Article
Plant Sciences
Aslihan Cetinbas-Genc, Orcun Toksoz, Chiara Piccini, Ozkan Kilin, Nuzhet Cenk Sesal, Giampiero Cai
Summary: This study examined the effects of UV-B radiation on hazelnut pollen. The results showed that exposure to UV-B at different times and distances adversely affected pollen viability, germination rate, tube length, as well as the levels of antioxidant molecules and UV-absorbing compounds.
Article
Cell Biology
Laura Hoen, Christoph Rudisch, Michael Wick, Daniela Indenbirken, Adam Grundhoff, Florian Wegwitz, Stefan Kalkhof, Janosch Hildebrand
Summary: This study investigates the interference between osmotic stress and DNA damage response and finds that osmotic stress affects the UV-induced DNA damage response.
Article
Agricultural Engineering
Yaohan Li, Haodong Xia, Eman Shawky, Shengzhi Liu, Minglei Tao, Amin Liu, Kaisa Sulaiman, Jingkui Tian, Wei Zhu
Summary: This study investigated the stress response mechanism of leaf epidermis to UV-B radiation through tissue-specific proteomics. The results showed that changes in proteins involved in light reaction and Calvin cycle were not simultaneous, antioxidant enzymes exhibited different patterns, and the levels of H2O2 and Ca2+ increased after treatments. A proposed mechanism suggested that the photosystems perceive the stimulus of UV-B radiation to produce reactive oxygen species, and then the antioxidant system and protein homeostasis system were induced through the Ca2+ crosstalk with reactive oxygen species signaling pathway.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Plant Sciences
Alistair W. R. Seddon, Daniela Festi, Mayke Nieuwkerk, Ragnhild Gya, Borge Hamre, Linn Cecilie Kruger, Silje A. H. Ostman, T. Matthew Robson
Summary: This study examines the relationship between Pinus pollen and UV-B radiation, showing a positive correlation between para-coumaric acid and UV-B radiation with an optimal accumulation period of 12-19 days. Population-level factors influence this relationship, emphasizing the need for careful consideration of factors affecting pollen representation in sediments for quantitative reconstructions of long-term changes in springtime UV-B radiation. Mechanistic understanding of local factors mediating the UV-B response across different populations is essential for future improvements in reconstructing UV-B radiation variations.
JOURNAL OF ECOLOGY
(2021)
Article
Environmental Sciences
Dongqi Kan, Yu Zhang, Jiancheng Zeng, Hairong Lian, Lei Feng, Yifan Feng, Xiaojie Liu, Cui Han, Jiaxin Yang
Summary: In this study, the effects of UV-B radiation on the monogonont rotifer Brachionus asplanchnoidis were investigated. UV-B radiation caused adverse effects on growth and reproduction, with oxidative damage and DNA repair-related genes up-regulation. These findings highlight the importance of considering both ecological and molecular responses in assessing the impact of UV-B radiation on aquatic organisms.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Plant Sciences
Maria Lujan Sheridan, Lucio Simonelli, Marisol Giustozzi, Paula Casati
Summary: Exposure to UV-B radiation inhibits primary root elongation in Arabidopsis thaliana plants. This study investigates the cellular and molecular mechanisms underlying this inhibition, revealing that it is caused by a decrease in cell proliferation in the meristematic zone of the primary roots. The study also identifies the transcription factor GROWTH REGULATING FACTOR 3 (GRF3) as a regulator of cell proliferation in UV-B irradiated roots.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Dermatology
Xiaoli Min, Meiling Zheng, Yaqin Yu, Jiali Wu, Qiqi Kuang, Zhi Hu, Lianlian Ouyang, Shuang Lu, Ming Zhao
Summary: This study reveals that UVB irradiation activates human endogenous retroviruses (HERVs), leading to immune response. The study also suggests that UVB-induced overexpression of HERV-dsRNA promotes the production of type I interferon, which contributes to skin inflammatory response and skin lesions in SLE/DLE.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Forestry
Priscila Ramirez-Aliaga, Inmaculada Foyo-Moreno, Paloma Carinanos
Summary: Atmospheric conditions and pollutants can affect the quality and biological functions of pollen, especially under environmental stress in urban areas. This study analyzed the impact of UV-B radiation and polluting gases on the viability and maturity of pollen from four tree species, and found that species exposed to environmental stress had lower viability and were more affected by UV-B radiation and atmospheric pollutants.
Article
Plant Sciences
Maria Sol Gomez, Maria Lujan Sheridan, Paula Casati
Summary: UV-B radiation affects plant growth by inhibiting cell proliferation, controlled in part by transcription factors from the E2F family. E2Fa and E2Fb were found to have distinct and non-redundant roles in regulating leaf size, root elongation, and DNA damage responses in Arabidopsis plants exposed to UV-B. E2Fa regulates primary root elongation, cell proliferation, and programmed cell death in the meristematic zone, while E2Fb contributes to gene expression involved in the DNA damage response and cell cycle progression.
Article
Parasitology
Eder Yaveth Reyes-Cruz, Alberto Yairh Limon-Flores, Angel Francisco Gonzalez-Mireles, Mayra Alejandra Rodriguez-Serrato, Aracely Lopez-Monteon, Angel Ramos-Ligonio
Summary: This study evaluated the effect of UV-B light as a risk factor affecting components of the innate immune response in cutaneous leishmaniasis caused by Leishmania mexicana. The results showed that UV-B radiation led to changes in tissue architecture, increased mast cells, increased IL-10+ and MOMA2+ cells, and altered cytokine profile in the skin lesions of infected mice.
Article
Medicine, Research & Experimental
Veronica A. Bahamondes Lorca, Bernardo D. Bastidas Mayorga, Lingying Tong, Shiyong Wu
Summary: This study revealed a novel mechanism explaining the sustained high levels of phosphorylated eIF2 alpha in HaCaT cells post-UVB, mainly through the inhibition of ATF4 and GADD34 translation.
Article
Biology
Otilia Gag, Stefania Dinu, Horatiu Manea, Iasmina Marcovici, Iulia Pinzaru, Ramona Popovici, Zorin Crainiceanu, Zsolt Gyori, Gheorghe Iovanescu, Sorin Chiriac
Summary: This study evaluated the phototoxic effects of UVA and UVB radiation on healthy and pathologic skin cells. The results showed that UVA had no cytotoxicity on the tested cells, while UVB significantly reduced cell viability and induced apoptosis. The combination of UVA and UVB resulted in the highest cytotoxicity. The findings provide insights into the behavior of normal and cancer skin cells under UVR treatments.
Article
Plant Sciences
Karina E. Martinez-Silvestre, Jose Alfredo Santiz-Gomez, Maria Celina Lujan-Hidalgo, Nancy Ruiz-Lau, Yazmin Sanchez-Roque, Federico A. Gutierrez-Miceli
Summary: This study aimed to evaluate the effect of UV-B radiation on the growth and synthesis of bioactive compounds in tempisque callus. The highest callus formation index was obtained using TDZ and 2,4-D at a concentration of 1 mg/mL. Continuous exposure to UV-B radiation for four hours per day over four weeks resulted in the greatest increase in phenols and flavonoids concentration. The callus obtained from leaves explants had the highest concentrations of quercetin, kaempferol, and gallic acid.
Article
Plant Sciences
Taishan Li, Hisayo Yamane, Ryutaro Tao
Summary: UV-B light promotes blueberry fruit growth, sugar accumulation, and coloration, while also regulating the expression of genes involved in anthocyanin biosynthesis. UV-B treatments may influence anthocyanin accumulation in blueberry fruits by modulating the expression of MYB transcription factors.
HORTICULTURE RESEARCH
(2021)
Article
Plant Sciences
Shijie Wu, Kaiqiang Yu, Xiaoli Ding, Fuyang Song, Xinhua Liang, Zhenkai Li, Li Peng
Summary: The study investigated the impact of UV-B radiation on UVR8 and ROS signaling pathways, antioxidant system, and wax synthesis in Glycyrrhiza uralensis. Results showed that the plant exhibited dynamic and ordered changes in response to enhanced UV-B radiation, indicating different strategies are employed during adaptation.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Editorial Material
Allergy
Athanasios Damialis, Stefanie Gilles, Claudia Traidl-Hoffmann
Editorial Material
Allergy
Kari C. Nadeau, Ioana Agache, Marek Jutel, Isabella Annesi Maesano, Mubeccel Akdis, Vanitha Sampath, Gennaro D'Amato, Lorenzo Cecchi, Claudia Traidl-Hoffmann, Cezmi A. Akdis
Article
Allergy
Ruth Karlina, Claudia Flexeder, Stephanie Musiol, Madhumita Bhattacharyya, Evelyn Schneider, Irem Altun, Silvia Gschwendtner, Avidan U. Neumann, Jana Nano, Michael Schloter, Annette Peters, Holger Schulz, Carsten B. Schmidt-Weber, Marie Standl, Claudia Traidl-Hoffmann, Francesca Alessandrini, Siegfried Ussar
Summary: The study found that asthma is associated with insulin resistance in humans, but challenges with house dust mites have opposing effects on glucose homeostasis in mice, due to increased energy expenditure, reduced adipose inflammation, and hepatosteatosis.
Article
Gastroenterology & Hepatology
Christoph Roemmele, Maria Kahn, Stephan Zellmer, Anna Muzalyova, Gertrud Hammel, Christina Bartenschlager, Albert Beyer, Jonas Rosendahl, Tilo Schlittenbauer, Johannes Zenk, Bilal Al-Nawas, Roland Frankenberger, Juergen Hoffmann, Christoph Arens, Frank Lammert, Claudia Traidl-Hoffmann, Helmut Messmann, Alanna Ebigbo
Summary: This study investigated the risk factors for SARS-CoV-2 infection among healthcare workers (HCWs) in medical disciplines with aerosol-generating procedures (AGP). The results showed that regions with higher incidence rates, hospital settings, and HCWs in gastrointestinal endoscopy (GIE) had a significantly increased risk of infection.
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2023)
Letter
Allergy
Zeinab Fneish, Jennifer Becker, Felix Mulenge, Bibiana Costa, Luise Krajewski, Veronica Duran, Annett Ziegler, Vivien Sommer, Claudia Traidl-Hoffmann, Stefanie Gilles, Ulrich Kalinke
Article
Environmental Sciences
Jose M. Maya-Manzano, Jose Oteros, Jesus Rojo, Claudia Traidl-Hoffmann, Carsten Schmidt-Weber, Jeroen Buters
Summary: This study investigated the drivers of pollen allergen potency and its variations in different locations and times. The findings suggest that factors such as meteorological parameters and inorganic pollutants can influence the pollen allergen potency, and the extent of allergen exposure can vary under different weather conditions.
ENVIRONMENTAL RESEARCH
(2022)
Article
Cell Biology
Julian Rapp, Malte Jung, Rhena F. U. Klar, Julian Wolf, Jakob Arnold, Oliver Gorka, Olaf Gross, Clemen Lange, Hansjurgen Agostini, Guenther Schlunck, Felicitas Bucher
Summary: Aberrant angiogenesis is a hallmark of cardiovascular and retinal neovascular disease. The STAT3 signaling pathway represents a potential pharmacological target for these diseases due to its impact on angiogenesis. However, the effects of STAT3 activation on angiogenesis vary depending on the specific cytokine.
JOURNAL OF CELL SCIENCE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ella Bachmann, Stephan Zellmer, Maria Kahn, Anna Muzalyova, Alanna Ebigbo, Bilal Al-Nawas, Thomas Ziebart, Axel Meisgeier, Claudia Traidl-Hoffmann, Fabian Eckstein, Helmut Messmann, Tilo Schlittenbauer, Christoph Rommele
Summary: The aim of this study was to provide an overview of the challenges faced by the oral and maxillofacial surgery (OMS) workforce during the COVID-19 pandemic. The survey conducted in OMS hospitals and private practices revealed higher infection rates among healthcare workers in private practices compared to clinics. The study also found that pre-interventional testing and the use of personal protective equipment varied between hospitals and private practices. The decrease in procedures and revenue had a greater impact on hospitals. The authors emphasize the need for future measures to adjust infrastructure in hospitals to prevent further strain on staff and finances.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2022)
Article
Dermatology
Luise Rauer, Matthias Reiger, Madhumita Bhattacharyya, Patrick M. M. Brunner, James G. G. Krueger, Emma Guttman-Yassky, Claudia Traidl-Hoffmann, Avidan U. U. Neumann
Summary: This study investigated the skin microbiome of 48 adult patients with moderate-to-severe atopic dermatitis (AD) and found that the diversity of the skin microbiome is associated with patients' demographic and clinical cofactors, as well as disease severity. Specifically, the relative abundance of Staphylococcus aureus and the evenness of the microbiome were associated with AD severity. These findings are important for the development of personalized treatments for AD.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Immunology
Ying-Yin Chao, Alisa Puhach, David Frieser, Mahima Arunkumar, Laurens Lehner, Thomas Seeholzer, Albert Garcia-Lopez, Marlot van der Wal, Silvia Fibi-Smetana, Axel Dietschmann, Thomas Sommermann, Tamara Cikovic, Leila Taher, Mark S. Gresnigt, Sebastiaan J. Vastert, Femke van Wijk, Gianni Panagiotou, Daniel Krappmann, Olaf Gross, Christina E. Zielinski
Summary: In this study, it was discovered that human T cells express GSDME, which is associated with durable viability and the release of IL-1 alpha. This property is only present in a subset of human helper type 17 T cells with specificity for Candida albicans, regulated by the T cell-intrinsic NLRP3 inflammasome. The release of IL-1 alpha is mediated by a proteolytic cascade involving caspase-8, caspase-3, and GSDME cleavage, as well as T cell receptor stimulation and calcium-licensed calpain maturation of pro-IL-1 alpha form. This finding expands our understanding of the functional diversity and mechanism of T cells and has implications for antifungal immunity.
Article
Cell Biology
Laura Griewahn, Madeleine Mueller-Foxworth, Lukas Peintner, Manuela Wissler, Martina Weiss, Prisca Brauns-Schubert, Ramin Massoumi, Christoph Borner, Olaf Gross, Monica Yabal, Celine Charvet, Ulrich Maurer
Summary: SPATA2 bridges the interaction between CYLD and HOIP, a component of the LUBAC, thereby mediating the recruitment of CYLD to immune receptor complexes. In addition, SPATA2 competes with OTULIN for binding to HOIP, promoting autoubiquitylation of LUBAC and attenuating pro-inflammatory signaling. These findings highlight the independent functions of SPATA2 and CYLD in immune regulation.
Article
Multidisciplinary Sciences
Anke Schumann, Marion Brutsche, Monique Havermans, Sarah C. Gruenert, Stefan Koelker, Olaf Gross, Luciana Hannibal, Ute Spiekerkoetter
Summary: Methylmalonic aciduria (MMA-uria) is a condition caused by a lack of the enzyme methylmalonyl-CoA mutase (MUT) in mitochondria. It affects energy generation from certain amino acids, fatty acids, and cholesterol. Chronic kidney disease (CKD) is a known complication of MMA-uria. Research has shown that MMA-uria cells have increased creatinine levels and decreased antioxidant defense. Mitochondrial homeostasis is disrupted, with changes in metabolites and impaired energy generation from fatty acid oxidation. Potentially toxic metabolite methylcitrate is increased under high protein and isoleucine/valine conditions. Mitophagy is disabled, while autophagy is active, especially under high protein and isoleucine/valine conditions. Mitochondrial dynamics shift towards fission and the stress-resistance protein Sirtuin1 is down-regulated. Overall, these findings highlight the role of protein toxicity and provide insight into how accumulating toxic organic acids may contribute to CKD in MMA-uria.
SCIENTIFIC REPORTS
(2023)
Article
Gastroenterology & Hepatology
Frances Winkler, Anna Hipp, Carlos Ramirez, Bianca Martin, Matteo Villa, Emilia Neuwirt, Oliver Gorka, Jeroen Aerssens, Susanne E. Johansson, Nisha Rana, Sian Llewellyn-Lacey, David A. Price, Marcus Panning, Olaf Gross, Erika L. Pearce, Carl M. Hermann, Kathrin Schumann, Luciana Hannibal, Christoph Neumann-Haefelin, Tobias Boettler, Percy Knolle, Maike Hofmann, Dirk Wohlleber, Robert Thimme, Bertram Bengsch
Summary: Exhausted T cells with limited function are common in chronic HBV and HCV infection, but the relationship between metabolism and exhaustion states, the impact of antiviral therapy, and the role of metabolic checkpoints in dysfunction are not fully understood.
Article
Gastroenterology & Hepatology
Christoph Roemmele, Maria Kahn, Stephan Zellmer, Anna Muzalyova, Gertrud Hammel, Christina Bartenschlager, Albert Beyer, Jonas Rosendahl, Tilo Schlittenbauer, Johannes Zenk, Bilal Al-Nawas, Roland Frankenberger, Juergen Hoffmann, Christoph Arens, Frank Lammert, Claudia Traidl-Hoffmann, Helmut Messmann, Alanna Ebigbo
Summary: Healthcare workers (HCWs) have a high risk of SARS-CoV-2 infection, especially during aerosol-generating procedures (AGP). This study found that regions with higher incidence rates, hospital settings, and HCWs in gastrointestinal endoscopy (GIE) had a significantly increased risk of infection.
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2023)
Article
Biochemical Research Methods
Philipp Aktories, Philippe Petry, Paulo Glatz, Geoffroy Andrieux, Alexander Oschwald, Hannah Botterer, Oliver Gorka, Daniel Erny, Melanie Boerries, Philipp Henneke, Olaf Gross, Marco Prinz, Katrin Kierdorf
Summary: This study established an organotypic primary cell culture protocol that can obtain long-term monocultures of macrophages without prior purification, and largely maintain a TRM-like identity in vitro.
CELL REPORTS METHODS
(2022)
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)
