Article
Multidisciplinary Sciences
Stefanie Kurtz, Andrea Lucas-Hahn, Brigitte Schlegelberger, Gudrun Goehring, Heiner Niemann, Thomas C. Mettenleiter, Bjoern Petersen
Summary: This research explores the central role of the HMG domain in male porcine sex determination through a knockout experiment of the SRY gene with pathogenic modifications, resulting in genetically male pigs with internal female genitalia. The study could assist in solving the problem of sex preference in agriculture and establishes a more comparable large animal model for the study and development of interventions for human sex development disorders.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Malgorzata Lysiak, Anja Smits, Kenney Roy Roodakker, Elisabeth Sandberg, Anna Dimberg, Munila Mudaisi, Charlotte Bratthall, Michael Strandeus, Peter Milos, Martin Hallbeck, Peter Soderkvist, Annika Malmstrom
Summary: This study revealed a strong correlation between deletion of the SRY gene and reduced overall survival in male GBM patients. The findings suggest that deletions and reduced gene expression of chromosome Y genes, especially SRY, may play a role in the reduced survival of male GBM patients and are connected to major gliomagenesis pathways.
Article
Ecology
Duminda S. B. Dissanayake, Clare E. Holleley, Janine E. Deakin, Arthur Georges
Summary: Studies have shown that genotypic sex determination and environmental sex determination can coexist in some species, leading to the possibility of sex reversal. This research demonstrates sex reversal in the wild for the first time in adult populations of a reptile species with XX/XY sex determination, particularly at the highest elevations where the frequency of sex reversal is the highest.
Article
Genetics & Heredity
Yangyang Li, Zonggui Chen, Hairong Liu, Qiming Li, Xing Lin, Shuhui Ji, Rui Li, Shaopeng Li, Weiliang Fan, Haiping Zhao, Zuoyan Zhu, Wei Hu, Yu Zhou, Daji Luo
Summary: This study established a comprehensive database ASER by integrating sex reversal-related data of 18 species, providing researchers with a resource to query and reuse organized data to explore the mechanisms and applications of SRGs in animal breeding and human health. The database contains information on sex reversal-associated genes, their regulatory networks, conservation scores for whole genomes, expression dynamics during sex reversal processes, and spatial expression in the gonads. The ASER database is publicly available and can be accessed at http://aser.ihb.ac.cn/.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2021)
Article
Multidisciplinary Sciences
Gaorui Gong, Yang Xiong, Shijun Xiao, Xi-Yin Li, Peipei Huang, Qian Liao, Qingqing Han, Qiaohong Lin, Cheng Dan, Li Zhou, Fan Ren, Qi Zhou, Jian-Fang Gui, Jie Mei
Summary: We assembled highly homomorphic Y and X chromosomes in yellow catfish and discovered that the Y chromosome is at an early stage of differentiation with no clear evidence of evolutionary strata and recombination suppression. The accumulation of sex-antagonistic mutations and repetitive elements in the sex-determining region suggests their role in recombination suppression between young X and Y chromosomes. Additionally, we found distinct chromatin organizations and nuclear spatial organization in the YY supermales and XX females, indicating chromatin remodeling after sex reversal.
NATIONAL SCIENCE REVIEW
(2023)
Article
Neurosciences
Omkaram Gangisetty, Edward A. Mead, Dipak K. Sarkar
Summary: The study revealed that fetal alcohol exposure can lead to neurodevelopmental deficits in offspring by affecting Pomc gene expression through the male germline, with SRY playing a key role in this regulation. Additionally, SRY can regulate gene expression by binding to the Pomc promoter.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Matthew B. Couger, Scott W. Roy, Noelle Anderson, Landen Gozashti, Stacy Pirro, Lindsay S. Millward, Michelle Kim, Duncan Kilburn, Kelvin J. Liu, Todd M. Wilson, Clinton W. Epps, Laurie Dizney, Luis A. Ruedas, Polly Campbell
Summary: The sex chromosome system of the creeping vole is unique, with females having an unpaired X chromosome (X0) and the sex chromosome being one of the two X chromosomes, both carrying fragments of the ancestral Y chromosome. The consequences of this transformed sex chromosome system in this species include Y-like degeneration, expression of Y-linked genes in females, and X inactivation of the male-specific chromosome in male somatic cells.
Article
Andrology
Prafulla S. Ambulkar, Jwalant E. Waghmare, Poonam Verma Shivkumar, Pratibha Narang, Asoke K. Pal
Summary: Mutations in the SRY gene are associated with complete gonadal dysgenesis in females with 46,XY karyotype, leading to primary amenorrhea and underdeveloped secondary sexual characters. The presence of a nucleotide substitution in the HMG box domain of SRY gene was confirmed to cause 46,XY sex reversal female, affecting the nuclear transport of SRY protein and down regulation of male sex differentiation pathway.
Article
Biochemistry & Molecular Biology
Edina Nemeshazi, Veronika Bokony
Summary: Climate change and environmental pollution may increase sex-reversal frequency in wild populations, affecting sex ratios, population dynamics, and the evolution of sex determination. Reconsidering the Witschi's rule theory could help understand species differences in sex-reversal propensity and predict their vulnerability to anthropogenic environmental change.
Article
Cell & Tissue Engineering
Rui Yan, Suihan Wu, Wenxuan Wang, Meng Chu, Pengyu Liu
Summary: 46, XX male sex reversal syndrome (SRS) is a rare disease associated with the translocation of the sex-determining region Y gene (SRY). A new iPSC line (SMUSHi001-A) was generated from PBMCs of an SRS patient, providing a cell model for exploring the pathogenesis and potential therapeutic methods of SRS.
STEM CELL RESEARCH
(2021)
Article
Clinical Neurology
Adriana Gata-Garcia, Amit Porat, Lior Brimberg, Bruce T. Volpe, Patricio T. Huerta, Betty Diamond
Summary: The study evaluated the effects of sex chromosomes and hormones on the male bias in a murine model of ASD, showing that sex chromosomes are the main determinant of male bias in the maternal C6-induced model of ASD, with hormonal effects being less dominant.
FRONTIERS IN NEUROLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Jingfeng Peng, Yunfei Hou, Shici Wu, Zicong Li, Zhenfang Wu
Summary: The maternal Rlim allele is necessary for normal development of female mouse embryos. Inactivating the maternal Rlim allele in female embryos led to a higher proportion of male offspring but reduced litter size, which couldn't be compensated by superovulation. This study provides a potential approach for sex selection in livestock and prevention of sex-associated hereditary diseases in humans.
Review
Endocrinology & Metabolism
Hanhua Cheng, Rongjia Zhou
Summary: Significant progress has been made in the study of swamp eels' biology since their medicinal value was discovered 440 years ago. They are now considered an important model animal for sexual development research, with implications in economy and pharmaceuticals. Studies on their genomic history have revealed chromosome fission/fusion events and the intriguing natural intersex differentiation, while the identification of progenitors of germline stem cells has provided new insights into sex reversal. This review highlights the advances made in the field and presents unanswered questions for future investigations in vertebrate sexual development using this new model.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Multidisciplinary Sciences
Ahammad Kabir, Risa Ieda, Sho Hosoya, Daigaku Fujikawa, Kazufumi Atsumi, Shota Tajima, Aoi Nozawa, Takashi Koyama, Shotaro Hirase, Osamu Nakamura, Mitsutaka Kadota, Osamu Nishimura, Shigehiro Kuraku, Yasukazu Nakamura, Hisato Kobayashi, Atsushi Toyoda, Satoshi Tasumi, Kiyoshi Kikuchi
Summary: Recent studies have uncovered the diversity of sex chromosomes in vertebrates. Through studying closely related species in the genus Takifugu, researchers found that sex-determining genes have undergone translocations, and a shared supergene plays a crucial role in sex determination.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Philipp Kaufmann, R. Axel W. Wiberg, Konstantinos Papachristos, Douglas G. Scofield, Christian Tellgren-Roth, Elina Immonen
Summary: The Y chromosome in seed beetles has been found to affect male body size and sexual size dimorphism. Researchers discovered an additional copy of the gene target of rapamycin (TOR) on the Y chromosome, which may provide a male-specific opportunity to alter body size. Despite suppressed recombination, the Y chromosome has adaptive potential as a male-limited supergene.
MOLECULAR BIOLOGY AND EVOLUTION
(2023)
Article
Remote Sensing
Xuecao Li, Yuyu Zhou, Peng Gong
Summary: This study proposes a conceptual model to characterize the spatial sprawl pattern of urban clusters using Zipf's law and 30-year time series of global urban extent data. The study reveals different sprawl patterns at different scales, with small urban clusters growing slightly faster than large clusters globally. It also finds that Asia and Africa show equilibrium patterns of sprawl, while other continents mostly exhibit diffuse patterns. The study provides insights into urban development pathways and contributes to the development of future urban growth models.
REMOTE SENSING LETTERS
(2023)
Article
Environmental Sciences
Guojiang Yu, Zixuan Xie, Xuecao Li, Yixuan Wang, Jianxi Huang, Xiaochuang Yao
Summary: This study explores the relationship between urban form and socioeconomic activities using three-dimensional building height data from 38 cities in China. The results show that building height information can improve the correlation between urban form and nighttime light data, and it has the potential to help characterize socioeconomic activities.
Article
Environmental Sciences
Xianda Huang, Fu Xuan, Yi Dong, Wei Su, Xinsheng Wang, Jianxi Huang, Xuecao Li, Yelu Zeng, Shuangxi Miao, Jiayu Li
Summary: This study explores the potential of Chinese GF-1 PMS high-spatial-resolution images for corn lodging monitoring and finds a robust and efficient way to accurately identify corn lodging. The combination of spectral bands, optimized vegetation indexes, and texture features achieves an overall accuracy of 93.81% and a Kappa coefficient of 0.91 in classifying corn lodging. The random forest is an efficient, robust, and easy classifier, achieving high accuracy in identifying non-lodged, moderately lodged, and severely lodged areas.
Article
Urban Studies
Wanru He, Xuecao Li, Yuyu Zhou, Xiaoping Liu, Peng Gong, Tengyun Hu, Peiyi Yin, Jianxi Huang, Jianyu Yang, Shuangxi Miao, Xi Wang, Tinghai Wu
Summary: Cellular automata (CA) based models are widely used in urban sprawl modeling for sustainable urban planning. However, most existing urban CA models only consider abrupt conversion, ignoring the difference in urbanization levels among grids and the gradual increase in urban densities. In this study, we proposed an impervious surface area (ISA) based urban CA model that can simulate urban fractional change within each grid. The model was implemented in Beijing and evaluated through comparison and scenario analyses. Results showed that the ISA-based urban CA model captures the dynamics of urban sprawl better than the traditional urban CA model and has great potential in supporting sustainable urban development.
Article
Environmental Sciences
Shuangxi Miao, Yixuan Zhao, Jianxi Huang, Xuecao Li, Ruohan Wu, Wei Su, Yelu Zeng, Haixiang Guan, Mohamed A. M. Abd Elbasit, Junxiao Zhang
Summary: In July 2021, a flooding event in Henan caused significant losses in various fields and attracted global attention. A framework was proposed to detect the flooding area and evaluate the degree of loss using satellite time series data. The double-Gaussian model accurately extracted the flooding area, while satellite images supported the classification of disaster levels.
Article
Environmental Sciences
Buyu Su, Xiaoping Du, Haowei Mu, Chen Xu, Xuecao Li, Fang Chen, Xiaonan Luo
Summary: This study proposes the FEPVNet model with adaptive strategies for extracting photovoltaics (PVs) from multiple image sources, achieving precise PV extraction in images of different scales. The research also introduces three data migration strategies, improving the generalization performance of models trained on a single data source. The FEPVNet model shows significant potential for application in large-scale PV mapping.
Article
Environmental Sciences
Yi Dong, Fu Xuan, Ziqian Li, Wei Su, Hui Guo, Xianda Huang, Xuecao Li, Jianxi Huang
Summary: In this study, Landsat-8 and Sentinel-2 images were used to estimate corn residue coverage in Northeast China. The optimal combination of spectral indices and textural features, based on soil texture zoning, was used to establish the estimation model for improving accuracy. The results showed that most of the study area had corn residue coverage of 0.3 to 0.6, primarily distributed in the Songnen Plain. Based on the estimated results, implementing conservation tillage practices is crucial for protecting the black soil in Northeast China.
Article
Environmental Sciences
Wen Zhuo, Hai Huang, Xinran Gao, Xuecao Li, Jianxi Huang
Summary: The accuracy of crop yield estimation is examined through the joint assimilation of leaf area index (LAI) and soil moisture (SM) in this study, along with an analysis of the scale effect between remotely sensed data and crop model simulations. The results demonstrate that yield estimation at a 10 m grid size outperforms that at a 500 m grid size, using the same assimilation strategy. Furthermore, the accuracy of winter wheat yield estimation is higher when using the bivariate data assimilation method compared to the univariate method.
Article
Food Science & Technology
Faqin Lin, Xuecao Li, Ningyuan Jia, Fan Feng, Hai Huang, Jianxi Huang, Shenggen Fan, Philippe Ciais, Xiao-Peng Song
Summary: Ukraine and Russia, as major grain producers and exporters, have a significant impact on the global wheat market. The conflict between the two countries has led to reduced wheat production in Ukraine and disruptions in wheat trade. Analysis shows that the conflict will result in a drop in global wheat trade, soaring prices, and severe food insecurity, particularly for countries heavily reliant on Ukrainian wheat imports. Additionally, the trade blockade caused by the conflict will lead to price increases and welfare declines for affected countries.
GLOBAL FOOD SECURITY-AGRICULTURE POLICY ECONOMICS AND ENVIRONMENT
(2023)
Article
Biodiversity Conservation
Mengqing Geng, Xuecao Li, Haowei Mu, Guojiang Yu, Li Chai, Zhongwen Yang, Haimeng Liu, Jianxi Huang, Han Liu, Zhengshan Ju
Summary: Human activities have exerted significant pressure on the earth's ecosystems, resulting in degradation and carbon losses. This study examined the global human footprint (HFP) and human-induced aboveground biomass carbon (AGBC) losses from 2000 to 2018. The findings show a global increase in HFP, leading to the conversion of wilderness areas into highly modified regions and impacting global biomes' habitats. The study also identified accelerated AGBC loss driven by HFP expansion, particularly in tropical regions. Furthermore, AGBC is more vulnerable in the Global South compared to the Global North. Therefore, scientifically-guided planning of future human activities is crucial for protecting the Earth through mitigation and adaptation.
GLOBAL CHANGE BIOLOGY
(2023)
Article
Geography, Physical
Bo Yuan, Xuecao Li, Liang Zhou, Tiecheng Bai, Tengyun Hu, Jianxi Huang, Dongjie Liu, Yangchun Li, Jincheng Guo
Summary: This study investigates the annual dynamics and variations of surface urban heat island intensity (SUHII) in 1,028 cities worldwide. The results show that urban areas have an average nighttime SUHII of 0.69 degrees C, which increases towards higher latitudes. The intensity of SUHII is influenced by the height and layout of buildings, while the background climate regulates the annual pattern of land surface temperature.
ISPRS JOURNAL OF PHOTOGRAMMETRY AND REMOTE SENSING
(2023)
Article
Remote Sensing
Fu Xuan, Yi Dong, Jiayu Li, Xuecao Li, Wei Su, Xianda Huang, Jianxi Huang, Zixuan Xie, Ziqian Li, Hui Liu, Wancheng Tao, Yanan Wen, Ying Zhang
Summary: Northeast China, as a major grain bank in China, has a significant impact on food security. In order to address the challenges posed by increasing food demands and soil protection, crop rotation and fallowing policies have been implemented. This study utilizes time-series Landsat-8 OLI images and applies an automatic sampling approach using a hexagon strategy and tile-based classification using the random forest algorithm to monitor crop types and their changes in Northeast China. The resulting crop maps exhibit high credibility with overall accuracies ranging from 0.89 to 0.97 and demonstrate good agreement with city-level statistical data. The dataset generated from this study provides reliable long-term crop maps, which can be valuable for food security and regional agricultural production management.
INTERNATIONAL JOURNAL OF APPLIED EARTH OBSERVATION AND GEOINFORMATION
(2023)
Article
Materials Science, Multidisciplinary
Xiaona Yu, Jie Wang, Xue Li, Shuaishuai Ma, Wanbin Zhu, Hongliang Wang
Summary: In this study, pH/laccase responsive microcapsules were prepared to protect photosensitive avermectin and achieve tunable release performances. The microcapsules showed high encapsulation efficiency, sustained release, and antiphotolysis of avermectin. Furthermore, the release of avermectin was enhanced by laccase and alkaline conditions, making the microcapsules responsive to these trigger factors.
MATERIALS ADVANCES
(2023)
Article
Development Studies
Gang Xu, Mengyan Zhu, Bin Chen, Muhammad Salem, Zhibang Xu, Xuecao Li, Limin Jiao, Peng Gong
Summary: This study investigates the settlement scaling law in Africa using built-up areas derived from remote sensing data. The results show that the relationship between built-up area and population varies across different regions in Africa, with linear, sub-linear, and super-linear scaling observed. The study also finds that the settlement scaling exponent varies among different countries, and can be explained by factors such as built-up area share, metropolitan population share, GDP per capita, and proportion of slum dwellers.
HABITAT INTERNATIONAL
(2023)
Article
Geosciences, Multidisciplinary
Jose Luis Gomez-Dans, Philip Edward Lewis, Feng Yin, Kofi Asare, Patrick Lamptey, Kenneth Kobina Yedu Aidoo, Dilys Sefakor MacCarthy, Hongyuan Ma, Qingling Wu, Martin Addi, Stephen Aboagye-Ntow, Caroline Edinam Doe, Rahaman Alhassan, Isaac Kankam-Boadu, Jianxi Huang, Xuecao Li
Summary: Smallholder agriculture is essential for food production in sub-Saharan Africa, but yields are below their potential and are vulnerable to climate change impacts. This paper presents data collected in Ghana on crop locations, biophysical parameters, crop yield, and biomass. The data is used to evaluate cropland masks, develop an LAI retrieval method, create a maize classification dataset, and explore the relationship between LAI and crop yield. This dataset contributes to understanding crop evolution and distribution in smallholder farming systems.
EARTH SYSTEM SCIENCE DATA
(2022)
