Conformational plasticity of the ULK3 kinase domain

Nucleotide Binding, Evolutionary Insights, and Interaction Partners of the Pseudokinase Unc-51-like Kinase 4

(2020) Franziska Preuss et al.   STRUCTURE

Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer

(2020) Huiyu Ren et al.   JOURNAL OF MEDICINAL CHEMISTRY

Idea2Data: Toward a New Paradigm for Drug Discovery

(2019) Christos A. Nicolaou et al.   ACS Medicinal Chemistry Letters

Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2)

(2019) Apirat Chaikuad et al.   BIOCHEMICAL JOURNAL

The PSIPRED Protein Analysis Workbench: 20 years on

(2019) Daniel W A Buchan et al.   NUCLEIC ACIDS RESEARCH

Phosphorylation of Ci/Gli by Fused Family Kinases Promotes Hedgehog Signaling

(2019) Yuhong Han et al.   DEVELOPMENTAL CELL

Structural Characterization of the Aurora Kinase B “DFG-flip” Using Metadynamics

(2019) Naga Rajiv Lakkaniga et al.   AAPS Journal

High-Resolution Structure and Inhibition of the Schizophrenia-Linked Pseudokinase ULK4

(2019) Susmita Khamrui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemoproteomics and Chemical Probes for Target Discovery

(2018) Gerard Drewes et al.   TRENDS IN BIOTECHNOLOGY

Structures, Functions, and Dynamics of ESCRT-III/Vps4 Membrane Remodeling and Fission Complexes

(2018) John McCullough et al.   Annual Review of Cell and Developmental Biology

Millisecond dynamics of BTK reveal kinome-wide conformational plasticity within the apo kinase domain

(2017) Mohammad M. Sultan et al.   Scientific Reports

Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib

(2016) Sebastian Mathea et al.   ACS Chemical Biology

Atg1-independent induction of autophagy by theDrosophilaUlk3 homolog, ADUK

(2016) Christopher R. Braden et al.   FEBS Journal

ESCRT-III and Vps4: a dynamic multipurpose tool for membrane budding and scission

(2016) Manuel Alonso Y Adell et al.   FEBS Journal

Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors

(2015) Michael B. Lazarus et al.   ACS Chemical Biology

Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1

(2015) Michael B. Lazarus et al.   BIOORGANIC & MEDICINAL CHEMISTRY

ESCRTs are everywhere

(2015) J. H. Hurley   EMBO JOURNAL

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins

(2015) Anna Caballe et al.   eLife

Protein kinase inhibitor SU6668 attenuates positive regulation of Gli proteins in cancer and multipotent progenitor cells

(2014) Alla Piirsoo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The ULK1 complex

(2013) Pui-Mun Wong et al.   Autophagy

Genome-wide association uncovers shared genetic effects among personality traits and mood states

(2012) Michelle Luciano et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors

(2012) Timothy Forsyth et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural and Spectroscopic Analysis of the Kinase Inhibitor Bosutinib and an Isomer of Bosutinib Binding to the Abl Tyrosine Kinase Domain

(2012) Nicholas M. Levinson et al.   PLoS One

A Novel, Selective Inhibitor of Fibroblast Growth Factor Receptors That Shows a Potent Broad Spectrum of Antitumor Activity in Several Tumor Xenograft Models

(2011) G. Zhao et al.   MOLECULAR CANCER THERAPEUTICS

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Blood Pressure and Hypertension Are Associated With 7 Loci in the Japanese Population

(2010) Fumihiko Takeuchi et al.   CIRCULATION

Dual Function of UNC-51-like Kinase 3 (Ulk3) in the Sonic Hedgehog Signaling Pathway

(2010) Alla Maloverjan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein kinases: evolution of dynamic regulatory proteins

(2010) Susan S. Taylor et al.   TRENDS IN BIOCHEMICAL SCIENCES

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

xia2: an expert system for macromolecular crystallography data reduction

(2009) G. Winter   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Genome-wide association study of blood pressure and hypertension

(2009) Daniel Levy et al.   NATURE GENETICS