Irs2 deficiency alters hippocampus-associated behaviors during young adulthood

A discrete neuronal circuit induces a hibernation-like state in rodents

(2020) Tohru M. Takahashi et al.   NATURE

Transient Receptor Potential Vanilloid 4 Channels are Important Regulators of Parenchymal Arteriole Dilation and Cognitive Function

(2019) Janice M. Diaz‐Otero et al.   MICROCIRCULATION

Global Metabolic Shifts in Age and Alzheimer’s Disease Mouse Brains Pivot at NAD +/NADH Redox Sites

(2019) Yue Dong et al.   JOURNAL OF ALZHEIMERS DISEASE

Gut microbiota manipulation through probiotics oral administration restores glucose homeostasis in a mouse model of Alzheimer's disease

(2019) Laura Bonfili et al.   NEUROBIOLOGY OF AGING

Serine Phosphorylation of IRS1 Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD

(2019) Wei Wang et al.   Nutrients

Metformin treatment ameliorates diabetes-associated decline in hippocampal neurogenesis and memory via phosphorylation of insulin receptor substrate 1

(2018) Daisuke Tanokashira et al.   FEBS Open Bio

Diabetes is Not Associated with Alzheimer’s Disease Neuropathology

(2017) Maria Niures Pimentel dos Santos Matioli et al.   JOURNAL OF ALZHEIMERS DISEASE

Thermoregulatory disorders and illness related to heat and cold stress

(2016) William P. Cheshire   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Hyperglycemia and Diabetes Downregulate the Functional Expression of TRPV4 Channels in Retinal Microvascular Endothelium

(2015) Kevin Monaghan et al.   PLoS One

High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice

(2014) Steven E. Arnold et al.   NEUROBIOLOGY OF DISEASE

TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis

(2012) Li Ye et al.   CELL

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Brain Deletion of Insulin Receptor Substrate 2 Disrupts Hippocampal Synaptic Plasticity and Metaplasticity

(2012) Derek A. Costello et al.   PLoS One

IRS-2 Deficiency Impairs NMDA Receptor-Dependent Long-term Potentiation

(2011) Eduardo D. Martín et al.   CEREBRAL CORTEX

Insulin receptor substrate 2 is a negative regulator of memory formation

(2011) E. E. Irvine et al.   LEARNING & MEMORY

Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease

(2010) Dimitrios Kapogiannis et al.   LANCET NEUROLOGY

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

(2009) Richard Killick et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neuronal IGF-1 resistance reduces Aβ accumulation and protects against premature death in a model of Alzheimer’s disease

(2009) Susanna Freude et al.   FASEB JOURNAL

Catecholamine Regulation of Local Lactate Productionin Vivoin Skeletal Muscle and Adipose Tissue: Role of β-Adrenoreceptor Subtypes

(2007) Veronica Qvisth et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM