Discovery of indoline derivatives as anticancer agents via inhibition of tubulin polymerization

Discovery of highly potent tubulin polymerization inhibitors: Design, synthesis, and structure-activity relationships of novel 2,7-diaryl-[1,2,4]triazolo[1,5-a]pyrimidines

(2021) Xian-Sen Huo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of benzofuran-based 3,4,5-trimethoxybenzamide derivatives as novel tubulin polymerization inhibitors

(2020) Qiu Li et al.   BIOORGANIC CHEMISTRY

Discovery of tertiary amide derivatives incorporating benzothiazole moiety as anti-gastric cancer agents in vitro via inhibiting tubulin polymerization and activating the Hippo signaling pathway

(2020) Jian Song et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, and biological evaluation of 3,6-diaryl-[1,2,4]triazolo[4,3-a]pyridine analogues as new potent tubulin polymerization inhibitors

(2020) Fang Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of triazolothiadiazine derivatives as highly potent tubulin polymerization inhibitors: Structure-activity relationship, in vitro and in vivo study

(2020) Weifeng Ma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Molecular diversity of trimethoxyphenyl-1,2,3-triazole hybrids as novel colchicine site tubulin polymerization inhibitors

(2019) Dong-Jun Fu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Current advances of tubulin inhibitors as dual acting small molecules for cancer therapy

(2019) Kinsie E Arnst et al.   MEDICINAL RESEARCH REVIEWS

Steering the antitumor drug discovery campaign towards structurally diverse indolines

(2019) Amandeep Thakur et al.   BIOORGANIC CHEMISTRY

Novel tertiary sulfonamide derivatives containing benzimidazole moiety as potent anti-gastric cancer agents: Design, synthesis and SAR studies

(2019) Jian-Song et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Recent advances in trimethoxyphenyl (TMP) based tubulin inhibitors targeting the colchicine binding site

(2018) Ling Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of (1-aryl-1 H -pyrazol-4-yl) (3,4,5-trimethoxyphenyl)methanone derivatives as tubulin inhibitors

(2018) Min'an Zhai et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of novel 2-oxo-1,2-dihydroquinoline-4-carboxamide derivatives for the treatment of esophageal squamous cell carcinoma

(2018) Mai I. Shahin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Bioactive heterocycles containing a 3,4,5-trimethoxyphenyl fragment exerting potent antiproliferative activity through microtubule destabilization

(2018) Dong-Jun Fu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

(2018) Mei-Jung Lai et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antitubulin sulfonamides: The successful combination of an established drug class and a multifaceted target

(2018) Alba Vicente-Blázquez et al.   MEDICINAL RESEARCH REVIEWS

The rationale of indoleamine 2,3-dioxygenase inhibition for cancer therapy

(2017) Lieve Brochez et al.   EUROPEAN JOURNAL OF CANCER

Design and synthesis of indoline thiohydantoin derivatives based on enzalutamide as antiproliferative agents against prostate cancer

(2017) Minzan Zuo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Repurposing itraconazole as an anticancer agent

(2017) Hiroshi Tsubamoto et al.   Oncology Letters

Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors

(2016) Tadas Rimkus et al.   Cancers

Phase II Trial of Sorafenib in Patients with Chemotherapy Refractory Metastatic Esophageal and Gastroesophageal (GE) Junction Cancer

(2015) Yelena Y. Janjigian et al.   PLoS One

Synthesis and structure–activity relationship of 4-azaheterocycle benzenesulfonamide derivatives as new microtubule-targeting agents

(2014) Jun Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Cu(OTf)2 catalyzed three component reaction: Efficient synthesis of spiro[indoline-3,4′-pyrano[3,2-b]pyran derivatives and their anticancer potency towards A549 human lung cancer cell lines

(2013) K. Parthasarathy et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A first in human, safety, pharmacokinetics, and clinical activity phase I study of once weekly administration of the Hsp90 inhibitor ganetespib (STA-9090) in patients with solid malignancies

(2013) Jonathan W Goldman et al.   BMC CANCER