期刊
CHEMMEDCHEM
卷 16, 期 22, 页码 3418-3427出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.202100476
关键词
Pyrazine; 1; 2; 3-Triazole; Benzothiazole; SARS-CoV-2; Computational studies
资金
- Egyptian Cultural and Educational Bureau Scholarship
- Center for Undergraduate Research and Scholarship (CURS), Translational Research Program TRP) at Augusta University
- Egyptian Academy of Scientific Research and Technology (ASRT, Ideation Fund program) [7303]
This study developed a set of pyrazine-based small molecules, with some showing significant potency against SARS-CoV-2. Computational studies validated the biological data, and the selectivity index of these potent conjugates indicates higher efficacy compared to Favipiravir.
Currently, limited therapeutic options are available for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). We have developed a set of pyrazine-based small molecules. A series of pyrazine conjugates was synthesized by microwave-assisted click chemistry and benzotriazole chemistry. All the synthesized conjugates were screened against the SAR-CoV-2 virus and their cytotoxicity was determined. Computational studies were carried out to validate the biological data. Some of the pyrazine-triazole conjugates (5 d-g) and (S)-N-(1-(benzo[d]thiazol-2-yl)-2-phenylethyl)pyrazine-2-carboxamide 12 i show significant potency against SARS-CoV-2 among the synthesized conjugates. The selectivity index (SI) of potent conjugates indicates significant efficacy compared to the reference drug (Favipiravir).
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