Article
Peripheral Vascular Disease
Xuejun Yin, Ellie Paige, Maoyi Tian, Qiang Li, Liping Huang, Jie Yu, Anthony Rodgers, Paul Elliott, Yangfeng Wu, Bruce Neal
Summary: The SSaSS study found that potassium-enriched salt can have definitive effects on cardiovascular outcomes and death. By quantifying the amount of potassium-enriched salt used, researchers were able to estimate the impact on risk reduction and the potential for population-wide scale-up. The results showed that even a partial replacement of regular salt with potassium-enriched salt can deliver significant health gains.
Review
Food Science & Technology
K. Vinitha, Priyanka Sethupathy, J. A. Moses, C. Anandharamakrishnan
Summary: This review discusses various techniques for reducing sodium levels in food products, including physical and chemical modifications, psychological approaches, and novel non-thermal processing techniques. Some methods have been proven to be feasible and sustainable, but challenges remain in producing shelf-stable low-salt products.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Shin-Young Na, Mathangi Janakiraman, Alexei Leliavski, Gurumoorthy Krishnamoorthy
Summary: High salt consumption may suppress the development of central nervous system autoimmune diseases by increasing corticosterone levels, promoting the reinforcement of the blood-brain barrier, and controlling the entry of inflammatory T cells into the CNS.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Physics, Multidisciplinary
Chunyi Zhang, Shuwen Yue, Athanassios Z. Panagiotopoulos, Michael L. Klein, Xifan Wu
Summary: The dielectric permittivity of salt water decreases as more salt is dissolved, which is explained by saturation in the dielectric response of solvent water molecules. By using an advanced deep neural network (DNN) based on density functional theory data, the dielectric permittivity of sodium chloride solutions is studied. The computed decrease in dielectric permittivity as a function of concentration, using the DNN approach, agrees well with experimental results. The dominant effect causing this decrease is the intrusion of ionic hydration shells into the solvent hydrogen-bond network, disrupting dipolar correlations among water molecules and suppressing the collective response of solvent waters.
PHYSICAL REVIEW LETTERS
(2023)
Article
Environmental Sciences
Jana Isanta-Navarro, Shelley E. Arnott, Toni Klauschies, Dominik Martin-Creuzburg
Summary: The susceptibility of freshwater zooplankton to salinization depends on the dietary lipid supply, with sterols and PUFAs having opposite effects on salt tolerance. Assessment of the impact of salinization on freshwater ecosystem functioning should consider differences in phytoplankton community composition related to trophic state.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Peripheral Vascular Disease
Asako Kumagai, Satoru Takeda, Eisei Sohara, Shinichi Uchida, Hiroshi Iijima, Astuo Itakura, Daisuke Koya, Keizo Kanasaki
Summary: The study revealed that Mg2+ insufficiency exacerbates low COMT activity, inducing salt-sensitive hypertension (SSH) via the ATR1-SPAK-NCC axis due to 2-ME deficiency, suggesting a novel pathophysiological role linking COMT/2-ME deficiency with hypertensive syndrome.
Editorial Material
Urology & Nephrology
Matthew A. Bailey
Summary: Salbutamol activates NaCl cotransporter in the distal convoluted tubule and combined with high salt intake can induce hypertension in mice, which can be rescued by thiazide therapy. Phosphoproteomics identified protein phosphatase 1/inhibitor 1 as a distinct regulatory node for NaCl cotransporter activation by salbutamol. Salbutamol, commonly used in respiratory medicine, may contribute to salt sensitivity and cardiovascular risk in certain patients.
KIDNEY INTERNATIONAL
(2021)
Article
Immunology
Bettina Sehnert, Sandy Pohle, Cornelia Heuberger, Rita Rzepka, Maximilian Seidl, Falk Nimmerjahn, Nina Chevalier, Jens Titze, Reinhard E. Voll
Summary: The study demonstrates that low salt diet can significantly decrease the severity of experimental arthritis, while high salt diet exacerbates inflammation. Additionally, low salt diet not only benefits humoral immunity but also helps regulate cellular immunity in experimental arthritis models.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Food Science & Technology
Julian Andres Gomez-Salazar, Andrea Galvan-Navarro, Jose M. Lorenzo, Maria Elena Sosa-Morales
Summary: Health concerns drive salt reduction in diverse foods, including processed meats; ultrasound technology shows promise in reducing salt content in meat products by shortening curing time; optimization of ultrasound parameters is necessary due to variation in structure and composition among different meat products.
CURRENT OPINION IN FOOD SCIENCE
(2021)
Review
Food Science & Technology
Iga Rybicka, Amparo Goncalves, Helena Oliveira, Antonio Marques, Maria Leonor Nunes
Summary: This review paper describes different strategies to limit salt utilization in fish and shellfish products, including reducing salt content, replacing salt with substitutes, and adding flavor enhancers. By summarizing and analyzing 46 studies, the importance of various processing methods and parameters in ensuring optimal microbiological, physical, chemical, and sensory attributes of the products is determined.
Article
Engineering, Environmental
Mayank Saxena, Saroj Sharma, A. Bhattacharya
Summary: The study investigates the reusability and feasibility of polysulfone membrane structures, examining their rheological properties, membrane preparation processes, surface coatings, and performance changes. Results show improved salt rejection and significant defluoridation effects as the number of recycling stages increases, although separation efficiency decreases with higher fluoride concentrations.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Immunology
Chunlei Feng, Lingyun Li, Qing Li, Kirsten Switzer, Mingyao Liu, Shuhua Han, Biao Zheng
Summary: Research shows that omega-3 polyunsaturated fatty acids (n-3 PUFAs), particularly docosahexaenoic acid (DHA), regulate the functional activities of dendritic cells (DCs) to enhance anti-inflammatory effects in autoimmune diseases. By modulating DCs, DHA reduces proinflammatory cytokine production and increases regulatory T-cell induction capability.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Guan Yang, J. Luke Postoak, Wenqiang Song, Jennifer Martinez, Jianhua Zhang, Lan Wu, Luc Van Kaer
Summary: The study revealed a critical role of PIK3C3 in DC function and the pathogenicity of these cells during EAE, with important implications for the development of immunotherapies for autoimmune diseases such as MS.
Article
Multidisciplinary Sciences
Konstantin Huhn, Peter Linz, Franziska Pemsel, Bernhard Michalke, Stefan Seyferth, Christoph Kopp, Mohammad Anwar Chaudri, Veit Rothhammer, Arnd Doerfler, Michael Uder, Armin M. Nagel, Dominik N. Mueller, Anne Waschbisch, De-Hyung Lee, Tobias Baeuerle, Ralf A. Linker, Stefanie Haase
Summary: Novel MRI techniques reveal the skin as a significant compartment of sodium storage in health and disease, with potential links to MS immunopathology. Increased sodium content in skin, as detected by Na-23-MRI, may predict future disease activity in male patients with RRMS. The skin's role as a storage compartment for sodium and its potential implications in autoimmune neuroinflammation, such as in MS, warrant further investigation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Environmental Sciences
Mayank Saxena, Saroj Sharma, Amit Bhattacharya
Summary: The properties of polysulfone membranes coated with poly(vinyl alcohol) were improved through cross-linking, resulting in promising results for desalination. The number of recycling stages affected the salt separation performance, and the membranes also showed good defluoridation potential.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Allergy
Paulien Baeten, Lauren Van Zeebroeck, Markus Kleinewietfeld, Niels Hellings, Bieke Broux
Summary: Autoimmunity is caused by an unbalanced immune system, leading to various disorders. Patients with autoimmune diseases are commonly treated with broad-acting immunomodulatory drugs, but face risks of severe side effects. Regulatory T cells (Tregs) have the potential for cell therapy in autoimmune disorders, but require ex vivo manipulation to enhance their suppressive function.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2022)
Article
Dermatology
Andras Maifeld, Johannes Wild, Tine Karlsen, Natalia Rakova, Elisa Wistorf, Peter Linz, Rebecca Jung, Anna Birukov, Vladimir-Andrey Gimenez-Rivera, Nicola Wilck, Theda Bartolomaeus, Ralf Dechend, Markus Kleinewietfeld, Sofia K. Forslund, Andreas Krause, Georgios Kokolakis, Sandra Philipp, Bjoern E. Clausen, Anna Brand, Ari Waisman, Florian C. Kurschus, Joanna Wegner, Michael Schultheis, Friedrich C. Luft, Michael Boschmann, Marcus Kelm, Helge Wiig, Titus Kuehne, Dominik N. Muller, Susanne Karbach, Lajos Marko
Summary: Research shows that patients with psoriasis have higher levels of sodium and water in their skin compared to healthy individuals. This high sodium environment may lead to the expansion of pathogenic T helper 17 cells, exacerbating the condition.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Clinical Neurology
Bernadette Wigand, Ina Schlichte, Stefanie Schreiber, Johanna Heitmann, Thomas Meyer, Reinhard Dengler, Susanne Petri, Aiden Haghikia, Stefan Vielhaber, Susanne Vogt
Summary: Pain is prevalent in ALS patients and moderately impairs daily living functions, with pain intensity, quality, and pain-related impairment not significantly changing over time. Additionally, one third of the patients suffer from clinically relevant depressive symptoms, but there is no conclusive evidence of a link between pain intensity and depressive symptoms.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2022)
Article
Neurosciences
Maria Nazareth Gonzalez-Alvarado, Jessica Aprato, Melissa Baumeister, Magdalena Lippert, Arif B. Ekici, Philipp Kirchner, Tobias Welz, Alana Hoffmann, Juergen Winkler, Michael Wegner, Stefanie Haase, Ralf A. Linker
Summary: Recent studies have shown that oligodendrocytes play a role in immune regulation during neuroinflammation and interact with pathogenic T cells by upregulating immune-modulatory genes and adhesion molecules. Direct interaction between oligodendrocytes and Th1 cells results in significant changes in cell processes and gene expression, indicating a potential role of adhesion molecules in this interaction. Further research in this area could lead to new therapeutic strategies for enhancing oligodendrocyte protection and remyelination potential.
Letter
Peripheral Vascular Disease
Lajos Marko, Anne Dorr, Peter Linz, Anton H. van den Meiracker, Ingrid M. Garrelds, Titus Kuehne, Ralf Dechend, A. H. Jan Danser, Anne Floercken, Dominik N. Mueller
Letter
Allergy
Rebeca Arroyo-Hornero, Helena Aegerter, Ibrahim Hamad, Beatriz Corte-Real, Katrien Staes, Bas van Der Woning, Kenneth Verstraete, Savvas N. Savvides, Bart N. Lambrecht, Markus Kleinewietfeld
Article
Multidisciplinary Sciences
Davide G. Franchina, Henry Kurniawan, Melanie Grusdat, Carole Binsfeld, Luana Guerra, Lynn Bonetti, Leticia Soriano-Baguet, Anouk Ewen, Takumi Kobayashi, Sophie Farinelle, Anna Rita Minafra, Niels Vandamme, Anais Carpentier, Felix K. Borgmann, Christian Jager, Ying Chen, Markus Kleinewietfeld, Vasilis Vasiliou, Michel Mittelbronn, Karsten Hiller, Philipp A. Lang, Dirk Brenner
Summary: This study reveals that deficiency of glutamate cysteine ligase (Gclc), the enzyme for glutathione synthesis, has differential impacts on the homeostasis of follicular and marginal zone B cells (FoB and MZB), specifically impairing FoB activation and downstream antiviral immunity.
NATURE COMMUNICATIONS
(2022)
Correction
Multidisciplinary Sciences
Julia Schewe, Eric Seidel, Sofia Forslund, Lajos Marko, Jorg Peters, Dominik N. Muller, Christoph Fahlke, Gabriel Stolting, Ute Scholl
NATURE COMMUNICATIONS
(2022)
Article
Nutrition & Dietetics
Ibrahim Hamad, Alessio Cardilli, Beatriz F. Corte-Real, Aleksandra Dyczko, Jaco Vangronsveld, Markus Kleinewietfeld
Summary: Dietary habits, particularly a high-salt diet, can influence the composition and function of the gut microbiome, leading to potential impacts on the immune system and disease development. This study explored the effects of different sodium chloride contents in food on the gut microbiome composition in mice, revealing distinct compositions under high-salt diet compared to control diets.
Article
Clinical Neurology
Maria Kuehne, Laura Polotzek, Aiden Haghikia, Tino Zaehle, Janek S. Lobmaier
Summary: This study investigated the influence of facial mimicry on facial emotion recognition. The results showed that the emotional recognition of the control group was affected by facial mimicry manipulation, while Parkinson's disease patients had impairments in their ability to detect emotion changes. Furthermore, the study found that the facial emotion recognition abilities of Parkinson's disease patients were completely unaffected by mimicry manipulation.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Anne-Maj Samuelsson, Theda Ulrike Patricia Bartolomaeus, Harithaa Anandakumar, Irene Thowsen, Elham Nikpey, Jianhua Han, Lajos Marko, Kenneth Finne, Olav Tenstad, Johannes Eckstein, Nikolaus Berndt, Titus Kuehne, Sarah Kedziora, Ibrahim Sultan, Trude Skogstrand, Tine Karlsen, Harri Nurmi, Sofia K. Forslund, Entela Bollano, Kari Alitalo, Dominik N. Muller, Helge Wiig
Summary: This study investigates the role of VEGF-B in cardiac proteomic and metabolic adaptation in heart failure, and finds that VEGF-B TG accelerates metabolic maladaptation, leading to structural cardiomyopathy and systolic heart failure.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cell Biology
Beatriz F. Corte-Real, Ibrahim Hamad, Rebeca Arroyo Hornero, Sabrina Geisberger, Joris Roels, Lauren Van Zeebroeck, Aleksandra Dyczko, Marike W. van Gisbergen, Henry Kurniawan, Allon Wagner, Nir Yoset, Susanne N. Y. Weiss, Klaus G. Schmetterer, Agnes Schroeder, Luka Krampert, Stefanie Haase, Hendrik Bartolomaeus, Niels Hellings, Yvan Saeys, Ludwig J. Dubois, Dirk Brenner, Stefan Kempa, David A. Hafler, Johannes Stegbauer, Ralf A. Linker, Jonathan Jantsch, Dominik N. Mueller, Markus Kleinewietfeld
Summary: High salt induces metabolic reprogramming in human Tregs, leading to pro-inflammatory features and FOXP3 downregulation, which has important implications for autoimmunity.
Article
Nutrition & Dietetics
Alessio Cardilli, Ibrahim Hamad, Aleksandra Dyczko, Sofie Thijs, Jaco Vangronsveld, Dominik N. Mueller, Stephan P. Rosshart, Markus Kleinewietfeld
Summary: This article investigates the effect of a high-salt diet on the gut microbiota of laboratory and wild mice. The results show that the high-salt diet leads to a decrease in microbial diversity and significant changes in microbial composition in laboratory mice, while the gut microbiota of wild mice remains relatively unaffected. This finding has important implications for future translational microbiome research.
Article
Cell Biology
Claudia Alexandra Dumitru, Hannah Schroeder, Frederik Till Alexander Schaefer, Jan Friedrich Aust, Nina Kresse, Carl Ludwig Raven Siebert, Klaus-Peter Stein, Aiden Haghikia, Ludwig Wilkens, Christian Mawrin, Ibrahim Erol Sandalcioglu
Summary: Progesterone Receptor Membrane Component 1 (PGRMC1) is found to promote tumour growth and progression in glioblastoma (GBM). PGRMC1 is associated with the expression of ITGB1 and TCF 1/7 and enhances Interleukin-8 production in GBM cells. Additionally, high expression of PGRMC1 alters the sensitivity of GBM cells to specific drugs.
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)