Article
Orthopedics
Je Hoon Jeong, Eun-Sun Jin, Ji Yeon Kim, JoongKee Min, Sang Ryong Jeon, Minsu Lee, Kyoung Hyo Choi
Summary: The study aimed to evaluate the efficacy of highly concentrated tricalcium phosphate (TCP) biocomposite screws on local bone formation in an osteoporotic rabbit model. Results demonstrated improved new bone formation around the implant in the group using highly concentrated TCP biocomposite materials. Pathological assessments and tissue staining indicated better bone formation in the group treated with highly concentrated TCP biocomposite materials.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Roberta Lotti, Claudio Giacinto Atene, Emma Dorotea Zanfi, Matteo Bertesi, Tommaso Zanocco-Marani
Summary: Pemphigus is a life-threatening autoimmune disease characterized by pathogenic autoantibodies targeting specific desmoglein proteins, leading to keratinocyte separation. Various disease models, including in vitro, ex vivo and in vivo mouse models, allow for testing different hypotheses regarding disease initiation and evaluating the efficacy of experimental therapies. These models also help in assessing the pathogenicity of specific Pemphigus autoantibodies and investigating previously unidentified autoantigens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
William Phillip Pereira Da Silva, Leonardo Alan Delanora, Barbara Ribeiro Rios, Maria Eloise de Sa Simon, Cortino Sukotjo, Leonardo P. Faverani
Summary: This study compared senile rats (SENIL) with young ovariectomized rats (OXV) to select a critical animal model for assessing bone repair with implant installation. The results showed that the SENIL group had lower cell viability, more critical gene expression, lower alkaline phosphatase activity, and mineralization nodules. In vivo histometric and biomechanical analysis also indicated inferior bone condition in the SENIL group. Confocal microscopy revealed fragile bones in the SENIL group. Microtomography results were similar between the groups. These findings suggest that the senile model can provide a more critical bone condition for investigating biomaterial properties and topographic changes.
JOURNAL OF APPLIED ORAL SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Zoya Saifi, Sadat Shafi, Tanya Ralli, Shreshta Jain, Divya Vohora, Showkat Rasool Mir, Abdulsalam Alhalmi, Omar M. Noman, Ahmad Alahdab, Saima Amin
Summary: The results of this study demonstrate that mPEG-RIS-HA-TCS nanoparticles have excellent potential for the treatment of osteoporosis and can minimize the adverse effects typically induced by oral administration of RIS.
Article
Engineering, Biomedical
Islam Bouakaz, Christophe Drouet, David Grossin, Elisabeth Cobraiville, Gregory Nolens
Summary: Bone repair is a challenging task in regenerative medicine, especially for large defects. This study explores the use of TPMS porous structures as bone substitutes, fabricated using a 3D printing technique. The scaffolds were evaluated for their percolation, absorption, and mechanical properties, and implanted in a large animal model for 6 months. The results demonstrate the bone-forming capability of the TPMS scaffolds, with better performance than the clinical standard at early implantation time.
ACTA BIOMATERIALIA
(2023)
Review
Veterinary Sciences
Federico Ghiselli, Barbara Rossi, Andrea Piva, Ester Grilli
Summary: This article discusses the importance of gastrointestinal health in animals and the use of in vitro and ex vivo models to better understand and improve animal gut health.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Materials Science, Multidisciplinary
P. Lavanya, N. Vijayakumari
Summary: Biocomposites fabricated using copper and manganese substituted hydroxyapatite with chitosan and polyvinyl pyrrolidone showed promising material characteristics, including strong inhibitory effects on bacteria and compatibility with blood, as well as promoting osteoblast cell proliferation in vitro.
BULLETIN OF MATERIALS SCIENCE
(2021)
Article
Cell Biology
Weilong Diwu, Xin Dong, Omaima Nasif, Sulaiman Ali Alharbi, Jian Zhao, Wei Li
Summary: The study focuses on the fabrication of a composite material, HAP-Se/LA-PEG-AS/VCR, for bone regeneration purposes. The composite is coated on a titanium implant through electrophoretic deposition (EPD) and shows excellent biocompatibility and drug-release properties. Through characterization, morphology analysis, and in vitro studies, it is found that the composite is suitable for bone regeneration with great biocompatibility.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
H. Ait Said, H. Mabroum, M. Lahcini, H. Oudadesse, A. Barroug, H. Ben Youcef, H. Noukrati
Summary: Hydroxyapatite (HA) and chitosan (CS) biopolymer are widely investigated for biomedical purposes, particularly in the orthopedic field as bone substitutes or drug release systems. By combining HA and CS, researchers have achieved an excellent balance between mechanical performance and biocompatibility. The porous structure and reactivity of the HA-CS composite also make it suitable for drug delivery directly to bone sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Surgery
Amaia Ojanguren, Roumen Parapanov, Anne Debonneville, Jerome Lugrin, Csaba Szabo, Arpad Hasenauer, Lorenzo Rosner, Michel Gonzalez, Jean-Yannis Perentes, Thorsten Krueger, Lucas Liaudet
Summary: Ex vivo lung perfusion (EVLP) serves as a platform for pharmacologic repair before lung transplantation (LTx). This study demonstrates that transient heat application during EVLP can effectively recondition damaged lungs and improve their outcomes after transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Materials Science, Multidisciplinary
R. Ramachandran, S. Ramya, E. Shinyjoy, L. Kavitha, D. Gopi
Summary: This study focuses on the fabrication of a biocomposite material derived from rice fields snail shells, which shows potential for orthopedic applications. The experimental results demonstrate that the composite coating exhibits excellent anticorrosion, antimicrobial, and biocompatible properties.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Engineering, Biomedical
Mehrnoosh Neshatian, James Holcroft, Anil Kishen, Grace De Souza, Bernhard Ganss
Summary: In this study, bio-inspired bio-nano complexes were created using amelotin (AMTN) or AMTN with an engineered collagen-binding site (AMTN-Col) to coat hydroxyapatite nanoparticles (HANP), and their ability to promote collagen mineralization was evaluated. The results showed that these bio-nano complexes could accelerate mineral formation and enhance the bond strength at the resin-dentin interface.
MATERIALS TODAY BIO
(2022)
Article
Pharmacology & Pharmacy
Fahad Pervaiz, Rabia Mushtaq, Sobia Noreen
Summary: A polymeric nanoparticle-loaded gel system was developed for topical terbinafine delivery to enhance the treatment of superficial fungal infections. Results showed improved drug retention in skin layers and better removal of fungal burden in in vivo studies compared to control and marketed formulations.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hiroki Katagiri, Yacine El Tawil, Niklaus P. Lang, Jean-Claude Imber, Anton Sculean, Masako Fujioka-Kobayashi, Nikola Saulacic
Summary: This study evaluated the influence of additional hydroxyapatite in collagen-based matrices and membrane placement on bone formation in calvarial defects. Results showed that mineralized collagen-based matrices induced more small bony islands in central areas of defects, but complete defect closure was not observed. Membrane placement decreased bone density and height, with significant effects on bone height in the central area, but did not improve osteogenic capacity.
Review
Pharmacology & Pharmacy
Maria Bogdanova, Arsenii Zabirnyk, Anna Malashicheva, Daria Semenova, John-Peder Escobar Kvitting, Mari-Liis Kaljusto, Maria del Mar Perez, Anna Kostareva, Kare-Olav Stenslokken, Gareth J. Sullivan, Arkady Rutkovskiy, Jarle Vaage
Summary: This article provides an overview of the molecular and cellular mechanisms involved in calcification of the aortic valve, which is the most common valve disease in the Western world. Various methods for evaluating calcification in different settings, including imaging techniques, are presented. Special emphasis is placed on translational studies using human primary cell cultures as a model for drug screening. While animal models are also discussed, none of them accurately mimic human calcific aortic valve disease.
FRONTIERS IN PHARMACOLOGY
(2022)