Engineered BDNF producing cells as a potential treatment for neurologic disease

Gene Transfer of Brain-derived Neurotrophic Factor (BDNF) Prevents Neurodegeneration Triggered by FXN Deficiency

(2016) Yurika Katsu-Jiménez et al.   MOLECULAR THERAPY

Human Mesenchymal Stem Cells Genetically Engineered to Overexpress Brain-derived Neurotrophic Factor Improve Outcomes in Huntington's Disease Mouse Models

(2016) Kari Pollock et al.   MOLECULAR THERAPY

Developing stem cell therapies for juvenile and adult-onset Huntington's disease

(2015) Kyle D Fink et al.   Regenerative Medicine

Neural Stem Cells Rescue Cognitive and Motor Dysfunction in a Transgenic Model of Dementia with Lewy Bodies through a BDNF-Dependent Mechanism

(2015) Natalie R.S. Goldberg et al.   Stem Cell Reports

Sustained Mobilization of Endogenous Neural Progenitors Delays Disease Progression in a Transgenic Model of Huntington’s Disease

(2013) Abdellatif Benraiss et al.   Cell Stem Cell

Early BDNF Treatment Ameliorates Cell Loss in the Entorhinal Cortex of APP Transgenic Mice

(2013) A. H. Nagahara et al.   JOURNAL OF NEUROSCIENCE

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

(2013) Bai Lu et al.   NATURE REVIEWS NEUROSCIENCE

Epigenetic regulation of BDNF expression in the primary sensory neurons after peripheral nerve injury: Implications in the development of neuropathic pain

(2013) H. Uchida et al.   NEUROSCIENCE

Dysregulation of REST-regulated coding and non-coding RNAs in a cellular model of Huntington's disease

(2012) Chiara Soldati et al.   JOURNAL OF NEUROCHEMISTRY

Reduced brain-derived neurotrophic factor (BDNF) mRNA expression and presence of BDNF-immunoreactive granules in the spinocerebellar ataxia type 6 (SCA6) cerebellum

(2012) Makoto Takahashi et al.   NEUROPATHOLOGY

Brain-Derived Neurotrophic Factor from Bone Marrow-Derived Cells Promotes Post-Injury Repair of Peripheral Nerve

(2012) Yoshinori Takemura et al.   PLoS One

Adenoviral Astrocyte-Specific Expression of BDNF in the Striata of Mice Transgenic for Huntington’s Disease Delays the Onset of the Motor Phenotype

(2011) Leticia Arregui et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Sustained induction of neuronal addition to the adult rat neostriatum by AAV4-delivered noggin and BDNF

(2011) A Benraiss et al.   GENE THERAPY

Roles of BDNF in spinal neuroplasticity in cats subjected to partial dorsal ganglionectomy

(2011) Rong Rong et al.   GROWTH FACTORS

Brain-Derived Neurotrophic Factor in Patients with Huntington's Disease

(2011) Chiara Zuccato et al.   PLoS One

Self-amplifying autocrine actions of BDNF in axon development

(2011) P.-L. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesenchymal stem cells for the sustained in vivo delivery of bioactive factors

(2010) Todd Meyerrose et al.   ADVANCED DRUG DELIVERY REVIEWS

Arrest of adult hippocampal neurogenesis in mice impairs single- but not multiple-trial contextual fear conditioning.

(2010) Michael R. Drew et al.   BEHAVIORAL NEUROSCIENCE

Genetically engineered mesenchymal stem cells reduce behavioral deficits in the YAC 128 mouse model of Huntington's disease

(2010) Nicholas D. Dey et al.   BEHAVIOURAL BRAIN RESEARCH

Mesenchymal stem cells for the treatment of neurodegenerative disease

(2010) Nanette Joyce et al.   Regenerative Medicine

Exercise-induced motor improvement after complete spinal cord transection and its relation to expression of brain-derived neurotrophic factor and presynaptic markers

(2009) Matylda Macias et al.   BMC NEUROSCIENCE

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

Mechanisms, locations, and kinetics of synaptic BDNF secretion: An update

(2009) Volkmar Leßmann et al.   NEUROSCIENCE RESEARCH

Direct Evidence of Mesenchymal Stem Cell Tropism for Tumor and Wounding Microenvironments Using In Vivo Bioluminescent Imaging

(2009) Shannon Kidd et al.   STEM CELLS

Adenosine receptors and asthma

(2008) R A Brown et al.   BRITISH JOURNAL OF PHARMACOLOGY

Distinct Role of Long 3′ UTR BDNF mRNA in Spine Morphology and Synaptic Plasticity in Hippocampal Neurons

(2008) Juan Ji An et al.   CELL

AAV–BDNF mediated attenuation of quinolinic acid-induced neuropathology and motor function impairment

(2008) A P Kells et al.   GENE THERAPY

Blood level of brain-derived neurotrophic factor mRNA is progressively reduced in rodent models of Huntington's disease: Restoration by the neuroprotective compound CEP-1347

(2008) Paola Conforti et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

In Vivo Biosafety Model to Assess the Risk of Adverse Events From Retroviral and Lentiviral Vectors

(2008) Gerhard Bauer et al.   MOLECULAR THERAPY

Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats

(2008) S. Arancibia et al.   NEUROBIOLOGY OF DISEASE

A Biological Function for the Neuronal Activity-Dependent Component of Bdnf Transcription in the Development of Cortical Inhibition

(2008) Elizabeth J. Hong et al.   NEURON

Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior

(2008) M. Bergami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lentiviral-Transduced Human Mesenchymal Stem Cells Persistently Express Therapeutic Levels of Enzyme in a Xenotransplantation Model of Human Disease

(2008) Todd E. Meyerrose et al.   STEM CELLS