Review
Cardiac & Cardiovascular Systems
Pedro L. Valenzuela, Luis M. Ruilope, Alejandro Santos-Lozano, Matthias Wilhelm, Nicolle Kraenkel, Carmen Fiuza-Luces, Alejandro Lucia
Summary: There is a parallel between the pandemic of physical inactivity and the prevalence of cardiovascular disease. Regular physical activity and exercise can prevent and manage cardiovascular disease by improving metabolic health, reducing inflammation, and promoting cardiovascular adaptations. This review discusses the cardiovascular effects of physical activity and exercise, as well as the safe implementation in patients with cardiovascular disease.
EUROPEAN HEART JOURNAL
(2023)
Review
Urology & Nephrology
Nicolette C. Bishop, James O. Burton, Matthew P. M. Graham-Brown, David J. Stensel, Joao L. Viana, Emma L. Watson
Summary: This review discusses the potential mechanisms by which exercise can benefit people with kidney disease, such as chronic inflammation, cardiovascular health, lipid metabolism, insulin resistance, sarcopenia, and bone health. The authors emphasize the need for further research to enhance the benefits of exercise for this population. Existing evidence suggests that exercise can improve chronic inflammation, cardiorespiratory function, muscle and bone strength, and metabolic markers in patients with chronic kidney disease, kidney failure, or kidney transplants. However, the underlying mechanisms and clinical evidence are limited, primarily from short-duration exercise intervention studies. More research is needed to confirm these mechanisms and provide evidence for targeted exercise interventions in larger populations.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Physiology
Bent R. Ronnestad, Sjur J. Ofsteng, Fabio Zambolin, Truls Raastad, Daniel Hammarstrom
Summary: This study compared the effects of short-interval training and long-interval training on endurance performance in cyclists. The results showed that short-interval training led to greater improvements in maximal oxygen uptake and power output at a blood lactate concentration of 4 mmol.L-1 compared to long-interval training.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2021)
Review
Nutrition & Dietetics
Jeronimo Aragon-Vela, Olivia Gonzalez-Acevedo, Julio Plaza-Diaz, Rafael A. Casuso, Jesus R. Huertas
Summary: This systematic review evaluates the efficacy of seawater consumption in long-duration sport events. The results indicate that consuming seawater can accelerate the recovery of aerobic capacity and muscle capacity, while reducing lactate production after running exercise.
Review
Food Science & Technology
Zhihao Qu, Ailing Liu, Penghui Li, Changwei Liu, Wenjun Xiao, Jianan Huang, Zhonghua Liu, Sheng Zhang
Summary: (-)-Epicatechin (EC) is a flavanol found in tea, cocoa, vegetables, fruits, and cereals, and has various health benefits including antioxidant and anti-inflammatory activities, enhancement of muscle performance, improvement of cardiovascular and cerebrovascular symptoms, prevention of diabetes, and protection of the nervous system.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Cell Biology
Timothy M. Moore, Sindre Lee, Thomas Olsen, Marco Morselli, Alexander R. Strumwasser, Amanda J. Lin, Zhenqi Zhou, Aaron Abrishami, Steven M. Garcia, Jennifer Bribiesca, Kevin Cory, Kate Whitney, Theodore Ho, Timothy Ho, Joseph L. Lee, Daniel H. Rucker, Christina Q. A. Nguyen, Akshay T. S. Anand, Aidan Yackly, Lorna Q. Mendoza, Brayden K. Leyva, Claudia Aliman, Daniel J. Artiga, Yonghong Meng, Sarada Charugundla, Calvin Pan, Vida Jedian, Marcus M. Seldin, In Sook Ahn, Graciel Diamante, Montgomery Blencowe, Xia Yang, Etienne Mouisel, Matteo Pellegrini, Lorraine P. Turcotte, Kare I. Birkeland, Frode Norheim, Christian A. Drevon, Aldons J. Lusis, Andrea L. Hevener
Summary: Physical activity leads to beneficial adaptations in metabolism in both humans and rodents. Research on middle-aged men and diverse strains of female mice revealed genetic drivers of relevant traits, including exercise volume, muscle metabolism, adiposity, and hepatic lipids. While some genes expressed in skeletal muscle are similar between mice and humans, adipose tissue's response to exercise-induced weight loss seems to be controlled by species and underlying genotype. The study generated prediction models for metabolic trait responsiveness to exercise, providing a framework for personalized exercise prescription. Accessible web-based applications were developed for data mining and hypothesis development using the human and mouse data.
Article
Biochemistry & Molecular Biology
Haruna Fujiyoshi, Tatsuro Egawa, Eriko Kurogi, Takumi Yokokawa, Kohei Kido, Tatsuya Hayashi
Summary: Endurance exercise-induced muscle adaptations are mediated by TLR4, and TLR4-mediated inflammatory responses may be involved in the mechanism of adaptation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Sport Sciences
Heath M. Burton, Anthony S. Wolfe, Emre Vardarli, Remzi Satiroglu, Edward F. Coyle
Summary: The study found that reducing daily steps can affect acute and short-term adaptations to intense aerobic training, especially showing more pronounced effects on metabolic responses and stress reactions.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Review
Physiology
Aaron L. Slusher, Edmund O. Acevedo
Summary: Starting from Hans Selye's stress physiology, researchers have been investigating the physiological mechanisms linking stress to health and disease. They have focused on the link between psychological stress and cardiovascular disease (CVD), the leading cause of death in the United States. Studies have shown that psychological stress is an independent risk factor for CVD, and it can lead to increased systemic inflammation, contributing to CVD development. Physical activity has been found to buffer against the harmful effects of psychological stress by strengthening stress response systems and immune system, reducing stress-induced inflammation, and attenuating mechanisms associated with CVD development. Additionally, the COVID-19 pandemic has provided a model for understanding the stress-health relationship.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Sport Sciences
Kristian Berge, Vincent L. Aengevaeren, Arend Mosterd, Birgitta K. Velthuis, Magnus N. Lyngbakken, Torbjorn Omland, Casper G. Schalkwijk, Thijs M. H. Eijsvogels
Summary: The study found that levels of advanced glycation end products (AGE) and dicarbonyl compounds in plasma are not predictive of the presence of coronary plaques, plaque characteristics, or coronary artery calcium (CAC) scores in middle-aged and older athletes.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Review
Neurosciences
Benjamin J. Ryan, Nisha Charkoudian, Michael J. Joyner
Summary: In recent years, there have been many new approaches to improve physical performance for athletes, the military, and other applications. The goal of this discussion is to review and quantify the potential impact of these approaches using physiological insights. The evaluation ranges from transformative to ineffective or undetermined. For example, an increase of arterial oxygen partial pressure by 10% may not have a significant impact on healthy individuals at sea level, but it could be beneficial at high altitude or for certain patient populations. The importance of quantitative evaluation and the role of integrative physiologists in appraising these approaches are highlighted.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Physiology
T. W. Jones, L. Eddens, J. Kupusarevic, D. C. M. Simoes, M. J. W. Furber, K. A. Van Someren, G. Howatson
Summary: This study investigates the effects of endurance stimuli intensity on the adaptation in strength and endurance following concurrent training, as well as the impact of training status on the acute molecular response to concurrent exercise. The results indicate that the intensity of endurance activity does not affect performance outcomes after concurrent training, and training status has no effect on the molecular responses assessed.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yasina B. Somani, Laween Uthman, Vincent L. Aengevaeren, Laura Rodwell, Gregory Y. H. Lip, Maria T. E. Hopman, Niels Van Royen, Thijs M. H. Eijsvogels, Dick H. J. Thijssen
Summary: Prolonged exercise can lead to the release of cardiac troponin. The magnitude of troponin release decreases with successive days of exercise in healthy individuals and those with cardiovascular risk factors, but not in patients with established cardiovascular disease.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Hematology
Matthew Nayor, Priya Gajjar, Venkatesh L. Murthy, Patricia E. Miller, Raghava S. Velagaleti, Martin G. Larson, Ramachandran S. Vasan, Gregory D. Lewis, Gary F. Mitchell, Ravi V. Shah
Summary: By measuring the changes in blood pressure and vascular stiffness, the cardiac and vascular components of exercise blood pressure can be analyzed. The study found that higher peak exercise blood pressure is associated with both higher arterial stiffness and higher cardiac-peripheral performance, especially in women. Therefore, studying the response of blood pressure to exercise in relation to vascular and cardiac physiology can reveal mechanisms of hypertension and clarify the clinical interpretation of exercise blood pressure.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ralf Gaebel, Cajetan Lang, Praveen Vasudevan, Larissa Luhrs, Katherine Athayde Teixeira de Carvalho, Eltyeb Abdelwahid, Robert David
Summary: Cardiovascular diseases are a leading cause of death in industrialized nations and have a significant impact on healthcare costs. Obesity and sedentary lifestyle contribute to an increased risk of heart-related complications, and there is a lack of comprehensive understanding and evidence on the underlying mechanisms and effective interventions. Therefore, there is a need for intensified research efforts in order to prevent and effectively manage cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Koen M. van der Sluijs, Esmee A. Bakker, Tim J. Schuijt, Jayaraj Joseph, Maryam Kavousi, Geert-Jan Geersing, Frans H. Rutten, Yvonne A. W. Hartman, Dick H. J. Thijssen, Thijs M. H. Eijsvogels
Summary: It is reported that COVID-19 has long-term effects on cardiovascular health and physical functioning. This study compared cardiovascular risk factors, arterial stiffness, and physical functioning in nonhospitalized COVID-19 patients at 6 months post-infection. The study found that one in three nonhospitalized patients with COVID-19 reported residual symptoms, especially fatigue, at a median of 6 months post-infection, but no differences in cardiovascular risk factors or arterial stiffness were observed between the COVID-19 group and the control group.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Vincent L. Aengevaeren, Arend Mosterd, Esmee A. Bakker, Thijs L. Braber, Hendrik M. Nathoe, Sanjay Sharma, Paul D. Thompson, Birgitta K. Velthuis, Thijs M. H. Eijsvogels
Summary: According to the study, the intensity rather than the volume of exercise is associated with the progression of coronary atherosclerosis in middle-aged and older male athletes. Vigorous intensity exercise is associated with less coronary artery calcification (CAC) progression, while very vigorous intensity exercise is associated with greater CAC and calcified plaque progression.
Article
Nutrition & Dietetics
Marcia Spoelder, Lotte Koopmans, Yvonne A. W. Hartman, Coen C. W. G. Bongers, Merle C. A. Schoofs, Thijs M. H. Eijsvogels, Maria T. E. Hopman
Summary: This study compared the effects of pea protein and whey protein on exercise-induced muscle damage in older adults. The results showed that 13 days of pea protein supplementation did not attenuate muscle damage, while the whey protein group had significantly lower creatine kinase concentrations after exercise.
Editorial Material
Medicine, General & Internal
Giuseppe Lippi, Brandon Michael Henry, Fabian Sanchis-Gomar
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Neeltje A. E. Allard, Lando Janssen, Bart Lagerwaard, Malou A. H. Nuijten, Coen C. W. G. Bongers, Richard J. Rodenburg, Paul D. Thompson, Thijs M. H. Eijsvogels, Willem J. J. Assendelft, Tom J. J. Schirris, Silvie Timmers, Maria T. E. Hopman
Summary: This study aimed to determine the effect of prolonged moderate-intensity exercise on markers of muscle injury in statin users and whether statin-associated muscle symptoms exacerbate this injury. The results showed that statin use and the presence of statin-associated muscle symptoms do not aggravate exercise-induced muscle injury, and there is no relationship between muscle injury markers and leukocyte CoQ10 levels.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Thijs P. Kerstens, Jerremy Weerts, Arie P. J. van Dijk, Gert Weijers, Christian Knackstedt, Thijs M. H. Eijsvogels, David Oxborough, Vanessa P. M. van Empel, Dick H. J. Thijssen
Summary: In this study, the association between LV-SVL parameters and adverse events in patients with HFpEF was examined. Early diastolic slope was found to be significantly associated with adverse events, while the association between LV peak strain and adverse events disappeared after correction for potential confounders.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Bram M. A. van Bakel, Iris A. de Koning, Esmee A. Bakker, Gheorghe A. M. Pop, Etienne Cramer, Robert-Jan M. van Geuns, Dick H. J. Thijssen, Thijs M. H. Eijsvogels
Summary: This study aimed to investigate changes in physical activity (PA) and sedentary behavior (SB) during the acute phase of myocardial infarction (MI). It was found that patients with MI had high levels of sedentary time during hospitalization, but this decreased significantly after discharge, and there was an increase in light and moderate-vigorous intensity PA. The improvements in PA and SB were similar for different patient groups, except for those who underwent coronary artery bypass grafting.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Cardiac & Cardiovascular Systems
Fernando de la Guia-Galipienso, Koldo Ugedo-Alzaga, Gonzalo Grazioli, Francisco Javier Quesada-Ocete, Eloisa Feliu-Rey, Marco V. Perez, Aurelio Quesada-Dorador, Fabian Sanchis-Gomar
Summary: Arrhythmogenic cardiomyopathy (ACM) is a disease characterized by progressive replacement of myocardium by fibro-adipose material, leading to ventricular arrhythmias and sudden cardiac death. It is more common in males and usually onset in the 2nd to 4th decade of life. ACM is one of the most common causes of sudden cardiac death in young patients, especially athletes. Exercise can worsen right ventricular function in hereditary ACM.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Manon Kloosterman, Machteld J. Boonstra, Rob W. Roudijk, Mimount Bourfiss, Iris van der Schaaf, Birgitta K. Velthuis, Thijs M. H. Eijsvogels, Feddo P. Kirkels, Peter M. van Dam, Peter Loh
Summary: This study used body surface potential mapping to identify abnormal QRS and STT patterns in variant carriers of PKP2 who had normal 12 lead ECGs. This helps in detecting early signs of the disease.
Editorial Material
Physiology
Thijs M. H. Eijsvogels, Vincent L. Aengevaeren
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Niels A. Stens, Esmee A. Bakker, Asier Manas, Laurien M. Buffart, Francisco B. Ortega, Duck-chul Lee, Paul D. Thompson, Dick H. J. Thijssen, Thijs M. H. Eijsvogels
Summary: According to the meta-analysis, daily step counts of approximately 2,600 and 2,800 already yield significant benefits in terms of reducing mortality and cardiovascular disease. Further increasing the step count up to approximately 8,800 and 7,200 steps per day leads to progressive risk reductions. There are additional mortality benefits from moderate to high step cadences.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Carl J. Lavie, Charles A. German, Fabian Sanchis-Gomar
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Koen M. van der Sluijs, Jos Thannhauser, Iris M. Visser, P. M. Nabeel, Kiran V. Raj, Afrah E. F. Malik, Koen D. Reesink, Thijs M. H. Eijsvogels, Esmee A. Bakker, Prabhdeep Kaur, Jayaraj Joseph, Dick H. J. Thijssen
Summary: This study compares arterial stiffness between White Europeans and South Asians and finds that ethnicity is associated with central arterial stiffness but not with local arterial stiffness. Moreover, ethnicity seems to modify associations between arterial stiffness measures and cardiovascular disease risk factors.
Review
Sport Sciences
Tessa M. van de Kerkhof, Coen C. W. G. Bongers, Julien D. Periard, Thijs M. H. Eijsvogels
Summary: Cooling interventions can effectively attenuate the decline in exercise performance in hot conditions, with pre-cooling appearing to be more effective during constant workload exercise. However, no differences were found in the effectiveness of different cooling types.
Article
Sport Sciences
Iris Apolonia de Koning, B. M. A. van Bakel, Hajar Rotbi, Robert-Jan M. Van Geuns, G. Etienne Cramer, Gheorghe A. M. Pop, Thijs Eijsvogels, Dick H. J. Thijssen
Summary: Regular exercise prior to myocardial infarction (MI) may lead to lower post-MI cardiac biomarker concentrations, indicating the cardiovascular health benefits of exercise.
BMJ OPEN SPORT & EXERCISE MEDICINE
(2023)