Review
Medicine, Research & Experimental
Danial Khayatan, Seyed Mehrad Razavi, Zahra Najafi Arab, Amir Hossein Niknejad, Kiana Nouri, Saeideh Momtaz, Eric Gumpricht, Tannaz Jamialahmadi, Amir Hossein Abdolghaffari, George E. Barreto, Amirhossein Sahebkar
Summary: This article reviews the mechanisms and effects of curcumin in traumatic brain injury (TBI). The findings reveal that curcumin exhibits protective effects on TBI through modulation of cell signaling pathways and immune regulation. However, further clinical experiments are needed to validate the precise mechanisms and function of curcumin in TBI.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Clinical Neurology
Frances Corrigan, Ing Chee Wee, Lyndsey E. Collins-Praino
Summary: This review aims to examine the long-term effects of traumatic brain injury (TBI) on motor function and found that severe injury leads to persistent motor deficits, while mild injury may result in subtle fine motor deficits. However, there is still limited knowledge about the relationship between the severity of injury and long-term motor outcomes. Further research is needed to establish standardized assessment procedures and conduct longitudinal studies to understand the interaction between TBI and aging.
FRONTIERS IN NEUROLOGY
(2023)
Review
Neurosciences
Kaushal Arora, Vishal Vats, Nalin Kaushik, Deepanshu Sindhawani, Vaishali Saini, Divy Mohan Arora, Yogesh Kumar, Etash Vashisht, Govind Singh, Prabhakar Kumar Verma
Summary: Traumatic brain injury (TBI) is a global issue that severely impacts cognitive, behavioral, psychological, and other health problems. While there are drugs available for treatment, there is a need for more development to find better and more effective treatments for TBI.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Clinical Neurology
Andrea L. C. Schneider, Carrie B. Peltz, Yixia Li, Amber Bahorik, Raquel C. Gardner, Kristine Yaffe
Summary: This study found that traumatic brain injury (TBI) is associated with long-term stroke risk, with differences observed in age, sex, race and ethnicity, and time since TBI diagnosis. The highest risk of stroke occurs in the first year after TBI diagnosis, but the risk remains elevated for more than 10 years. Both mild and moderate/severe/penetrating TBI increase the risk of stroke compared to individuals without TBI. Older individuals have a stronger association between TBI and stroke, while Black veterans have a weaker association compared to other races and ethnicities. These findings suggest that veterans with prior TBI should be targeted for primary stroke prevention measures.
Article
Critical Care Medicine
Georgina Perez Garcia, Gissel M. Perez, Rita De Gasperi, Miguel A. Gama Sosa, Alena Otero-Pagan, Dylan Pryor, Rania Abutarboush, Usmah Kawoos, Patrick R. Hof, David G. Cook, Sam Gandy, Stephen T. Ahlers, Gregory A. Elder
Summary: The study reveals that rats exposed to blast injury exhibit persistent cognitive and trauma-related behavioral traits, which may gradually appear and persist for months after the injury.
JOURNAL OF NEUROTRAUMA
(2021)
Review
Clinical Neurology
Grace M. Turner, Christel McMullan, Olalekan Lee Aiyegbusi, Danai Bem, Tom Marshall, Melanie Calvert, Jonathan Mant, Antonio Belli
Summary: This study found that traumatic brain injury is an independent risk factor for stroke, with patients experiencing significantly increased risk of stroke post-traumatic brain injury which may persist up to five years. Meta-analysis results also indicate that traumatic brain injury may increase the risk of stroke, and certain medications may be associated with either reduced or increased risk of stroke.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Critical Care Medicine
Sara M. Lippa, Louis M. French, Tracey A. Brickell, Angela E. Driscoll, Megan E. Glazer, Corie E. Tippett, Jamie K. Sullivan, Rael T. Lange
Summary: This study found that PTSD symptoms were more strongly related to cognitive performance in individuals with a history of complicated mild/moderate TBI compared to those with severe/penetrating TBI. The impact of PTSD symptoms on cognition should be considered in individuals with complicated mild/moderate TBI.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Psychology, Clinical
Katrine M. Ineson, Annette Erlangsen, Merete Nordentoft, Michael E. Benros, Trine Madsen
Summary: This study found that individuals with prior hospital diagnosed traumatic brain injury (TBI) had higher rates of suicide attempts and violent crimes compared to individuals without TBI. Multiple TBI and temporal proximity to TBI were associated with increased rates of suicide attempts and violent crimes.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Geriatrics & Gerontology
Naushad Ahmad Khan, Mohammad Asim, Ayman El-Menyar, Kabir. H. H. Biswas, Sandro Rizoli, Hassan Al-Thani
Summary: Developing effective disease-modifying therapies for neurodegenerative diseases requires reliable diagnostic and progression indicators. Extracellular vesicles (EVs) play an important role in intercellular communication and transport of cell-specific cargos. EVs may have implications in traumatic brain injury (TBI) and other neurodegenerative diseases. EVs have therapeutic potential and can represent intracellular processes. EV-based biomarkers for TBI are more reflective of cellular damage and neuroinflammation.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Medical Laboratory Technology
Yaokun Zhuang, Wenhua Wang, Long Chen, Wei Lu, Min Xu
Summary: The study demonstrates that serum Apelin-13 concentration may serve as a prognostic biomarker for severe traumatic brain injury. The decline in serum Apelin-13 concentration is closely associated with increasing severity and can independently predict short-term mortality in patients with sTBI.
CLINICA CHIMICA ACTA
(2021)
Review
Medicine, General & Internal
Zara Raza, Syeda F. Hussain, Suzanne Ftouni, Gershon Spitz, Nick Caplin, Russell G. Foster, Renata S. M. Gomes
Summary: Military personnel and veterans are exposed to unique risk factors such as TBI, PTSD, combat, blast exposure, and chemical exposure, which may increase the risk of dementia. Sleep problems have also been associated with dementia risk in this population.
MILITARY MEDICAL RESEARCH
(2021)
Article
Clinical Neurology
Kasper Lolk, Julie W. Dreier, Jakob Christensen
Summary: The study found that the risk of epilepsy following traumatic brain injury increases with the repetition and severity of the injury, with females more likely to develop epilepsy after mild injuries and males more likely after severe injuries. These risks remain elevated for decades post-injury.
Article
Behavioral Sciences
Claire Kostelnik, Irwin Lucki, Kwang H. Choi, Caroline A. Browne
Summary: This review outlines the increased risk of PTSD following mTBI in military populations and emphasizes the importance of establishing translationally relevant animal models. It also evaluates the translational relevance of fear conditioning paradigms and addresses the lack of research on fear memory enhancement over time post mTBI. Additionally, potential neurobiological substrates implicated in altered fear memory post mTBI are discussed.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Wiley Gillam, Nikhil Godbole, Shourya Sangam, Alyssa Detommaso, Marco Foreman, Brandon Lucke-Wold
Summary: This review aimed to explore how neurologic injury can lead to Post-Traumatic Stress Disorder (PTSD), focusing on traumatic brain injury, subarachnoid hemorrhage, and stroke as common neurologic injuries. The altered activity in the limbic system may be associated with characteristic symptoms of PTSD. However, early diagnosis and appropriate treatment are lacking in these patients.
Article
Biochemistry & Molecular Biology
Riaz Ahmad, Amjad Khan, Inayat Ur Rehman, Hyeon Jin Lee, Ibrahim Khan, Myeong Ok Kim
Summary: Research shows that lupeol has inhibitory effects on inflammation, oxidative stress, and apoptosis caused by TBI. Experimental results indicate that lupeol can reverse behavioral and memory disturbances induced by TBI, reduce ROS/LPO generation, increase antioxidant protein levels, and inhibit neuronal apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychology, Clinical
Andrew M. Bryant, Zachary Y. Kerr, Samuel R. Walton, William B. Barr, Kevin M. Guskiewicz, Michael A. McCrea, Benjamin L. Brett
Summary: No significant association was found between subjective cognition and objective measures of cognitive functioning among former collegiate football players. However, a greater self-reported concussion history was inversely associated with subjective cognition. Distress was significantly related to all subjective cognition metrics as well as performance on delayed recall and verbal fluency. Sleep quality was only significantly related to timed visuospatial sequencing.
CLINICAL NEUROPSYCHOLOGIST
(2023)
Article
Clinical Neurology
Benjamin L. Brett, Zachary Yukio Kerr, Avinash Chandran, Samuel Walton, Neelum T. Aggarwal, Katherine Gifford, Rebekah Mannix, J. D. DeFreese, Ruben J. Echemendia, Kevin M. Guskiewicz, William P. Meehan, Michael A. McCrea
Summary: Anxiety and fatigue are the most robust factors associated with subjective cognitive difficulties in former professional football players, regardless of a diagnosis of mild cognitive impairment. Self-reported deficits may be less reliable in the presence of these factors, highlighting the importance of multidimensional assessment.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2023)
Article
Clinical Neurology
Pietro Scaduto, Julie C. Lauterborn, Conor D. Cox, Anna Fracassi, Tommaso Zeppillo, Berenice A. Gutierrez, C. Dirk Keene, Paul K. Crane, Shubhabrata Mukherjee, William K. Russell, Giulio Taglialatela, Agenor Limon
Summary: Individuals at different stages of Alzheimer's disease (AD) exhibit abnormal electroencephalographic activity, which is linked to network hyperexcitability and cognitive decline. This study investigates whether pro-excitatory changes at the synaptic level occur in brain areas affected early in AD, and if they are present in mild cognitive impairment (MCI). The findings suggest that early shifts in the excitatory to inhibitory balance contribute to cognitive impairment in AD continuum.
ACTA NEUROPATHOLOGICA
(2023)
Article
Clinical Neurology
Pamela J. McMillan, Sarah J. Benbow, Rikki Uhrich, Aleen Saxton, Misa Baum, Timothy Strovas, Jeanna M. Wheeler, Jeremy Baker, Nicole F. Liachko, C. Dirk Keene, Caitlin S. Latimer, Brian C. Kraemer
Summary: Alzheimer's disease and related disorders are characterized by neurofibrillary tangles and other neuropathological lesions composed of tau protein. Recent studies have shown that aggregated tau forms distinct conformational variants specific to different types of tauopathy disorders. However, the factors driving the formation of these distinct pathological tau conformations remain unknown.
Editorial Material
Sport Sciences
Ruben J. Echemendia, Benjamin L. Brett, Steven Broglio, Gavin A. Davis, Christopher C. Giza, Kevin M. Guskiewicz, Kimberly G. Harmon, Stanley Herring, David R. Howell, Christina L. Master, Tamara C. Valovich McLeod, Michael McCrea, Dhiren Naidu, Jon Patricios, Margot Putukian, Samuel R. Walton, Kathryn J. Schneider, Joel S. Burma, Jared M. Bruce
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Review
Sport Sciences
Jason B. Tabor, Benjamin L. Brett, Lindsay Nelson, Timothy Meier, Linden C. Penner, Andrew R. Mayer, Ruben J. Echemendia, Thomas McAllister, William P. Meehan, Jon Patricios, Michael Makdissi, Silvia Bressan, Gavin A. Davis, Zahra Premji, Kathryn J. Schneider, Henrik Zetterberg, Michael McCrea
Summary: This systematic review examined the role of fluid-based biomarkers, advanced neuroimaging, genetic testing, and emerging technologies in defining and assessing neurobiological recovery after sport-related concussion (SRC). A total of 205 studies were included, showing that neuroimaging and fluid-based biomarkers can detect the acute effects of concussion and track neurobiological recovery after injury. Emerging technologies have also shown potential in the assessment of SRC. However, there is insufficient evidence to recommend the use of these tools in clinical practice.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Editorial Material
Sport Sciences
Gavin A. Davis, Ruben J. Echemendia, Osman Hassan Ahmed, Vicki Anderson, C. Blauwet, Benjamin L. Brett, Steven Broglio, Jared M. Bruce, Joel S. Burma, Gerard A. Gioia, Christopher C. Giza, Kevin M. Guskiewicz, Kimberly G. Harmon, Stanley Herring, Michael Makdissi, Christina L. Master, Michael McCrea, Tamara C. Valovich McLeod, William P. Meehan III, Dhiren Naidu, Jon Patricios, Laura K. Purcell, Margot Putukian, Kathryn J. Schneider, Samuel R. Walton, Keith Owen Yeates, Roger Zemek
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Clinical Neurology
Heather Maioli, Rhonda Mittenzwei, Jane B. Shofer, Kathryn P. Scherpelz, Desiree Marshall, Amber L. Nolan, Peter T. Nelson, C. Dirk Keene, Caitlin S. Latimer
Summary: LATE-NC, a proteinopathy associated with cognitive impairment in the elderly population, can be effectively distinguished using a condensed protocol (CP) that utilizes a single tissue block and immunostain. This study demonstrates the CP's ability to discriminate between different stages of LATE-NC, making it applicable in clinical practice.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2023)
Article
Critical Care Medicine
Kristen Dams-O'Connor, Hibah O. Awwad, Stuart Hoffman, Mary Jo Pugh, Victoria E. Johnson, C. Dirk Keene, Linda McGavern, Pratik Mukherjee, Lisa Opanashuk, Nsini Umoh, George Sopko, Henrik Zetterberg
Summary: Traumatic Brain Injury (TBI) is a risk factor for Alzheimer's disease and related dementias, and further research is needed to understand the mechanisms and impact of TBI on the development of these diseases. The research recommendations for studying TBI as an AD/ADRD risk factor were re-evaluated and refined during the ADRD Summit in 2022.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Clinical Neurology
Benjamin Brett, Nancy K. Temkin, Jason O. Barber, David Okonkwo, Murray G. Stein, Yelena Bodien, John Corrigan, Ramon T. Diaz-Arrastia, Joseph A. Giacino, Michael T. McCrea, Geoffrey D. Manley, Lindsay Nelson
Summary: This study examined the long-term impact of traumatic brain injury (TBI) on functional, cognitive, and psychiatric outcomes. The findings suggest that functional outcomes may change over the course of 6 years following the injury. The study highlights the importance of ongoing monitoring, rehabilitation, and support to improve long-term quality of life and independence for TBI patients.
Article
Multidisciplinary Sciences
Zhi Huang, Gennifer E. Merrihew, Eric B. Larson, Jea Park, Deanna Plubell, Edward J. Fox, Kathleen S. Montine, Caitlin S. Latimer, C. Dirk Keene, James Y. Zou, Michael J. MacCoss, Thomas J. Montine
Summary: Resilience to Alzheimer's disease is a rare combination of high disease burden without dementia, which provides valuable insights into limiting clinical impact. Lowering soluble A beta concentration may suppress severe cognitive impairment along the Alzheimer's disease continuum.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Gennifer E. Merrihew, Jea Park, Deanna Plubell, Brian C. Searle, C. Dirk Keene, Eric B. Larson, Randall Bateman, Richard J. Perrin, Jasmeer P. Chhatwal, Martin R. Farlow, Catriona A. McLean, Bernardino Ghetti, Kathy L. Newell, Matthew P. Frosch, Thomas J. Montine, Michael J. MacCoss
Summary: Alzheimer's disease (AD) is a complex and devastating neurodegenerative disease with limited treatment options. In order to understand the molecular changes specific to AD, researchers have constructed a unique human brain sample cohort that includes different types of AD and normal individuals. By using advanced proteomics techniques, they have generated a high-quality dataset at the peptide and protein level, providing valuable insights into the molecular signatures of the disease. The data have been deposited in a public database and are readily accessible for further analysis.
Article
Orthopedics
Michael J. Aderman, Benjamin L. Brett, Jeremy D. Ross, Steven R. Malvasi, Gerald McGinty, Jonathan C. Jackson, Carlos A. Estevez, Rachel M. Brodeur, Steven J. Svoboda, Michael A. McCrea, Steven P. Broglio, Thomas W. McAllister, Paul F. Pasquina, Kenneth L. Cameron, Megan H. Roach
Summary: The purpose of this study was to describe the endorsement of specific concussion symptom clusters at the initiation of a graduated return-to-activity (GRTA) protocol and examine the association between symptom cluster endorsement and GRTA protocol duration. The results showed that participants endorsing physical or sensitivity symptom clusters had GRTA protocols prolonged by 16% to 19% compared with participants not endorsing that respective cluster.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Neuroimaging
Benjamin L. Brett, Alex D. Cohen, Michael A. McCrea, Yang Wang
Summary: This study investigated the differences in cerebral blood flow and cognitive performance in adolescent athletes after participating in contact sports. The results showed that contact sport athletes exhibited changes in cerebral blood flow and cognition compared to non-contact sport athletes, which may be related to long-term adverse outcomes.
NEUROIMAGE-CLINICAL
(2023)
Article
Psychology, Applied
J. D. DeFreese, Erianne A. Weight, Landon B. Lempke, Samuel R. Walton, Zachary Yukio Kerr, Benjamin L. Brett, Avinash Chandran, Rebekah Mannix, Ruben J. Echemendia, Michael A. McCrea, William P. Meehan III, Kevin M. Guskiewicz
Summary: Transitioning from professional football life has significant implications for the health and well-being of former NFL players. This study examined the experiences of former NFL players during this transition, identifying factors that facilitated the process and factors that made it difficult. The most commonly reported facilitators were having a career transition plan/options and social support, while difficulties related to structure and identity were identified as challenges. These findings highlight targeted intervention areas to enhance the well-being of NFL players during their transition from sport.
JOURNAL OF CLINICAL SPORT PSYCHOLOGY
(2023)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)