Article
Peripheral Vascular Disease
Sayuri Tokioka, Naoki Nakaya, Kumi Nakaya, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Hirohito Metoki, Takahisa Murakami, Michihiro Satoh, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N. Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa
Summary: Depressive symptoms are associated with masked hypertension and may be one of its risk factors.
HYPERTENSION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Joshua M. Bock, Ian M. Greenlund, Virend K. Somers, Sarah E. Baker
Summary: Patients with obstructive sleep apnea (OSA) have a higher risk of developing cardiovascular diseases, especially hypertension. However, potential sex differences in the sympathetic regulation of blood pressure in this population have not been investigated. This review aims to discuss the literature linking sympathetic nerve activity to hypertension in OSA, highlight recent experimental data supporting the hypothesis of sex differences in the regulation of sympathetic nerve activity in OSA, and explore potential sex differences in peripheral adrenergic signaling that may contribute to or offset cardiovascular risk in OSA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Peripheral Vascular Disease
Jussara M. do Carmo, Alexandre A. da Silva, John E. Hall
Summary: This study found that MR blockade alone did not significantly affect blood pressure and heart rate in obese rats, while combined treatment with AT1R antagonists could reduce blood pressure. There are important differences in blood pressure responses to chronic AT1R blockade based on gender.
AMERICAN JOURNAL OF HYPERTENSION
(2021)
Article
Peripheral Vascular Disease
Ailsa F. Ralph, Celine Grenier, Hannah M. Costello, Kevin Stewart, Jessica R. Ivy, Neeraj Dhaun, Matthew A. Bailey
Summary: High salt intake leads to hypertension, affecting renal and vascular function in C57BL6/J mice, with a rapid increase in blood pressure observed in male mice within 4 days of dietary switch. The high-salt diet also increases renal artery sensitivity and urinary excretion of adrenaline in these mice.
Article
Peripheral Vascular Disease
Chin-Chou Huang, Chia-Min Chung, Hsin-Bang Leu, Po-Hsun Huang, Tao-Cheng Wu, Liang-Yu Lin, Shing-Jong Lin, Wen-Harn Pan, Jaw-Wen Chen
Summary: The study found that Chinese men with hypertension had higher sympathetic nervous system (SNS) activity than women, and SNS activity was specifically associated with 24-hour ambulatory blood pressure in men but not women. This suggests that different treatment strategies for hypertension should be considered based on the patient's sex.
JOURNAL OF CLINICAL HYPERTENSION
(2021)
Article
Peripheral Vascular Disease
Yusuke Sata, Sandra L. Burke, Nina Eikelis, Anna M. D. Watson, Cindy Gueguen, Kristy L. Jackson, Gavin W. Lambert, Kyungjoon Lim, Kate M. Denton, Markus P. Schlaich, Geoffrey A. Head
Summary: Renal denervation, whether total or afferent, can effectively reduce hypertension and sympathetic activity in chronic kidney disease (CKD) rabbits, suggesting that renal afferents play a significant role in driving elevated blood pressure in this model.
Article
Biochemistry & Molecular Biology
Tatiana Ivanova, Maria Churnosova, Maria Abramova, Denis Plotnikov, Irina Ponomarenko, Evgeny Reshetnikov, Inna Aristova, Inna Sorokina, Mikhail Churnosov
Summary: The aim of the study was to investigate the sex-specific features of the correlation between GWAS-significant polymorphisms and HTN. The study found differences in the involvement of HTN-associated SNPs between men and women in European subjects of Russia. BP/HTN-related genes and SNPs were characterized by pronounced polyvector functionality in both men and women, with immune mechanisms being the main signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Michael Boehm, Konstantinos Tsioufis, David E. Kandzari, Kazuomi Kario, Michael A. Weber, Roland E. Schmieder, Raymond R. Townsend, Saarraaken Kulenthiran, Christian Ukena, Stuart Pocock, Sebastian Ewen, Joachim Weil, Martin Fahy, Felix Mahfoud
Summary: This analysis evaluated the impact of baseline heart rate on blood pressure reduction after renal denervation. The results showed a greater reduction in blood pressure at 3 months post renal denervation for patients with baseline heart rate >= 70 beats/min.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Mazher Mohammed, Blessing Ogunlade, Mona Elgazzaz, Clara Berdasco, Navya Lakkappa, Ioana Ghita, Jessie J. Guidry, Srinivas Sriramula, Jiaxi Xu, Luke Restivo, Michelle A. Mendiola Pla, Dawn E. Bowles, Andreas M. Beyer, Xinping Yue, Eric Lazartigues, Catalin M. Filipeanu
Summary: This study aimed to identify E3 ubiquitin ligases associated with ACE2 ubiquitination in neurogenic hypertension and establish their clinical relevance. By combining bioinformatics and proteomics, the researchers were able to identify Nedd4-2 as the first E3 ubiquitin ligase involved in ACE2 ubiquitination in Ang-II-mediated hypertension. They also demonstrated the important role of ACE2 in GABAergic neurons in maintaining inhibitory tone and regulating pre-sympathetic activity. These findings provide a new understanding of the development of neurogenic hypertension and potential therapeutic strategies. Rating: 9/10.
CARDIOVASCULAR RESEARCH
(2023)
Article
Peripheral Vascular Disease
Orna Reges, Amy E. Krefman, Shakia T. Hardy, Yuichiro Yano, Paul Muntner, Lindsay R. Pool, Penny Gordon-Larsen, Yaojie Wang, Donald M. Lloyd-Jones, Norrina B. Allen
Summary: This study aimed to assess the associations between age-related blood pressure slope and demographic, clinical, behavioral, psychosocial, and neighborhood characteristics in different race-sex groups. The results showed that there were variations in blood pressure increases among different groups, and these increases were associated with various factors.
Article
Neurosciences
Lyndsey N. Matus, Olivia D. Flessland, Patrick J. Mueller
Summary: The RVLM may contribute to sex-based differences in CVD, with female rats showing greater sympathetic activity and lower resting blood pressure following activation. Sedentary conditions promote higher sympathetic output regardless of age and sex, while the interaction between female reproductive cycle and sedentary conditions plays a complex role in CVD incidences.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Physiology
Chao Ye, Fen Zheng, Jing-Xiao Wang, Xiao-Li Wang, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu
Summary: Excessive sympathetic activation plays a crucial role in the pathogenesis of hypertension. The study found that the renal stimulation enhances sympathetic activity, contributing to the development of hypertension. The excitation of renal reflex is enhanced in the early stage of hypertension and attenuated in the later stage of hypertension in SHR, indicating the involvement of abnormal ERR in the development of hypertension.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Peripheral Vascular Disease
Han Ma, Fangchao Liu, Jianxin Li, Jichun Chen, Jie Cao, Shufeng Chen, Xiaoqing Liu, Xueli Yang, Keyong Huang, Chong Shen, Ling Yu, Yingxin Zhao, Xianping Wu, Liancheng Zhao, Ying Li, Dongsheng Hu, Jianfeng Huang, Xiangfeng Lu, Dongfeng Gu
Summary: Based on a study conducted in China, the association between socioeconomic status (SES) and hypertension remains uncertain. Individuals with lower SES are at a higher risk of developing hypertension compared to those with higher SES. Moreover, women are more susceptible to the adverse effects of lower SES on hypertension.
Article
Biochemistry & Molecular Biology
Jing Li, Xinchun Yang, Xin Zhou, Jun Cai
Summary: Studies have shown a close association between gut microbiome and hypertension, with gut dysbiosis and metabolites playing a significant role in blood pressure control. Future research should focus on verifying the mechanisms through which the gut regulates blood pressure and exploring the feasibility of intervention strategies targeting gut dysbiosis for individuals with hypertension.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Cardiac & Cardiovascular Systems
Andrew W. D'Souza, Sarah L. Hissen, Kazumasa Manabe, Ryosuke Takeda, Takuro Washio, Geoff B. Coombs, Belinda Sanchez, Qi Fu, J. Kevin Shoemaker
Summary: Sympathetic vascular transduction is attenuated in older adults compared to young adults, and there is an inverse relationship between the central and peripheral arcs of the baroreflex. Age and sex have independent and interactive effects on sympathetic vascular transduction and sympathetic neurohemodynamic balance in humans.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Neurosciences
L. J. B. Briant, T. M. Reinbothe, I. Spiliotis, C. Miranda, B. Rodriguez, P. Rorsman
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jonathan C. L. Rodrigues, Tamas Erdei, Amardeep Ghosh Dastidar, Gergley Szantho, Amy E. Burchell, Laura E. K. Ratcliffe, Emma C. Hart, Angus K. Nightingale, Julian F. R. Paton, Nathan E. Manghat, Mark C. K. Hamilton
EUROPEAN RADIOLOGY
(2019)
Article
Multidisciplinary Sciences
Elisa Vergari, Jakob G. Knudsen, Reshma Ramracheya, Albert Salehi, Quan Zhang, Julie Adam, Ingrid Wernstedt Asterholm, Anna Benrick, Linford J. B. Briant, Margarita V. Chibalina, Fiona M. Gribble, Alexander Hamilton, Benoit Hastoy, Frank Reimann, Nils J. G. Rorsman, Ioannis I. Spiliotis, Andrei Tarasov, Yanling Wu, Frances M. Ashcroft, Patrik Rorsman
NATURE COMMUNICATIONS
(2019)
Article
Peripheral Vascular Disease
Sandra Neumann, Amy E. Burchell, Jonathan C. L. Rodrigues, Christopher B. Lawton, Daniel Burden, Melissa Underhill, Matthew D. Kobetic, Zoe H. Adams, Jonathan C. W. Brooks, Angus K. Nightingale, Julian F. R. Paton, Mark C. K. Hamilton, Emma C. Hart
Review
Peripheral Vascular Disease
Thomas C. Hinton, Zoe H. Adams, Richard P. Baker, Katrina A. Hope, Julian F. R. Paton, Emma C. Hart, Angus K. Nightingale
Article
Radiology, Nuclear Medicine & Medical Imaging
Jonathan C. L. Rodrigues, Galina Strelko, Esther A. H. Warnert, Amy E. Burchell, Sandra Neumann, Laura E. K. Ratcliffe, Ashley D. Harris, Benjamin Chant, Ruth Bowles, Angus K. Nightingale, Richard G. Wise, Julian F. R. Paton, Emma C. Hart
EUROPEAN RADIOLOGY
(2020)
Article
Endocrinology & Metabolism
Gaelle R. Carrat, Elizabeth Haythorne, Alejandra Tomas, Leena Haataja, Andreas Mueller, Peter Arvan, Alexandra Piunti, Kaiying Cheng, Mutian Huang, Timothy J. Pullen, Eleni Georgiadou, Theodoros Stylianides, Nur Shabrina Amirruddin, Victoria Salem, Walter Distaso, Andrew Cakebread, Kate J. Heesom, Philip A. Lewis, David J. Hodson, Linford J. Briant, Annie C. H. Fung, Richard B. Sessions, Fabien Alpy, Alice P. S. Kong, Peter Benke, Federico Torta, Adrian Kee Keong Teo, Isabelle Leclerc, Michele Solimena, Dale B. Wigley, Guy A. Rutter
MOLECULAR METABOLISM
(2020)
Article
Endocrinology & Metabolism
Joely A. Kellard, Nils J. G. Rorsman, Thomas G. Hill, Sarah L. Armour, Martijn van de Bunt, Patrik Rorsman, Jakob G. Knudsen, Linford J. B. Briant
MOLECULAR METABOLISM
(2020)
Article
Peripheral Vascular Disease
Matthew D. Kobetic, Amy E. Burchell, Laura E. K. Ratcliffe, Sandra Neumann, Zoe H. Adams, Regina Nolan, Angus K. Nightingale, Julian F. R. Paton, Emma C. Hart
Summary: The study found that untreated hypertensive men have lower sympathetic transduction compared to normotensive individuals, indicating that higher levels of MSNA are required to produce the same level of vasoconstrictor tone.
JOURNAL OF HUMAN HYPERTENSION
(2022)
Article
Peripheral Vascular Disease
Nathan E. Manghat, Elizabeth Robinson, Konstantina Mitrousi, Jonathan C. L. Rodrigues, Thomas Hinton, Julian F. R. Paton, Richard G. Wise, Angus K. Nightingale, Emma C. Hart
Summary: Variants in the posterior anatomy of the cerebral circulation are associated with hypertension and poor cerebral perfusion in young adults, indicating potential long-term consequences on cerebrovascular health.
Article
Cardiac & Cardiovascular Systems
Katrina Hope, Ben Chant, Thomas Hinton, Adrian H. Kendrick, Angus K. Nightingale, Julian F. R. Paton, Emma C. Hart
Summary: This study compared the V-E/VCO2 slope in patients with hypertension and normotensive individuals. It found that ventilatory efficiency is impaired in people with hypertension without heart failure. Future research is needed to determine if those hypertensive patients with elevated V-E/VCO2 slopes are at risk of developing heart failure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Zoe H. Adams, Hazel C. Blythe, Nisha Charkoudian, Timothy B. Curry, Michael J. Joyner, Adrian H. Kendrick, Angus K. Nightingale, Ana P. Abdala Sheikh, Emma C. Hart
Summary: Respiratory modulation of sympathetic nerve activity is reduced in postmenopausal females, which is associated with higher resting blood pressure.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
Elisa Vergari, Geoffrey Denwood, Albert Salehi, Quan Zhang, Julie Adam, Ahmed Alrifaiy, Ingrid Wernstedt Asterholm, Anna Benrick, Margarita Chibalina, Lena Eliasson, Claudia Guida, Thomas G. Hill, Alexander Hamilton, Reshma Ramracheya, Frank Reimann, Nils J. G. Rorsman, Ioannis Spilliotis, Andrei Tarasov, Jonathan N. Walker, Patrik Rorsman, Linford J. B. Briant
Article
Cardiac & Cardiovascular Systems
Jonathan C. L. Rodrigues, Matthew F. R. Jaring, Melissa C. Werndle, Konstantina Mitrousi, Stephen M. Lyen, Angus K. Nightingale, Mark C. K. Hamilton, Stephanie L. Curtis, Nathan E. Manghat, Julian F. R. Paton, Emma C. Hart
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2019)
Article
Physiology
Reshma Ramracheya, Caroline Chapman, Margarita Chibalina, Haiqiang Dou, Caroline Miranda, Alejandro Gonzalez, Yusuke Moritoh, Makoto Shigeto, Quan Zhang, Matthias Braun, Anne Clark, Paul R. Johnson, Patrik Rorsman, Linford J. B. Briant
PHYSIOLOGICAL REPORTS
(2018)