期刊
BRAIN RESEARCH BULLETIN
卷 171, 期 -, 页码 56-66出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2021.03.006
关键词
Social memory; Neurogenesis; Hippocampus; Olfactory bulb; Social isolation
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq 425430/2018-9]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (PNPD)
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais [2429007/2018]
Social memory is crucial in guiding behavior in a social context, with the hippocampus, especially the CA2 region, identified as a neural substrate for social memory. Olfactory bulb neural ensembles may also play a role in encoding social memory traces. While much remains to be explored in the neurobiological foundations of social memory, attention to neurogenesis is essential for further understanding.
Social memory (SM) is a key element in social cognition and it encompasses the neural representation of conspecifics, an essential information to guide behavior in a social context. Here we evaluate classical and cutting-edge studies on neurobiology of SM, using as a guiding principle behavioral tasks performed in adult rodents. Our review highlights the relevance of the hippocampus, especially the CA2 region, as a neural substrate for SM and suggest that neural ensembles in the olfactory bulb may also encode SM traces. Compared to other hippocampus-dependent memories, much remains to be done to describe the neurobiological foundations of SM. Nonetheless, we argue that special attention should be paid to neurogenesis. Finally, we pinpoint the remaining open question on whether the hippocampal adult neurogenesis acts through pattern separation to permit the discrimination of highly similar stimuli during behavior.
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