标题
The interaction of SET and protein phosphatase 2A as target for cancer therapy
作者
关键词
SET, PP2A, I2PP2A, Targeted therapy, Cancer therapies, Protein-protein interaction, Phosphatase, Kinase
出版物
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Volume 1876, Issue 1, Pages 188578
出版商
Elsevier BV
发表日期
2021-06-09
DOI
10.1016/j.bbcan.2021.188578
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Isoliensinine: A Natural Compound with “Drug-Like” Potential
- (2021) Yan Cheng et al. Frontiers in Pharmacology
- The Function of NM23-H1/NME1 and Its Homologs in Major Processes Linked to Metastasis
- (2020) Barbara Mátyási et al. PATHOLOGY & ONCOLOGY RESEARCH
- A new regulatory mechanism of protein phosphatase 2A activity via SET in acute myeloid leukemia
- (2020) Elena Arriazu et al. Blood Cancer Journal
- Synergic effect of OP449 and FTY720 on oral squamous cell carcinoma
- (2020) Renata Nishida Goto et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Targeting SET to restore PP2A activity disrupts an oncogenic CIP2A-feedforward loop and impairs triple negative breast cancer progression
- (2019) Chun-Yu Liu et al. EBioMedicine
- SET protein accumulation prevents cell death in head and neck squamous cell carcinoma through regulation of redox state and autophagy
- (2019) Amanda Tomie Ouchida et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Deregulation of SET is Associated with Tumor Progression and Predicts Adverse Outcome in Patients with Early-Stage Colorectal Cancer
- (2019) Ion Cristóbal et al. Journal of Clinical Medicine
- Protocadherin 7 is overexpressed in castration resistant prostate cancer and promotes aberrant MEK and AKT signaling
- (2019) Gauri Shishodia et al. PROSTATE
- A novel FTY720 analogue targets SET-PP2A interaction and inhibits growth of acute myeloid leukemia cells without inducing cardiac toxicity
- (2019) Carmen Vicente et al. CANCER LETTERS
- Non-genomic mechanisms of protein phosphatase 2A (PP2A) regulation in cancer
- (2018) Otto Kauko et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Antagonizing SET augments the effects of radiotherapy in hepatocellular carcinoma through reactivating PP2A-mediated AKT downregulation
- (2018) Chao-Yuan Huang et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis
- (2018) Shuhei Enjoji et al. MOLECULAR CANCER RESEARCH
- A comprehensive and perspective view of oncoprotein SET in cancer
- (2018) Buuvee Bayarkhangai et al. Cancer Medicine
- p53 Function is Compromised by Inhibitor 2 of Phosphatase 2A in Sonic Hedgehog Medulloblastoma
- (2018) Yun Wei et al. MOLECULAR CANCER RESEARCH
- SET Overexpression is Associated with Worse Recurrence-Free Survival in Patients with Primary Breast Cancer Receiving Adjuvant Tamoxifen Treatment
- (2018) Yu-Hsiang Huang et al. Journal of Clinical Medicine
- SET alpha and SET beta mRNA isoforms in chronic lymphocytic leukaemia
- (2018) Danielle M. Brander et al. BRITISH JOURNAL OF HAEMATOLOGY
- EGFR-independent Elk1/CIP2A signalling mediates apoptotic effect of an erlotinib derivative TD52 in triple-negative breast cancer cells
- (2017) Chun-Yu Liu et al. EUROPEAN JOURNAL OF CANCER
- Identification of PP2A/Set Binding Sites and Design of Interacting Peptides with Potential Clinical Applications
- (2017) Lu Tian et al. International Journal of Peptide Research and Therapeutics
- Overexpression of SET oncoprotein is associated with tumor progression and poor prognosis in human gastric cancer
- (2017) Xiaoning Yuan et al. ONCOLOGY REPORTS
- SET contributes to the epithelial-mesenchymal transition of pancreatic cancer
- (2017) Hardik R. Mody et al. Oncotarget
- PROTOCADHERIN 7 Acts through SET and PP2A to Potentiate MAPK Signaling by EGFR and KRAS during Lung Tumorigenesis
- (2016) Xiaorong Zhou et al. CANCER RESEARCH
- SET protein overexpression contributes to paclitaxel resistance in MCF-7/S cells through PI3K/Akt pathway
- (2016) Weipeng Zhang et al. JOURNAL OF DRUG TARGETING
- Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode
- (2016) Donglai Wang et al. NATURE
- Upregulation of the oncoprotein SET determines poor clinical outcomes in hepatocellular carcinoma and shows therapeutic potential
- (2016) M-H Hung et al. ONCOGENE
- A Comprehensive Review on Chemical Profiling ofNelumbo Nucifera: Potential for Drug Development
- (2016) Bhesh Raj Sharma et al. PHYTOTHERAPY RESEARCH
- Isoliensinine induces dephosphorylation of NF-kB p65 subunit at Ser536 via a PP2A-dependent mechanism in hepatocellular carcinoma cells: roles of impairing PP2A/I2PP2A interaction
- (2016) Guangwen Shu et al. Oncotarget
- MYC-dependent recruitment of RUNX1 and GATA2 on the SET oncogene promoter enhances PP2A inactivation in acute myeloid leukemia
- (2016) Raffaella Pippa et al. Oncotarget
- Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia
- (2016) Nameeta P. Richard et al. Oncotarget
- Potential role for inhibition of protein phosphatase 2A tumor suppressor in salivary gland malignancies
- (2015) Johannes Routila et al. GENES CHROMOSOMES & CANCER
- CIP2A high expression is a poor prognostic factor in normal karyotype acute myeloid leukemia
- (2015) E. Barragan et al. HAEMATOLOGICA
- Isoliensinine, a Bioactive Alkaloid Derived from Embryos of Nelumbo nucifera, Induces Hepatocellular Carcinoma Cell Apoptosis through Suppression of NF-κB Signaling
- (2015) Guangwen Shu et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Eviction of linker histone H1 by NAP-family histone chaperones enhances activated transcription
- (2015) Qian Zhang et al. Epigenetics & Chromatin
- SET antagonist enhances the chemosensitivity of non-small cell lung cancer cells by reactivating protein phosphatase 2A
- (2015) Man-Hsin Hung et al. Oncotarget
- Overexpression of PP2A inhibitor SET oncoprotein is associated with tumor progression and poor prognosis in human non-small cell lung cancer
- (2015) Hao Liu et al. Oncotarget
- Discovery of a small molecule targeting SET-PP2A interaction to overcome BCR-ABLT315I mutation of chronic myeloid leukemia
- (2015) Shuzhen Wang et al. Oncotarget
- Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis
- (2015) Xiaoyong Hu et al. Scientific Reports
- A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation
- (2015) Guang Yang et al. Cell Reports
- CIP2A high expression is a poor prognostic factor in normal karyotype acute myeloid leukemia
- (2015) E. Barragan et al. HAEMATOLOGICA
- SET-mediated NDRG1 inhibition is involved in acquisition of epithelial-to-mesenchymal transition phenotype and cisplatin resistance in human lung cancer cell
- (2014) Hao Liu et al. CELLULAR SIGNALLING
- Deregulation of the PP2A Inhibitor SET Shows Promising Therapeutic Implications and Determines Poor Clinical Outcome in Patients with Metastatic Colorectal Cancer
- (2014) I. Cristobal et al. CLINICAL CANCER RESEARCH
- 67-kDa Laminin Receptor-dependent Protein Phosphatase 2A (PP2A) Activation Elicits Melanoma-specific Antitumor Activity Overcoming Drug Resistance
- (2014) Shuntaro Tsukamoto et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models
- (2014) Lays M Sobral et al. Molecular Cancer
- Targeting Inhibitors of the Tumor Suppressor PP2A for the Treatment of Pancreatic Cancer
- (2014) Amy S. Farrell et al. MOLECULAR CANCER RESEARCH
- Targeting c-MYC by antagonizing PP2A inhibitors in breast cancer
- (2014) M. Janghorban et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies
- (2013) J. J. Oaks et al. BLOOD
- Inhibition of Ku70 acetylation by INHAT subunit SET/TAF-Iβ regulates Ku70-mediated DNA damage response
- (2013) Kee-Beom Kim et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells
- (2013) Paolo Neviani et al. JOURNAL OF CLINICAL INVESTIGATION
- Ser9 phosphorylation causes cytoplasmic detention of I2PP2A/SET in Alzheimer disease
- (2013) Guang Yu et al. NEUROBIOLOGY OF AGING
- Sorafenib and pemetrexed toxicity in cancer cells is mediated via SRC-ERK signaling
- (2012) M. Danielle Bareford et al. CANCER BIOLOGY & THERAPY
- Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis
- (2012) Sahar A. Saddoughi et al. EMBO Molecular Medicine
- SET protein accumulates in HNSCC and contributes to cell survival: Antioxidant defense, Akt phosphorylation and AVOs acidification
- (2012) Andréia M. Leopoldino et al. ORAL ONCOLOGY
- Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2PP2A/SET
- (2011) Lisette Arnaud et al. FEBS LETTERS
- Overexpression of SET is a recurrent event associated with poor outcome and contributes to protein phosphatase 2A inhibition in acute myeloid leukemia
- (2011) I. Cristobal et al. HAEMATOLOGICA
- Apolipoprotein E and Peptide Mimetics Modulate Inflammation by Binding the SET Protein and Activating Protein Phosphatase 2A
- (2011) D. J. Christensen et al. JOURNAL OF IMMUNOLOGY
- Targeting SET/I2PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy
- (2011) C H Switzer et al. ONCOGENE
- Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis
- (2010) Jeffrey A. Cohen et al. NEW ENGLAND JOURNAL OF MEDICINE
- Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling
- (2008) Archana Mukhopadhyay et al. FASEB JOURNAL
- Characterization of Ser338Phosphorylation for Raf-1 Activation
- (2008) Mengwei Zang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Is NF-κB a good target for cancer therapy? Hopes and pitfalls
- (2008) Véronique Baud et al. NATURE REVIEWS DRUG DISCOVERY
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