Editorial Material
Biotechnology & Applied Microbiology
Xiao-Man Sun, Ying-Shuang Xu, He Huang
Summary: Thraustochytrids can accumulate high biomass and lipid content, exhibit broad substrate utilization capacity and effective metabolic pathways without genetic modification, showing great promise for future development.
TRENDS IN BIOTECHNOLOGY
(2021)
Article
Environmental Sciences
Shuangfei Li, Boyu Wang, Liangxu Liu, Yingjie Song, Chuhan Lv, Xingyu Zhu, Yanqing Luo, Christopher H. K. Cheng, Huapu Chen, Xuewei Yang, Tao Li
Summary: The study demonstrates that adding Aurantiochytrium sp. to diets can significantly improve the growth performance and immune response of Trachinotus ovatus. With increased microalgae content, the growth rate and feed utilization efficiency of fish were enhanced, along with increased fatty acid content in blood and tissues, resulting in improved immunity and disease resistance in fish.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Yu Chen, Wen Li, Song Kwon, Yixin Wang, Zhaoting Li, Quanyin Hu
Summary: In this study, ferritin-targeting PROTACs were developed to induce iron overload stress inside cancer cells and investigate subsequent cellular behaviors. The screened compound, DeFer-2, degraded ferritin and elevated free iron content, leading to caspase 3GSDME-mediated pyroptosis in cancer cells. Furthermore, DeFer-2 was loaded into an albumin-based nano-formulation, which effectively inhibited tumor growth and prolonged the survival time of mice.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Biochemistry & Molecular Biology
J. McDaniel
Summary: Neutrophils play a critical role in maintaining a stable immune system, but their hypo- or hyper-activation can lead to the onset or exacerbation of inflammatory conditions. Marine omega-3 fatty acids rapidly alter neutrophil function by changing their fatty acid composition, impacting eicosanoid synthesis, blocking transcription factors, and disrupting lipid rafts to reduce pro-inflammatory gene expression. Clinical trials in the past 15 years have shown the effects of marine omega-3 fatty acid supplementation on neutrophil function.
CELL BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Nutrition & Dietetics
Jing Chen, Johan Garssen, Frank Redegeld
Summary: The study showed cell type-dependent anticancer potential of DHA and EPA. Both compounds induced apoptosis in MM cells via multiple pathways and enhanced bortezomib chemosensitivity by activating NF-kappa B signaling pathway. Timing of concurrent treatment with bortezomib and DHA or EPA is crucial for optimal therapeutic outcomes.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Terue Kawabata, Hideoki Fukuoka, Michiru Harada, Kumiko Shoji, Yoshinori Kubo, Chisato Mori, Kenichi Sakurai, Takeshi Ohkubo, Kyoichi Oshida, Yuichiro Yamashiro
Summary: The increase in fetal requirements of long-chain polyunsaturated fatty acids during pregnancy alters maternal fatty acid metabolism, and FADS gene polymorphisms may change blood fatty acid composition differently. The study investigated the relationship between a FADS1 SNP and maternal serum LCPUFA levels in Japanese pregnant women. The results showed that LCPUFAs significantly decreased as pregnancy progressed and certain fatty acids were significantly associated with the number of minor FADS1 SNP alleles, indicating genotype effects become more obvious later in pregnancy.
Article
Nutrition & Dietetics
Antonio Gazquez, Maria J. Gimenez-Banon, Maria T. Prieto-Sanchez, Carmen Martinez-Gracia, Clara Suarez, Marina Santaella-Pascual, Lina Galdo-Castineira, Carmen Ballesteros-Meseguer, Jesus Vioque, Miriam Martinez-Villanueva, Francisco Aviles-Plaza, Jose A. Noguera-Velasco, Eva Morales, Luis Garcia-Marcos, Elvira Larque
Summary: Maternal supplementation of DHA during pregnancy enhances maternal and fetal DHA levels regardless of pre-pregnancy BMI, but may have a reduced effect in newborns of mothers with GDM.
Article
Fisheries
Michail I. Gladyshev, Alexander A. Makhrov, Nadezhda N. Sushchik, Olesia N. Makhutova, Anastasia E. Rudchenko, Dmitrii A. Balashov, Evgenii V. Vinogradov, Valentina S. Artamonova
Summary: This study examined the composition and contents of fatty acids (FA) in fillets of seven strains of rainbow trout. The results showed that the diet composition and genetics played a role in the FA composition of the fish. The Steelhead strain of rainbow trout demonstrated a higher ability to regulate its FA composition, particularly regarding the important acids EPA and DHA. Furthermore, FA markers were identified that can be used to differentiate between wild and farmed rainbow trout.
Article
Environmental Sciences
Vaishali P. Bagul, Uday S. Annapure
Summary: This study isolated fast-growing thraustochytrids from mangrove habitat and investigated the influence of seasonal variation on their fatty acid composition. The presence of high DHA-producing thraustochytrids in lower temperature seasons was confirmed, highlighting the importance of environmental temperature conditions and fatty acid composition as a dietary biomarker. Additionally, the ecological significance of thraustochytrids in DHA enrichment in the marine food web was revealed.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2021)
Article
Cardiac & Cardiovascular Systems
Richard L. Weinberg, Robert D. Brook, Melvyn Rubenfire, Kim A. Eagle
Summary: Omega-3 polyunsaturated fatty acids play a key role in heart-healthy diet, and can be obtained through fatty fish consumption or fish oil supplementation. They not only treat hypertriglyceridemia, but also prevent cardiovascular events, with additional benefits such as reducing inflammation and improving plaque stability.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Deanne H. Hryciw, Courtney A. Jackson, Nirajan Shrestha, David Parsons, Martin Donnelley, Andrew J. McAinch
Summary: Essential fatty acid deficiency is common in Cystic Fibrosis (CF) patients, but pancreatic supplementation does not solve the issue, suggesting a different underlying pathology. Although the pathological mechanisms are largely unknown, CF animal models have been developed to study the molecular mechanisms associated with CF, including the relationship between CFTR and essential fatty acids. Further research is needed to fully understand the essential fatty acid status in these animal models and to identify the best model for developing therapeutics.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Environmental Sciences
Priyanshi Sikka, Tapan Behl, Sanchay Sharma, Aayush Sehgal, Saurabh Bhatia, Ahmed Al-Harrasi, Sukhbir Singh, Neelam Sharma, Lotfi Aleya
Summary: Ω-3 fatty acids are recognized for their benefits on physical and mental health, primarily obtained from fish and fish products. Adequate intake of Ω-3 fatty acids can improve brain function and neuronal function, reduce depressive symptoms, and have fewer side effects compared to antidepressants.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Nutrition & Dietetics
Melanie Gsoellpointner, Margarita Thanhaeuser, Fabian Eibensteiner, Robin Ristl, Bernd Jilma, Renate Fuiko, Sophia Brandstetter, Angelika Berger, Nadja Haiden
Summary: This study analyzed the intake of polyunsaturated fatty acids (PUFAs) during complementary feeding (CF) in very low birth weight (VLBW) infants and its impact on neurodevelopment. The results showed that higher intake of total PUFAs, docosahexaenoic acid (DHA), and arachidonic acid (AA) was associated with improved cognitive and motor function at 12 months of age. However, the dietary intake of AA and DHA did not meet the recommended levels, highlighting the need to increase PUFA, DHA, and AA intake during CF for better neurodevelopmental outcomes in VLBW infants.
Article
Nutrition & Dietetics
Maria Dolores Mesa, Fernando Gil, Pablo Olmedo, Angel Gil
Summary: This study aims to estimate the amount of n-3 LC-PUFA provided by commonly consumed fishes, shrimps, and mollusks, to conduct a risk-benefit analysis of fish consumption. Consuming 2-3 servings of a variety of fishery products per week can help meet recommended n-3 LC-PUFA levels while maintaining a balance to avoid potential risks from contaminants.
Review
Nutrition & Dietetics
Maja Tomczyk, Jeffery L. Heileson, Miroslaw Babiarz, Philip C. Calder
Summary: Fatty fish and certain species of algae are the only natural sources of EPA and DHA, which have various beneficial effects for athletes. Due to limited intake and fluctuating content, athletes may consider using supplements to ensure sufficient EPA and DHA levels.
Article
Mycology
B. Devadatha, E. B. G. Jones, K. L. Pang, M. A. Abdel-Wahab, K. D. Hyde, J. Sakayaroj, A. H. Bahkali, M. S. Calabon, V. V. Sarma, S. Sutreong, S. N. Zhang
Summary: This study provides a multidimensional review of mangrove fungi, exploring their diversity, geographical distribution, and association with different host substrates. The research reveals a wide range of fungal taxa in mangroves, with varied distributions across different oceans and countries, contributing to our understanding of global mangrove mycobiota.
Article
Biotechnology & Applied Microbiology
Mo Aqib Raza Khan, Bo-Wei Wang, Yih-Yu Chen, Ting-Hsuan Lin, Hsiu-Chin Lin, Yu-Liang Yang, Ka-Lai Pang, Chih-Chuang Liaw
Summary: Biofouling is a common issue in oceans worldwide, and the demand for nontoxic antifouling paints is increasing due to human activities and the environmental impact of certain coatings. Research has shown that using marine natural products as antifouling agents is effective in inhibiting barnacle settlement, providing a potential solution for combating biofouling.
Article
Mycology
Mark Seasat Calabon, E. B. Gareth Jones, Kevin D. Hyde, Saranyaphat Boonmee, Sanja Tibell, Leif Tibell, Ka-Lai Pang, Rungtiwa Phookamsak
Summary: Research on lignicolous aquatic fungi in Thailand, Sweden, and the UK led to the discovery of three new Halobyssothecium species, with revisions and transfers of taxa within Lentitheciaceae based on phylogenetic analyses. Detailed descriptions and illustrations of the new species were provided.
MYCOLOGICAL PROGRESS
(2021)
Review
Mycology
Ka-Lai Pang, Brandon T. Hassett, Ami Shaumi, Sheng-Yu Guo, Jariya Sakayaroj, Michael Wai-Lun Chiang, Chien-Hui Yang, E. B. Gareth Jones
Summary: Fungal diseases in marine animals are primarily caused by Microsporidia, followed by Ascomycota, while Basidiomycota are mainly known for causing respiratory diseases in marine mammals. With the intensification of aquaculture practices, global warming, and marine pollution, outbreaks of fungal diseases in marine animals may increase.
FUNGAL BIOLOGY REVIEWS
(2021)
Review
Plant Sciences
E. B. Gareth Jones, Ka-Lai Pang
Summary: The sand dunes of Gronhoj, Jutland, Denmark, introduced by Jorgen Koch, is a unique habitat for marine fungi. The high diversity of marine fungi obtained from this site has provided valuable resources for various research areas in marine mycology. A list of 102 species of marine fungi documented for Denmark is also provided in this review.
Article
Ecology
Hsin-Yo Chou, Michael Wai-Lun Chiang, Wan-Rou Lin, Sung-Yuan Hsieh, E. B. Gareth Jones, Sheng-Yu Guo, Ka-Lai Pang
Summary: The study found that Aspergillus terreus NTOU4989 is a thermotolerant fungus, with optimal growth conditions at 25 degrees C and pH 3. The presence of metal ions did not significantly affect its metabolic activity, and it was able to decompose wood and algae.
Article
Environmental Sciences
Jiezhang Mo, Linrong Han, Runnan Lv, Michael W. L. Chiang, Rong Fan, Jiahua Guo
Summary: Exposure to TCS has been shown to inhibit growth and photosynthetic activity in cyanobacteria. This study investigated the toxic effects of TCS on Anabaena flos-aquae and identified the signaling pathways involved in the growth inhibition. The findings provide new insights into the transcriptomic responses of A. flos-aquae to TCS toxicity.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Article
Microbiology
E. B. Gareth Jones, Sundari Ramakrishna, Sabaratnam Vikineswary, Diptosh Das, Ali H. Bahkali, Sheng-Yu Guo, Ka-Lai Pang
Summary: This review explores the response mechanisms of marine fungi and fungal-like organisms to salinity variations, and reveals that marine fungi have a greater capacity to adapt to higher salinities compared to terrestrial and freshwater fungi. They require a range of physiological and genetic characteristics to respond to the challenges brought by climate change.
Article
Biochemistry & Molecular Biology
Pingping Dong, Ziqing Cai, Bingfeng Li, Yueqin Zhu, Alice K. Y. Chan, Michael W. L. Chiang, Chun Hang Au, Wing Kin Sung, Tan To Cheung, Chung Mau Lo, Kwan Man, Nikki P. Lee
Summary: The study reveals a novel function of HFE in promoting cytokinesis during mitotic cell division in HCC, independent of its iron-regulating ability. Clinical analysis shows that upregulation of HFE is associated with larger tumors and poor prognosis. The findings lay the groundwork for the development of tumor intolerable therapeutics.
Article
Biochemistry & Molecular Biology
Hsiao-Yang Hsi, Shih-Wei Wang, Chia-Hsiung Cheng, Ka-Lai Pang, Jyh-Yih Leu, Szu-Hsing Chang, Yen-Tung Lee, Yueh-Hsiung Kuo, Chia-Ying Huang, Tzong-Huei Lee
Summary: In this study, a fungal strain Penicillium sumatraense SC29 isolated from the marine brown alga Sargassum cristaefolium was identified, and six compounds were isolated from its liquid fermented products. Among them, penisterine D (4) showed anti-angiogenic activity without cytotoxic effects. This makes it a promising candidate for further preclinical investigation.
Article
Chemistry, Multidisciplinary
Justin Shum, Lawrence Cho-Cheung Lee, Michael Wai-Lun Chiang, Yun-Wah Lam, Kenneth Kam-Wing Lo
Summary: This article reports a novel targeting strategy that combines an enzyme-instructed self-assembly (EISA) moiety and a strained cycloalkyne to create bioorthogonal sites in cancer cells. These sites can serve as triggers for activation of transition metal-based probes, specifically new ruthenium(II) complexes with a tetrazine unit, enabling controllable phosphorescence and singlet oxygen generation. The study also demonstrates that the hydrophobic regions provided by the large supramolecular assemblies further enhance the environment-sensitive emission of the complexes, making them highly advantageous for biological imaging. Additionally, the (photo)cytotoxicity of the large supramolecular assemblies containing the complexes was investigated, with results showing that cellular localization (extracellular and intracellular) significantly impacts the efficiency of the photosensitizers.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Plant Sciences
Sheng-Yu Guo, E. B. Gareth Jones, Michael W. L. Chiang, Ka-Lai Pang
Summary: This study investigated the combined effects of salinity and temperature on the growth rate of Alphamyces chaetifer and Gorgonomyces haynaldii. The results showed that both fungi grew well at low salinity (4 or below), but no growth was observed at high salinity (16 or 32).
Article
Plant Sciences
Ka-Lai Pang, I-An Chen, Michael Wai-Lun Chiang, Ami Shaumi, Sung-Yuan Hsieh, Sheng-Yu Guo
Summary: This study explored the morphological diversity of arenicolous marine fungi at 11 sandy beaches in Taiwan. Phylogenetic analysis revealed four previously unknown clades of Corollospora spp., with differences in ascospore morphology. A total of 13 species of arenicolous marine fungi were identified, with Taan Beach having the highest species richness and diversity.
Review
Plant Sciences
Mark S. Calabon, E. B. Gareth Jones, Ka-Lai Pang, Mohamed A. Abdel-Wahab, Jing Jin, Bandarupalli Devadatha, Resurreccion B. Sadaba, Carlo Chris Apurillo, Kevin D. D. Hyde
Summary: This article revises the diversity of known marine fungi, presenting new species and taxonomic changes. A total of 1898 species from nine phyla, 33 classes, 107 orders, 273 families, 767 genera are documented. The first marine member of Aphelidiomycota, Pseudaphelidium drebesii, is reported, along with additions to the Mortierellomycota phylum and six subclasses. The checklist also includes 641 new species in 228 genera, with four new combinations proposed.
