Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci

An unbiased lipid phenotyping approach to study the genetic determinants of lipids and their association with coronary heart disease risk factors

(2019) Eric L Harshfield et al.   JOURNAL OF PROTEOME RESEARCH

Lysophosphatidylinositol-acyltrasferase-1 (LPIAT1) is involved in cytosolic Ca2+ oscillations in macrophages

(2019) Shinya Takemasu et al.   GENES TO CELLS

Genetic architecture of human plasma lipidome and its link to cardiovascular disease

(2019) Rubina Tabassum et al.   Nature Communications

Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study

(2018) Tanya M Teslovich et al.   HUMAN MOLECULAR GENETICS

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

(2018) Anubha Mahajan et al.   NATURE GENETICS

Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic Phenotypes

(2018) Pooja Jha et al.   Cell Systems

Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species

(2018) Pooja Jha et al.   Cell Systems

Genomic atlas of the human plasma proteome

(2018) Benjamin B. Sun et al.   NATURE

ProGeM: a framework for the prioritization of candidate causal genes at molecular quantitative trait loci

(2018) David Stacey et al.   NUCLEIC ACIDS RESEARCH

Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation

(2018) Claus Brandt et al.   CELL

Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program

(2018) Derek Klarin et al.   NATURE GENETICS

PNPLA3, TM6SF2, and MBOAT7 Genotypes and Coronary Artery Disease

(2017) Nynke Simons et al.   GASTROENTEROLOGY

Discovery and fine-mapping of loci associated with MUFAs through trans-ethnic meta-analysis in Chinese and European populations

(2017) Yao Hu et al.   JOURNAL OF LIPID RESEARCH

Efficiency and safety of varying the frequency of whole blood donation (INTERVAL): a randomised trial of 45 000 donors

(2017) Emanuele Di Angelantonio et al.   LANCET

Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity

(2017) Danish Saleheen et al.   NATURE

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

(2017) Joanna M M Howson et al.   NATURE GENETICS

The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease

(2016) William J. Astle et al.   CELL

XBP1: A Pivotal Transcriptional Regulator of Glucose and Lipid Metabolism

(2016) Christina Piperi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mendelian randomization to assess causal effects of blood lipids on coronary heart disease

(2016) Stephen Burgess et al.   Current Opinion in Endocrinology Diabetes and Obesity

Efficient Bayesian mixed-model analysis increases association power in large cohorts

(2015) Po-Ru Loh et al.   NATURE GENETICS

Genetic background in nonalcoholic fatty liver disease: A comprehensive review

(2015) Fabio Salvatore Macaluso   WORLD JOURNAL OF GASTROENTEROLOGY

Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

(2015) Harmen H. M. Draisma et al.   Nature Communications

Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese

(2015) Clara S. Tang et al.   Nature Communications

Mechanistic insights revealed by lipid profiling in monogenic insulin resistance syndromes

(2015) Michael Eiden et al.   Genome Medicine

Fast randomization of large genomic datasets while preserving alteration counts

(2014) Andrea Gobbi et al.   BIOINFORMATICS

Common Genetic Variants Contribute to Primary Hypertriglyceridemia Without Differences Between Familial Combined Hyperlipidemia and Isolated Hypertriglyceridemia

(2014) I. De Castro-Oros et al.   Circulation-Cardiovascular Genetics

An atlas of genetic influences on human blood metabolites

(2014) So-Youn Shin et al.   NATURE GENETICS

Genome-Wide Association Study of Metabolic Traits Reveals Novel Gene-Metabolite-Disease Links

(2014) Rico Rueedi et al.   PLoS Genetics

Genome-Wide Association Study Identifies Novel Loci Associated With Concentrations of Four Plasma Phospholipid Fatty Acids in the De Novo Lipogenesis Pathway

(2013) Jason H.Y. Wu et al.   Circulation-Cardiovascular Genetics

Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci

(2013) Daphna Weissglas-Volkov et al.   JOURNAL OF MEDICAL GENETICS

Discovery and refinement of loci associated with lipid levels

(2013) Cristen J Willer et al.   NATURE GENETICS

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations

(2012) Ayşe Demirkan et al.   PLoS Genetics

Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data

(2011) Jan Krumsiek et al.   BMC Systems Biology

Metabolomics as a tool for cardiac research

(2011) Julian L. Griffin et al.   Nature Reviews Cardiology

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Additive effects of LPL, APOA5 and APOEvariant combinations on triglyceride levels and hypertriglyceridemia: results of the ICARIA genetic sub-study

(2010) María-José Ariza et al.   BMC Medical Genetics

Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia

(2010) Christopher T Johansen et al.   NATURE GENETICS

Genotype imputation for genome-wide association studies

(2010) Jonathan Marchini et al.   NATURE REVIEWS GENETICS

From Sugar to Fat

(2009) Laurie H. Glimcher et al.   Annals of the New York Academy of Sciences

The Pakistan Risk of Myocardial Infarction Study: a resource for the study of genetic, lifestyle and other determinants of myocardial infarction in South Asia

(2009) Danish Saleheen et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Forty-Three Loci Associated with Plasma Lipoprotein Size, Concentration, and Cholesterol Content in Genome-Wide Analysis

(2009) Daniel I. Chasman et al.   PLoS Genetics

A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies

(2009) Bryan N. Howie et al.   PLoS Genetics

Lysophospholipid Acyltransferases and Arachidonate Recycling in Human Neutrophils

(2008) Miguel A. Gijón et al.   JOURNAL OF BIOLOGICAL CHEMISTRY