Review
Biochemistry & Molecular Biology
Shermaine W. Y. Low, Thomas B. Connor, Iris S. Kassem, Deborah M. Costakos, Shyam S. Chaurasia
Summary: Small leucine-rich proteoglycans (SLRPs) serve a crucial role in maintaining retinal homeostasis by participating in the organization of extracellular matrix, regulation of cell growth, and cell-matrix interactions in several upstream signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Alina Khramova, Roberto Boi, Vincent Friden, Anna Bjoernson Granqvist, Ulf Nilsson, Olav Tenstad, Eystein Oveland, Boerje Haraldsson, Kerstin Ebefors, Jenny Nystrom
Summary: The capillary endothelium, including that of the glomeruli, have a luminal cell surface layer (ESL) composed of various components, crucial for maintaining a normal filtration barrier and preventing proteinuria. Experiment results showed that elution with high salt solution could reduce ESL thickness, cause albuminuria and decrease GFR. Dysregulation of PGs in DKD patients suggests their importance in ESL function and prevention of proteinuria.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Eimi Suzuki, Takayoshi Sumioka, Shizuya Saika, Masayasu Miyajima, Shingo Yasuda, Hiroki Iwanishi, Yukihisa Takada, Kana Ichikawa, Jhuwala Venkatakrishnan, Chia-Yang Liu, Winston Whei-Yang Kao, Yuka Okada
Summary: Loss of lumican perturbs the healing pattern of a penetrating incision in mouse corneal stroma, accompanied by suppression of myofibroblast generation.
Article
Dermatology
Xue Xu, Pin Ha, Emily Yen, Chenshuang Li, Zhong Zheng
Summary: Small leucine-rich proteoglycans (SLRPs) play a crucial role in regulating tendon structure and biomechanics, offering a promising method for tendon injury management. However, current knowledge on the role of SLRPs in tendon development and regeneration is limited, requiring further investigations.
ADVANCES IN WOUND CARE
(2022)
Review
Ophthalmology
Mei-Chi Tsui, Hsin-Yu Liu, Hsiao-Sang Chu, Wei-Li Chen, Fung-Rong Hu, Winston W. -Y. Kao, I-Jong Wang
Summary: Lumican, a keratan sulfate proteoglycan, plays versatile roles in the pathogenesis of eye diseases. It is involved in the maintenance of tissue homogeneity and shows upregulation in pathological conditions such as fibrosis, scar tissue formation, inflammatory responses, and immune anomaly. This review focuses on the role of lumican in the pathogenesis of inherited congenital and acquired eye diseases such as cornea dystrophy, cataract, glaucoma, and chorioretinal diseases.
Article
Ophthalmology
Sabeeh Kamil, Rajiv R. Mohan
Summary: Corneal stromal wound healing is a complex process involving apoptosis, proliferation, migration, and transdifferentiation of keratocytes. The central player guiding stromal responses is TGF-beta signaling, while other major regulators include myofibroblasts, basement membrane, collagen fibrils, and small leucine-rich proteoglycans. Understanding the roles of these regulators has helped develop novel therapies to prevent corneal opacity.
Article
Immunology
Mengliang Wu, Laura E. Downie, Lisa J. Hill, Holly R. Chinnery
Summary: The study found that topical decorin can regulate the dynamics of immune cells during the acute phase after corneal injury, promote corneal regeneration, and potentially achieve this by regulating the expression of nerve-related and cytokine genes.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Ophthalmology
Suneel Gupta, Filiz Buyank, Nihant R. Sinha, DeAna G. Grant, Prashant R. Sinha, Renato V. Iozzo, Shyam S. Chaurasia, Rajiv R. Mohan
Summary: This study investigated the role of decorin in stromal fibrillogenesis and corneal transparency. The results showed that decorin plays a critical role in regulating collagen fibril assembly and maintaining corneal transparency.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Ophthalmology
Steven E. Wilson
Summary: The TGF beta-1, -2 and -3 isoforms, transcribed from different genes, share the same regulatory mechanisms and signal transduction pathways. Despite the traditional belief that TGF beta-1 and TGF beta-2 are pro-fibrotic while TGF beta-3 is anti-fibrotic, this review suggests that TGF beta-3 actually shares more similarities in regulating fibrotic gene expression with TGF beta-1 and TGF beta-2. The complex interplay between these three isoforms and various proteins controls the healing process in response to injury and the resolution of fibrosis in different organs.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Dermatology
Jihane Frikeche, Celine Couteau, Christos Roussakis, Laurence J. M. Coiffard
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2015)
Article
Multidisciplinary Sciences
Ranjita N. Gowda, Rachel Redfern, Jihane Frikeche, Sudarshan Pinglay, James William Foster, Carolina Lema, Leslie Cope, Shukti Chakravarti
Article
Biochemistry & Molecular Biology
F. Volpin, J. Casaos, J. Sesen, A. Mangraviti, J. Choi, N. Gorelick, J. Frikeche, T. Lott, R. Felder, S. J. Scotland, T. S. K. Eisinger-Mathason, H. Brem, B. Tyler, N. Skuli
Review
Hematology
Jihane Frikeche, Zinaida Peric, Eolia Brissot, Marc Gregoire, Beatrice Gaugler, Mohamad Mohty
EXPERIMENTAL HEMATOLOGY
(2012)
Article
Immunology
Debdut Naskar, George Maiti, Arijit Chakraborty, Arunava Roy, Dhrubajyoti Chattopadhyay, Malini Sen
JOURNAL OF IMMUNOLOGY
(2014)
Article
Multidisciplinary Sciences
George Maiti, Debdut Naskar, Malini Sen
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2012)
Article
Multidisciplinary Sciences
Vishal Shinde, Nan Hu, Alka Mahale, George Maiti, Yassine Daoud, Charles G. Eberhart, Azza Maktabi, Albert S. Jun, Samar A. Al-Swailem, Shukti Chakravarti
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Vishal Shinde, Nara Sobreira, Elizabeth S. Wohler, George Maiti, Nan Hu, Giuliana Silvestri, Sonia George, Jonathan Jackson, Aravinda Chakravarti, Colin E. Willoughby, Shukti Chakravarti
Summary: The study identified multiple genes involved in keratoconus, regulating cytoskeleton, protein trafficking, response to injury and inflammation, providing insights into the pathogenesis of this common corneal defect involving a complex genetic basis.
HUMAN MOLECULAR GENETICS
(2021)
Review
Immunology
Asim Biswas, Rahul Subhra Mandal, Suparna Chakraborty, George Maiti
Summary: The impact of SARS-CoV-2 and COVID-19 susceptibility is influenced by age and health status, with a challenge in inducing effective immune responses in elderly populations. While the stalk domain of spike protein plays a minor role in viral neutralization, mutations in the receptor-binding domain may reduce vaccine efficacy across ages. A proposal for chimeric vaccines combining multiple proteins aims at addressing these challenges.
INTERNATIONAL REVIEWS OF IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
George Maiti, Jihane Frikeche, Carly Yuen-Man Lam, Asim Biswas, Vishal Shinde, Marie Samanovic, Jonathan C. Kagan, Mark J. Mulligan, Shukti Chakravarti
Summary: The ECM protein lumican plays a significant role in regulating infections and inflammation, promoting TLR4 response while restricting TLR9 in immune cells. Lumican may be internalized by immune cells to modulate their transcriptional programs and effector responses, suggesting potential therapeutic applications in future treatments.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
George Maiti, Sean Ashworth, Tansol Choi, Shukti Chakravarti
Summary: This review focuses on the emerging immune regulatory functions of small leucine-rich proteoglycans (SLRP) such as lumican, keratocan, fibromodulin, biglycan, and decorin. These SLRPs have been extensively studied as structural components in the extracellular matrix, but their immune regulatory roles in inflammation and disease are not well understood. By investigating the leucine-rich repeat (LRR) motifs of SLRP core proteins and their relationships with other pathogen recognition receptors, this review aims to provide molecular clarity on the immune regulatory functions of SLRPs.
Article
Multidisciplinary Sciences
George Maiti, Maithe Rocha Monteiro de Barros, Nan Hu, Igor Dolgalev, Mona Roshan, James W. Foster, Aristotelis Tsirigos, Karl J. Wahlin, Shukti Chakravarti
Summary: This study elucidated the transcriptomic cell fate map of 4-month-old human cornea organoids and human donor corneas, showing that the organoids contain cell clusters resembling cells of the corneal epithelium, stroma, and endothelium, with subpopulations capturing signatures of early developmental states.
Article
Ophthalmology
He-Yan Li, Li Dong, Xu-Han Shi, Rui-Heng Zhang, Wen-Da Zhou, Hao-Tian Wu, Chu-Yao Yu, Yi-Tong Li, Yi-Fan Li, Jost B. Jonas, Wen-Bin Wei, Yue-Ming Liu
Summary: This study aimed to examine the intraocular tolerability of cetuximab when applied intravitreally, and its effect on axial elongation. The results showed that intravitreal injections of cetuximab could reduce axial elongation in a dose-dependent and number of treatment-dependent manner, without causing intraocular toxic effects.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
James D. Cole, John A. McDaniel, Joelle Nilak, Ashley Ban, Carlos Rodriguez, Zuhaad Hameed, Marta Grannonico, Peter A. Netland, Hu Yang, Ignacio Provencio, Xiaorong Liu
Summary: Aniridia is a panocular condition characterized by the loss of iris, caused mainly by mutations in the PAX6 gene. This study assessed the effects of Pax6-haploinsufficiency on retinal morphology and vision in Pax6Sey mice. The results showed elevated intraocular pressure and declining visual acuity in Pax6Sey mice, along with local retinal damage and a possible neuroinflammatory response.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Subao Jiang, Ning Xia, Francesco Buonfiglio, Elsa W. Boehm, Qi Tang, Norbert Pfeiffer, Dominik Olinger, Huige Li, Adrian Gericke
Summary: This study found that a high-fat diet induces endothelial dysfunction in the ophthalmic artery, leading to impaired vascular function in the eye. The high-fat diet triggers oxidative stress and involves RAGE and NOX2.
EXPERIMENTAL EYE RESEARCH
(2024)
Review
Ophthalmology
Mala Upadhyay, Vera L. Bonilha
Summary: The sodium iodate (NaIO3) model is a valuable tool in studying dry AMD and evaluating the retinal structure. Through extensive research, it has been found that the death of RPE cells caused by NaIO3 injection is closely related to vision loss in patients with dry AMD. Therefore, studying NaIO3 can provide insights into the mechanisms of RPE and photoreceptor cell death and contribute to understanding RPE degeneration in AMD.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Vicki Chrysostomou, Katharina C. Bell, Sze Woei Ng, Samyuktha Suresh, Gayathri Karthik, Marion Millet, Yingying Chung, Jonathan G. Crowston
Summary: We present a new experimental model for inducing retinal ganglion cell (RGC) dysfunction and degeneration in mice. This model allows for the reliable induction of RGC dysfunction and loss, with the resilience of the optic nerve being dependent on the age of the animal. The time-defined nature of the functional and structural changes observed in this model will facilitate the study of glial responses and the evaluation of neuroprotective treatments after intraocular pressure (IOP) injury.
EXPERIMENTAL EYE RESEARCH
(2024)
