Article
Immunology
Xue Wang, Yunhe Qu, Yuan Wang, Xiang Wang, Jialei Xu, Hailing Zhao, Donglin Zheng, Lin Sun, Guihua Tai, Yifa Zhou, Hairong Cheng
Summary: The polysaccharides from Pleurotus eryngii, specifically APEP-A-b, have been found to have positive effects on immunity and gut microbiota. APEP-A-b can increase lymphocyte proliferation, NK cell activity, and phagocytic capacity of peritoneal cavity phagocytes. It also increases the proportion of CD4(+) and CD8(+) T cells in the lamina propria and induces changes in the gut microbiota composition. These findings are important for the development of polysaccharides derived from Pleurotus eryngii.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tania Petraglia, Tiziana Latronico, Angela Fanigliulo, Aniello Crescenzi, Grazia Maria Liuzzi, Rocco Rossano
Summary: This study evaluated the antioxidant and neuroprotective activity of an enriched polysaccharide fraction (EPF) obtained from the fruiting body of cultivated P. eryngii. The EPF showed high content of (1-3; 1-6)-beta-D-glucans and exhibited significant scavenging activities against DPPH, superoxide, hydroxyl, and nitric oxide radicals. It also demonstrated biocompatibility and reduced oxidative stress in DI-TNC1 cells. These findings suggest that polysaccharides extracted from P. eryngii could be used as functional food to enhance antioxidant defenses.
Article
Food Science & Technology
Hongbo Li, Suya Xie, Shangqiao Cao, Liangbin Hu, Dan Xu, Jiayi Zhang, Haizhen Mo, Zhenbin Liu
Summary: This study investigated the role of Pleurotus eryngii mycelia in transforming high-calorie potato starch into low-calorie beta-glucan. Results showed that the 3D printing culture system promoted the bioconversion efficiency of mycelia, demonstrating high potential for preparing low-calorie food.
Article
Chemistry, Applied
Christiane F. Ellefsen, Linda Lindstad, Leesa J. Klau, Finn L. Aachmann, Marianne Hiorth, Anne Berit C. Samuelsen
Summary: This study extracted and characterized the β-glucans from the edible mushroom Pleurotus eryngii, and found that they contain structurally different polysaccharides. However, these polysaccharides were unable to induce the production of proinflammatory cytokines in LPS-differentiated THP-1 cells, despite being able to activate the human dectin-1a receptor.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Applied
Hellen Abreu, Matheus Zavadinack, Fhernanda R. Smiderle, Thales R. Cipriani, Lucimara M. C. Cordeiro, Marcello Iacomini
Summary: Polysaccharides from P. eryngii mushroom were extracted using low-cost technologies, resulting in different fractions with immunostimulatory properties on THP-1 macrophages. The main polysaccharides included Mannogalactan and various β-glucans, which were not cytotoxic and induced different cellular responses. This simple technique allows the obtainment of fractions with distinct immunomodulatory activities, showing the potential for future biological effects research.
CARBOHYDRATE POLYMERS
(2021)
Article
Medicine, General & Internal
Xinghan Liu, Yujun Xu, Yi Li, Yuchen Pan, Shuli Zhao, Yayi Hou
Summary: The nanocomposite FMT-beta-glucan can suppress melanoma growth by inducing the activation of M1 macrophages in the tumor microenvironment.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Chemistry, Applied
Xuan Feng, Fan Li, Mingming Ding, Ran Zhang, Tongfei Shi, Yuyuan Lu, Wei Jiang
Summary: Through MD simulation and docking techniques, we investigated the recognition mechanism between bglc and Dectin-1, revealing the important roles of Trp221, His223, and Tyr228 in stabilizing the recognition complex and the clear preference of the recognition mode on the relative direction of triple-helix bglc.
CARBOHYDRATE POLYMERS
(2022)
Article
Food Science & Technology
Michele O'Sullivan, Elaine Dempsey, Sarah Case, Emer E. Hackett, Anna E. Ledwith, Hannah Prendeville, Tara O'Brien, Faye Lewis, Dearbhla M. Murphy, Supriya Yadav, Jude Wilson, Sinead C. Corr, Frederick J. Sheedy
Summary: Mushrooms have been valued as an edible and medical resource for thousands of years. Research on powdered A. bisporus mushrooms shows that they can attenuate immune signaling triggered by microbial ligands and inhibit the development of colitis in vivo. This study highlights the importance of mushrooms in developing complementary approaches to modulate chronic inflammation and disease.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Zehua Liu, Wenhua Lian, Qiang Long, Ruoyu Cheng, Giulia Torrieri, Baoding Zhang, Artturi Koivuniemi, Mohammad Mahmoudzadeh, Alex Bunker, Han Gao, Hongbin He, Yun Chen, Jouni Hirvonen, Rongbin Zhou, Qiang Zhao, Xiaofeng Ye, Xianming Deng, Helder A. Santos
Summary: This study presents a method for preparing ligand-free targeted nanoparticles (NPs) for the heart, and demonstrates their potential for improving cardiac ischemic/reperfusion (I/R) injury.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Polymer Science
Kazuki Sumiya, Hiroto Izumi, Takuya Matsunaga, Motoko Tanaka, Kazuo Sakurai
Summary: This paper introduces a new quantized complex that has the ability to accurately control the quantity of AS-ODNs, and is more easily taken up by cells compared to conventional complexes, thus providing higher efficiency in antisense therapy.
Article
Immunology
Bart G. J. Moerings, Priscilla de Graaff, Matthew Furber, Renger F. Witkamp, Reno Debets, Jurriaan J. Mes, Jeroen van Bergenhenegouwen, Coen Govers
Summary: This study investigates the effects of beta-glucans from different sources on immune cell trained immunity and resilience, showing correlation with activation of the Dectin-1 receptor. However, Dectin-1 receptor activation is not the sole predictor for beta-glucan-mediated trained immunity. The modified in vitro model focuses on macrophage responses and can be applied to assess the potential of dietary polysaccharides to induce trained immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Shuang Lv, Xiaolin Zhu, Zhenbin Liu, Liangbin Hu, Dan Xu, Bimal Chitrakar, Haizhen Mo, Hongbo Li
Summary: This study evaluated the feasibility of preparing papery food using Pleurotus eryngii as a raw material through the papermaking process. The results showed that PSP and PMP were more popular among consumers in terms of formability, mouth feel, and overall palatability, with PSP also exhibiting better moisture resistance and thermal decomposition performance.
Article
Chemistry, Applied
Zhaomin Zheng, Qilin Huang, Yu Kang, Yonggang Liu, Wei Luo
Summary: The study investigated the influence of molecular size and chain conformation of water-soluble yeast beta-glucan on its interaction with Dectin-1, revealing that higher molecular weight beta-glucan exhibited a spherical conformation while smaller molecular weight beta-glucan showed a stiff chain conformation. The interaction between beta-glucan and Dectin-1 was found to be easier for spherical beta-glucan with longer side chains.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Multidisciplinary
Fangyi Xu, Jingyao Mu, Yun Teng, Xiangcheng Zhang, Kumaran Sundaram, Mukesh K. Sriwastva, Anil Kumar, Chao Lei, Lifeng Zhang, Qiaohong M. Liu, Jun Yan, Craig J. McClain, Michael L. Merchant, Huang-Ge Zhang
Summary: Understanding and controlling the activities of microglia can improve brain health, and oral administration of oat nanoparticles can effectively prevent alcohol-induced brain inflammation.
Article
Immunology
Patricia Kellen Martins Oliveira-Brito, Gabriela Yamazaki de Campos, Julia Garcia Guimaraes, Leticia Serafim da Costa, Edanielle Silva de Moura, Javier Emilio Lazo-Chica, Maria Cristina Roque-Barreira, Thiago Aparecido da Silva
Summary: This study developed an immunization strategy using a selective Dectin-1 agonist as an adjuvant to treat Cryptococcus gattii infection. The strategy improved immune response and reduced lung infection.
Article
Chemistry, Medicinal
Martin Jakubec, Christian Totland, Frode Rise, Elahe Jafari Chamgordani, Britt Paulsen, Louis Maes, An Matheeussen, Lise-Lotte Gundersen, Oyvind Halskau
Article
Marine & Freshwater Biology
J. Sam Murray, Tomohiro Nishimura, Sarah C. Finch, Lesley L. Rhodes, Jonathan Puddick, D. Tim Harwood, Michaela E. Larsson, Martina A. Doblin, Priscilla Leung, Meng Yan, Frode Rise, Alistair L. Wilkins, Michele R. Prinsep
Article
Biochemistry & Molecular Biology
Yuan-Feng Zou, Yan-Yun Zhang, Berit Smestad Paulsen, Frode Rise, Zheng-Li Chen, Ren-Yong Jia, Li-Xia Li, Xu Song, Bin Feng, Hua-Qiao Tang, Chao Huang, Zhong-Qiong Yin
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Biochemistry & Molecular Biology
Geir Kildahl-Andersen, Eli Gjerlaug-Enger, Frode Rise, Anna Haug, Bjorg Egelandsdal
Summary: The study analyzed specific fatty acids in pig and beef tissues using high-resolution NMR, obtaining quantitative data for composition and distribution. A method for determining saturated fatty acid composition in pork was also developed. The results could support decisions related to fatty acid profiles and stimulate further method developments in high field NMR.
Article
Polymer Science
Nico Koenig, Lutz Willner, Goran Carlstrom, Thomas Zinn, Kenneth D. Knudsen, Frode Rise, Daniel Topgaard, Reidar Lund
Article
Multidisciplinary Sciences
Malgorzata Zawadzka, Beatrix Racz, Dario Ambrosini, Carl Henrik Goerbitz, Jens Preben Morth, Alistair L. Wilkins, Anja Osteby, Katja Benedikte Presto Elgstoen, Elsa Lundanes, Frode Rise, Amund Ringvold, Steven Ray Wilson
Summary: Research discovered an unknown UV-absorbing compound in the aqueous humor of geese, yet the protective compound X was not found. It is possible that the level of UV protective compound in goose aqueous humor is lower than previously identified compounds, or that it may have degraded during the isolation and chromatographic purification processes used.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yuan-Feng Zou, Mengsi Chen, Yu-Ping Fu, Zhong-Kai Zhu, Yan-Yun Zhang, Berit Smestad Paulsen, Frode Rise, Yu-Long Chen, Yong-Zhi Yang, Ren-Yong Jia, Li-Xia Li, Xu Song, Hua-Qiao Tang, Bin Feng, Cheng Lv, Gang Ye, Ding-Tao Wu, Zhong-Qiong Yin, Chao Huang
Summary: The study extracted a pectic polysaccharide, PGP-I-I, from Platycodon grandiflorus roots, which was found to promote cellular antioxidant defense and protect against oxidative damage.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Agriculture, Multidisciplinary
Yuan-Feng Zou, Yan-Yun Zhang, Berit S. Paulsen, Frode Rise, Zheng-Li Chen, Ren-Yong Jia, Li-Xia Li, Xu Song, Bin Feng, Hua-Qiao Tang, Chao Huang, Gang Ye, Zhong-Qiong Yin
Summary: The pectic polysaccharides CPP-1 and CTP-1 from Codonopsis pilosula and Codonopsis tangshen roots can protect cells against oxidative stress and may serve as potential natural antioxidant sources. Structural differences in polysaccharides from different sources of C. pilosula may result in different antioxidative activities. These findings have implications for the development of pectin-containing health products.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Biochemistry & Molecular Biology
Milada Vitova, Vojtech Lanta, Maria Cizkova, Martin Jakubec, Frode Rise, Oyvind Halskau, Katerina Bisova, Samuel Furse
Summary: This study demonstrates significant changes in the biosynthesis of the three most abundant phospholipid classes during the normal cell cycle of D. quadricauda, with implications for the physical properties of membranes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Food Science & Technology
Alistair L. Wilkins, Thomas Rundberget, Morten Sandvik, Frode Rise, Brent K. Knudsen, Jane Kilcoyne, Beatriz Reguera, Pilar Rial, Elliott J. Wright, Sabrina D. Giddings, Michael J. Boundy, Cheryl Rafuse, Christopher O. Miles
Summary: Two high-mass polar compounds, identified as 24-O-beta-D-glucosides of okadaic acid and dinophysistoxin-2, were isolated from Dinophysis blooms and contaminated shellfish. The study also identified other similar compounds in a range of extracts from different locations, providing insights into the toxicology, metabolism, and biosynthesis of marine biotoxins in the okadaic acid group.
Article
Chemistry, Physical
Kaiqi Xu, Athanasios Chatzitakis, Paul Hoff Backe, Qiushi Ruan, Junwang Tang, Frode Rise, Magnar Bjoras, Truls Norby
Summary: This study achieved stable and efficient reduction of CO2 to formate in a bio-hybrid PEC cell using a novel cathode and efficient regeneration mechanism, approaching the efficiency of natural photosynthesis.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2021)
Article
Chemistry, Medicinal
J. Sam Murray, Sarah C. Finch, Elizabeth M. Mudge, Alistair L. Wilkins, Jonathan Puddick, D. Tim Harwood, Lesley L. Rhodes, Roel van Ginkel, Frode Rise, Michele R. Prinsep
Summary: Identifying compounds responsible for toxicity in Gambierdiscus species is crucial in determining their role in ciguatera poisoning. Two new MTX analogs, MTX-6 and MTX-7, were isolated from G. cheloniae CAWD232 and G. honu CAWD242, respectively. This study provides the most extensive structural characterization of an MTX analog since the complete structure of MTX-1 in 1993.
Article
Nanoscience & Nanotechnology
Christiane F. Ellefsen, Anna-Maria Struzek, Regina Scherliess, Marianne Hiorth, Anne Berit C. Samuelsen
Summary: In this study, small-scale methods for preparing dectin-1a binding microparticles from Albatrellus ovinus alkali-soluble beta-glucans were investigated. The precipitation method was found to be more successful in yielding microparticles in the desired size range. The prepared particles showed the same binding activity to dectin-1a as baker's-yeast-derived beta-glucan particles, indicating their potential as activators of the innate immune system.
ACS APPLIED BIO MATERIALS
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
