Impact of age, hypercholesterolemia, and the vitamin D receptor on brain endogenous β‐amyloid peptide accumulation in mice

New Evidence for P-gp-Mediated Export of Amyloid-β Peptides in Molecular, Blood-Brain Barrier and Neuronal Models

(2020) Amanda B. Chai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alterations in gene expression in vitamin D-deficiency: Down-regulation of liver Cyp7a1 and renal Oat3 in mice

(2018) Holly P. Quach et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Endogenous Murine Amyloid-β Peptide Assembles into Aggregates in the Aged C57BL/6J Mouse Suggesting These Animals as a Model to Study Pathogenesis of Amyloid-β Plaque Formation

(2018) Barbara Ahlemeyer et al.   JOURNAL OF ALZHEIMERS DISEASE

Low serum 25-hydroxyvitamin D increases cognitive impairment in elderly people

(2018) Mayumi Sakuma et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Vitamin D3-Enriched Diet Correlates with a Decrease of Amyloid Plaques in the Brain of AβPP Transgenic Mice

(2018) Jin Yu et al.   JOURNAL OF ALZHEIMERS DISEASE

Enhanced Brain Amyloid-β Clearance by Rifampicin and Caffeine as a Possible Protective Mechanism Against Alzheimer's Disease

(2018) Hisham Qosa et al.   JOURNAL OF ALZHEIMERS DISEASE

Biology and Mechanisms of Action of the Vitamin D Hormone

(2017) J. Wesley Pike et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Oxidative stress-induced cognitive impairment in obesity can be reversed by vitamin D administration in rats

(2017) Ghazaleh Hajiluian et al.   NUTRITIONAL NEUROSCIENCE

Late age increase in soluble amyloid-beta levels in the APP23 mouse model despite steady-state levels of amyloid-beta-producing proteins

(2016) Leen Janssen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

1,25-Dihydroxyvitamin D3 regulates expression of LRP1 and RAGE in vitro and in vivo, enhancing Aβ1–40 brain-to-blood efflux and peripheral uptake transport

(2016) Y.-X. Guo et al.   NEUROSCIENCE

Characterization of a sensitive mouse Aβ40 PD biomarker assay for Alzheimer's disease drug development in wild-type mice

(2016) Yanmei Lu et al.   Bioanalysis

High Cholesterol Diet Increases Expression of Cholesterol 24-Hydroxylase and BACE1 in Rat Hippocampi: Implications for the Effect of Diet Cholesterol on Memory

(2016) Mitra Nikasa et al.   Iranian Red Crescent Medical Journal

Age-Related Decline in Brain and Hepatic Clearance of Amyloid-Beta is Rectified by the Cholinesterase Inhibitors Donepezil and Rivastigmine in Rats

(2015) Loqman A. Mohamed et al.   ACS Chemical Neuroscience

CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer’s disease

(2015) Fathia Djelti et al.   BRAIN

A high-cholesterol diet enriched with polyphenols from Oriental plums (Prunus salicina) improves cognitive function and lowers brain cholesterol levels and neurodegenerative-related protein expression in mice

(2015) Ping-Hui Kuo et al.   BRITISH JOURNAL OF NUTRITION

Cholesterol-induced astrocyte activation is associated with increased amyloid precursor protein expression and processing

(2015) Evangelina Avila-Muñoz et al.   GLIA

Effect of Cholesterol Reduction on Receptor Signaling in Neurons

(2015) Kenji Fukui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New Mouse Model of Alzheimer’s

(2014) Per Nilsson et al.   ACS Chemical Neuroscience

1 ,25-Dihydroxyvitamin D3 Reduces Cerebral Amyloid-  Accumulation and Improves Cognition in Mouse Models of Alzheimer's Disease

(2014) M. R. Durk et al.   JOURNAL OF NEUROSCIENCE

ATP-binding cassette transporter A1: From metabolism to neurodegeneration

(2014) Radosveta Koldamova et al.   NEUROBIOLOGY OF DISEASE

Vitamin D Receptor Activation Down-regulates the Small Heterodimer Partner and Increases CYP7A1 to Lower Cholesterol

(2013) Edwin C.Y. Chow et al.   GASTROENTEROLOGY

Impact of Vitamin D on Amyloid Precursor Protein Processing and Amyloid-β Peptide Degradation in Alzheimer's Disease

(2013) Marcus O.W. Grimm et al.   Neurodegenerative Diseases

A Reliable Way to Detect Endogenous Murine β-Amyloid

(2013) Andrew F. Teich et al.   PLoS One

1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells

(2012) Matthew R. Durk et al.   JOURNAL OF NEUROCHEMISTRY

Vitamin D mitigates age-related cognitive decline through the modulation of pro-inflammatory state and decrease in amyloid burden

(2012) Teresita L Briones et al.   Journal of Neuroinflammation

Higher Vitamin D Dietary Intake Is Associated With Lower Risk of Alzheimer's Disease: A 7-Year Follow-up

(2012) C. Annweiler et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Gender-Divergent Profile of Bile Acid Homeostasis during Aging of Mice

(2012) Zidong Donna Fu et al.   PLoS One

Apolipoprotein E Promotes β-Amyloid Trafficking and Degradation by Modulating Microglial Cholesterol Levels

(2011) C. Y. Daniel Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice

(2011) Markus Krohn et al.   JOURNAL OF CLINICAL INVESTIGATION

1 ,25-Dihydroxyvitamin D3 Up-Regulates P-Glycoprotein via the Vitamin D Receptor and Not Farnesoid X Receptor in Both fxr(-/-) and fxr(+/+) Mice and Increased Renal and Brain Efflux of Digoxin in Mice In Vivo

(2011) E. C. Y. Chow et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Association of Alzheimer disease pathology with abnormal lipid metabolism: The Hisayama Study

(2011) T. Matsuzaki et al.   NEUROLOGY

Region-specific distribution of β-amyloid peptide and cytokine expression in TgCRND8 mice

(2011) Keran Ma et al.   NEUROSCIENCE LETTERS

APP processing in Alzheimer's disease

(2011) Yun-wu Zhang et al.   Molecular Brain

Changes with Age in the Activities of β-Secretase and the Aβ-Degrading Enzymes Neprilysin, Insulin-Degrading Enzyme and Angiotensin-Converting Enzyme

(2010) J. Scott Miners et al.   BRAIN PATHOLOGY

Amyloid Efflux Transporter Expression at the Blood-Brain Barrier Declines in Normal Aging

(2010) Gerald D. Silverberg et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The genes encoding cytokines IL-2, IL-10 and IL-12B are primary 1α,25(OH)2D3 target genes

(2010) Juha M. Matilainen et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

(2010) E. Y. Bryleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Cholesterol 24-Hydroxylase: An Enzyme of Cholesterol Turnover in the Brain

(2009) David W. Russell et al.   Annual Review of Biochemistry

Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease

(2009) R. Deane et al.   CNS & Neurological Disorders-Drug Targets

ABCG2 Is Upregulated in Alzheimer's Brain with Cerebral Amyloid Angiopathy and May Act as a Gatekeeper at the Blood-Brain Barrier for A 1-40 Peptides

(2009) H. Xiong et al.   JOURNAL OF NEUROSCIENCE

Calcitriol inhibits TNF-α-induced inflammatory cytokines in human trophoblasts

(2009) Lorenza Díaz et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease

(2008) Miles C. Miller et al.   BRAIN RESEARCH

High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice

(2008) Lakshmi Thirumangalakudi et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of β-amyloid levels in the brain of cholesterol-fed rabbit, a model system for sporadic Alzheimer’s disease

(2008) R.P. Jaya Prasanthi et al.   MECHANISMS OF AGEING AND DEVELOPMENT

ApoE Promotes the Proteolytic Degradation of Aβ

(2008) Qingguang Jiang et al.   NEURON

Cholesterol retention in Alzheimer's brain is responsible for high β- and γ-secretase activities and Aβ production

(2007) Huaqi Xiong et al.   NEUROBIOLOGY OF DISEASE