Article
Immunology
James I. King, Felipe Melo-Gonzalez, Bert Malengier-Devlies, Roser Tacho-Pinot, Marlene S. Magalhaes, Suzanne H. Hodge, Xavier Romero Ros, Rebecca Gentek, Matthew R. Hepworth
Summary: Group 3 innate lymphoid cells (ILC3) play critical roles in immunity, barrier integrity and tissue homeostasis in the gastrointestinal tract. They are primarily tissue-resident cells, present from embryonic stages and persist into adulthood. However, the mechanisms of how mature ILC3 are maintained in adult tissues are poorly understood. This study demonstrates that lymphoid tissue-inducer-like (LTi-like) ILC3 are a quiescent population that persist for extended periods of time in the healthy adult intestinal tract. During bacterial infection, LTi-like ILC3 exhibit minimal hematopoietic replenishment and remain non-proliferative, while producing cytokines. Survival of LTi-like ILC3 is dependent on the balance between metabolic activity and anti-apoptotic programs. The pro-survival protein Bcl-2 is required for their survival, but can be partially dispensable if mitochondrial respiration is inhibited. In conclusion, this study highlights the importance of LTi-like ILC3 as a tissue-resident population that can survive independently in the intestinal microenvironment.
MUCOSAL IMMUNOLOGY
(2023)
Review
Immunology
Daniela E. Kirwan, Deborah L. W. Chong, Jon S. Friedland
Summary: In 2019, 10 million people developed symptomatic tuberculosis (TB) disease, resulting in 1.2 million deaths. The tissue destruction in TB is mainly mediated by enzymes, particularly matrix metalloproteinases (MMPs) secreted by leukocytes and stromal cells. Platelets are implicated in TB immunopathology, with high platelet counts in TB patients correlating with disease severity and a hypercoagulable profile. Platelets likely drive TB immunopathology by influencing other immune cells, such as monocytes, leading to increased activation markers, MMP secretion, and enhanced phagocytosis. Targeted anti-platelet agents are being considered for the treatment of TB as part of host-directed therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Yanjing Li, Shaojingya Gao, Sirong Shi, Dexuan Xiao, Shuanglin Peng, Yang Gao, Ying Zhu, Yunfeng Lin
Summary: The tFNA-based delivery of resveratrol (RSB) can improve insulin sensitivity and alleviate inflammation in high-fat diet-fed mice by modulating immune responses and macrophage phenotype. The synthesized nanoparticles, tFNAs-RSV, show potential as a therapeutic approach for treating insulin resistance and obesity-related metabolic diseases by targeting immune cell activation and inflammation.
NANO-MICRO LETTERS
(2021)
Article
Endocrinology & Metabolism
Di Wu, Luni Hu, Mengwei Han, Yichen Deng, Yime Zhang, Guanqun Ren, Xingyu Zhao, Zongxian Li, Peng Li, Yinlian Zhang, Shanwen Chen, Jun Li, Yanyan Shi, Jianxin Xue, Pengyuan Wang, Chao Zhong
Summary: In this study, the researchers found that a metabolic reconfiguration in colonic lymphoid tissue inducer (LTi) cells regulated by PD-1 signaling modulates inflammatory states in the gut during anti-PD-1 immunotherapy.
Review
Oncology
Anneloes van Duijn, Sjoerd H. Van der Burg, Ferenc A. Scheeren
Summary: This article focuses on the interactions between myeloid immune cells and anti-tumor immune responses in the tumor microenvironment. Blocking the CD47/SIRP alpha axis can enhance adaptive immune response. The potential therapeutic role of CD47/SIRP alpha axis is discussed in tumors with acquired resistance to classic immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Seika Hashimoto-Hill, Luisa Colapietro, Vivienne Woo, Simona Antonacci, Jordan Whitt, Laura Engleman, Theresa Alenghat
Summary: This study demonstrates that consuming rice bran can reduce the risk of intestinal infection, and the phytate component in it plays a role by promoting innate immune response in intestinal epithelial cells. This effect is dependent on the metabolism of phytate by commensal bacteria.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Ziyuan Zhou, Xiaxia Pan, Lanjuan Li
Summary: Hepatic macrophages play a crucial role in liver inflammation and their interaction with gut microbiota impacts liver diseases, indicating therapeutic potential in targeting hepatic macrophages.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Allergy
Bilal Alashkar Alhamwe, Zhan Gao, Fahd Alhamdan, Hani Harb, Matthieu Pichene, Abel Garnier, Jihad El Andari, Andreas Kaufmann, Peter L. Graumann, Dorthe Kesper, Christian Daviaud, Holger Garn, Joerg Tost, Daniel P. Potaczek, Martin J. Blaser, Harald Renz
Summary: This research identifies a novel mechanism by which early-life exposure to Acinetobacter lwoffii (AL) can prevent chronic inflammatory diseases such as asthma. The study found that AL triggers a proinflammatory immune response characterized by elevated levels of IL-6 and subsequent IL-10 production in CD4(+) T-cells. This immune response, along with changes in the gastrointestinal microbiome, contribute to the protection against asthma.
Review
Immunology
Chang Sun, Xing Zhou, Ting Guo, Jia Meng
Summary: Osteoarthritis (OA) is a chronic degenerative joint disease characterized by cartilage damage and synovial inflammation. Recent research has recognized the role of gut microbiota dysbiosis in OA, which can trigger host immune responses and aggravate the disease. However, the mechanisms modulating the interactions between gut microbiota and host immunity in OA are still unclear. Future research should focus on identifying specific pathogens or changes in gut microbiota composition related to OA and validating the application of gut microbiota modulation in disease onset through immune cell modifications and gene regulation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Trevor Ung, Nakisha S. Rutledge, Adam M. Weiss, Aaron P. Esser-Kahn, Peter Deak
Summary: This article summarizes the recent advancements in immunology and chemistry in targeted vaccine technology, including cellular targets, methods of targeting, and their effects on immune responses. The relationships between vaccine targets and subsequent adaptive immune responses are crucial for effective vaccine design, potentially leading to more effective, disease-specific vaccines.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Thomas Plante-Bordeneuve, Charles Pilette, Antoine Froidure
Summary: The interaction between lung epithelium and the immune system plays a crucial role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Pathways such as DAMPs-PAMPs are highlighted as potential mechanisms involved in disease progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Tianmeng Yan, Zhenying Zhang
Summary: Bullous pemphigoid (BP) is an autoimmune blistering disease primarily affecting elderly individuals. It presents with heterogeneous manifestations, typically characterized by microscopically subepidermal separation and mixed inflammatory infiltrate. The development mechanism of BP remains unclear. B cells are involved in pathogenic autoantibody production, and other immune cells such as T cells, type II inflammatory cytokines, eosinophils, mast cells, neutrophils, and keratinocytes also contribute to the pathogenesis of BP. This review focuses on the roles and crosstalk between innate and adaptive immune cells in BP.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Sarah Cormican, Matthew D. Griffin
Summary: Innate immune cells play a key role in kidney inflammation and fibrosis, with the CX3CL1-CX3CR1 signaling pathway being closely linked to acute and chronic kidney diseases. Targeting this pathway may offer potential benefits for patients with CKD.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jeremy Goc, Mengze Lv, Nicholas J. Bessman, Anne-Laure Flamar, Sheena Sahota, Hiroaki Suzuki, Fei Teng, Gregory G. Putzel, Gerard Eberl, David R. Withers, Janelle C. Arthur, Manish A. Shah, Gregory F. Sonnenberg
Summary: Research shows that ILC3s play a protective role in cancer, and alterations in CRC may lead to dysfunctional adaptive immunity, tumor progression, and immunotherapy resistance.
Review
Gastroenterology & Hepatology
Ghada Tafesh-Edwards, Ioannis Eleftherianos
Summary: The gut epithelia of animals house complex microbial communities that play a crucial role in maintaining immune and cellular homeostasis. These microbial populations have adapted to the gut environment and regulate intestinal stem cells, promoting a healthy gut barrier and epithelial self-renewal. Disruption of these populations is associated with inflammatory disorders and cancerous lesions of the intestine, but the molecular mechanisms controlling gut-microbe interactions are still not fully understood.
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)