Candidalysin triggers epithelial cellular stresses that induce necrotic death

Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells

(2021) Marina Pekmezovic et al.   Nature Microbiology

Role of Mitochondrial Calcium and the Permeability Transition Pore in Regulating Cell Death

(2020) Tyler M. Bauer et al.   CIRCULATION RESEARCH

Candidalysin Is a Potent Trigger of Alarmin and Antimicrobial Peptide Release in Epithelial Cells

(2020) Jemima Ho et al.   Cells

Metabolic competition between host and pathogen dictates inflammasome responses to fungal infection

(2020) Timothy M. Tucey et al.   PLoS Pathogens

Oral epithelial IL-22/STAT3 signaling licenses IL-17–mediated immunity to oral mucosal candidiasis

(2020) Felix E. Y. Aggor et al.   Science Immunology

Dectin-1-induced RIPK1 and RIPK3 activation protects host against Candida albicans infection

(2019) Mengtao Cao et al.   CELL DEATH AND DIFFERENTIATION

CARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment

(2019) Rebecca A. Drummond et al.   NATURE IMMUNOLOGY

Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor

(2019) Jemima Ho et al.   Nature Communications

Candidalysin Is Required for Neutrophil Recruitment and Virulence During Systemic Candida albicans Infection

(2019) Marc Swidergall et al.   JOURNAL OF INFECTIOUS DISEASES

Candidalysin: discovery and function in Candida albicans infections

(2019) Julian R Naglik et al.   CURRENT OPINION IN MICROBIOLOGY

IL-36 and IL-1/IL-17 Drive Immunity to Oral Candidiasis via Parallel Mechanisms

(2018) Akash H. Verma et al.   JOURNAL OF IMMUNOLOGY

Processing of Candida albicans Ece1p Is Critical for Candidalysin Maturation and Fungal Virulence

(2018) Jonathan P. Richardson et al.   mBio

Candida albicans -Induced Epithelial Damage Mediates Translocation through Intestinal Barriers

(2018) Stefanie Allert et al.   mBio

The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes

(2018) Lydia Kasper et al.   Nature Communications

Regulation of necrotic cell death: p53, PARP1 and cyclophilin D-overlapping pathways of regulated necrosis?

(2016) Yuan Ying et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Phagosomal Neutralization by the Fungal Pathogen Candida albicans Induces Macrophage Pyroptosis

(2016) Slavena Vylkova et al.   INFECTION AND IMMUNITY

Candidalysin is a fungal peptide toxin critical for mucosal infection

(2016) David L. Moyes et al.   NATURE

Intestinal Cell Tight Junctions Limit Invasion of Candida albicans through Active Penetration and Endocytosis in the Early Stages of the Interaction of the Fungus with the Intestinal Barrier

(2016) Marianne Goyer et al.   PLoS One

The Ins and Outs of Mitochondrial Calcium

(2015) T. Finkel et al.   CIRCULATION RESEARCH

Induction of apoptosis in oral squamous carcinoma cells by pyrrolo-1,5-benzoxazepines

(2015) KATE O'CALLAGHAN et al.   Molecular Medicine Reports

Global analysis of fungal morphology exposes mechanisms of host cell escape

(2015) Teresa R. O’Meara et al.   Nature Communications

The novel proteasome inhibitor carfilzomib activates and enhances extrinsic apoptosis involving stabilization of death receptor 5

(2015) Bo Han et al.   Oncotarget

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Pathogen Candida albicans Hijacks Pyroptosis for Escape from Macrophages

(2014) N. Uwamahoro et al.   mBio

Candida albicans Triggers NLRP3-Mediated Pyroptosis in Macrophages

(2013) Melanie Wellington et al.   EUKARYOTIC CELL

Candida albicans secreted aspartic proteases 4–6 induce apoptosis of epithelial cells by a novel Trojan horse mechanism

(2013) Hao Wu et al.   FASEB JOURNAL

Protection Against Epithelial Damage During Candida albicans Infection Is Mediated by PI3K/Akt and Mammalian Target of Rapamycin Signaling

(2013) David L. Moyes et al.   JOURNAL OF INFECTIOUS DISEASES

Candida albicans induces pro-inflammatory and anti-apoptotic signals in macrophages as revealed by quantitative proteomics and phosphoproteomics

(2013) Jose Antonio Reales-Calderón et al.   Journal of Proteomics

Induction of apoptosis in oral epithelial cells byCandida albicans

(2012) C. Cunha Villar et al.   Molecular Oral Microbiology

Glycosylation of Candida albicans Cell Wall Proteins Is Critical for Induction of Innate Immune Responses and Apoptosis of Epithelial Cells

(2012) Jeanette Wagener et al.   PLoS One

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

Candida albicans induces early apoptosis followed by secondary necrosis in oral epithelial cells

(2010) C.C. Villar et al.   Molecular Oral Microbiology

Role of the Mitochondrion in Programmed Necrosis

(2010) Christopher P. Baines   Frontiers in Physiology

Cellular interactions ofCandida albicanswith human oral epithelial cells and enterocytes

(2009) Frederic Dalle et al.   CELLULAR MICROBIOLOGY

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY