期刊
CARBOHYDRATE POLYMERS
卷 261, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.117863
关键词
Codonopsis pilosula; Polysaccharides; Extraction; Structural features; Biological activities; Toxicities
资金
- National Natural Science Foundation of China [82074094]
- Open Research Fund of Chengdu University of Traditional Chinese Medicine Key Laboratory of Systematic Research of Distinctive Chinese Medicine Resources in Southwest China [2020XSGG002]
- Xinglin Scholar Research Promotion Project of Chengdu University of Traditional Chinese Medicine [CDTD2018014]
- Science and Technology Project of Zunyi [ZSKH-HZ-(2020)-78]
Codonopsis pilosula polysaccharides have multiple biological activities, such as immunomodulatory, antitumor, antioxidant, neuroprotective, and antiviral effects, supporting their therapeutic potentials and sanitarian functions.
Codonopsis pilosula (Franch.) Nannf., as a well-known homology plant of medicine and food, has the function of replenishing the Qi, strengthening the spleen and tonifying the lung, nourishing the blood and engendering the liquid in traditional Chinese medicine. Accumulating evidence has demonstrated that the C. pilosula polysaccharides (CPPs) are one of the major and representative pharmacologically active macromolecules and present multiple biological activities both in vitro and in vivo methods, such as immunomodulatory, antitumor, antioxidant, neuroprotective, antiviral, anti-inflammatory, anti-fatigue, hypoglycemic, anti-hypoxia, renoprotective, gastroprotective, hepatoprotective, and prebiotic. The purpose of the present review is to provide comprehensively and systematically reorganized information in the extraction and purification, structure characterization, biological activities and the underlying mechanisms of action as well as toxicities of CPPs to support their therapeutic potentials and sanitarian functions. New valuable insights for the future researches regarding CPPs were also proposed in the fields of therapeutic agents and functional foods.
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