Article
Biochemistry & Molecular Biology
Abdullah F. AlAsmari, Metab Alharbi, Faleh Alqahtani, Fawaz Alasmari, Mohammed AlSwayyed, Sami I. Alzarea, Ibrahim A. Al-Alallah, Adel Alghamdi, Hassan M. Hakami, Meshal K. Alyousef, Youssef Sari, Nemat Ali
Summary: The study showed that diosmin has a protective effect against doxorubicin-induced hepatotoxicity by restoring hepatic antioxidant factors, reducing inflammatory and apoptotic proteins and genes.
Article
Immunology
Wei Zhang, Lu Xiang, Peng Luo, Dili Xie
Summary: Cardiovascular aging is a significant factor contributing to cardiovascular disease, and alpha-lactalbumin has been found to have anti-aging potential in attenuating cardiovascular aging, inflammation, and oxidative stress. Both in vitro and in vivo experiments support this finding, suggesting that alpha-lactalbumin could be a promising anti-aging functional food in the future.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Genetics & Heredity
Di Ye, Yongqi Feng, Heng Pan, Xiyi Lu, Zhen Wang, Menglong Wang, Jianfang Liu, Yao Xu, Jishou Zhang, Mengmeng Zhao, Shuwan Xu, Jing Ye, Jun Wan
Summary: Previous studies have shown the importance of bone morphogenetic proteins (BMPs) in cardiovascular diseases. In this study, the role of Kielin/chordin-like protein (KCP) in cardiac aging was investigated. The results demonstrated that KCP knockout aggravated cardiac aging by increasing oxidative stress, inflammation, and cardiomyocyte apoptosis.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Medicine, Research & Experimental
Guoding Cao, Monan Lin, Wei Gu, Zaiyu Su, Yagan Duan, Wuqi Song, Hailiang Liu, Fengmin Zhang
Summary: The FOX family of transcription factors, including the FOXA to FOXS subfamilies, play important roles in various biological processes. FOXO3, a member of the FOXO subfamily, has diverse biological effects that are primarily regulated by its phosphorylation. Phosphorylation of FOXO3 affects its subcellular localization and transcriptional activity, and it is involved in various biological processes such as inflammation, autophagy, apoptosis, and DNA damage repair. Moreover, FOXO3 also contributes to the development of diseases and the aging process, and targeting FOXO3 may offer new therapeutic strategies for age-related diseases and longevity.
Review
Cell Biology
Maria Eugenia Matzkin, Ricardo Saul Calandra, Soledad Paola Rossi, Andrzej Bartke, Monica Beatriz Frungieri
Summary: The male reproductive system undergoes aging primarily affecting the testes, resulting in decreased sexual hormone levels, altered sperm quality, and reduced fertility. Inflammation, oxidation, and apoptosis are predictors of aging-related diseases, with pro-inflammatory molecules and reactive oxygen species identified as contributing factors for testicular aging. The impact of age-related testicular changes on fertility, reproductive health, and lifespan remains incompletely understood, motivating research into anti-aging interventions and therapies utilizing pharmaceuticals or natural alternatives with anti-inflammatory, antioxidant, and anti-apoptotic properties.
Review
Dentistry, Oral Surgery & Medicine
R. Aquino-Martinez
Summary: Accelerated cellular senescence plays a crucial role in periodontitis progression, as it combines the damaging effects of major risk factors. Recent advances reveal that young cells exposed to sublethal oxidative stress undergo accelerated senescence, leading to tissue destruction and limited regeneration. Senescent cells contribute to chronic inflammation, and their accumulation triggers a two-source periodontal inflammation. Moreover, senescent cells transmit senescence to nearby healthy cells, exacerbating the condition. Understanding the role of premature DNA damage-driven cellular senescence in periodontitis is crucial for developing new therapeutic strategies.
JOURNAL OF DENTAL RESEARCH
(2023)
Review
Medicine, Research & Experimental
Nyshadham S. N. Chaitanya, Arpita Devi, Sibani Sahu, Phaniendra Alugoju
Summary: This review focuses on the multifunctional roles of Trehalose in cancer treatment, highlighting its ability to target various cellular processes and proteins within the cell, with potential therapeutic value against cancer.
Article
Biochemistry & Molecular Biology
Rosalba Siracusa, Ramona D'Amico, Marika Cordaro, Alessio Filippo Peritore, Tiziana Genovese, Enrico Gugliandolo, Rosalia Crupi, Daniela Impellizzeri, Salvatore Cuzzocrea, Roberta Fusco, Rosanna Di Paola
Summary: CDDO-Me demonstrated anti-fibrotic, anti-inflammatory, and anti-oxidative effects in the treatment of endometriosis, effectively suppressing the disease by modulating the Nrf2 and NF-κB pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Food Science & Technology
Phaniendra Alugoju, V. K. D. Krishna Swamy, Naga Venkata Anusha Anthikapalli, Tewin Tencomnao
Summary: The translation section discusses the impact of age-related diseases on societal and healthcare expenditure, as well as the importance of anti-aging strategies. It then lists the various protective effects of astaxanthin, covering multiple organs and diseases, including neurodegenerative diseases, bone-related diseases, cancers, cardiovascular disorders, diabetes-associated complications, eye disorders, gastric disorders, kidney disorders, liver diseases, pulmonary disorders, muscle disorders, and skin diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Roland Gal, Robert Halmosi, Ferenc Gallyas Jr, Michael Tschida, Pornthira Mutirangura, Kalman Toth, Tamas Alexy, Laszlo Czopf
Summary: Cardiovascular diseases (CVDs) are a major cause of illness and death worldwide. Unhealthy dietary habits have been shown to contribute to the development of CVDs. Natural polyphenols, found in fruits, vegetables, and red wine, play a clear role in improving cardiovascular health. This review summarizes the results of pre-clinical and clinical trials on important natural polyphenols such as resveratrol and flavonoids, their sources and biosynthesis, and their regulatory effect on signal transduction pathways. Additionally, scientific evidence is provided regarding the cardiovascular benefits of moderate, long-term red wine consumption.
Review
Biochemistry & Molecular Biology
Mariam El Assar, Alejandro Alvarez-Bustos, Patricia Sosa, Javier Angulo, Leocadio Rodriguez-Manas
Summary: Functional status is crucial for healthy aging, and impairment in skeletal muscle and the cardiovascular system can compromise this status. Increased oxidative stress and inflammation contribute to functional decline in aging individuals. Physical activity and exercise training have positive effects on skeletal muscle and cardiovascular health in older adults.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Roland Gal, Laszlo Deres, Kalman Toth, Robert Halmosi, Tamas Habon
Summary: Resveratrol, a natural polyphenol, has been extensively studied for its beneficial effects on the cardiovascular system, including signal transduction pathways, energy metabolism, anti-inflammatory, and antioxidant properties. Research indicates its potential protective role in cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Pedro Ferreira-Santos, Rosalia Carron, M. Jose Montero, M. Angeles Sevilla
Summary: Lycopene treatment improved age-associated harmful changes in hypertension, cardiovascular and renal remodeling, and indicators of oxidant-antioxidant systems in both young and adult SHR.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Environmental Sciences
Huimiao Feng, Ping Zhou, Feixue Liu, Wei Zhang, Haitao Yang, Xueqing Li, Jingquan Dong
Summary: This study investigated the effects of abamectin exposure on the respiratory system of carp. It found that abamectin caused toxicity through oxidative stress, inflammation, apoptosis, and inhibition of autophagy.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Fatemehsadat Seyedaghamiri, Fereshteh Farajdokht, Seyed Mehdi Vatandoust, Javad Mahmoudi, Aytak Khabbaz, Saeed Sadigh-Eteghad
Summary: The study showed that sericin can promote episodic and avoidance memories, as well as social behavior in aged mice by modulating hippocampal inflammation, oxidative stress, and apoptosis markers.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Immunology
Mercedes Marquez-Coello, Cristina Ruiz-Sanchez, Andres Martin-Aspas, Clotilde Fernandez Gutierrez Del alamo, Francisco Illanes-Alvarez, Sara Cuesta-Sancho, Jose-Antonio Giron-Gonzalez
Summary: The study found that in HIV-infected patients, untreated patients had significantly increased expression of T and B cell immunomodulatory molecules by PMN at baseline and after 12 months of ART, while patients with undetectable viral load after 101 months of ART had lower expression levels. This suggests that ART can reduce bacterial translocation levels and decrease the expression of B cell modulators, but the expression of T cell modulators remains elevated.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Paola Montes, Ana Guerra-Librero, Paloma Garcia, Maria Elena Cornejo-Calvo, Maria del Senor Lopez, Tomas de Haro, Laura Martinez-Ruiz, Germaine Escames, Dario Acuna-Castroviejo
Summary: This study investigated the impact of the hypomethylating agent 5-azacitidine on the redox status and inflammation in MDS patients. The results showed that MDS patients had a lower redox status and higher CAT activity compared to healthy subjects. The progression of the disease was associated with increased GPx activity, GSSG/GSH ratio, LPO, and AOPP levels, and decreased CAT activity. The study also found changes in pro-inflammatory cytokines and plasma nitrite plus nitrate levels, but no association between inflammation and oxidative stress was observed.
Article
Biochemistry & Molecular Biology
Agustin Hidalgo-Gutierrez, Eliana Barriocanal-Casado, Maria Elena Diaz-Casado, Pilar Gonzalez-Garcia, Riccardo Zenezini Chiozzi, Dario Acuna-Castroviejo, Luis Carlos Lopez
Summary: This study demonstrates the potential of beta-resorcylic acid (beta-RA) in treating primary mitochondrial diseases and age-related conditions such as obesity and hepatic steatosis. It acts through different cellular mechanisms, affecting mitochondrial metabolism and adipogenesis, ultimately leading to improved health outcomes.
Review
Gastroenterology & Hepatology
Sara Cuesta-Sancho, Mercedes Marquez-Coello, Francisco Illanes-Alvarez, Denisse Marquez-Ruiz, Ana Arizcorreta, Fatima Galan-Sanchez, Natalia Montiel, Manuel Rodriguez-Iglesias, Jose-Antonio Giron-Gonzalez
Summary: Loss of follow-up or reinfections hinder the goal of hepatitis C eradication, and chronic HCV infection can cause various liver and extrahepatic alterations. The situation of coinfected individuals is also unique.
WORLD JOURNAL OF HEPATOLOGY
(2022)
Article
Andrology
Rocio Nunez Calonge, Jose Andres Guijarro, Carolina Andres, Susana Cortes, Massimiliano Saladino, Pedro Caballero, Roman Kireev
Summary: This study investigates the relationships between lipid levels and ovarian response and sperm concentration. The results show an inverse and significant correlation between lipid profiles in follicular fluid and plasma with ovarian response and the number of matured oocytes recovered. Additionally, seminal lipid levels are found to be predictors of seminal quality.
REVISTA INTERNACIONAL DE ANDROLOGIA
(2022)
Review
Biochemistry & Molecular Biology
Paula Aranda-Martinez, Jose Fernandez-Martinez, Yolanda Ramirez-Casas, Ana Guerra-Librero, Cesar Rodriguez-Santana, Germaine Escames, Dario Acuna-Castroviejo
Summary: The zebrafish is an excellent model for studying human diseases, with its highly conserved pineal gland, biological clock, and circadian rhythms. Melatonin plays important roles in regulating various physiological processes in zebrafish, such as sleep/wake rhythm and antioxidant activity. The zebrafish model provides valuable insights into the mechanisms of action of melatonin and its beneficial effects on pathophysiological processes involved in human diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Marisol Fernandez-Ortiz, Ramy K. A. Sayed, Yolanda Roman-Montoya, Maria Angeles Rol de Lama, Jose Fernandez-Martinez, Yolanda Ramirez-Casas, Javier Florido-Ruiz, Iryna Rusanova, Germaine Escames, Dario Acuna-Castroviejo
Summary: This study investigated the impact of aging and NLRP3 expression on the cardiac circadian system, and found that melatonin can restore the rhythmicity of clock genes affected by age or NLRP3 activation, suggesting it as a promising therapy to placate inflammaging and restore circadian rhythm in heart muscle.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Gabriela C. Lopez-Armas, Arailym Yessenbekova, Rocio E. Gonzalez-Castaneda, Kevin J. Arellano-Arteaga, Ana Guerra-Librero, Nurzhanyat Ablaikhanova, Javier Florido, Germaine Escames, Dario Acuna-Castroviejo, Iryna Rusanova
Summary: This study investigates oxidative damage and inflammatory markers in T2DM patients through blood sample analysis. The relative expression levels of c-miR-21 and c-miR-126 are also analyzed. The results show that T2DM patients have increased oxidative damage and inflammatory response, and c-miR-21 and c-miR-126 may be potential markers for VC development in the future.
Review
Biochemistry & Molecular Biology
Javier Florido, Cesar Rodriguez-Santana, Laura Martinez-Ruiz, Alba Lopez-Rodriguez, Dario Acuna-Castroviejo, Iryna Rusanova, Germaine Escames
Summary: ROS are highly reactive molecules that regulate important signaling pathways. Tumor cells have altered redox balance compared to normal cells, making them susceptible to anti-tumoral therapy targeting ROS levels and antioxidant system capacity. Melatonin has potential as an innovative cancer treatment, but its mechanism of action remains unclear, limiting its clinical applications.
Article
Biochemistry & Molecular Biology
Patricia Perez-Guerrero, Francisco Illanes-Alvarez, Denisse Marquez-Ruiz, Irene Campana-Gomez, Sara Cuesta-Sancho, Mercedes Marquez-Coello, Jose-Antonio Giron-Gonzalez
Summary: Peripheral blood PMNs forming NETs in patients with SARS-CoV-2 pneumonia are associated with inflammatory and endothelial activation markers and inversely correlated with oxygenation parameters. Survivors show a decrease in NETs and endothelial-derived parameters.
Review
Biochemistry & Molecular Biology
Cesar Rodriguez-Santana, Javier Florido, Laura Martinez-Ruiz, Alba Lopez-Rodriguez, Dario Acuna-Castroviejo, Germaine Escames
Summary: The circadian clock system plays a crucial role in regulating various physiological processes, and disruptions in this system have been linked to diseases such as cancer. Tumor cells exhibit abnormal circadian machinery, which affects cell cycle, repair mechanisms, and energy metabolism. Melatonin, produced by the pineal gland, has been shown to regulate clock gene expression in cancer cells, suggesting its potential anti-neoplastic effects. This review aims to explore the role of clock genes in cancer and the mechanisms through which melatonin regulates the tumor's circadian machinery, with the goal of proposing future clinical treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Alfonso Mansilla-Rosello, Jorge Hernandez-Magdalena, Mireia Dominguez-Bastante, Carmen Olmedo-Martin, Ana Comino-Pardo, Germaine Escames, Dario Acuna-Castroviejo
Summary: A double-blind, placebo-controlled trial was conducted to investigate the effects of IV melatonin therapy on redox status and inflammatory responses in surgical patients with severe sepsis. IV melatonin at a dose of 60 mg per day was administered to patients for 5 days. Melatonin treatment resulted in decreased redox status and improved disease progression compared to the placebo group. The melatonin group also had reduced levels of procalcitonin and neutrophil to lymphocyte ratio, as well as shorter hospital stays and lower mortality rates compared to the placebo group.
JOURNAL OF PINEAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Ayauly Duisenbek, Gabriela C. Lopez-Armas, Miguel Perez, Maria D. Aviles Perez, Jose Miguel Aguilar Benitez, Victor Roger Pereira Perez, Juan Gorts Ortega, Arailym Yessenbekova, Nurzhanyat Ablaikhanova, Germaine Escames, Dario Acuna-Castroviejo, Iryna Rusanova
Summary: Metabolic diseases, such as type 2 diabetes, dyslipidemia, and atherosclerosis, are characterized by elevated oxidative stress and chronic inflammation caused by genetic background and environmental factors. These diseases lead to vascular complications due to increased oxidative stress, inflammation, and prothrombotic events in cells, including endothelial cells. The activation of the NF-kB pathway and NLRP3 inflammasome are potential mediators of metabolic inflammation. MicroRNAs play a role in metabolic memory and vessel damage development, particularly in controlling anti-oxidative enzymes and mitochondrial functions related to inflammation. New therapeutic targets are being sought to mitigate oxidative stress and inflammation despite acquired metabolic memory.
Article
Biochemistry & Molecular Biology
Cesar Rodriguez-Santana, Alba Lopez-Rodriguez, Laura Martinez-Ruiz, Javier Florido, Olga Cela, Nazzareno Capitanio, Yolanda Ramirez-Casas, Dario Acuna-Castroviejo, Germaine Escames
Summary: The circadian clock regulates physiological processes, including mitochondrial activity, through rhythmic changes. Melatonin, the principal regulator of clock gene expression, is associated with increased mitochondrial activity and has antiproliferative effects. However, the direct links between circadian clock gene expression, mitochondrial activity, and the antiproliferative effects of melatonin in head and neck squamous cell carcinoma remain unknown.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Jose Fernandez-Martinez, Yolanda Ramirez-Casas, Paula Aranda-Martinez, Alba Lopez-Rodriguez, Ramy K. A. Sayed, Germaine Escames, Dario Acuna-Castroviejo
Summary: Sarcopenia is an age-related disease characterized by the reduction in muscle mass, strength, and function. The study suggests that chronodisruption, particularly alterations in the Bmal1 clock gene, contributes to the development of sarcopenia. The results also indicate that exercise and melatonin can be effective therapeutic interventions for sarcopenia.
JOURNAL OF PINEAL RESEARCH
(2023)
