4.7 Article

Highly sensitive detection of anti-cancer drug based on bimetallic reduced graphene oxide nanocomposite

期刊

CHEMOSPHERE
卷 287, 期 -, 页码 -

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2021.132281

关键词

Reduced graphene oxide; Regorafenib; Uric acid; Pomegranate peel extract; Cyclic voltammetry

资金

  1. National Research Foundation of Korea government (MSIT) [NRF-2019R1A2C2084065]
  2. UGC BSR Meritorious fellowship (UGC, New Delhi, India)
  3. DST inspire, DST New Delhi, India [IF.160123]

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A high-performance electrochemical sensor for regorafenib detection was developed using bimetallic Pd-Ru nanoparticles anchored on reduced graphene oxide derived from pomegranate peel extract. The sensor exhibited good electrocatalytic activity and detection range, as well as excellent selectivity and sensitivity in real sample analysis. This strategy could be applied for the development of electrochemical sensors for other target analytes.
Herein, we describe a high-performance electrochemical sensor for the detection of regorafenib (REG) using bimetallic Pd-Ru nanoparticles anchored on pomegranate peel extract (PPE) derived reduced graphene oxide (Pd-Ru/rGO). PPE was employed to neutralize the extremely acidic graphene then cast-off along with the metal precursor for the duration of the chemical reduction to accomplish well dispersed Pd-Ru nanoparticles. Bimetallic Pd-Ru/rGO nanocomposites were synthesized using a facile chemical reduction method. Under optimal conditions, based on the differential pulse voltammetric studies it has been confirmed that the fabricated sensors has good electrocatalytic activity toward the detection of REG, spanning over the linear dynamic range of 0.5-300 nM. Moreover, the sensor exhibited a low limit of detection of 1.6 nM and a limit of quantification of 4.8 nM. The electrochemical sensor unveiled admirable selectivity and sensitivity, reproducibility, and repeatability. The fabricated sensor was suitable for real sample analysis (pharmaceutical tablet, human blood plasm, wastewater) with satisfactory recovery. The strategy presented herein can be employed in the development of electrochemical sensors for other target analytes.

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