Article
Pharmacology & Pharmacy
Jiansong Zhao, Ying Wei, Jian Xiong, Hongbing Liu, Gaoshuai Lv, Jingyi Zhao, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Yu Zhang
Summary: This study aimed to develop a nanosystem for the treatment of periodontitis by delivering minocycline hydrochloride (MH) with controlled release and good retention properties. Insoluble ion-pairing (IIP) complexes were constructed to improve the encapsulation efficiency of hydrophilic MH in PLGA nanoparticles. A nanogenerator was then used to encapsulate the complexes into PLGA nanoparticles to form MH-NPs. These MH-NPs were dispersed into thermosensitive gels to prepare a multifunctional system (MH-NPs-in-gels) that could continuously release the drug for 21 days in vitro.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Applied
Jiacai Chen, Tao Guo, Xiaohong Ren, Ting Yang, Kaikai Zhang, Yuhua Guo, Xiaojin Chen, Shuangying Gui, Shujun Wang, Qianqian Li, Can Peng, Jiwen Zhang, Li Wu
Summary: Potassium iodide cyclodextrin metal-organic frameworks (KI-CD-MOF) were prepared to carry iodine for wound infection treatment. The inclusion mechanism of iodine in KI-CD-MOF was studied and confirmed through various characterizations. The highly-dispersed iodide ions in KI-CD-MOF were shown to improve iodine solubility, stability, and bacteriostatic effects.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Inorganic & Nuclear
Weishu Ni, Ling Zhang, Hengrui Zhang, Chenghui Zhang, Ke Jiang, Xianying Cao
Summary: Chemotherapy is an important and effective clinical treatment for cancer, but precise controlled release and targeted therapy are challenging. Drug carriers have emerged as a solution to these problems. This study utilized the MOF-on-MOF strategy to develop a core-shell-structured nanomaterial capable of pH and GSH dual-responsive controlled drug release. Additionally, the nanomaterial exhibited peroxidase-like catalytic activity and significant inhibitory effects on cancer cells.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Tong Liu, Yi Zhao, Min Song, Xinghan Pang, Xiaofei Shi, Jingjing Jia, Lifeng Chi, Guang Lu
Summary: In this study, researchers achieved the synthesis of ordered macroporous single crystals of imine-linked COFs (COF-300 and COF-303) through a template-assisted modulated strategy. The introduced macropores greatly shortened the microporous diffusion path in COF-300 single crystals, allowing all micropores to be fully accessible for iodine adsorption.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Liang Zhang, Lei-Lei Yang, Shu-Cheng Wan, Qi-Chao Yang, Yao Xiao, Hexiang Deng, Zhi-Jun Sun
Summary: A series of three-dimensional (3D) covalent organic frameworks (COFs) were designed and synthesized as inducers for immunogenic cell death (ICD) in cancer immunotherapy. These COFs exhibit outstanding ICD-inducing efficiency and one member, COF-609, showed significant therapeutic effects in a mouse model of breast cancer.
Article
Engineering, Chemical
Nazanin Mokhtari, Mohammad Dinari
Summary: This paper presents a method to remove radio iodine, one of the essential gaseous pollutions in nuclear energy consumption, using an amine-linked covalent organic framework (COF). The flexibility and abundance of NH groups in the COF structure provide a great medium for iodine adsorption from both liquid and gas phases. The experiment results show that NH-COF has better iodine adsorption performance than Hz-COF in both gas phase and solution, indicating its excellent adaptability and high adsorption capacity.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Yi-Xuan Yang, Xi-Hao Tang, Jia-Lin Wu, Zhao-Yi Dong, Yi-Lun Yan, Sheng-Run Zheng, Jun Fan, Xinle Li, Songliang Cai, Wei-Guang Zhang
Summary: In this study, a ketone hydrazone-linked COF was transformed into a hydrazone-linked one through mild oxidation, demonstrating improved crystallinity and chemical stability. The hydrazone-linked COF exhibited higher iodine uptake compared to its precursor, possibly due to the favorable interaction between iodine molecules and hydrazide moieties. This work presents a facile approach for accessing crystalline hydrazide-linked COFs.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Xu Han, Gerard Boix, Mateusz Balcerzak, Oscar Hernando Moriones, Mary Cano-Sarabia, Pilar Cortes, Neus Bastus, Victor Puntes, Montserrat Llagostera, Inhar Imaz, Daniel Maspoch
Summary: This study reports the development of a metal-organic framework based composite for the controlled release of iodine, which exhibits antibacterial properties without causing drug resistance. The composite was successfully integrated into a polymer to create antibacterial films, which showed effective long-term release of iodine. In vitro tests confirmed the antibacterial activity of these films against gram-positive and gram-negative bacteria.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Qianjun Zhi, Wenping Liu, Rong Jiang, Xiaoning Zhan, Yucheng Jin, Xin Chen, Xiya Yang, Kang Wang, Wei Cao, Dongdong Qi, Jianzhuang Jiang
Summary: This study successfully synthesized two new two-dimensional piperazine-linked CoPc-based covalent organic frameworks and further investigated their structure and photocatalytic performance. The experimental results demonstrated that these new materials exhibit excellent photocatalytic activity under visible light irradiation, with CoPc-BTM-COF showing a record-breaking high hydrogen peroxide yield and apparent quantum yield.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Mojdeh Nakhaei, Kamran Akhbari, Alireza Davoodi
Summary: The study focuses on synthesizing a biocide by encapsulating iodine in the metal-organic framework MOF-808, resulting in a highly stable material that effectively inhibits bacterial growth.
Article
Agriculture, Multidisciplinary
Xiaodan Pan, Shahid Ahmed Junejo, Chin Ping Tan, Bin Zhang, Xiong Fu, Qiang Huang
Summary: In this study, gamma-cyclodextrin metal-organic frameworks (MOFs) were used for encapsulating thymol via cocrystallization and high-temperature adsorption methods. The encapsulation capacity, storage stability, and antibacterial activity of thymol were significantly improved with the use of gamma-CD-MOFs compared to gamma-CD alone. The inclusion complexes prepared by gamma-CD-MOFs showed higher stability, sustainability, and antibacterial activity, making them a promising complex material for industrial and agricultural applications.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Chemistry, Multidisciplinary
Lingyan Zhang, Jinheng Li, Huixin Zhang, Yu Liu, Yumeng Cui, Fenchun Jin, Ke Wang, Guiyan Liu, Yanli Zhao, Yongfei Zeng
Summary: Two 2-dimensional covalent organic frameworks with high crystallinity and large specific surface area were synthesized, showing high iodine uptake due to physical-chemical adsorption, making them among the best porous materials for iodine adsorption.
CHEMICAL COMMUNICATIONS
(2021)
Article
Polymer Science
Kazuaki Kato, Masayuki Taniguchi, Kohzo Ito
Summary: A series of mechanically interlocked supramolecular glasses were prepared by incorporating small amounts of polymer into a bio-based cyclic oligosaccharide. The mechanical properties of the rigid glassy materials could be tuned by the substituents on the oligosaccharide. The inclusion of polymer enabled the transformation of fragile oligosaccharide derivatives into tough bio-based plastics.
Article
Materials Science, Multidisciplinary
Jeong-Min Seo, Ji Eun Lee, Hyuk-Jun Noh, Sang Kyu Kwak, Jong-Beom Baek
Summary: The formation of crystalline PI-2DPs has been explored by controlling the reaction conditions and studying the rate of amic acid intermediates. The findings suggest that the formation rate of amic acid intermediates and the pk values of triamine monomers play crucial roles in the crystallinity of PI-2DPs, providing criteria for their design and synthesis.
ACS MATERIALS LETTERS
(2022)
Article
Agricultural Engineering
Hongyu Tian, Lina Zhang, Xiao Sun, Jing Cui, Jingjing Dong, Liang Wu, Yanfeng Wang, Lingli Wang, Min Zhang, Zhiguang Liu, Panfang Lu
Summary: The bio-based cross-linked polyurethane coating prepared from alkali-hydrolyzed lignocellulose, together with the self-healing bis (2-hydroxyethyl) disulfide, can effectively improve the performance of the polyurethane coating, prolong the controlled-release longevity of urea, and has great potential for sustainable agriculture.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Chemistry, Analytical
Kena Zhao, Tao Guo, Xian Sun, Ting Xiong, Xiaohong Ren, Li Wu, Rui Yang, Huimin Sun, Senlin Shi, Jiwen Zhang
Summary: Quantitative detection of different forms of SN-38 in biological samples is cumbersome and difficult. By revisiting the mechanism of supramolecular complexation-enhanced fluorescence spectroscopy, a highly sensitive and selective spectrofluorimetric method was established for quantitative analysis of SN-38 in plasma and cellular pharmacokinetics in A549 cells. The method is able to optimize the determination of SN-38 and provide reference for elucidating the biodistribution of SN-38.
Editorial Material
Biochemistry & Molecular Biology
Tao Guo, Hong-Xuan Lin
JOURNAL OF GENETICS AND GENOMICS
(2021)
Article
Pharmacology & Pharmacy
Xiaojin Chen, Tao Guo, Kaikai Zhang, Jiacai Chen, Caifen Wang, Xiaohong Ren, Qin Wang, Yingchao Yang, Chongjing Liu, Wen Tan, Shuangying Gui, Li Wu, Jiwen Zhang
Summary: The study found that Cyclodextrin metal-organic framework (CD-MOF) has a promising effect on improving the solubility and bioavailability of isosteviol (STV). The inclusion mechanism plays a primary role when STV loading ratio is low, while the nanocluster mechanism is responsible for the increased bioavailability at high loading ratios.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Pharmacology & Pharmacy
Yong Zhou, Meijuan Zhang, Caifen Wang, Xiaohong Ren, Tao Guo, Zeying Cao, Jiwen Zhang, Lixin Sun, Li Wu
Summary: D-Limonene was loaded into a biodegradable gamma-cyclodextrin metal-organic framework to improve its stability and achieve efficient pulmonary delivery, showing promise for the development of dry powder inhalers. The interaction between D-Limonene and gamma-CD-MOF was revealed through various characterizations and molecular docking studies. Aerosolization of D-Limonene@gamma-CD-MOF for inhalation demonstrated satisfactory results, with a significant increase in bioavailability compared to oral administration.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Food Science & Technology
Yong Zhou, Jing Feng, Hui Peng, Tao Guo, Jian Xiao, Weifeng Zhu, Wei Qian, Jiwen Zhang, Li Wu
Summary: An efficient and eco-friendly method of preparing allicin@alpha-CD inclusion was designed, effectively masking the unpleasant odor of allicin and improving its stability, which provides a promising approach for the industrialization of allicin-related formulations.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Yujie Liu, Panpan Zhou, Zeying Cao, Wanhui Liang, Jiazhi Yan, Huipeng Xu, Li Wu, Lixin Sun, Likun Gong, Can Peng, Tao Guo, Caifen Wang, Jiwen Zhang
Summary: The inclusion and nanocluster formed in CD-MOF can improve the solubility and bioavailability of insoluble drugs. This study shows that GA@nano-CD-MOF has enhanced bioavailability and unique biphasic release kinetics, allowing for more flexible pharmaceutical applications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Nanoscience & Nanotechnology
Ting Yang, Tao Guo
Summary: This article uses probability theory and Mathematica software to study the distribution of angular speeds generated by randomly moving particles. The probability density expression of this distribution is derived successfully and its accuracy is verified using simulation data. The research confirms that the angular speed follows a Maxwell distribution with a specified scale parameter.
Article
Engineering, Chemical
Panpan Zhou, Zeying Cao, Yujie Liu, Tao Guo, Rui Yang, Manli Wang, Xiaohong Ren, Li Wu, Lixin Sun, Can Peng, Caifen Wang, Jiwen Zhang
Summary: A unique composite particle consisting of gamma-cyclodextrin metal-organic framework (MOF) and 18 beta-Glycyrrhetinic acid (GA) was developed as a dry powder inhaler (DPI) for the treatment of idiopathic lung fibrosis (IPF). The particle showed biphasic release in both in vitro and in vivo conditions, providing relief for lung fibrosis.
Article
Multidisciplinary Sciences
Hai Zhang, Ji-Fu Zhou, Yi Kan, Jun-Xiang Shan, Wang-Wei Ye, Nai-Qian Dong, Tao Guo, You-Huang Xiang, Yi-Bing Yang, Ya-Chao Li, Huai-Yu Zhao, Hong-Xiao Yu, Zi-Qi Lu, Shuang-Qin Guo, Jie-Jie Lei, Ben Liao, Xiao-Rui Mu, Ying-Jie Cao, Jia-Jun Yu, Youshun Lin, Hong-Xuan Lin
Summary: The study identified two genes, TT3.1 and TT3.2, that enhance rice thermotolerance by facilitating the communication between the plasma membrane and chloroplasts. They found that upon heat stress, TT3.1 translocates to endosomes where it ubiquitinates TT3.2 for degradation, implying its role as a potential thermosensor. The accumulation of mature TT3.2 proteins in chloroplasts is crucial for protecting thylakoids from heat stress.
Article
Chemistry, Applied
Jiacai Chen, Tao Guo, Xiaohong Ren, Ting Yang, Kaikai Zhang, Yuhua Guo, Xiaojin Chen, Shuangying Gui, Shujun Wang, Qianqian Li, Can Peng, Jiwen Zhang, Li Wu
Summary: Potassium iodide cyclodextrin metal-organic frameworks (KI-CD-MOF) were prepared to carry iodine for wound infection treatment. The inclusion mechanism of iodine in KI-CD-MOF was studied and confirmed through various characterizations. The highly-dispersed iodide ions in KI-CD-MOF were shown to improve iodine solubility, stability, and bacteriostatic effects.
CARBOHYDRATE POLYMERS
(2022)
Article
Pharmacology & Pharmacy
Ying Zhang, Jiacai Chen, Zaiyong Zhang, Huajie Zhu, Wuzhen Ma, Xiangyu Zhao, Manli Wang, Caifen Wang, Weidong Chen, Abid Naeem, Jiwen Zhang, Tao Guo, Li Wu
Summary: In this study, a novel type of beta-cyclodextrin metal-organic framework (beta-CD-POF(I)) was successfully synthesized, which exhibited excellent drug adsorption capacity and enhanced stability. The stability of vitamin A palmitate (VAP) was effectively improved by encapsulating it into the channel formed by the dicyclodextrin pairs in beta-CD-POF(I). The mechanism of stability enhancement for VAP was determined to be due to the constraint and separation effects of beta-CD pairs on VAP.
Article
Chemistry, Physical
Ting Yang, Huiyun Xu, Yong Zhou, Ying Zhang, Caifen Wang, Abid Naeem, Wenting Wu, Jiwen Zhang, Li Wu, Tao Guo
Summary: In this study, the diffusion coefficient of alpha-lipoic acid (LA) in gamma-cyclodextrin metal-organic framework (CD-MOF) crystals was determined using mathematical modeling and new experimental measurements. The adhesion force between LA and the dicyclodextrin cavity in the CD-MOF was identified as chemisorption dominated by hydrogen binding. It was discovered that the stability enhancement of LA in CD-MOF was due to the combined actions of the high binding free energy and steric hindrance.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Multidisciplinary Sciences
Tao Guo
Summary: Prior studies have not considered the characteristics of stochastic-constrained particles within randomly moving particle swarms. This study presents a generalized diffusion equation that accounts for the velocity and location aggregation effects observed from the parent particle swarm. The equation approximates the Schrodinger equation in the microcosmic case and describes the dynamics of total mass distribution in the macrocosmic case.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Ting La, Song Chen, Tao Guo, Xiao Hong Zhao, Liu Teng, Dandan Li, Michael Carnell, Yuan Yuan Zhang, Yu Chen Feng, Nicole Cole, Alexandra C. Brown, Didi Zhang, Qihan Dong, Jenny Y. Wang, Huixia Cao, Tao Liu, Rick F. Thorne, Feng-Min Shao, Xu Dong Zhang, Lei Jin
Summary: Dual labeling of p27 and Ki67 enabled visualization, isolation, and analysis of quiescent cells, revealing the high selectivity of c-Myc in activating OXPHOS genes in quiescent cells. These results establish a rigorous experimental system for investigating cellular quiescence and propose OXPHOS as a potential avenue to counter cancer cells in quiescence.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
