G-quadruplex stabilization via small-molecules as a potential anti-cancer strategy

Evaluation of an Analogue of the Marine ε-PLL Peptide as a Ligand of G-quadruplex DNA Structures

(2020) Maria Marzano et al.   Marine Drugs

Small-molecule G-quadruplex stabilizers reveal a novel pathway of autophagy regulation in neurons

(2020) Jose F Moruno-Manchon et al.   eLife

Kinetics, conformation, stability, and targeting of G-quadruplexes from a physiological perspective

(2020) Zheng Tan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The regulation and functions of DNA and RNA G-quadruplexes

(2020) Dhaval Varshney et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of Influenza A virus propagation by benzoselenoxanthenes stabilizing TMPRSS2 Gene G-quadruplex and hence down-regulating TMPRSS2 expression

(2020) Li-Wen Shen et al.   Scientific Reports

A drug-like imidazole-benzothiazole conjugate inhibits malignant melanoma by stabilizing the c-MYC G-quadruplex

(2020) Tian-Ying Wu et al.   BIOORGANIC CHEMISTRY

Specific stabilization of promoter G-Quadruplex DNA by 2,6-disubstituted amidoanthracene-9,10-dione based dimeric distamycin analogues and their selective cancer cell cytotoxicity

(2020) Soma Roy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, docking studies and antitumor activity of phenanthroimidazole derivatives as promising c-myc G-quadruplex DNA stabilizers

(2020) Qiong Wu et al.   BIOORGANIC CHEMISTRY

A Small Molecule Stabilizer of the MYC G4-Quadruplex Induces Endoplasmic Reticulum Stress, Senescence and Pyroptosis in Multiple Myeloma

(2020) Snehal M. Gaikwad et al.   Cancers

Small Molecule Fluorescent Probes for G- Quadruplex Visualization as Potential Cancer Theranostic Agents

(2019) Pallavi Chilka et al.   MOLECULES

Non-canonical DNA/RNA structures during Transcription-Coupled Double-Strand Break Repair: Roadblocks or Bona fide repair intermediates?

(2019) Nadine Puget et al.   DNA REPAIR

Genetic interactions of G-quadruplexes in humans

(2019) Katherine G Zyner et al.   eLife

Mission Possible: Advances in MYC Therapeutic Targeting in Cancer

(2019) Brittany L. Allen-Petersen et al.   BIODRUGS

Design, synthesis of 4,5-diazafluorene derivatives and their anticancer activity via targeting telomeric DNA G-quadruplex

(2019) Kang Zhou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New substituted quinoxalines inhibit triple-negative breast cancer by specifically downregulating the c-MYC transcription

(2019) Ming-Hao Hu et al.   NUCLEIC ACIDS RESEARCH

In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells

(2019) Justin J. Montoya et al.   BMC CANCER

Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule

(2018) Chiara Marchetti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a New Four-Leaf Clover-Like Ligand as a Potent c-MYC Transcription Inhibitor Specifically Targeting the Promoter G-Quadruplex

(2018) Ming-Hao Hu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Destabilization of DNA G-Quadruplexes by Chemical Environment Changes during Tumor Progression Facilitates Transcription

(2018) Hisae Tateishi-Karimata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genome-wide mapping of endogenous G-quadruplex DNA structures by chromatin immunoprecipitation and high-throughput sequencing

(2018) Robert Hänsel-Hertsch et al.   Nature Protocols

G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy

(2018) Emanuela Ruggiero et al.   NUCLEIC ACIDS RESEARCH

Cell penetrating thiazole peptides inhibit c-MYC expression via site-specific targeting of c-MYC G-quadruplex

(2018) Debasish Dutta et al.   NUCLEIC ACIDS RESEARCH

Noncanonical secondary structures arising from non-B DNA motifs are determinants of mutagenesis

(2018) Ilias Georgakopoulos-Soares et al.   GENOME RESEARCH

Site-specific amino acid substitution in dodecameric peptides determines the stability and unfolding of c-MYC quadruplex promoting apoptosis in cancer cells

(2018) Pallabi Sengupta et al.   NUCLEIC ACIDS RESEARCH

HERC2 Facilitates BLM and WRN Helicase Complex Interaction with RPA to Suppress G-Quadruplex DNA

(2018) Wenwen Wu et al.   CANCER RESEARCH

Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex

(2018) David R. Calabrese et al.   Nature Communications

Synthetic lethality and cancer

(2017) Nigel J. O'Neil et al.   NATURE REVIEWS GENETICS

The impact of replication stress on replication dynamics and DNA damage in vertebrate cells

(2017) Hervé Técher et al.   NATURE REVIEWS GENETICS

Monomolecular G-quadruplex structures with inversion of polarity sites: new topologies and potentiality

(2017) Antonella Virgilio et al.   NUCLEIC ACIDS RESEARCH

G-Quadruplexes: Prediction, Characterization, and Biological Application

(2017) Chun Kit Kwok et al.   TRENDS IN BIOTECHNOLOGY

Non-Canonical G-quadruplexes cause the hCEB1 minisatellite instability in Saccharomyces cerevisiae

(2017) Aurèle Piazza et al.   eLife

Quadruplex nucleic acids as targets for anticancer therapeutics

(2017) Stephen Neidle   Nature Reviews Chemistry

Quadruplex Nucleic Acids as Novel Therapeutic Targets

(2016) Stephen Neidle   JOURNAL OF MEDICINAL CHEMISTRY

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds

(2016) Jutta Zimmer et al.   MOLECULAR CELL

G-quadruplex structures mark human regulatory chromatin

(2016) Robert Hänsel-Hertsch et al.   NATURE GENETICS

Telomere targeting with a novel G-quadruplex-interactive ligand BRACO-19 induces T-loop disassembly and telomerase displacement in human glioblastoma cells

(2016) Guangtong Zhou et al.   Oncotarget

Small Molecule Microarrays Enable the Identification of a Selective, Quadruplex-Binding Inhibitor of MYC Expression

(2015) Kenneth M. Felsenstein et al.   ACS Chemical Biology

Short loop length and high thermal stability determine genomic instability induced by G-quadruplex-forming minisatellites

(2015) A. Piazza et al.   EMBO JOURNAL

High-throughput sequencing of DNA G-quadruplex structures in the human genome

(2015) Vicki S Chambers et al.   NATURE BIOTECHNOLOGY

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

G-quadruplex DNA and ligand interaction in living cells using NMR spectroscopy

(2015) Gilmar F. Salgado et al.   Chemical Science

Mutagenic consequences of a single G-quadruplex demonstrate mitotic inheritance of DNA replication fork barriers

(2015) Bennie Lemmens et al.   Nature Communications

Formation and stabilization of the telomeric antiparallel G-quadruplex and inhibition of telomerase by novel benzothioxanthene derivatives with anti-tumor activity

(2015) Wen Zhang et al.   Scientific Reports

G-Quadruplex on Oligo Affinity Support (G4-OAS): An Easy Affinity Chromatography-Based Assay for the Screening of G-Quadruplex Ligands

(2014) Domenica Musumeci et al.   ANALYTICAL CHEMISTRY

Oncogenic KRAS signalling in pancreatic cancer

(2014) S Eser et al.   BRITISH JOURNAL OF CANCER

FANCJ promotes DNA synthesis through G-quadruplex structures

(2014) P. Castillo Bosch et al.   EMBO JOURNAL

Small Molecules Targeting c-Myc Oncogene: Promising Anti-Cancer Therapeutics

(2014) Bing-Jia Chen et al.   International Journal of Biological Sciences

Elevated Levels of G-Quadruplex Formation in Human Stomach and Liver Cancer Tissues

(2014) Giulia Biffi et al.   PLoS One

Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA

(2014) Ruobo Zhou et al.   eLife

G-Quadruplex DNA as a Molecular Target for Induced Synthetic Lethality in Cancer Cells

(2013) Keith I. E. McLuckie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pif1 family helicases suppress genome instability at G-quadruplex motifs

(2013) Katrin Paeschke et al.   NATURE

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Detection of G-quadruplex DNA in mammalian cells

(2013) A. Henderson et al.   NUCLEIC ACIDS RESEARCH

Small-molecule–induced DNA damage identifies alternative DNA structures in human genes

(2012) Raphaël Rodriguez et al.   Nature Chemical Biology

DNA secondary structures: stability and function of G-quadruplex structures

(2012) Matthew L. Bochman et al.   NATURE REVIEWS GENETICS

Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells

(2012) Sebastian Müller et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Identification of Novel Quadruplex Ligands from Small Molecule Libraries by FRET-Based High-Throughput Screening

(2011) Armin Benz et al.   CHEMBIOCHEM

Demonstration that Drug-targeted Down-regulation of MYC in Non-Hodgkins Lymphoma Is Directly Mediated through the Promoter G-quadruplex

(2011) Robert V. Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA secondary structures and epigenetic determinants of cancer genome evolution

(2011) Subhajyoti De et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genetic instability triggered by G-quadruplex interacting Phen-DC compounds in Saccharomyces cerevisiae

(2010) Aurèle Piazza et al.   NUCLEIC ACIDS RESEARCH

PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy

(2010) E Salvati et al.   ONCOGENE

Oncogenes and Tumor Suppressor Genes

(2010) E. Y. H. P. Lee et al.   Cold Spring Harbor Perspectives in Biology

Mutagenic Capacity of Endogenous G4 DNA Underlies Genome Instability in FANCJ-Defective C. elegans

(2008) Evelien Kruisselbrink et al.   CURRENT BIOLOGY

Design of Selective G-quadruplex Ligands as Potential Anticancer Agents

(2008) Jia-Heng Tan et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability

(2008) Y. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY