Notoginsenoside R1 activates the NAMPT-NAD+-SIRT1 cascade to promote postischemic angiogenesis by modulating Notch signaling

Insights into the dual role of angiogenesis following stroke

(2020) Ruslan Rust   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Notoginseng leaf triterpenes ameliorates mitochondrial oxidative injury via the NAMPT-SIRT1/2/3 signaling pathways in cerebral ischemic model rats

(2020) Weijie Xie et al.   Journal of Ginseng Research

Dl-3-N-butylphthalide promotes angiogenesis and upregulates sonic hedgehog expression after cerebral ischemia in rats

(2019) Pan-Ting Zhou et al.   CNS Neuroscience & Therapeutics

Tetramethylpyrazine attenuates blood-brain barrier disruption in ischemia/reperfusion injury through the JAK/STAT signaling pathway

(2019) Pian Gong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The protective effect of ligustrazine on rats with cerebral ischemia–reperfusion injury via activating PI3K/Akt pathway

(2019) Y Ding et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Tetramethylpyrazine Inhibits Platelet Adhesion and Inflammatory Response in Vascular Endothelial Cells by Inhibiting P38 MAPK and NF-κB Signaling Pathways

(2019) Han Zhang et al.   INFLAMMATION

DL-3-n-butylphthalide promotes dendrite development in cortical neurons subjected to oxygen-glucose deprivation/reperfusion

(2018) Peng Zhang et al.   CELL BIOLOGY INTERNATIONAL

Neuroprotective Effect and Mechanism of Action of Tetramethylpyrazine Nitrone for Ischemic Stroke Therapy

(2018) Gaoxiao Zhang et al.   NEUROMOLECULAR MEDICINE

Tetramethylpyrazine‑2′O‑sodium ferulate provides neuroprotection against neuroinflammation and brain injury in MCAO/R rats by suppressing TLR-4/NF-κB signaling pathway

(2018) Peipei Zhou et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Puerariae Lobatae Radix with chuanxiong Rhizoma for treatment of cerebral ischemic stroke by remodeling gut microbiota to regulate the brain–gut barriers

(2018) Runzhi Chen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Effects of Ginkgo biloba on dementia: An overview of systematic reviews

(2017) Qiuju Yuan et al.   JOURNAL OF ETHNOPHARMACOLOGY

Dl-3-n-Butylphthalide Treatment Enhances Hemodynamics and Ameliorates Memory Deficits in Rats with Chronic Cerebral Hypoperfusion

(2017) Zhilin Xiong et al.   Frontiers in Aging Neuroscience

Mass Spectrometry Imaging of Kidney Tissue Sections of Rat Subjected to Unilateral Ureteral Obstruction

(2017) Huihui Liu et al.   Scientific Reports

Tetramethylpyrazine Protects Against Oxygen-Glucose Deprivation-Induced Brain Microvascular Endothelial Cells Injury via Rho/Rho-kinase Signaling Pathway

(2016) Guang Yang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Endoplasmic reticulum stress-induced neuronal inflammatory response and apoptosis likely plays a key role in the development of diabetic encephalopathy

(2016) Zhouguang Wang et al.   Oncotarget

A Review of Recent Advances in Neuroprotective Potential of 3-N-Butylphthalide and Its Derivatives

(2016) Idriss Ali Abdoulaye et al.   Biomed Research International

Cardiovascular Actions and Therapeutic Potential of Tetramethylpyrazine (Active Component Isolated fromRhizoma Chuanxiong): Roles and Mechanisms

(2016) Ming Guo et al.   Biomed Research International

Tetramethylpyrazine inhibits neutrophil activation following permanent cerebral ischemia in rats

(2015) Cheng-Yi Chang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of Tetramethylpyrazine on Functional Recovery and Neuronal Dendritic Plasticity after Experimental Stroke

(2015) Jun-Bin Lin et al.   Evidence-based Complementary and Alternative Medicine

Tetramethylpyrazine Promotes Migration of Neural Precursor Cells via Activating the Phosphatidylinositol 3-Kinase Pathway

(2015) Xiangying Kong et al.   MOLECULAR NEUROBIOLOGY

Ligustrazine monomer against cerebral ischemia-reperfusion injury

(2015) Qing-chun Mu et al.   Neural Regeneration Research

dl-3-n-butylphthalide inhibits platelet activation via inhibition of cPLA2-mediated TXA2synthesis and phosphodiesterase

(2015) Jianqin Ye et al.   PLATELETS

Ligustrazine reduces blood-brain barrier permeability in a rat model of focal cerebral ischemia and reperfusion

(2015) FENG TAN et al.   Experimental and Therapeutic Medicine

Angiotensin-(1-7) induces cerebral ischaemic tolerance by promoting brain angiogenesis in a Mas/eNOS-dependent pathway

(2014) Teng Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Suppression of NADPH oxidase- and mitochondrion-derived superoxide by Notoginsenoside R1 protects against cerebral ischemia–reperfusion injury through estrogen receptor-dependent activation of Akt/Nrf2 pathways

(2014) X. Meng et al.   FREE RADICAL RESEARCH

Vascular Endothelial Growth Factor Promotes Pericyte Coverage of Brain Capillaries, Improves Cerebral Blood Flow During Subsequent Focal Cerebral Ischemia, and Preserves the Metabolic Penumbra

(2013) Anil Zechariah et al.   STROKE

Intranasal Ginsenoside Rb1 Targets the Brain and Ameliorates Cerebral Ischemia/Reperfusion Injury in Rats

(2011) Tingting Lu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Pharmacokinetic study of a novel stroke therapeutic, 2-[[(1,1-dimethylethyl)oxidoimino]methyl]-3,5,6-trimethylpyrazine, by a simple HPLC–UV method in rats

(2011) Sha Li et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Rehmannia glutinosa Ameliorates Scopolamine-Induced Learning and Memory Impairment in Rats

(2011) Bombi Lee   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Angiogenic effect of saponin extract fromPanax notoginsengon HUVECsin vitroand zebrafishin vivo

(2008) Si-Jia Hong et al.   PHYTOTHERAPY RESEARCH