Review
Medicine, General & Internal
Dongyang Feng, Linlin Fu, Xinyu Du, Lan Yao
Summary: In this study, we investigated a case of rhabdomyolysis caused by self-administration of diquat solution in a suicide attempt. The patient was diagnosed based on symptoms, ultrasound examination, and biochemical markers, and was successfully treated.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Satoshi Saito, Mutsumi Iijima, Ryotaro Ikeguchi, Kentaro Ishizuka, Kazuo Kitagawa
Summary: We report four cases of asymptomatic levetiracetam-induced rhabdomyolysis. Despite continuous fluid replacement, serum creatine kinase (CK) levels continued to rise without symptoms. Rapid improvement was observed when levetiracetam was replaced with lacosamide. Routine blood tests should be performed after initiation of levetiracetam due to the occasional occurrence of asymptomatic rhabdomyolysis.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Urology & Nephrology
Luniu Xiao, Xiao Ran, Yanxia Zhong, Yue Le, Shusheng Li
Summary: This study investigated whether serum creatine kinase (CK) levels can serve as a marker for discontinuing continuous renal replacement therapy (CRRT) in patients with acute kidney injury (AKI) following rhabdomyolysis. The clinical outcomes were compared between patients with different CK levels after CRRT termination. The study found that higher CK levels and worse renal functions predicted the necessity of CRRT. After CRRT termination, the experimental group with CK > 5,000 U/L showed a significantly shorter in-hospital length of stay and ICU length of stay compared to the control group with CK < 5,000 U/L. These findings suggest that CRRT termination may be independent of CK levels in rhabdomyolysis-associated AKI patients, depending on their renal function recovery.
Article
Genetics & Heredity
Maxwell L. Summerlin, Debra S. Regier, Jamie L. Fraser, Kimberly A. Chapman, Dariush Kafashzadeh, Charles Billington, Monisha Kisling, Angela Grochowsky, Nicholas Ah Mew, Natasha Shur
Summary: Treatment guidelines for rhabdomyolysis vary, with options often limited to fluids and supportive therapy when a conclusive diagnosis is evasive. In two cases of acute rhabdomyolysis, the use of dexamethasone correlated with symptom relief, decreased CK values, and expedited discharge. The consideration of dexamethasone in conjunction with standard therapy for acute rhabdomyolysis may be beneficial based on our cases, discussions, and literature review.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2021)
Article
Critical Care Medicine
Virginie Tarazona, Samy Figueiredo, Sophie Hamada, Jonas Pochard, Ryan W. Haines, John R. Prowle, Jacques Duranteau, Bernard Vigue, Anatole Harrois
Summary: This study demonstrates that in trauma patients, admission myoglobin performs better than CK in predicting AKI, and myoglobin adds predictive value to established models of AKI prediction.
ANNALS OF INTENSIVE CARE
(2021)
Article
Pediatrics
Giacomo Brisca, Marcello Mariani, Daniela Pirlo, Marta Romanengo, Angela Pistorio, Alberto Gaiero, Chiara Panicucci, Emanuela Piccotti, Claudio Bruno
Summary: Background: Benign acute childhood myositis (BACM) is a self-limited syndrome associated with viral infections characterized by symmetric lower extremity pain. Although the acute presentation commonly concerns parents and healthcare providers, the prognosis of BACM is generally excellent. Most patients can be managed with hydration, rest, analgesics, and careful follow-up without the need for hospitalization.
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Article
Urology & Nephrology
Xiayin Li, Ming Bai, Yan Yu, Feng Ma, Lijuan Zhao, Yajuan Li, Hao Wu, Lei Zhou, Shiren Sun
Summary: This study aimed to evaluate the impact of the timing of continuous renal replacement therapy (CRRT) on the prognosis of patients with rhabdomyolysis (RM). The results showed that initiating CRRT before 4.8 hours after peak CK occurrence was associated with lower 90-day patient mortality.
Article
Medicine, General & Internal
Andy K. H. Lim, Ajinkya Bhonsle, Karen Zhang, Joy Hong, Kuo L. C. Huang, Joseph Nim
Summary: This study found an association between hyponatremia and the severity of rhabdomyolysis, even after adjusting for confounders. The study also found that patients with psychotic and alcohol use disorders were more likely to develop hyponatremia and rhabdomyolysis compared to the general population.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Lei Li, Zhenning Liu
Summary: Tetanus is a rapidly progressive infection that can lead to various complications, including rare rhabdomyolysis with acute anuria renal failure. Treatment of tetanus requires timely control of muscle spasms, appropriate blood purification therapy, and immunoglobulin treatment.
Article
Medicine, General & Internal
Antonia-Therese Kietaibl, Maria Fangmeyer-Binder, Gabor Goendoer, Marcus Saemann, Peter Fasching
Summary: This study reports a case of a 19-year-old Austrian male of African descent with acute viral myositis and massive CK elevation up to 440,000 IU/L without any signs of AKI. Extensive serological and autoimmune blood work-up did not show evidence for viral originators or autoimmune diseases. This case suggests that AKI might be completely absent in AVM with extreme CK elevation. Potential causes, differential diagnosis, and management of this clinical phenotype are discussed.
WIENER KLINISCHE WOCHENSCHRIFT
(2021)
Article
Pediatrics
Chon In Kuok, Winnie Kwai Yu Chan
Summary: The prevalence of acute kidney injury (AKI) in pediatric non-traumatic rhabdomyolysis was 18.5%. Factors associated with AKI development included positive urine tests, high white cell count, lower serum bicarbonate on admission, and high peak serum CK levels.
PEDIATRIC NEPHROLOGY
(2021)
Article
Pathology
Hanock Unni Samuel, T. Balasubramaniyan, S. Thirumavalavan, C. Vasudevan, R. P. Senthil Kumar, V Murugesan, Anila Abraham
Summary: Rhabdomyolysis is a potentially life-threatening clinical syndrome characterized by skeletal muscle cell breakdown and release of specific substances into the bloodstream and tissue gaps. Acute kidney injury is one of its most serious complications, leading to various pathophysiological changes. Early, prompt diagnosis and treatment can help prevent complications.
INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Hongjiao Gao, Qiao Xiang, Jindie Li, Meng Yu, Yalin Lan, Junqiang Ba, Yan Liu, Haoming Tian
Summary: Patients with Sheehan's syndrome are prone to elevated serum muscle enzymes, which may be associated with hypothyroidism and hyponatremia. Routine monitoring of serum muscle enzymes is important for patient management.
Article
Critical Care Medicine
Philippe Laitselart, Jean Derely, Jean-Louis Daban, Stephane De Rudnicki, Nicolas Libert
Summary: There is a significant positive correlation between creatine kinase (CK) and liver enzymes in war wounded with rhabdomyolysis, indicating that hepatic damage occurs when rhabdomyolysis is severe and associated with elevated bilirubin and alkaline phosphatase (ALP).
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Medicine, General & Internal
J. J. P. Buitendag, M. Q. Patel, S. Variawa, J. Fichardt, B. Mostert, A. Goliath, D. L. Clarke, G. Oosthuizen
Summary: The study found that the negative correlation between venous bicarbonate (HCO3) and creatinine was weak, but significantly better in predicting acute kidney injury compared to the weak positive correlation of creatine kinase (CK) and creatinine. It is recommended in resource-constrained settings to measure HCO3 to assess crush injury patients and consider CK as a complementary modality.
SAMJ SOUTH AFRICAN MEDICAL JOURNAL
(2021)
Article
Medicine, Research & Experimental
Yan Zhu, Chengshan Li, Aichen Sun, Yuanye Wang, Shengnian Zhou
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2015)
Article
Biochemistry & Molecular Biology
Zhifu Yang, Lizhen Wang, Wei Zhang, Xinxin Wang, Shengnian Zhou
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2016)
Article
Clinical Neurology
Shengnian Zhou, Xian Sun, Liqing Liu, Xuefeng Wang, Kunbin Liu
NEUROLOGICAL RESEARCH
(2008)
Article
Biochemistry & Molecular Biology
Mingli Zhang, Xueying Zhou, Wei Jiang, Min Li, Ruijiao Zhou, Shengnian Zhou
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Cardiac & Cardiovascular Systems
Wei Jiang, Hongzhi Geng, Xiaoqing Lv, Jing Ma, Fuchen Liu, Pengfei Lin, Chuanzhu Yan
Summary: This study demonstrated that idebenone acts as a mitochondrial protective agent by inhibiting NLPR3 activation via the SIRT3-SOD2-mtROS pathway, significantly reducing plaque burden and plaque size while stabilizing atherosclerotic plaques. Up-regulation and down-regulation of proteins were found in idebenone-treated mice, with SIRT3, SOD2, and NLRP3 expression significantly regulated both in vivo and in vitro. Furthermore, idebenone protected against endothelial cell damage and inhibited the production of mitochondrial reactive oxygen species in cholesterol-treated HUVECs.
CARDIOVASCULAR DRUGS AND THERAPY
(2021)
Article
Neurosciences
Wenjing Luo, Huiming Xu, Li Xu, Wei Jiang, Chen Chen, Yanyu Chang, Chunxin Liu, Zhenming Tian, Xiusheng Qiu, Chichu Xie, Xuejia Li, Haijia Chen, Shuiqing Lai, Longjun Wu, Yaxiong Cui, Changyong Tang, Wei Qiu
Summary: This study found that the drug edaravone, by activating the mTORC1 signaling pathway, promotes the maturation of oligodendrocyte progenitor cells and enhances remyelination in NMOSD. Edaravone demonstrated significant remyelination ability in experiments and has potential therapeutic effects for treating NMOSD lesion repair.
Article
Pharmacology & Pharmacy
Wenfei Yu, Wei Jiang, Wenjing Wu, Guangyu Wang, Dandan Zhao, Chuanzhu Yan, Pengfei Lin
Summary: This study aimed to investigate the anti-atherosclerotic effect of the combination of idebenone and statins. The results showed that both idebenone and statins reduced plaque burden and increased plaque stability, with the combined treatment showing even better effects. Additionally, the combination therapy also reduced oxidative stress and cell apoptosis. In conclusion, combining idebenone and statins appears to be a promising strategy for further preventing atherosclerosis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Li Xu, Huiming Xu, Siqi Chen, Wei Jiang, Shabbir Khan Afridi, Yuge Wang, Xin Ren, Yipeng Zhao, Shuiqing Lai, Xiusheng Qiu, Yu-Wen Alvin Huang, Yaxiong Cui, Hui Yang, Wei Qiu, Changyong Tang
Summary: Inhibiting the complement C3 signaling pathway has been found to alleviate tissue injury and improve motor and visual impairments in neuromyelitis optica (NMO).
Article
Cell Biology
Haoyang Li, Li Xu, Wei Jiang, Xiusheng Qiu, Huiming Xu, Fan Zhu, Yu Hu, Shuzhen Liang, Chengcheng Cai, Wei Qiu, Zhengqi Lu, Yaxiong Cui, Changyong Tang
Summary: This study reveals that cognitive impairment is associated with a decline in adult hippocampal neurogenesis (AHN). Pleiotrophin (PTN) expression decreases with aging, leading to impaired AHN and poor learning and memory. The study shows that PTN interacts with protein tyrosine phosphatase receptor type Z1 (PTPRZ1) to promote neural stem and progenitor cell (NSPC) proliferation and differentiation through AKT signaling. Overexpression of PTN or pharmacological activation of AKT signaling in aging mice restores AHN and improves memory deficits.
Article
Multidisciplinary Sciences
Wei Jiang, Fan Zhu, Huiming Xu, Li Xu, Haoyang Li, Xin Yang, Shabbir Khan Afridi, Shuiqing Lai, Xiusheng Qiu, Chunxin Liu, Huilu Li, Youming Long, Yuge Wang, Kevin Connolly, Jack A. Elias, Chun Geun Lee, Yaxiong Cui, Yu-Wen Alvin Huang, Wei Qiu, Changyong Tang
Summary: Chitinase-3-like protein 1 (CHI3L1) is a reliable biomarker for inflammatory central nervous system (CNS) conditions and is associated with neurodegeneration and autoimmune disorders. This study found that elevated CHI3L1 expression correlates with cognitive impairment in patients with neuromyelitis optica (NMO). CHI3L1 inhibits the proliferation and neuronal differentiation of neural stem cells, leading to decreased hippocampal neurogenesis and impaired learning behaviors. Blocking the CHI3L1/CRTH2/beta-catenin cascade restores neurogenesis and improves cognitive deficits, suggesting potential therapeutic development in neuroinflammatory disorders.
