Computational modeling in melanoma for novel drug discovery

Genetic progression of malignant melanoma

(2016) J. Tímár et al.   CANCER AND METASTASIS REVIEWS

Computational modeling of the expansion of human cord blood CD133+hematopoietic stem/progenitor cells with different cytokine combinations

(2015) Francesca Gullo et al.   BIOINFORMATICS

Insight into molecular dynamics simulation of BRAF(V600E) and potent novel inhibitors for malignant melanoma

(2015) Calvin Yu-Chian Chen et al.   International Journal of Nanomedicine

Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)

(2015) GEORGE MIHAI NITULESCU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Agent based modeling of the effects of potential treatments over the blood–brain barrier in multiple sclerosis

(2015) Marzio Pennisi et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Computational modelling approaches to vaccinology

(2015) Francesco Pappalardo et al.   PHARMACOLOGICAL RESEARCH

Systems biology approaches for advancing the discovery of effective drug combinations

(2015) Karen A Ryall et al.   Journal of Cheminformatics

Melanoma

(2015) Dirk Schadendorf et al.   Nature Reviews Disease Primers

Induction of T-cell memory by a dendritic cell vaccine: a computational model

(2014) Francesco Pappalardo et al.   BIOINFORMATICS

Mathematical modeling for novel cancer drug discovery and development

(2014) Ping Zhang et al.   Expert Opinion on Drug Discovery

Emerging targeted therapies for melanoma treatment (Review)

(2014) ANGELA RUSSO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Constraint-based models predict metabolic and associated cellular functions

(2014) Aarash Bordbar et al.   NATURE REVIEWS GENETICS

Analysis of the B-RAFV600E mutation in cutaneous melanoma patients with occupational sun exposure

(2014) SAVERIO CANDIDO et al.   ONCOLOGY REPORTS

Data-Derived Modeling Characterizes Plasticity of MAPK Signaling in Melanoma

(2014) Marti Bernardo-Faura et al.   PLoS Computational Biology

Modeling Biology Spanning Different Scales: An Open Challenge

(2014) Filippo Castiglione et al.   Biomed Research International

PI3K and MEK inhibitor combinations: examining the evidence in selected tumor types

(2013) Carolyn D. Britten   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Formalizing an Integrative, Multidisciplinary Cancer Therapy Discovery Workflow

(2013) M. F. McGuire et al.   CANCER RESEARCH

Big data in biomedicine

(2013) Fabricio F. Costa   DRUG DISCOVERY TODAY

Analyzing methods for path mining with applications in metabolomics

(2013) Somnath Tagore et al.   GENE

Modeling cancer immunotherapy: Assessing the effects of lymphocytes on cancer cell growth and motility

(2013) R.A. Ramos et al.   PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS

Multi-scale agent-based modeling on melanoma and its related angiogenesis analysis

(2013) Jun Wang et al.   Theoretical Biology and Medical Modelling

Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance

(2012) Edita Aksamitiene et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Clinical development of phosphatidylinositol 3-kinase inhibitors for cancer treatment

(2012) Irene Brana et al.   BMC Medicine

Mathematical modeling of biological systems

(2012) S. Motta et al.   BRIEFINGS IN BIOINFORMATICS

A Mathematical Model of Immune-System-Melanoma Competition

(2012) Marzio Pennisi   Computational and Mathematical Methods in Medicine

The Combination of Exposure-Response and Case-Control Analyses in Regulatory Decision Making

(2012) Jun Yang et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Chronic renoprotective effect of pulsatile perfusion machine RM3 and IGL-1 solution in a preclinical kidney transplantation model

(2012) Raphael Thuillier et al.   Journal of Translational Medicine

Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial

(2012) Axel Hauschild et al.   LANCET

Sensitivity to the MEK inhibitor E6201 in melanoma cells is associated with mutant BRAF and wildtype PTEN status

(2012) Sara A Byron et al.   Molecular Cancer

Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma

(2012) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multi-Parametric Analysis and Modeling of Relationships between Mitochondrial Morphology and Apoptosis

(2012) Yara Reis et al.   PLoS One

Routine Multiplex Mutational Profiling of Melanomas Enables Enrollment in Genotype-Driven Therapeutic Trials

(2012) Christine M. Lovly et al.   PLoS One

Mathematical and Computational Models in Tumor Immunology

(2012) F. Pappalardo et al.   Mathematical Modelling of Natural Phenomena

Multiscale Cancer Modeling

(2011) Thomas S. Deisboeck et al.   Annual Review of Biomedical Engineering

Novel Computational Approaches to Polypharmacology as a Means to Define Responses to Individual Drugs

(2011) Lei Xie et al.   Annual Review of Pharmacology and Toxicology

Gene alterations in the PI3K/PTEN/AKT pathway as a mechanism of drug-resistance (Review)

(2011) Massimo Libra   INTERNATIONAL JOURNAL OF ONCOLOGY

Virtual Screening Data Fusion Using Both Structure- and Ligand-Based Methods

(2011) Fredrik Svensson et al.   Journal of Chemical Information and Modeling

Combining cellular automata and lattice Boltzmann method to model multiscale avascular tumor growth coupled with nutrient diffusion and immune competition

(2011) Davide Alemani et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

(2011) Paul B. Chapman et al.   NEW ENGLAND JOURNAL OF MEDICINE

SimB16: Modeling Induced Immune System Response against B16-Melanoma

(2011) Francesco Pappalardo et al.   PLoS One

Fast integration of heterogeneous data sources for predicting gene function with limited annotation

(2010) Sara Mostafavi et al.   BIOINFORMATICS

Mass Action Stoichiometric Simulation Models: Incorporating Kinetics and Regulation into Stoichiometric Models

(2010) Neema Jamshidi et al.   BIOPHYSICAL JOURNAL

Modeling the competition between lung metastases and the immune system using agents

(2010) Marzio Pennisi et al.   BMC BIOINFORMATICS

In silico Modeling and In vivo Efficacy of Cancer-Preventive Vaccinations

(2010) A. Palladini et al.   CANCER RESEARCH

Advances in computational methods to predict the biological activity of compounds

(2010) Chanin Nantasenamat et al.   Expert Opinion on Drug Discovery

In silico designing and optimization of anti-breast cancer antibody mimetic oligopeptide targeting HER-2 in women

(2010) Bashir A. Akhoon et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Rational design of HIV vaccine and microbicides: report of the EUROPRISE annual conference

(2010) Britta Wahren et al.   Journal of Translational Medicine

Fuzzy modeling of signal transduction networks

(2009) Zuyi Huang et al.   CHEMICAL ENGINEERING SCIENCE

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

How is mRNA expression predictive for protein expression? A correlation study on human circulating monocytes

(2008) Yanfang Guo et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Efficacy of Weekly Docetaxel and Bevacizumab in Mesenchymal Chondrosarcoma: A New Theranostic Method Combining Xenografted Biopsies with a Mathematical Model

(2008) Boris Gorelik et al.   CANCER RESEARCH

Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling

(2008) Scott M. Wilhelm et al.   MOLECULAR CANCER THERAPEUTICS

The future of biocuration

(2008) Doug Howe et al.   NATURE

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology