期刊
CELLULAR & MOLECULAR IMMUNOLOGY
卷 18, 期 10, 页码 2307-2312出版社
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/s41423-021-00743-3
关键词
SARS-CoV-2; Vaccines; T cells; COVID-19
类别
资金
- Singapore Ministry of Health's National Medical Research Council under its COVID-19 Research Fund [COVID19RF3-0060]
- Singapore Ministry of Health's National Medical Research Council [MOH-000019 (MOH-StaR17Nov-0001)]
- National Research Foundation, Singapore [NRF-CRP17-2017-06]
Virus-specific T cells during SARS-CoV-2 infection can play a dual role in either protection or pathogenesis, highlighting the importance of studying the function of these cells for future therapeutic and preventative strategies.
During viral infections, antibodies and T cells act together to prevent pathogen spread and remove virus-infected cells. Virus-specific adaptive immunity can, however, also trigger pathological processes characterized by localized or systemic inflammatory events. The protective and/or pathological role of virus-specific T cells in SARS-CoV-2 infection has been the focus of many studies in COVID-19 patients and in vaccinated individuals. Here, we review the works that have elucidated the function of SARS-CoV-2-specific T cells in patients and in vaccinated individuals. Understanding whether SARS-CoV-2-specific T cells are more linked to protection or pathogenesis is pivotal to define future therapeutic and prophylactic strategies to manage the current pandemic.
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