Article
Psychiatry
Oluwagbenga Dada, Christopher Adanty, Nasia Dai, Richie Jeremian, Sauliha Alli, Philip Gerretsen, Ariel Graff, John Strauss, Vincenzo De Luca
Summary: The study found evidence of epigenetic age acceleration associated with psychosis severity in individuals with schizophrenia, using two different algorithms for DNAm age analysis.
PSYCHIATRY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Thao Van Cao, Heidi G. Sutherland, Miles C. Benton, Larisa M. Haupt, Rodney A. Lea, Lyn R. Griffiths
Summary: DNA methylation is an epigenetic factor that can change over a lifespan. This research explores the relationship between age-related CpGs, gene expression, and body fat phenotypes. The study identifies genes and CpGs associated with age and body fat regulation, suggesting new targets for future studies.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Biology
Samuel N. Bogan, Marie E. Strader, Gretchen E. Hofmann
Summary: This study investigates the effects of DNA methylation on gene expression and splicing in the larvae of the purple sea urchin. It finds that differential gene body methylation has stronger effects on gene expression among genes with poorly accessible transcriptional start sites, and the baseline transcript abundance influences the direction of this effect. Considering the interactions between methylation and chromatin accessibility, the transcriptional responses to maternal conditioning are significantly increased, suggesting that the relationship between methylation and gene regulation is partially explained by chromatin state.
Article
Environmental Sciences
Thomas Sol Dourdin, Guillaume Riviere, Alexandre Cormier, Carole Di Poi, Killian Guyomard, Manuella Rabiller, Farida Akcha, Thierno Bah Sadialiou, Pauline Le Monier, Rossana Sussarellu
Summary: Early exposure to an environmentally relevant pesticide mixture induces multi-scale latent effects possibly affecting life history traits in the Pacific oyster, Crassostrea gigas. The study found that exposure to a combination of 18 pesticides and metals at environmental concentrations during the embryo-larval stage resulted in disturbed swimming behavior, increased size and weight at specific time points, and altered expression of development-related genes. Additionally, DNA methylation analyses showed significant modifications in exposed larvae, marked by a demethylation trend.
ENVIRONMENTAL POLLUTION
(2023)
Article
Genetics & Heredity
Ryan J. Corbett, Andrea M. Luttman, Kaitlin E. Wurtz, Janice M. Siegford, Nancy E. Raney, Laura M. Ford, Catherine W. Ernst
Summary: The weaning stress in piglets results in genome-wide methylation changes associated with differential gene expression, reduced T cell activation, and altered HPA axis response.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Aleksandra Gorska, Maria Urbanowicz, Lukasz Grochowalski, Michal Seweryn, Marta Sobalska-Kwapis, Tomasz Wojdacz, Magdalena Lange, Marta Gruchala-Niedoszytko, Justyna Jarczak, Dominik Strapagiel, Magdalena Gorska-Ponikowska, Iwona Pelikant-Malecka, Leszek Kalinowski, Boguslaw Nedoszytko, Danuta Gutowska-Owsiak, Marek Niedoszytko
Summary: This study aimed to identify the differential methylation profiles and gene expression patterns associated with mastocytosis, a heterogenous disease of the mast cells. Genome-wide DNA methylation analysis was performed on peripheral blood samples from mastocytosis patients and healthy controls. The results showed significant differences in methylation levels of selected regions, including 31 genes located within the regulatory regions. Additionally, three oncogenes-FOXQ1, TWIST1, and ERG-were found to be differentially methylated in mastocytosis patients for the first time. These findings provide insights into the methylation landscape of mastocytosis and potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Chantel L. Martin, Cavin K. Ward-Caviness, Radhika Dhingra, Tarek M. Zikry, Sandro Galea, Derek E. Wildman, Karestan C. Koenen, Monica Uddin, Allison E. Aiello
Summary: Living in adverse neighborhood environments may accelerate epigenetic aging, while positive neighborhood attributes could buffer these effects.
Article
Immunology
Krisann K. Oursler, Vincent C. Marconi, Zeyuan Wang, Ke Xu, Monty Montano, Kaku So-Armah, Amy C. Justice, Yan Sun
Summary: The associations between epigenetic age acceleration markers and physiologic frailty and mortality in people with HIV provide insight into accelerated aging and support the development of interventions for preventing and treating age-related diseases in this population.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Geriatrics & Gerontology
Fedor Galkin, Polina Mamoshina, Kirill Kochetov, Denis Sidorenko, Alex Zhavoronkov
Summary: DNA methylation aging clocks have become an invaluable tool in biogerontology research, with deep learning showing promise as an accurate method for predicting age. The newly presented DeepMAge clock demonstrates biological relevance by assigning higher predicted age to individuals with certain health-related conditions.
Article
Psychology, Clinical
Anthony S. Zannas, Sarah D. Linnstaedt, Xinming An, Jennifer S. Stevens, Nathaniel G. Harnett, Alyssa R. Roeckner, Katelyn I. Oliver, David R. Rubinow, Elisabeth B. Binder, Karestan C. Koenen, Kerry J. Ressler, Samuel A. McLean
Summary: Psychological trauma exposure and PTSD are associated with advanced epigenetic age. This study found that epigenetic age measured at the time of trauma may predict the subsequent development of PTSD. The neural substrates underlying posttraumatic outcomes associated with epigenetic aging are unclear.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Lei Lei, Xinxin Xu, Chengchen Gong, Bowen Lin, Fang Li
Summary: This study identified candidate genes of ovarian endometriosis through integrated analysis of genome-wide gene expression and DNA methylation profiles, revealing the significance of DNA methylation in gene expression.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Young-Dan Cho, Woo-Jin Kim, Sungtae Kim, Young Ku, Hyun-Mo Ryoo
Summary: The study found that the surface roughness of titanium implants affects their osteogenic potential, with sandblasted/large-grit/acid-etched (SLA) surfaces showing superior osteogenic response compared to machined surfaces, likely due to a different epigenetic landscape, particularly DNA methylation of the Alp gene.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Man Li, Litao Bao, Ping Zhu, Shuxia Wang
Summary: This study investigated the impact of metformin on the epigenetic age in subjects with type 2 diabetes mellitus (DM). The results showed an association between metformin intake and slower epigenetic aging.
FRONTIERS IN GENETICS
(2022)
Article
Biology
Jessica Pazzaglia, Emanuela Dattolo, Miriam Ruocco, Alex Santillan-Sarmiento, Lazaro Marin-Guirao, Gabriele Procaccini
Summary: This study analyzed the dynamics of DNA methylation (DNAm) in marine plants in response to environmental changes. The results showed that temperature and nutrient conditions had significant effects on DNAm, highlighting the potential role of environmental factors in regulating species adaptation and phenotypic differences.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Cell Biology
Qi Gao, Fang Chen, Lijun Zhang, Ai Wei, Yongxiang Wang, Zhiwei Wu, Wangsen Cao
Summary: In this study, it was found that DNA methylation alterations in renal aging play significant roles, with suppression of NRF2 and KLOTHO leading to elevated DNMT expression and gene promoter hypermethylation. Treatment with DNMT inhibitor or natural polyphenol oleuropein reversed the epigenetic suppression of antiaging factors and mitigated structural and functional changes in aging kidneys.
Article
Statistics & Probability
Shengtong Han, Hongmei Zhang, Gabrielle A. Lockett, Nandini Mukherjee, John W. Holloway, Wilfried Karmaus
ANNALS OF APPLIED STATISTICS
(2015)
Review
Allergy
Gabrielle A. Lockett, Johanna Huoman, John W. Holloway
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2015)
Article
Genetics & Heredity
Todd M. Everson, Genevieve Lyons, Hongmei Zhang, Nelis Soto-Ramirez, Gabrielle A. Lockett, Veeresh K. Patil, Simon K. Merid, Cilla Soderhall, Erik Melen, John W. Holloway, S. Hasan Arshad, Wilfried Karmaus
Article
Allergy
V. Bion, G. A. Lockett, N. Soto-Ramirez, H. Zhang, C. Venter, W. Karmaus, J. W. Holloway, S. H. Arshad
Letter
Allergy
P-A. Dugue, Y. M. Geurts, R. L. Milne
Article
Allergy
G. A. Lockett, N. Soto-Ramirez, M. A. Ray, T. M. Everson, C-J. Xu, V. K. Patil, W. Terry, A. Kaushal, F. I. Rezwan, S. L. Ewart, U. Gehring, D. S. Postma, G. H. Koppelman, S. H. Arshad, H. Zhang, W. Karmaus, J. W. Holloway
Article
Allergy
I-Jen Wang, Lawrence Shih-Hsin Wu, Gabrielle A. Lockett, Wilfried J. J. Karmaus
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2016)
Article
Entomology
J. P. Green, E. J. Almond, J. Williamson, J. Field
Article
Biotechnology & Applied Microbiology
Meredith A. Ray, Xin Tong, Gabrielle A. Lockett, Hongmei Zhang, Wilfried J. J. Karmaus
BIOMED RESEARCH INTERNATIONAL
(2016)
Article
Physiology
Andrew D. Nguyen, Kerri DeNovellis, Skyler Resendez, Jeremy D. Pustilnik, Nicholas J. Gotelli, Joel D. Parker, Sara Helms Cahan
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2017)
Article
Ecology
Edward J. Almond, Timothy J. Huggins, Liam P. Crowther, Joel D. Parker, Andrew F. G. Bourke
AMERICAN NATURALIST
(2019)