期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 27, 期 53, 页码 13418-13425出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202102016
关键词
cancer cell membrane; chemodynamic therapy; chemotherapy; single-atom catalysts
资金
- National Natural Science Foundation of China [22076073, 21775063]
- Natural Science Foundation of Shandong [ZR2020KB008]
This study presents a multifunctional single-atom catalytic sites (SACs) type for enhanced cancer treatment, with the ability to selectively release drugs and induce tumor-specific Fenton reactions in the tumor microenvironment. The nanoagent modified with cell membrane demonstrates better in vivo therapeutic performance, breaking through the limitations of single-pathway therapy by combining chemodynamic therapy and chemotherapy.
To fulfill the demand of precision and personalized medicine, single-atom catalysts (SACs) have emerged as a frontier in biomedical fields due to enzyme-mimic catalysis. Herein, we present a biocompatible and versatile nanoagent consisting of single-atom iron-containing nanoparticles (SAF NPs), DOX and A549 cell membrane (CM). The designed porous iron-based SACs originally served as a drug-carrying nanoplatform to release DOX selectively in a tumor microenvironment (TME) for chemotherapy (CT) due to their high loading capacity (155 %) for DOX; this signifies that SACs are promising candidates for universal cargo delivery. Besides, the designed single-atom nanoagent can perform like peroxidase, which effectively triggers an in situ tumor-specific Fenton reaction to generate abundant toxic hydroxyl radicals (.OH) selectively in the acidic TME for chemodynamic therapy (CDT). With the combination of CDT and CT, the constructed SAF NPs@DOX@CM nanoagent demonstrates better in vivo therapeutic performance than single-pathway therapy. In the meantime, after modification with CM, SAF NPs@DOX@CM can achieve homologous binding to target tumor tissues and avoid early clearance. This study presents a type of multifunctional SACs for enhanced cancer treatment via the capacity of a drug carrier combined with the enzymatic therapies of single-atom catalytic sites.
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