology
Paula Perez-Pardo, Hemraj B. Dodiya, Phillip A. Engen, Christopher B. Forsyth, Andrea M. Huschens, Maliha Shaikh, Robin M. Voigt, Ankur Naqib, Stefan J. Green, Jeffrey H. Kordower, Kathleen M. Shannon, Johan Garssen, Aletta D. Kraneveld, Ali Keshavarzian
Article
Neurosciences
Hemraj B. Dodiya, Christopher B. Forsyth, Robin M. Voigt, Phillip A. Engen, Jinal Patel, Maliha Shaikh, Stefan J. Green, Ankur Naqib, Avik Roy, Jeffrey H. Kordower, Kalipada Pahan, Kathleen M. Shannon, Ali Keshavarzian
NEUROBIOLOGY OF DISEASE
(2020)
Article
Clinical Neurology
Kathleen M. Shannon
Article
Clinical Neurology
Ying Zhang, Junyi Zhou, Carissa R. Gehl, Jeffrey D. Long, Hans Johnson, Vincent A. Magnotta, Daniel Sewell, Kathleen Shannon, Jane S. Paulsen
Summary: This study found that Mild Cognitive Impairment (MCI) may serve as an indicator of early disease in Huntington's disease gene-mutation carriers; single-domain MCI, two-domain MCI, and dementia may represent appropriate cognitive impairment staging.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Madelyn C. Houser, W. Michael Caudle, Jianjun Chang, George T. Kannarkat, Yuan Yang, Sean D. Kelly, Danielle Oliver, Valerie Joers, Kathleen M. Shannon, Ali Keshavarzian, Malu Gamez Tansey
Summary: This study identifies peripheral inflammatory mechanisms in PD patients and explores their potential to impact central dopaminergic pathways in mice. The findings suggest a sex-specific interaction between gastrointestinal inflammation and neurologic vulnerability, with importance of CD8(+) T-cells in the process in male mice.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Review
Clinical Neurology
Kathleen M. Shannon
Summary: The etiology of Parkinson's disease is still unknown, but there is growing evidence of an inflammatory component to the illness. The presence of pro-inflammatory bacteria in the gut microbiota, decreased gut barrier function, and systemic exposure to bacterial antigens suggests a role for gut-derived sterile inflammation in Parkinson's disease. Preclinical evidence supports the idea that systemic inflammation can affect the central nervous system through vagal pathways or the systemic circulation.
FRONTIERS IN NEUROLOGY
(2022)
Review
Neurosciences
Kathleen M. Shannon
Summary: The cause of Parkinson's disease is unknown, but environmental factors may influence its risk. Infection and changes in commensal bacteria are associated with the genesis of PD, possibly through an inflammatory mechanism.
JOURNAL OF PARKINSONS DISEASE
(2022)
