Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway

PI3K/AKT/mTOR signaling in gastric cancer: Epigenetics and beyond

(2020) Sadegh Fattahi et al.   LIFE SCIENCES

Shikonin derivatives for cancer prevention and therapy

(2019) Joelle C. Boulos et al.   CANCER LETTERS

Design, synthesis and biological evaluation of benzoylacrylic acid shikonin ester derivatives as irreversible dual inhibitors of tubulin and EGFR

(2019) Wen-Xue Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Critical Role of PTEN/PI3K/AKT Signaling Pathway in Shikonin-Induced Apoptosis and Proliferation Inhibition of Chronic Myeloid Leukemia

(2018) Yu Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Breast Cancer Epidemiology in Gulf Cooperation Council Countries: A Regional and International Comparison

(2018) Salman M. Albeshan et al.   Clinical Breast Cancer

Design and characterization of α -lipoic acyl shikonin ester twin drugs as tubulin and PDK1 dual inhibitors

(2018) Hong-Yan Lin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Shikonin exerts antitumor activity in Burkitt’s lymphoma by inhibiting C-MYC and PI3K/AKT/mTOR pathway and acts synergistically with doxorubicin

(2018) Fan Ni et al.   Scientific Reports

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Synthesis and biological evaluation of novel Jiyuan Oridonin A-1,2,3-triazole-azole derivatives as antiproliferative agents

(2018) Yu Ke et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tannic acid-inspired paclitaxel nanoparticles for enhanced anticancer effects in breast cancer cells

(2018) Pallabita Chowdhury et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Anti-tumor activity of Shikonin against afatinib resistant non-small cell lung cancer via negative regulation of PI3K/Akt signaling pathway

(2018) Baiying Li et al.   BIOSCIENCE REPORTS

Discovery of (4-bromophenyl)(3-hydroxy-4-methoxyphenyl)methanone through upregulating hTERT induces cell apoptosis and ERS

(2017) Xiu Cheng et al.   Cell Death & Disease

Shikonin Derivative DMAKO-05 Inhibits Akt Signal Activation and Melanoma Proliferation

(2016) Yao-yao Yang et al.   Chemical Biology & Drug Design

Fascaplysin Induces Caspase Mediated Crosstalk Between Apoptosis and Autophagy Through the Inhibition of PI3K/AKT/mTOR Signaling Cascade in Human Leukemia HL-60 Cells

(2015) Suresh Kumar et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Role of PI3K/Akt/mTOR and MEK/ERK pathway in Concanavalin A induced autophagy in HeLa cells

(2014) Bibhas Roy et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Receptor-Defined Subtypes of Breast Cancer in Indigenous Populations in Africa: A Systematic Review and Meta-Analysis

(2014) Amanda Eng et al.   PLOS MEDICINE

Integration of Different “-omics” Technologies Identifies Inhibition of the IGF1R-Akt-mTOR Signaling Cascade Involved in the Cytotoxic Effect of Shikonin against Leukemia Cells

(2013) Benjamin Wiench et al.   Evidence-based Complementary and Alternative Medicine

Targeting triple-negative breast cancer: optimising therapeutic outcomes

(2012) K. Gelmon et al.   ANNALS OF ONCOLOGY

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

(2011) Brian D. Lehmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Deciphering the Role of PI3K/Akt/mTOR Pathway in Breast Cancer Biology and Pathogenesis

(2010) Priscilla F. McAuliffe et al.   Clinical Breast Cancer

Triple-Negative Breast Cancer

(2010) William D. Foulkes et al.   NEW ENGLAND JOURNAL OF MEDICINE

SYUNZ-16, a newly synthesized alkannin derivative, induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of AKT/FOXO signal pathway

(2009) Rong Deng et al.   INTERNATIONAL JOURNAL OF CANCER