Induction of T regulatory cells by the superagonistic anti-CD28 antibody D665 leads to decreased pathogenic IgG autoantibodies against desmoglein 3 in a HLA-transgenic mouse model of pemphigus vulgaris

The return of the prodigal son and the extraordinary development route of antibody TGN1412 - lessons for drug development and clinical pharmacology

(2015) Marcel J. H. Kenter et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Pathogenic IgG Antibodies against Desmoglein 3 in Pemphigus Vulgaris Are Regulated by HLA-DRB1*04:02–Restricted T Cells

(2014) Rüdiger Eming et al.   JOURNAL OF IMMUNOLOGY

Pemphigus: Associations and management guidelines: Facts and controversies

(2013) Eleonora Ruocco et al.   CLINICS IN DERMATOLOGY

Human regulatory T cells are selectively activated by low-dose application of the CD28 superagonist TGN1412/TAB08

(2013) Paula Tabares et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Depletion with PC61 mAb beforeToxoplasma gondiiinfection eliminates mainly Tregs in BALB/c mice, but activated cells in C57BL/6J mice

(2011) Eda Patricia Tenorio et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Antigen-independent development of Foxp3+ regulatory T cells suppressing autoantibody production in experimental pemphigus vulgaris

(2011) T. Yokoyama et al.   INTERNATIONAL IMMUNOLOGY

Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells

(2010) D Eastwood et al.   BRITISH JOURNAL OF PHARMACOLOGY

Type 1 Diabetes in BioBreeding Rats Is Critically Linked to an Imbalance between Th17 and Regulatory T Cells and an Altered TCR Repertoire

(2010) J. van den Brandt et al.   JOURNAL OF IMMUNOLOGY

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

(2008) Qizhi Tang et al.   NATURE IMMUNOLOGY