Article
Biochemistry & Molecular Biology
Diego Sbardella, Grazia Raffaella Tundo, Massimo Coletta, Gianluca Manni, Francesco Oddone
Summary: Steroid-induced glaucoma is a severe eye condition characterized by rapidly increasing intraocular pressure due to metabolic dysregulation of Trabecular Meshwork Cells. Exposure to steroids inhibits the autophagy process in TMCs, possibly through the Ubiquitin Proteasome System.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Wungrak Choi, Hyoung Won Bae, Hye Jung Shin, Eun Woo Kim, Chan Yun Kim, Min Kim, Gong Je Seong
Summary: This study developed two nomograms to predict a safety zone for intravitreal DEX implantation. These can be used to identify individuals who may be safely prescribed steroid treatments and for whom extra caution should be exercised.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Cell Biology
Philip Mzyk, Humberto Hernandez, Thanh Le, Jose Ricardo Ramirez, Colleen M. M. McDowell
Summary: This review examines the role of Toll-like receptor 4 (TLR4) signaling in the trabecular meshwork and its interplay with endogenous activators (damage-associated molecular patterns (DAMPs)) and extracellular matrix (ECM), as well as its effect on intraocular pressure.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Shayshadri Mallick, Malini Sharma, Ajay Kumar, Yiqin Du
Summary: Glaucoma is characterized by elevated intraocular pressure which can lead to vision loss and eventual blindness, and stem cell transplantation shows promise in repairing trabecular meshwork dysfunction and providing a more direct and effective treatment approach.
Article
Pharmacology & Pharmacy
Longxiang Huang, Zhenni Wei, Xiaohui Wang, Chunlin Lan, Yihua Zhu, Qin Ye
Summary: This study demonstrates that AZD6738 can decrease intraocular pressure and inhibit fibrotic response in the eye, offering a potential therapeutic option for glaucoma treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Tomislav Sarenac, Anela Becic Turkanovic, Peter Ferme, Tomaz Gracner
Summary: Currently, there is no effective treatment for glaucomatous optic neuropathy, with the current focus being on reducing intraocular pressure (IOP). Studies have shown that selective laser trabeculoplasty (SLT) is a safe and effective method for reducing IOP in eyes with open-angle glaucoma or ocular hypertension. The European Glaucoma Society has recognized SLT as a first-line or adjunctive treatment for these conditions, highlighting its clinical significance. In this review, we discuss the old and new roles of SLT, particularly in clinical practice, and explore its updated appeal and future developments.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
William Bachman, Rupalatha Maddala, Ayon Chakraborty, Camelia Eldawy, Nikolai P. Skiba, Ponugoti Rao
Summary: Clinical use of glucocorticoids is associated with increased intraocular pressure, a major risk factor for glaucoma. Glucocorticoids have been found to induce changes in actin cytoskeletal organization, cell adhesion, extracellular matrix, and other cellular activities in trabecular meshwork (TM) cells, which play a crucial role in aqueous humor dynamics and intraocular pressure regulation. However, there is limited understanding of the molecular mechanisms underlying these changes in TM cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Ophthalmology
Jun Wang, Hanke Wang, Yalong Dang
Summary: Glaucoma, a leading cause of irreversible blindness, can be prevented and treated by reducing intraocular pressure. ROCK inhibitors are a new class of glaucoma drugs that have a good safety profile and exert neuroprotective effects. Netarsudil and ripasudil are commonly used ROCK inhibitors.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Qing Sang, Rong Du, Chen Xin, Ningli Wang
Summary: This study preliminarily estimated the effects of pilocarpine eye drops and trabeculotomy tunneling trabeculoplasty (3T) on trabecular meshwork (TM) pulsatile motion. Pilocarpine eye drops attenuated TM pulsatile motion, and 3T surgery reduced intraocular pressure (IOP) without affecting the pulsatile motion status of the TM.
Article
Cell Biology
Hotaka Nemoto, Megumi Honjo, Satoko Arai, Toru Miyazaki, Makoto Aihara
Summary: The function of AIM protein in regulating phagocytic capacity of TM cells suggests its potential use in treating glaucoma.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Ophthalmology
Yujia Zhou, Christopher M. Pruet, Chengbo Fang, Cheryl L. Khanna
Summary: This study compared the response of selective laser trabeculoplasty (SLT) in different types of glaucoma. The results showed that SLT had the best response and the lowest failure rate in steroid-induced glaucoma, although high baseline intraocular pressure may affect the outcome. Caution should be exercised when using SLT in uveitic glaucoma.
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
(2022)
Article
Ophthalmology
Laurentius J. (Rene) van Rijn, Catharina A. Eggink, Sarah F. Janssen
Summary: In this retrospective study, the safety and efficacy of 360 degrees circumferential trabeculotomy for steroid induced glaucoma of short duration were evaluated. The results showed that the surgery was particularly effective, with most patients experiencing a significant reduction in intraocular pressure and not needing to use pressure-lowering medications.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Magdalena Schneider, Ramona Pawlak, Gregor R. Weber, Andrea E. Dillinger, Sabrina Kuespert, Renato V. Iozzo, Harry A. Quigley, Andreas Ohlmann, Ernst R. Tamm, Rudolf Fuchshofer
Summary: Primary open-angle glaucoma is a neurodegenerative disorder characterized by degeneration of optic nerve axons, with intraocular pressure identified as the major risk factor for its development involving molecular mechanisms like TGF-beta. Decorin has been found to play an important role in intraocular pressure and optic nerve damage.
Article
Ophthalmology
Kota Aoshima, Satoshi Inagaki, Yuya Takagi, Shinsuke Nakamura, Hideaki Hara, Masamitsu Shimazawa
Summary: Intraocular pressure (IOP) is a major risk factor for glaucoma. Existing treatments for reducing IOP often do not target the trabecular meshwork (TM), which is the main pathway for aqueous humor drainage. This study discovered an inhibitor that targets the ALK5 protein, which reduces IOP and may provide a new treatment option for glaucoma by targeting the TM.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Rishi K. Somvanshi, Shenglong Zou, Salam Kadhim, Sapna Padania, Eric Hsu, Ujendra Kumar
Summary: CBN promotes neuroprotection, abrogates changes in ECM protein, and normalizes the IOP levels in the eye, indicating its therapeutic potential for glaucoma.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Neurosciences
Mohd Aizuddin Mohd Lazaldin, Igor Iezhitsa, Renu Agarwal, Nor Salmah Bakar, Puneet Agarwal, Nafeeza Mohd Ismail
EUROPEAN JOURNAL OF NEUROSCIENCE
(2020)
Article
Microbiology
Kirill Lotonin, Alexey Smirnov
EUROPEAN JOURNAL OF PROTISTOLOGY
(2020)
Article
Geochemistry & Geophysics
Michael Klibanov, Alexey Smirnov, Vo A. Khoa, Anders J. Sullivan, Lam H. Nguyen
Summary: This study addresses an inverse scattering problem for synthetic aperture radar (SAR) data in through-the-wall imaging, utilizing a fully nonlinear model that shows better accuracy in estimating dielectric constants and target locations compared to the commonly used linearized models. The results demonstrate the effectiveness of the proposed method in accurately estimating dielectric constants and target locations hidden behind walls.
IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
(2021)
Article
Chemistry, Physical
Zahra Jamshidi, Sahar Ashtari-Jafari, Aleksei Smirnov, Elena Solovyeva
Summary: Experimental and theoretical investigations on the surface-enhanced resonant Raman spectroscopy (SERRS) of 4,4'-diaminotolane absorbed on silver reveal unique features compared to normal Raman and SERS on gold. The dependence of SERS spectra on excitation lines has been studied, and theoretical calculations based on the Herzberg-Teller correction show good agreement with experimental results, highlighting the importance of charge-transfer transitions in enhancing both totally and non-totally symmetric modes.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Multidisciplinary Sciences
Denis Kurkin, Dmitry A. Bakulin, Evgeny Morkovin, Anna Kalatanova, Igor E. Makarenko, Artem R. Dorotenko, Nikolay S. Kovalev, Marina A. Dubrovina, Dmitry V. Verkholyak, Elizaveta E. Abrosimova, Alexey Smirnov, Maksim Shmidt, Ivan N. Tyurenkov
Summary: This study compared the neuroprotective activity of Cerebrolysin(R), Actovegin(R), and Cortexin(R) in rodent models of acute and chronic brain ischemia. Cortexin(R) or Cerebrolysin(R) significantly improved recovery of neurological functions and reduced the severity of impairments in rats, while Cortexin(R) also reduced brain tissue necrosis and improved antioxidant system function. Radioactively labeled Cortexin(R) crossed the blood-brain barrier in mice with concentrations equal to 6-8% of concentrations found in whole blood. In vitro binding assays showed Cortexin(R) had high or moderate binding to various receptors, suggesting its effects may be related to glutamatergic and GABAergic actions.
Article
Anatomy & Morphology
Sergey Dydykin, Friedrich Paulsen, Tatyana Khorobykh, Natalya Mishchenko, Marina Kapitonova, Sergey Gupalo, Tatyana Bogoyavlenskaya, Vadim Agadzhanov, Pashad Salikhov
Summary: This study conducted anatomical research to identify key anatomical landmarks in thoracoscopic surgery, providing safe navigation during esophagus dissection. An algorithm was proposed to allow direct visualization of these landmarks before the operation.
SURGICAL AND RADIOLOGIC ANATOMY
(2022)
Article
Psychology, Clinical
Emma Heard, Andrew Smirnov, Luciana Massi, Linda A. Selvey
Summary: This study investigates barriers and enablers to DAA treatment of HCV in general practice settings in Australia, finding that a range of initiatives are required to support the uptake of DAA. Furthermore, addressing stigma and discrimination affecting people who inject drugs in community healthcare settings remains necessary.
JOURNAL OF SUBSTANCE ABUSE TREATMENT
(2021)
Article
Psychology, Clinical
Abdullah Ahmed Alghamdi, Coral Gartner, Jake Najman, Andrew Smirnov
Summary: Research shows that young adults who consistently co-administer cannabis with tobacco are more likely to have frequent and persistent tobacco smoking in the long term. Therefore, young adults who use cannabis should be advised to avoid co-administering cannabis with tobacco, making them an important target group for tobacco cessation interventions.
JOURNAL OF PSYCHOACTIVE DRUGS
(2022)
Article
Substance Abuse
Abdullah Ahmed Alghamdi, Coral Gartner, Jake M. Najman, Gary Chan, Andrew Smirnov
Summary: The study found that individuals who always co-administered cannabis with tobacco used cannabis more frequently in the last month. Sometimes co-administering cannabis and tobacco predicted more frequent cannabis use in the future, but did not predict high levels of use in the long term (4 1/2 years).
SUBSTANCE USE & MISUSE
(2022)
Article
Surgery
Olga Zhukova, Sergey Dydykin, Eliska Kubikova, Natalia Markova, Yuriy Vasil'ev, Marina Kapitonova
Summary: This study assessed the effectiveness and safety of an innovative method of thread facelift, which provides additional support to the ligamentous structures of the face and neck. The results showed high satisfaction and efficacy in both experts and patients after 2 years of follow-up.
ARCHIVES OF PLASTIC SURGERY-APS
(2022)
Article
Chemistry, Physical
Elena V. Solovyeva, Aleksei N. Smirnov, Vasilisa O. Svinko, Aleksei S. Strelnikov, Alisa I. Shevchuk, Sergei G. Kazarian
Summary: In this study, the effect of linker rigidity and conjugation degree on the morphology and optical properties of aggregates formed by silver nanoparticles (NPs) was systematically investigated. The concentration profiles obtained for effective NP linking were found to be non-monotonic. Transmission electron microscopy and absorption spectroscopy revealed that stilbene and tolane compounds effectively linked the silver NPs, forming quasi-spherical aggregates and elongated dimers/trimers, while bibenzyl compound exhibited surface-initiated azo conversion instead of NPs bridging. It was observed that the degree of NP aggregation decreased with increasing aromaticity and springiness of the linker molecule. The ability of rigid diamines to assemble nanoparticles with a finite degree of aggregation, even at high concentrations, distinguishes them advantageously from aliphatic bifunctional linkers. Highly stable plasmonic aggregates suitable for nano- and meta-materials and imaging applications can be obtained using this method.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Education, Scientific Disciplines
Yuriy L. Vasil'ev, Sergey S. Dydykin, Artem D. Kashtanov, Ekaterina V. Molotok, Alexandra A. Lyakisheva, Olesya V. Kytko, Marina Kapitonova, Alexandr A. Vorobyov, Ekaterina V. Litvina, Vladimir I. Filimonov, Alexandr I. Bezhin, Alexandr V. Kolsanov
Summary: Anatomy is taught using computer-assisted learning tools, including virtual anatomy dissection tables. Two popular tables, Anatomage and Pirogov, were compared through surveys of anatomy educators in Russian universities. The overall satisfaction ratings were not significantly different between the two tables. However, Anatomage was rated higher for accuracy of displayed anatomical details and suitability for teaching senior students, while Pirogov was rated higher for ergonomics and teaching basic anatomy to junior students.
ANATOMICAL SCIENCES EDUCATION
(2023)
Review
Medicine, Research & Experimental
Mohammad Daniel Shafiq Hassan, Norhafiza Razali, Amy Suzana Abu Bakar, Noor Fahitah Abu Hanipah, Renu Agarwal
Summary: Connective tissue growth factor (CTGF) is a signaling molecule involved in many physiological and pathophysiological processes. Its upregulation is associated with fibrotic diseases and glaucoma. It may serve as a potential therapeutic target in glaucoma management.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
T. S. Bulatova, N. A. Bogachev, A. A. Betina, A. N. Smirnov, E. V. Solovieva, M. Yu. Skripkin, A. S. Mereshchenko
Summary: The nanocrystalline phosphor NaGd0.7Eu0.3F4 with the most intensive luminescence among NaGd1-xEuxF4 (x = 0-1) compounds was successfully obtained by hydrothermal synthesis, and its properties were characterized, showing the highest luminescent performance.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Eduard A. Bariev, Ivan I. Krasnyuk, Maria N. Anurova, Elena O. Bakhrushina, Valery V. Smirnov, Alexander I. Bardakov, Natalya B. Demina, Ivan I. Krasnyuk
Article
Ophthalmology
He-Yan Li, Li Dong, Xu-Han Shi, Rui-Heng Zhang, Wen-Da Zhou, Hao-Tian Wu, Chu-Yao Yu, Yi-Tong Li, Yi-Fan Li, Jost B. Jonas, Wen-Bin Wei, Yue-Ming Liu
Summary: This study aimed to examine the intraocular tolerability of cetuximab when applied intravitreally, and its effect on axial elongation. The results showed that intravitreal injections of cetuximab could reduce axial elongation in a dose-dependent and number of treatment-dependent manner, without causing intraocular toxic effects.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
James D. Cole, John A. McDaniel, Joelle Nilak, Ashley Ban, Carlos Rodriguez, Zuhaad Hameed, Marta Grannonico, Peter A. Netland, Hu Yang, Ignacio Provencio, Xiaorong Liu
Summary: Aniridia is a panocular condition characterized by the loss of iris, caused mainly by mutations in the PAX6 gene. This study assessed the effects of Pax6-haploinsufficiency on retinal morphology and vision in Pax6Sey mice. The results showed elevated intraocular pressure and declining visual acuity in Pax6Sey mice, along with local retinal damage and a possible neuroinflammatory response.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Subao Jiang, Ning Xia, Francesco Buonfiglio, Elsa W. Boehm, Qi Tang, Norbert Pfeiffer, Dominik Olinger, Huige Li, Adrian Gericke
Summary: This study found that a high-fat diet induces endothelial dysfunction in the ophthalmic artery, leading to impaired vascular function in the eye. The high-fat diet triggers oxidative stress and involves RAGE and NOX2.
EXPERIMENTAL EYE RESEARCH
(2024)
Review
Ophthalmology
Mala Upadhyay, Vera L. Bonilha
Summary: The sodium iodate (NaIO3) model is a valuable tool in studying dry AMD and evaluating the retinal structure. Through extensive research, it has been found that the death of RPE cells caused by NaIO3 injection is closely related to vision loss in patients with dry AMD. Therefore, studying NaIO3 can provide insights into the mechanisms of RPE and photoreceptor cell death and contribute to understanding RPE degeneration in AMD.
EXPERIMENTAL EYE RESEARCH
(2024)
Article
Ophthalmology
Vicki Chrysostomou, Katharina C. Bell, Sze Woei Ng, Samyuktha Suresh, Gayathri Karthik, Marion Millet, Yingying Chung, Jonathan G. Crowston
Summary: We present a new experimental model for inducing retinal ganglion cell (RGC) dysfunction and degeneration in mice. This model allows for the reliable induction of RGC dysfunction and loss, with the resilience of the optic nerve being dependent on the age of the animal. The time-defined nature of the functional and structural changes observed in this model will facilitate the study of glial responses and the evaluation of neuroprotective treatments after intraocular pressure (IOP) injury.
EXPERIMENTAL EYE RESEARCH
(2024)
